Sonja Ständer

Summary

Country: Germany

Publications

  1. ncbi request reprint Hydroxyethyl starch-induced pruritus: clinical characteristics and influence of dose, molecular weight and substitution
    Sonja Ständer
    Department of Dermatology and Competence Center Chronic Pruritus KCP, University Hospital of Munster, Von Esmarch Str 58, DE 48149 Münster, Germany
    Acta Derm Venereol 94:282-7. 2014
  2. doi request reprint Pruritus assessment in clinical trials: consensus recommendations from the International Forum for the Study of Itch (IFSI) Special Interest Group Scoring Itch in Clinical Trials
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital of Münster Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 93:509-14. 2013
  3. ncbi request reprint [Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a review]
    S Ständer
    Kompetenzzentrum Chronischer Pruritus KCP, Klinik für Hautkrankheiten, Universitatsklinikum Munster, Von Esmarch Str 58, 48149 Munster, Deutschland
    Hautarzt 64:611-22; quiz 623-4. 2013
  4. doi request reprint Gender differences in chronic pruritus: women present different morbidity, more scratch lesions and higher burden
    S Ständer
    Competence Centre Chronic Pruritus, Department of Dermatology, University Hospital of Munster, Albert Schweitzer Campus 1, D 48149, Munster, Germany
    Br J Dermatol 168:1273-80. 2013
  5. ncbi request reprint Medical treatment of pruritus
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital Munster, Germany
    Expert Opin Emerg Drugs 17:335-45. 2012
  6. doi request reprint [Assessment of pruritus - current standards and implications for clinical practice : consensus paper of the Action Group Pruritus Parameter of the International Working Group on Pruritus Research (AGP)]
    S Ständer
    Klinik für Hautkrankheiten und Kompetenzzentrum Chronischer Pruritus, Universitatsklinikum Munster, Deutschland
    Hautarzt 63:521-2, 524-31. 2012
  7. ncbi request reprint Chronic pruritus
    S Ständer
    Department of Dermatology, Competence Center Chronic Pruritus, University Hospital Munster, Munster, Germany
    G Ital Dermatol Venereol 147:161-9. 2012
  8. ncbi request reprint [Chronic pruritus: principals of diagnostics and therapy]
    S Ständer
    Klinik und Poliklinik für Hautkrankheiten, Klinische Neurodermatologie, Universitatsklinikum Munster, Von Esmarchstrasse 58, 48149 Munster, Germany
    Hautarzt 58:627-36; quiz 637. 2007
  9. ncbi request reprint Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin
    S Ständer
    Department of Dermatology and Boltzmann Institute for Immuno and Cell Biology of the Skin, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Br J Dermatol 156:1020-6. 2007
  10. ncbi request reprint [Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus]
    S Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster, Von Esmarchstrasse 58, 48149 Munster
    Hautarzt 57:801-7. 2006

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Hydroxyethyl starch-induced pruritus: clinical characteristics and influence of dose, molecular weight and substitution
    Sonja Ständer
    Department of Dermatology and Competence Center Chronic Pruritus KCP, University Hospital of Munster, Von Esmarch Str 58, DE 48149 Münster, Germany
    Acta Derm Venereol 94:282-7. 2014
    ..There were no significant differences between HES 130/0.4 and HES 200/0.5 in pruritus latency, duration or severity. HES-induced pruritus thus may occur at any dose, molecular weight or substitution...
  2. doi request reprint Pruritus assessment in clinical trials: consensus recommendations from the International Forum for the Study of Itch (IFSI) Special Interest Group Scoring Itch in Clinical Trials
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital of Münster Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 93:509-14. 2013
    ..This paper presents our current recommendations. The set of measures we recommend includes pruritus intensity scales, instruments for assessment of scratch lesions, chronic pruritus course, quality of life and patient benefits. ..
  3. ncbi request reprint [Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a review]
    S Ständer
    Kompetenzzentrum Chronischer Pruritus KCP, Klinik für Hautkrankheiten, Universitatsklinikum Munster, Von Esmarch Str 58, 48149 Munster, Deutschland
    Hautarzt 64:611-22; quiz 623-4. 2013
    ..Although or even because DRESS represents a diagnostic challenge, detailed knowledge about this disease is of utmost importance to enable early therapeutic actions...
  4. doi request reprint Gender differences in chronic pruritus: women present different morbidity, more scratch lesions and higher burden
    S Ständer
    Competence Centre Chronic Pruritus, Department of Dermatology, University Hospital of Munster, Albert Schweitzer Campus 1, D 48149, Munster, Germany
    Br J Dermatol 168:1273-80. 2013
    ..Although sex and gender are increasingly perceived as important factors in medicine, there is only very little knowledge on these issues in patients with chronic pruritus (CP)...
  5. ncbi request reprint Medical treatment of pruritus
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital Munster, Germany
    Expert Opin Emerg Drugs 17:335-45. 2012
    ..However, research on pruritus has been disregarded for a long time, most likely because pruritus used to be considered as a subtype of pain...
  6. doi request reprint [Assessment of pruritus - current standards and implications for clinical practice : consensus paper of the Action Group Pruritus Parameter of the International Working Group on Pruritus Research (AGP)]
    S Ständer
    Klinik für Hautkrankheiten und Kompetenzzentrum Chronischer Pruritus, Universitatsklinikum Munster, Deutschland
    Hautarzt 63:521-2, 524-31. 2012
    ..Additional methodological developments and studies are required in order to define a robust set of instruments for measuring pruritus in daily practice and in clinical studies...
  7. ncbi request reprint Chronic pruritus
    S Ständer
    Department of Dermatology, Competence Center Chronic Pruritus, University Hospital Munster, Munster, Germany
    G Ital Dermatol Venereol 147:161-9. 2012
    ..The antipruritic therapy is still based on symptomatic regimens and target-specific therapies urgently needed...
  8. ncbi request reprint [Chronic pruritus: principals of diagnostics and therapy]
    S Ständer
    Klinik und Poliklinik für Hautkrankheiten, Klinische Neurodermatologie, Universitatsklinikum Munster, Von Esmarchstrasse 58, 48149 Munster, Germany
    Hautarzt 58:627-36; quiz 637. 2007
    ..Next to conventional therapies such as antihistamines and corticosteroids, central effective substances can be applied preventing pruritus sensation on spinal or cerebral level...
  9. ncbi request reprint Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin
    S Ständer
    Department of Dermatology and Boltzmann Institute for Immuno and Cell Biology of the Skin, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Br J Dermatol 156:1020-6. 2007
    ..The only clinically relevant side-effect reported is transient application site burning and stinging itch at the beginning of topical therapy...
  10. ncbi request reprint [Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus]
    S Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster, Von Esmarchstrasse 58, 48149 Munster
    Hautarzt 57:801-7. 2006
    ..Recently, the expression of cannabinoid receptors on cutaneous sensory nerve fibers was described, so cannabinoid agonists seem a rational therapeutic option for pruritus...
  11. ncbi request reprint Chronic itch and pain--similarities and differences
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Eur J Pain 10:473-8. 2006
    ..Finally, itch and pain exhibit corresponding patterns of central sensitization. The knowledge of antagonistic interaction, but also of similar sensitization processes has major implication for antipruritic therapeutic approaches...
  12. ncbi request reprint [Diagnostic and therapeutic procedures in chronic pruritus]
    Sonja Ständer
    Abteilung Klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 4:350-70. 2006
  13. ncbi request reprint [Rational symptomatic therapy for chronic pruritus]
    S Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 57:403-10. 2006
    ..The most effective approach is to gradually combine therapies, always considering both the medical and financial impacts...
  14. ncbi request reprint [Clinical classification of chronic pruritus. Interdisciplinary consensus proposal for a diagnostic algorithm]
    S Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 57:390-4. 2006
    ..The proposed clinical classification is oriented at the clinical appearance of the patients and differentiates between disorders with or without primary or secondary skin lesions...
  15. ncbi request reprint Clinical classification of itch: a position paper of the International Forum for the Study of Itch
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 87:291-4. 2007
    ..It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care...
  16. ncbi request reprint Itch in atopic dermatitis - pathophysiology and treatment
    Sonja Ständer
    Department of Dermatology, Competence Center Pruritus, University of Munster, Germany
    Acta Dermatovenerol Croat 18:289-96. 2010
    ..The new findings suggest that target-specific therapies are most likely to control atopic dermatitis itch. To date, only few therapies are available and controlled studies are pending...
  17. ncbi request reprint Neurophysiological and neurochemical basis of modern pruritus treatment
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Muenster, Muenster, Germany
    Exp Dermatol 17:161-9. 2008
    ..In summary, these recent developments show that highlighting the basis of pruritus offers modern neurophysiological and neurochemical therapeutic models and the possibility to treat patients with refractory itching of different origin...
  18. ncbi request reprint [No recognizable dermatosis. What is the etiology of chronic pruritus?]
    Sonja Ständer
    Klin Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    MMW Fortschr Med 150:40-1. 2008
  19. ncbi request reprint Putative neuronal mechanisms of sensitive skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Exp Dermatol 18:417-23. 2009
    ..Furthermore, we discuss the role of neurotrophins and the influence of stress on sensitive skin...
  20. doi request reprint Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia
    Ngoc Quan Phan
    Competence Center for the Diagnosis and Treatment of Pruritus, Clinic and Polyclinic for Skin Diseases, University Hospital of Munster, Germany
    J Dtsch Dermatol Ges 8:88-91. 2010
    ..These nerves express cannabinoid receptors which exert a role in modulation of nociceptive symptoms. Therefore, topical therapy with cannabinoid receptor agonist seems likely to suppress local burning pain...
  21. pmc Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy
    Sonja Ständer
    Department of Dermatology, Neurodermatology and Competence Center Pruritus, University of Munster, Munster, Germany
    PLoS ONE 5:e10968. 2010
    ..Substance P (SP) is a major mediator of pruritus. As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus...
  22. doi request reprint Prevalence of chronic pruritus in Germany: results of a cross-sectional study in a sample working population of 11,730
    S Ständer
    Department of Dermatology, Competence Center Pruritus, University Hospital Munster, Munster, Germany
    Dermatology 221:229-35. 2010
    ..Pruritus is a frequent symptom in many diseases; its prevalence in German adults is unknown...
  23. doi request reprint Pathogenesis of pruritus
    Sonja Ständer
    Competence Center Chronic Pruritus, Department of Dermatology, University of Munster, Germany
    J Dtsch Dermatol Ges 9:456-63. 2011
    ..For example, kappa-opioid receptor agonists and neurokinin-1 antagonists have been found to relieve chronic pruritus...
  24. doi request reprint Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy
    B Schuhknecht
    Departments of Dermatology Neurology, Competence Center Chronic Pruritus, University Hospital Munster, D 48149 Munster, Germany
    Br J Dermatol 165:85-91. 2011
    ..Prurigo nodularis (PN) is a highly pruritic condition characterized by multiple hyperkeratotic nodules. Previous immunohistochemical studies demonstrated increased numbers of dermal nerve fibres...
  25. ncbi request reprint [Pruritus]
    S Ständer
    Abteilung Klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 57:378. 2006
  26. ncbi request reprint [Chronic itching. Etiology and therapeutic measures]
    Sonja Ständer
    Abteilung für klinische Neurodermatologie, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Med Monatsschr Pharm 29:51-5. 2006
  27. ncbi request reprint [Antipruritic effects of pimecrolimus and tacrolimus]
    S Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 54:413-7. 2003
    ..Moreover, the antipruritic potency may be related to a direct effect on nerve fibers leading to suppression of itch mediated by unknown mechanisms...
  28. ncbi request reprint [Wax model collection of the Department of Dermatology, University of Münster]
    S Ständer
    Universitäts Hautklinik, Westfälischen Wilhelms Universität Münster
    Hautarzt 52:662-6. 2001
    ..The Department of Dermatology in Münster is in the possession of 121 wax models, which are presented in this article...
  29. ncbi request reprint Pathophysiology of pruritus in atopic dermatitis: an overview
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:12-24. 2002
    ..This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD...
  30. ncbi request reprint Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles
    Sonja Ständer
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:42-51. 2002
    ..In conclusion, preserved MC-1R expression in adnexal epithelia suggests a functional role of proopiomelanocortin (POMC) in various malformations and neoplasms of the skin...
  31. ncbi request reprint Neurophysiology of pruritus: cutaneous elicitation of itch
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:1463-70. 2003
    ..This review focuses on the peripheral generation of itch, including neurotransmitters, neuropeptides, and inflammatory mediators...
  32. ncbi request reprint Hydroxyethyl starch does not cross the blood-brain or the placental barrier but the perineurium of peripheral nerves in infused animals
    S Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Germany
    Cell Tissue Res 310:279-87. 2002
    ..No HES storage was found in the central nervous system. Our findings clearly demonstrate that storage of HES is detectable only in small peripheral nerves, suggesting a cutaneous origin of the HES-induced pruritus...
  33. ncbi request reprint [Squamous epithelial carcinomas of the face with neurotropic growth]
    S Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 54:1087-94. 2003
    ..Perineural outgrowth into cerebral nerves may result in severe pain or neurological disturbances. In addition, these carcinomas more often recur or metastasize and therefore are associated with a poor prognosis...
  34. ncbi request reprint Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Regul Pept 110:75-83. 2002
    ..Together, our findings contribute to the understanding of the high antipruritic potency of opioid receptor antagonists in various skin and systemic diseases...
  35. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed in normal skin and cutaneous inflammatory diseases, but not in chronically UV-exposed skin and non-melanoma skin cancer
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University Clinics Münster, Munster, Germany
    Am J Dermatopathol 27:116-21. 2005
    ..Down-regulation of TRAIL might represent another example of a natural protection mechanism that is eliminated by chronic UV exposure...
  36. ncbi request reprint [Familial dyskeratotic comedones. A rare entity]
    S Ständer
    Universitäts Hautklinik der Westfälischen Wilhelms Universität Münster
    Hautarzt 52:533-6. 2001
    ..Familial dyskeratotic comedones are generally refractory to any therapy. We report on two sisters with familial dyskeratotic comedones successfully treated by CO2-laser therapy...
  37. ncbi request reprint [Control of section margins without any gaps in paraffin sections of melanoma of the face]
    S Ständer
    Universitäts Hautklinik der Westfälischen Wilhelms Universität Münster
    Hautarzt 51:826-32. 2000
    ..Malignant melanomas on sun-exposed skin are often poorly circumscribed and thus recur frequently. The aim of our clinical trial was to compare conventional to a modified micrographic surgery of primary melanoma...
  38. ncbi request reprint [Erythrokeratodermia variabilis (EKV)--a disorder due to altered epidermal expression of gap junction proteins]
    Sonja Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 3:354-8. 2005
    ..The mutation in connexin 31 is regarded therefore as causal for the clinical picture of the EKV. The unique upregulation of connexin 43 may occur as a consequence of the Cx31 mutation and temporarily compensate for this defect...
  39. ncbi request reprint [Pruritus--pathophysiology, clinical features and therapy--an overview]
    Sonja Ständer
    Universitäts Hautklinik Münster
    J Dtsch Dermatol Ges 1:105-18. 2003
    ..These observations led to the development of new therapeutic modalities. This paper gives an overview of itch pathophysiology, clinical types and therapies...
  40. ncbi request reprint [Pruritus--symptom of both skin and systemic diseases]
    Sonja Ständer
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    MMW Fortschr Med 147:44-6. 2005
    ..Treatment is directed initially to the underlying illness, and both topical and systemic antipruritic medications are available as flanking measures...
  41. ncbi request reprint Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    Sonja Ständer
    Department of Dermatology, University Hospital Munster, Germany
    J Dermatol Sci 38:177-88. 2005
    ..Cannabinoid receptors mediate the psychopharmacological action of marijuana and have been localized in the central and peripheral nervous system as well as on cells of the immune system...
  42. ncbi request reprint Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term study
    S Ständer
    Department of Dermatology, University of Munster, Germany
    Cell Tissue Res 304:261-9. 2001
    ..The condensation and final dissolution of the vacuoles may either indicate the release and subsequent redistribution of HES into the circulation or lysosomal degradation...
  43. ncbi request reprint Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
    ..After cessation of capsaicin therapy, neuropeptides re-accumulated in skin nerves. In conclusion, VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation...
  44. doi request reprint Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus
    Ngoc Quan Phan
    Competence Center for Chronic Pruritus, Department of Dermatology, University Hospital, Munster, Germany
    Acta Derm Venereol 92:502-7. 2012
    ..In conclusion, high reliability and concurrent validity was found for VAS, NRS and VRS. On re-test, higher correlation and less missing values were observed. A training session before starting a clinical trial is recommended...
  45. ncbi request reprint Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    J Biol Chem 279:6959-66. 2004
    ..Melanocortins such as alpha-MSH may therefore represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders...
  46. pmc Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers
    Astrid Stumpf
    Department of Psychosomatics and Psychotherapy, University of Muenster, Muenster, Germany
    PLoS ONE 8:e79123. 2013
    ..To our knowledge, this is the first fMRI study examining sex differences in perception and its modulation by distraction...
  47. doi request reprint Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response
    Mario Huesmann
    Competence Center Chronic Pruritus and Department of Dermatology, University Hospital Munster, Germany
    J Dtsch Dermatol Ges 11:158-68. 2013
    ..This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP...
  48. doi request reprint Chronic pruritus: targets, mechanisms and future therapies
    Esther Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care, Competence Center for the Diagnostic and Therapy of Chronic Pruritus, University of Munster, Munster, Germany
    Drug News Perspect 21:541-51. 2008
    ..The present review aims to provide an overview of current neurophysiological and neurochemical therapeutic models in chronic pruritus...
  49. ncbi request reprint Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
    ..Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines...
  50. doi request reprint Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study
    Sonja Ständer
    Department of Dermatology, Clinical Neurodermatology, University of Munster, Munster, Germany
    Acta Derm Venereol 89:45-51. 2009
    ..This should be confirmed in future double-blind studies...
  51. doi request reprint Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients
    Nils Weigelt
    Department of Dermatology, Neurodermatology and Competence Center Pruritus, University of Munster, Munster, Germany
    J Cutan Pathol 37:578-86. 2010
    ..To date, there has been no systematic investigation of the detailed histological features of prurigo nodularis (PN) in a large cohort of patients...
  52. doi request reprint Notalgia paraesthetica: a descriptive two-cohort study of 65 patients from Brazil and Germany
    Timo Huesmann
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital Munster, Germany
    Acta Derm Venereol 92:535-40. 2012
    ..7% of the involved areas. The significant reduction in intraepidermal nerve fiber density suggests that damage to the peripheral nerves is a more important aetiological factor than spinal changes in notalgia paraesthetica...
  53. ncbi request reprint Underlying diseases and co-factors in patients with severe chronic pruritus: a 3-year retrospective study
    Franz Sommer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Germany
    Acta Derm Venereol 87:510-6. 2007
    ..In conclusion, patients with chronic pruritus present a inhomgeneous collective with different underlying diseases, including malignancy, necessitating thorough investigation...
  54. doi request reprint Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study
    Martin Marziniak
    Department of Neurology, University Hospital Munster, Munster, Germany
    J Am Acad Dermatol 65:756-62. 2011
    ..Brachioradial pruritus (BRP) describes a rare form of itching occurring at the dorsolateral part of the forearms. Recent case reports suggest that BRP may be attributed to cervical lesions or spine neoplasms...
  55. doi request reprint Antipruritic treatment with systemic μ-opioid receptor antagonists: a review
    Ngoc Quan Phan
    Competence Center Pruritus, Department of Dermatology, University Hospital Munster, Munster, Germany
    J Am Acad Dermatol 63:680-8. 2010
    ..We will also evaluate recommendations for the use of MORA in daily medical practice...
  56. doi request reprint Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
    Georgeta Bocheva
    University of Munster, Munster, Germany
    J Invest Dermatol 129:1816-23. 2009
    ..In conclusion, our results suggest that PAR(2) is a substrate for matriptase in human skin in vivo. Deregulation of these proteins delineates SCC progression...
  57. doi request reprint Evaluation of the antipruritic effects of topical pimecrolimus in non-atopic prurigo nodularis: results of a randomized, hydrocortisone-controlled, double-blind phase II trial
    Dorothee Siepmann
    Competence Center Chronic Pruritus, Department of Dermatology, University Hospital of Munster, Munster, Germany
    Dermatology 227:353-60. 2013
    ..In the treatment of atopic dermatitis, pimecrolimus has high antipruritic effects...
  58. ncbi request reprint Modern aspects of cutaneous neurogenic inflammation
    Martin Steinhoff
    Department of Dermatology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Arch Dermatol 139:1479-88. 2003
    ..Understanding the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases...
  59. doi request reprint Aquagenic pruritus: associated diseases and clinical pruritus characteristics
    Tina Heitkemper
    Neurodermatology and Competence Center Pruritus, Clinic and Polyclinic for Dermatology, University Hospital of Munster, Germany
    J Dtsch Dermatol Ges 8:797-804. 2010
    ..This retrospective study aimed to determine the frequency and pruritus-specific parameter of systemic diseases in a series of patients...
  60. ncbi request reprint Treatment of pustular psoriasis with infliximab
    Carsten Weishaupt
    Clinic and Polyclinic for Skin Diseases, Munster University Hospital, Germany
    J Dtsch Dermatol Ges 5:397-9. 2007
    ..We suggest that infliximab is a therapeutic option for severe therapy-resistant pustular psoriasis because a single well-tolerated dose significantly ameliorates the patient's condition...
  61. ncbi request reprint Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis
    Anke Rattenholl
    Department of Dermatology and Interdisciplinary Center for Clinical Research IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 127:2245-52. 2007
    ..Thus, our results provide early experimental evidence for a tumor-protective role of PAR(2)...
  62. doi request reprint Neuropathic itch: diagnosis and management
    Astrid Stumpf
    Department of Psychosomatics and Psychotherapy, Competence Center of Chronic Pruritus, University Hospital Munster, 48149 Munster, Germany
    Dermatol Ther 26:104-9. 2013
    ..It is not always easy to establish the diagnosis because a variety of diseases can be responsible for this type of CP. The present study shows an overview of possible diseases, diagnostic tools, and the relevant therapy strategies...
  63. ncbi request reprint Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Eur J Immunol 34:2022-31. 2004
    ..Together, our results show that overexpression of IL-15 in the epidermis enhances both innate and adaptive cutaneous immunity...
  64. doi request reprint Lactase deficiency: a potential novel aetiological factor in chronic pruritus of unknown origin
    Sonja A Grundmann
    Department of Dermatology and Competence Center Chronic Pruritus, University Hospital, DE 48149 Münster, Germany
    Acta Derm Venereol 91:698-703. 2011
    ..In case of a positive test result, a lactose-free diet offers a low-cost, efficient and specific therapy in patients with chronic pruritus...
  65. doi request reprint Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review
    Ngoc Quan Phan
    Competence Center for Chronic Pruritus, Department of Dermatology, University Hospital, Munster, Germany
    Acta Derm Venereol 92:555-60. 2012
    ..The aim of this review is to provide an overview of the promising role of kappa- opioid receptors and their agonist in the pathophysiology and treatment of pruritus...
  66. ncbi request reprint IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Immunol 176:2896-901. 2006
    ..Though being primarily a proinflammatory cytokine through this capacity, IL-18 can also foster an immune response that is suppressed by UV radiation...
  67. ncbi request reprint Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 118:533-9. 2002
    ..By modulating interleukin-8 secretion, alpha-melanocyte-stimulating hormone may act as a modulator of inflammatory responses in the pilosebaceous unit...
  68. pmc CIS-based registration of quality of life in a single source approach
    Fleur Fritz
    Institute of Medical Informatics, University Munster, Domagkstrasse 9, 48149 Munster, Germany
    BMC Med Inform Decis Mak 11:26. 2011
    ..We therefore aimed at developing an efficient method to integrate quality of life information into the clinical information system (CIS) and thus make it available for clinical care and secondary use...
  69. doi request reprint Antipruritic effect of cyclosporine microemulsion in prurigo nodularis: results of a case series
    Dorothee Siepmann
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Munster, Germany
    J Dtsch Dermatol Ges 6:941-6. 2008
    ..The aim of this investigation was to assess the antipruritic efficiency of cyclosporine ME in therapy of prurigo nodularis...
  70. ncbi request reprint Psychological factors in prurigo nodularis in comparison with psoriasis vulgaris: results of a case-control study
    G Schneider
    Department of Psychosomatics and Psychotherapy, University of Muenster, Germany
    Br J Dermatol 154:61-6. 2006
    ..Whether these issues are specific for PN or are also common in other chronic skin diseases, e.g. psoriasis, has not been investigated until now...
  71. ncbi request reprint Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch
    G Schneider
    Department of Psychosomatics and Psychotherapy, University of Muenster, Muenster, Germany
    Clin Exp Dermatol 31:762-7. 2006
    ..While psychosomatic factors may be involved in eliciting as well as coping with chronic itch, psychiatric comorbidity often goes unrecognized in dermatological patients...
  72. ncbi request reprint Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus
    A Kuhn
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Br J Dermatol 163:83-92. 2010
    ..However, the CLASI does not give an accurate assessment of the severity in all disease subtypes...
  73. ncbi request reprint [Antipruritic efficacy of a high-dosage antihistamine therapy. Results of a retrospectively analysed case series]
    S Schulz
    Kompetenzzentrum Pruritus, Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    Hautarzt 60:564-8. 2009
    ..The aim of this investigation was to describe the efficacy and safety of high-dosage antihistamine treatment in patients with chronic pruritus of different origin...
  74. doi request reprint Keratoacanthoma with perineural invasion: an indicator for aggressive behavior?
    Yasmin Basoglu
    Department of Dermatology, University of Munster, Munster, Germany
    J Dtsch Dermatol Ges 6:952-5. 2008
    ..Our case suggests that perineural invasion may be an indicator for aggressive growth of head-and-neck KAs so that histologically-controlled excision is recommended...
  75. ncbi request reprint Modulation of cutaneous inflammation by angiotensin-converting enzyme
    Thomas E Scholzen
    Ludwig Boltzmann Institute of Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Immunol 170:3866-73. 2003
    ....
  76. ncbi request reprint Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects
    Gudrun Schneider
    Department of Psychosomatics and Psychotherapy, University of Munster, Domagkstr 22, D 48149 Munster, Germany
    Eur J Pain 12:834-41. 2008
    ....