Sonja Ständer

Summary

Country: Germany

Publications

  1. doi request reprint Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients
    Nils Weigelt
    Department of Dermatology, Neurodermatology and Competence Center Pruritus, University of Munster, Munster, Germany
    J Cutan Pathol 37:578-86. 2010
  2. doi request reprint Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study
    Sonja Ständer
    Department of Dermatology, Clinical Neurodermatology, University of Munster, Munster, Germany
    Acta Derm Venereol 89:45-51. 2009
  3. ncbi request reprint Putative neuronal mechanisms of sensitive skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Exp Dermatol 18:417-23. 2009
  4. ncbi request reprint Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
  5. ncbi request reprint Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    Sonja Ständer
    Department of Dermatology, University Hospital Munster, Germany
    J Dermatol Sci 38:177-88. 2005
  6. ncbi request reprint Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
  7. doi request reprint Chronic pruritus: targets, mechanisms and future therapies
    Esther Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care, Competence Center for the Diagnostic and Therapy of Chronic Pruritus, University of Munster, Munster, Germany
    Drug News Perspect 21:541-51. 2008
  8. ncbi request reprint Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    J Biol Chem 279:6959-66. 2004
  9. ncbi request reprint Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
  10. ncbi request reprint Itch in atopic dermatitis - pathophysiology and treatment
    Sonja Ständer
    Department of Dermatology, Competence Center Pruritus, University of Munster, Germany
    Acta Dermatovenerol Croat 18:289-96. 2010

Collaborators

Detail Information

Publications43

  1. doi request reprint Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients
    Nils Weigelt
    Department of Dermatology, Neurodermatology and Competence Center Pruritus, University of Munster, Munster, Germany
    J Cutan Pathol 37:578-86. 2010
    ..To date, there has been no systematic investigation of the detailed histological features of prurigo nodularis (PN) in a large cohort of patients...
  2. doi request reprint Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study
    Sonja Ständer
    Department of Dermatology, Clinical Neurodermatology, University of Munster, Munster, Germany
    Acta Derm Venereol 89:45-51. 2009
    ..This should be confirmed in future double-blind studies...
  3. ncbi request reprint Putative neuronal mechanisms of sensitive skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Exp Dermatol 18:417-23. 2009
    ..Furthermore, we discuss the role of neurotrophins and the influence of stress on sensitive skin...
  4. ncbi request reprint Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
    ..After cessation of capsaicin therapy, neuropeptides re-accumulated in skin nerves. In conclusion, VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation...
  5. ncbi request reprint Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    Sonja Ständer
    Department of Dermatology, University Hospital Munster, Germany
    J Dermatol Sci 38:177-88. 2005
    ..Cannabinoid receptors mediate the psychopharmacological action of marijuana and have been localized in the central and peripheral nervous system as well as on cells of the immune system...
  6. ncbi request reprint Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
    ..Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines...
  7. doi request reprint Chronic pruritus: targets, mechanisms and future therapies
    Esther Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care, Competence Center for the Diagnostic and Therapy of Chronic Pruritus, University of Munster, Munster, Germany
    Drug News Perspect 21:541-51. 2008
    ..The present review aims to provide an overview of current neurophysiological and neurochemical therapeutic models in chronic pruritus...
  8. ncbi request reprint Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    J Biol Chem 279:6959-66. 2004
    ..Melanocortins such as alpha-MSH may therefore represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders...
  9. ncbi request reprint Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
    ..In conclusion, preserved MC-1R expression in adnexal epithelia suggests a functional role of proopiomelanocortin (POMC) in various malformations and neoplasms of the skin...
  10. ncbi request reprint Itch in atopic dermatitis - pathophysiology and treatment
    Sonja Ständer
    Department of Dermatology, Competence Center Pruritus, University of Munster, Germany
    Acta Dermatovenerol Croat 18:289-96. 2010
    ..The new findings suggest that target-specific therapies are most likely to control atopic dermatitis itch. To date, only few therapies are available and controlled studies are pending...
  11. ncbi request reprint Neurophysiology of pruritus: cutaneous elicitation of itch
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:1463-70. 2003
    ..This review focuses on the peripheral generation of itch, including neurotransmitters, neuropeptides, and inflammatory mediators...
  12. ncbi request reprint Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Regul Pept 110:75-83. 2002
    ..Together, our findings contribute to the understanding of the high antipruritic potency of opioid receptor antagonists in various skin and systemic diseases...
  13. doi request reprint Evaluation of the Antipruritic Effects of Topical Pimecrolimus in Non-Atopic Prurigo Nodularis: Results of a Randomized, Hydrocortisone-Controlled, Double-Blind Phase II Trial
    Dorothee Siepmann
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital of Munster, Munster, Germany
    Dermatology 227:353-60. 2013
    ..However, a significant advantage of pimecrolimus over hydrocortisone was not found. Conclusion: The results suggest that the non-steroid pimecrolimus is an effective alternative for PN treatment. © 2013 S. Karger AG, Basel. ..
  14. ncbi request reprint Modern aspects of cutaneous neurogenic inflammation
    Martin Steinhoff
    Department of Dermatology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Arch Dermatol 139:1479-88. 2003
    ..Understanding the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases...
  15. doi request reprint Pruritus assessment in clinical trials: consensus recommendations from the International Forum for the Study of Itch (IFSI) Special Interest Group Scoring Itch in Clinical Trials
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital of Münster Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 93:509-14. 2013
    ..This paper presents our current recommendations. The set of measures we recommend includes pruritus intensity scales, instruments for assessment of scratch lesions, chronic pruritus course, quality of life and patient benefits. ..
  16. doi request reprint Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
    Georgeta Bocheva
    University of Munster, Munster, Germany
    J Invest Dermatol 129:1816-23. 2009
    ..In conclusion, our results suggest that PAR(2) is a substrate for matriptase in human skin in vivo. Deregulation of these proteins delineates SCC progression...
  17. ncbi request reprint Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis
    Anke Rattenholl
    Department of Dermatology and Interdisciplinary Center for Clinical Research IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 127:2245-52. 2007
    ..Thus, our results provide early experimental evidence for a tumor-protective role of PAR(2)...
  18. doi request reprint Pathogenesis of pruritus
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University of Munster, Germany
    J Dtsch Dermatol Ges 9:456-63. 2011
    ..For example, kappa-opioid receptor agonists and neurokinin-1 antagonists have been found to relieve chronic pruritus...
  19. pmc Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers
    Astrid Stumpf
    Department of Psychosomatics and Psychotherapy, University of Muenster, Muenster, Germany
    PLoS ONE 8:e79123. 2013
    ..To our knowledge, this is the first fMRI study examining sex differences in perception and its modulation by distraction...
  20. doi request reprint Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review
    Ngoc Quan Phan
    Competence Center for Chronic Pruritus, Department of Dermatology, University Hospital, Munster, Germany
    Acta Derm Venereol 92:555-60. 2012
    ..The aim of this review is to provide an overview of the promising role of kappa- opioid receptors and their agonist in the pathophysiology and treatment of pruritus...
  21. doi request reprint Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus
    Ngoc Quan Phan
    Competence Center for Chronic Pruritus, Department of Dermatology, University Hospital, Munster, Germany
    Acta Derm Venereol 92:502-7. 2012
    ..In conclusion, high reliability and concurrent validity was found for VAS, NRS and VRS. On re-test, higher correlation and less missing values were observed. A training session before starting a clinical trial is recommended...
  22. doi request reprint Notalgia paraesthetica: a descriptive two-cohort study of 65 patients from Brazil and Germany
    Timo Huesmann
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital Munster, Germany
    Acta Derm Venereol 92:535-40. 2012
    ..7% of the involved areas. The significant reduction in intraepidermal nerve fiber density suggests that damage to the peripheral nerves is a more important aetiological factor than spinal changes in notalgia paraesthetica...
  23. ncbi request reprint Underlying diseases and co-factors in patients with severe chronic pruritus: a 3-year retrospective study
    Franz Sommer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Germany
    Acta Derm Venereol 87:510-6. 2007
    ..In conclusion, patients with chronic pruritus present a inhomgeneous collective with different underlying diseases, including malignancy, necessitating thorough investigation...
  24. pmc Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy
    Sonja Ständer
    Department of Dermatology, Neurodermatology and Competence Center Pruritus, University of Munster, Munster, Germany
    PLoS ONE 5:e10968. 2010
    ..Substance P (SP) is a major mediator of pruritus. As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus...
  25. doi request reprint Medical treatment of pruritus
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital Munster, Germany
    Expert Opin Emerg Drugs 17:335-45. 2012
    ..However, research on pruritus has been disregarded for a long time, most likely because pruritus used to be considered as a subtype of pain...
  26. doi request reprint Antipruritic treatment with systemic μ-opioid receptor antagonists: a review
    Ngoc Quan Phan
    Competence Center Pruritus, Department of Dermatology, University Hospital Munster, Munster, Germany
    J Am Acad Dermatol 63:680-8. 2010
    ..We will also evaluate recommendations for the use of MORA in daily medical practice...
  27. ncbi request reprint IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Immunol 176:2896-901. 2006
    ..Though being primarily a proinflammatory cytokine through this capacity, IL-18 can also foster an immune response that is suppressed by UV radiation...
  28. ncbi request reprint Neurophysiological and neurochemical basis of modern pruritus treatment
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Muenster, Muenster, Germany
    Exp Dermatol 17:161-9. 2008
    ..In summary, these recent developments show that highlighting the basis of pruritus offers modern neurophysiological and neurochemical therapeutic models and the possibility to treat patients with refractory itching of different origin...
  29. ncbi request reprint Clinical classification of itch: a position paper of the International Forum for the Study of Itch
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 87:291-4. 2007
    ..It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care...
  30. ncbi request reprint [Pruritus--pathophysiology, clinical features and therapy--an overview]
    Sonja Ständer
    Universitäts Hautklinik Münster
    J Dtsch Dermatol Ges 1:105-18. 2003
    ..These observations led to the development of new therapeutic modalities. This paper gives an overview of itch pathophysiology, clinical types and therapies...
  31. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed in normal skin and cutaneous inflammatory diseases, but not in chronically UV-exposed skin and non-melanoma skin cancer
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University Clinics Münster, Munster, Germany
    Am J Dermatopathol 27:116-21. 2005
    ..Down-regulation of TRAIL might represent another example of a natural protection mechanism that is eliminated by chronic UV exposure...
  32. ncbi request reprint [Pruritus--symptom of both skin and systemic diseases]
    Sonja Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    MMW Fortschr Med 147:44-6. 2005
    ..Treatment is directed initially to the underlying illness, and both topical and systemic antipruritic medications are available as flanking measures...
  33. ncbi request reprint [Erythrokeratodermia variabilis (EKV)--a disorder due to altered epidermal expression of gap junction proteins]
    Sonja Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 3:354-8. 2005
    ..The mutation in connexin 31 is regarded therefore as causal for the clinical picture of the EKV. The unique upregulation of connexin 43 may occur as a consequence of the Cx31 mutation and temporarily compensate for this defect...
  34. doi request reprint Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia
    Ngoc Quan Phan
    Competence Center for the Diagnosis and Treatment of Pruritus, Clinic and Polyclinic for Skin Diseases, University Hospital of Munster, Germany
    J Dtsch Dermatol Ges 8:88-91. 2010
    ..These nerves express cannabinoid receptors which exert a role in modulation of nociceptive symptoms. Therefore, topical therapy with cannabinoid receptor agonist seems likely to suppress local burning pain...
  35. doi request reprint The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation
    Krisztián Gáspár
    Department of Dermatology, University Hospital, Duesseldorf, Germany
    J Dermatol Sci 71:12-21. 2013
    ..Recent studies provided insights into the recruitment and activation pathways of leukocytes in atopic dermatitis, however, the underlying mechanisms of tissue remodeling in atopic skin inflammation remain elusive...
  36. ncbi request reprint Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Eur J Immunol 34:2022-31. 2004
    ..Together, our results show that overexpression of IL-15 in the epidermis enhances both innate and adaptive cutaneous immunity...
  37. ncbi request reprint Chronic itch and pain--similarities and differences
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Eur J Pain 10:473-8. 2006
    ..Finally, itch and pain exhibit corresponding patterns of central sensitization. The knowledge of antagonistic interaction, but also of similar sensitization processes has major implication for antipruritic therapeutic approaches...
  38. doi request reprint Antipruritic effect of cyclosporine microemulsion in prurigo nodularis: results of a case series
    Dorothee Siepmann
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Munster, Germany
    J Dtsch Dermatol Ges 6:941-6. 2008
    ..The aim of this investigation was to assess the antipruritic efficiency of cyclosporine ME in therapy of prurigo nodularis...
  39. ncbi request reprint Modulation of cutaneous inflammation by angiotensin-converting enzyme
    Thomas E Scholzen
    Ludwig Boltzmann Institute of Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Immunol 170:3866-73. 2003
    ....
  40. doi request reprint Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects
    Gudrun Schneider
    Department of Psychosomatics and Psychotherapy, University of Munster, Domagkstr 22, D 48149 Munster, Germany
    Eur J Pain 12:834-41. 2008
    ....
  41. ncbi request reprint Pathophysiology of pruritus in atopic dermatitis: an overview
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:12-24. 2002
    ..This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD...
  42. doi request reprint Keratoacanthoma with perineural invasion: an indicator for aggressive behavior?
    Yasmin Basoglu
    Department of Dermatology, University of Munster, Munster, Germany
    J Dtsch Dermatol Ges 6:952-5. 2008
    ..Our case suggests that perineural invasion may be an indicator for aggressive growth of head-and-neck KAs so that histologically-controlled excision is recommended...
  43. ncbi request reprint Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 118:533-9. 2002
    ..By modulating interleukin-8 secretion, alpha-melanocyte-stimulating hormone may act as a modulator of inflammatory responses in the pilosebaceous unit...