- The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesisWenke Weidemann
Institut fur Biochemie und Molekularbiologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin Dahlem, Germany
FEBS Lett 580:6649-54. 2006..For two of them, the collapsin response mediator protein 1 and the promyelocytic leukemia zinc finger protein, we could verify protein-protein interaction with GNE...
- RNA-structural mimicry in Escherichia coli ribosomal protein L4-dependent regulation of the S10 operonUlrich Stelzl
Memorial Sloan Kettering Cancer Center, Cellular Biochemistry and Biophysics Program, New York, New York 10021, USA
J Biol Chem 278:28237-45. 2003..In vitro binding of L4 induces structural changes of the S10 leader RNA, providing a first clue for how protein L4 may provoke transcription termination...
- The value of high quality protein-protein interaction networks for systems biologyUlrich Stelzl
Max Delbrück Center for Molecular Medicine MDC, AG Neuroproteomics, Robert Rossle Str 10, D 13125 Berlin Buch, Germany
Curr Opin Chem Biol 10:551-8. 2006..In this way, combined PPI networks can become valuable resources for a systems-level understanding of cellular processes and complex phenotypes...
- Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arraysGerlinde Grelle
Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
Mol Cell Proteomics 5:234-44. 2006....
- The tetracycline resistance protein Tet(o) perturbs the conformation of the ribosomal decoding centreSean R Connell
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Mol Microbiol 45:1463-72. 2002..Therefore, the results for the first time demonstrate that the primary tetracycline binding site is correlated with tetracycline's inhibitory effect on protein synthesis...
- Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosomeDaniel N Wilson
Max Planck Institut fur Molekulare Genetik, AG Ribosomen, Ihnestr 73, Berlin, D 14195 Berlin, Germany
Curr Protein Pept Sci 3:1-53. 2002..Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution >7 A) and the atomic x-ray structures (>2.4 A) of the ribosome...
- Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseAstrid Blume
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Institut fur Biochemie und Molekularbiologie, Arnimallee 22, 14195 Berlin Dahlem, Germany
Biochem J 384:599-607. 2004..In conclusion, our results reveal that the activities, as well as the oligomeric structure, of this bifunctional enzyme seem to be organized and regulated in a complex manner...
- A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's diseaseHeike Goehler
Max Delbrueck Center for Molecular Medicine, 13125 Berlin Buch, Germany
Mol Cell 15:853-65. 2004..Moreover, GIT1 localizes to neuronal inclusions, and is selectively cleaved in HD brains, indicating that its distribution and function is altered during disease pathogenesis...
- A human protein-protein interaction network: a resource for annotating the proteomeUlrich Stelzl
Max Delbrueck Center for Molecular Medicine, 13092 Berlin Buch, Germany
Cell 122:957-68. 2005..Systematic human protein interaction screens can lead to a more comprehensive understanding of protein function and cellular processes...