M Steinhoff

Summary

Country: Germany

Publications

  1. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
  2. ncbi request reprint Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases
    Dirk Roosterman
    Departments of Surgery and Physiology, University of California San Francisco, San Francisco, California 94143 0660, USA
    J Biol Chem 279:30670-9. 2004
  3. ncbi request reprint Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis
    Anke Rattenholl
    Department of Dermatology and Interdisciplinary Center for Clinical Research IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 127:2245-52. 2007
  4. ncbi request reprint Indirect RT-PCR in-situ hybridization: a novel non-radioactive method for detecting glucose-dependent insulinotropic peptide
    M Steinhoff
    Clinical Research Unit for Gastrointestinal Endocrinology, Department of Internal Medicine, Philipps University Marburg, 35033 Marburg, Germany
    Regul Pept 97:187-94. 2001
  5. ncbi request reprint Successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta
    M Steinhoff
    Department of Dermatology, University of Munster, Von Esmarch Str 56, 48129 Munster, Germany
    Br J Dermatol 144:1067-9. 2001
  6. ncbi request reprint Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Muenster, Muenster, Germany
    J Invest Dermatol 126:1705-18. 2006
  7. ncbi request reprint Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response
    Martin Steinhoff
    Department of Dermatology and Boltzmann Institute for Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocr Rev 26:1-43. 2005
  8. ncbi request reprint Keratinocytes in epidermal immune responses
    M Steinhoff
    Department of Dermatology and Boltzmann Institute for Cell and Immunobiology of the Skin, University of Munster, 48129 Munster, Germany
    Curr Opin Allergy Clin Immunol 1:469-76. 2001
  9. doi request reprint A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Munster, Munster, Germany
    J Invest Dermatol 129:531-5. 2009
  10. ncbi request reprint Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells
    F Sachse
    Department of Otolaryngology, Head and Neck Surgery, University of Munster, Munster, Germany
    Int Arch Allergy Immunol 145:24-32. 2008

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
    ..Thrombin-induced PE and VD are mediated mainly by a non-neurogenic mechanism...
  2. ncbi request reprint Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases
    Dirk Roosterman
    Departments of Surgery and Physiology, University of California San Francisco, San Francisco, California 94143 0660, USA
    J Biol Chem 279:30670-9. 2004
    ....
  3. ncbi request reprint Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis
    Anke Rattenholl
    Department of Dermatology and Interdisciplinary Center for Clinical Research IZKF Münster, University of Munster, Munster, Germany
    J Invest Dermatol 127:2245-52. 2007
    ..Thus, our results provide early experimental evidence for a tumor-protective role of PAR(2)...
  4. ncbi request reprint Indirect RT-PCR in-situ hybridization: a novel non-radioactive method for detecting glucose-dependent insulinotropic peptide
    M Steinhoff
    Clinical Research Unit for Gastrointestinal Endocrinology, Department of Internal Medicine, Philipps University Marburg, 35033 Marburg, Germany
    Regul Pept 97:187-94. 2001
    ....
  5. ncbi request reprint Successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta
    M Steinhoff
    Department of Dermatology, University of Munster, Von Esmarch Str 56, 48129 Munster, Germany
    Br J Dermatol 144:1067-9. 2001
    ..Topical treatment with interferon-beta appears to be an effective, simple, non-invasive, cheap and low-risk alternative to other invasive or surgical therapeutic modalities...
  6. ncbi request reprint Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Muenster, Muenster, Germany
    J Invest Dermatol 126:1705-18. 2006
    ..A deeper understanding of these circuits is required for the development of novel antipruritic strategies...
  7. ncbi request reprint Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response
    Martin Steinhoff
    Department of Dermatology and Boltzmann Institute for Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Endocr Rev 26:1-43. 2005
    ..Novel compounds that can modulate PAR function may be potent candidates for the treatment of inflammatory or immune diseases...
  8. ncbi request reprint Keratinocytes in epidermal immune responses
    M Steinhoff
    Department of Dermatology and Boltzmann Institute for Cell and Immunobiology of the Skin, University of Munster, 48129 Munster, Germany
    Curr Opin Allergy Clin Immunol 1:469-76. 2001
    ..An understanding of keratinocytes as important regulators of the skin immune system opens new opportunities for the treatment of various skin diseases...
  9. doi request reprint A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch
    Martin Steinhoff
    Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Munster, Munster, Germany
    J Invest Dermatol 129:531-5. 2009
    ..New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus...
  10. ncbi request reprint Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells
    F Sachse
    Department of Otolaryngology, Head and Neck Surgery, University of Munster, Munster, Germany
    Int Arch Allergy Immunol 145:24-32. 2008
    ..Among others, serine and cysteine proteases have been identified as factors of virulence in S. epidermidis...
  11. doi request reprint Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity
    V Shpacovitch
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology of the Skin, University of Munster, Munster, Germany
    J Leukoc Biol 83:1309-22. 2008
    ..Understanding the mechanisms by which PARs exert the effects of serine proteases on immune cells may lead to new therapeutic strategies in inflammation, immune defense, and allergy...
  12. ncbi request reprint PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium
    C Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, IZK Münster and Boltzmann Institute for Immunobiology of the Skin, Munster, Germany
    Clin Exp Allergy 37:1009-22. 2007
    ..The effects of protease-activated receptor-2 (PAR-2) stimulation on inflammation mechanisms of chronic rhinosinusitis (CRS) are still unknown...
  13. pmc Transition of Sézary syndrome into mycosis fungoides after complete clinical and molecular remission under extracorporeal photophoresis
    C Assaf
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Clin Pathol 57:1325-8. 2004
    ..These findings indicate that the neoplastic cells in SS, MF, and LCL are derived from a common precursor T cell, despite the change in clinical phenotype...
  14. ncbi request reprint Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo
    Stephan Seeliger
    Department of Pediatrics, University of Munster, Munster, Germany
    FASEB J 17:1871-85. 2003
    ..Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases...
  15. ncbi request reprint Protease-activated receptors: novel PARtners in innate immunity
    V Shpacovitch
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology of the Skin, University of Munster, D 48149 Munster, Germany
    Trends Immunol 28:541-50. 2007
    ..Understanding protease-immune interactions could lead to novel strategies for the treatment of infectious and immune-related diseases...
  16. pmc Cutaneous T cell lymphoma and classic Hodgkin lymphoma of the B cell type within a single lymph node: composite lymphoma
    M Steinhoff
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Clin Pathol 57:329-31. 2004
    ..This report describes the manifestation of a true composite lymphoma within a single cervical lymph node, which is composed of a cutaneous T cell lymphoma and a classic Hodgkin lymphoma of B cell type--a very rare finding indeed...
  17. ncbi request reprint Neurophysiology of pruritus: cutaneous elicitation of itch
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Arch Dermatol 139:1463-70. 2003
    ..This review focuses on the peripheral generation of itch, including neurotransmitters, neuropeptides, and inflammatory mediators...
  18. ncbi request reprint Cytokines and chemokines orchestrate atopic skin inflammation
    Bernhard Homey
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    J Allergy Clin Immunol 118:178-89. 2006
    ..In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD...
  19. ncbi request reprint Pathophysiology of pruritus in atopic dermatitis: an overview
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    Exp Dermatol 11:12-24. 2002
    ..This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD...
  20. ncbi request reprint Pathway management in ambulatory wound care: defining local standards for quality improvement and interprofessional care
    Peter Hensen
    Department of Dermatology, University of Muenster, Von Esmarch Strasse 58, D 48149 Muenster, Germany
    Int Wound J 2:104-11. 2005
    ..Variances must be merely written down in detail. After 1 year in clinical practice, we state that the use of a clinical pathway for chronic wound management is an effective method of improving clinical processes and patient outcomes...
  21. ncbi request reprint Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin
    Sonja Ständer
    Department of Dermatology, University of Munster, Munster, Germany
    Regul Pept 110:75-83. 2002
    ..Together, our findings contribute to the understanding of the high antipruritic potency of opioid receptor antagonists in various skin and systemic diseases...
  22. doi request reprint Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease
    Anke Rattenholl
    Department of Dermatology, Interdisziplinares Zentrum fur Klinische Forschung IZKF, Ludwig Bolzmann Institute for Cell and Immunobiology of the Skin, University of Munster, Munster, Germany
    Drug News Perspect 21:369-81. 2008
    ..Activation of the receptor leads to the production of various cytokines and chemokines which modulate skin homeostasis, immune and inflammatory responses as well as tumor surveillance...
  23. ncbi request reprint Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage
    Thomas E Scholzen
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    FASEB J 18:1007-9. 2004
    ..Thus, SP, NKA, NK-1R, and NK-2R have important but differential roles in the regulation of cutaneous inflammatory responses...
  24. ncbi request reprint Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
    ..After cessation of capsaicin therapy, neuropeptides re-accumulated in skin nerves. In conclusion, VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation...
  25. doi request reprint Pathophysiology and therapy of pruritus in allergic and atopic diseases
    J Buddenkotte
    Deparment of Dermatology, Boltzmann Institute for Cell and Immunobiology of Skin, University Hospital Munster, Munster, Germany
    Allergy 65:805-21. 2010
    ..As the treatment of pruritus in allergic and atopic skin disease is still not satisfactory, knowing these pathways and mechanisms may lead to novel therapeutic approaches against this frequently encountered skin symptom...
  26. ncbi request reprint Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin
    S Ständer
    Department of Dermatology and Boltzmann Institute for Immuno and Cell Biology of the Skin, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Br J Dermatol 156:1020-6. 2007
    ..The only clinically relevant side-effect reported is transient application site burning and stinging itch at the beginning of topical therapy...
  27. ncbi request reprint Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells
    Corinna Moormann
    Department of Dermatology, IZKF Münster and Ludwig Boltzmann Institute for Cell and Immunbiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 126:746-55. 2006
    ..Thus, PAR2 may be an important regulator of skin mast cell function during cutaneous inflammation and hypersensitivity...
  28. ncbi request reprint IL-31: a new link between T cells and pruritus in atopic skin inflammation
    Eniko Sonkoly
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Allergy Clin Immunol 117:411-7. 2006
    ..IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor...
  29. ncbi request reprint Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B
    Jörg Buddenkotte
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 124:38-45. 2005
    ..Thus, PAR2 may play an important regulatory role of human KTC during inflammation and immune response...
  30. doi request reprint Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
    Georgeta Bocheva
    University of Munster, Munster, Germany
    J Invest Dermatol 129:1816-23. 2009
    ..In conclusion, our results suggest that PAR(2) is a substrate for matriptase in human skin in vivo. Deregulation of these proteins delineates SCC progression...
  31. ncbi request reprint Neuroimmune interactions in allergic skin diseases
    Ferda Cevikbas
    Department of Dermatology, IZKF Moenster and Boltzmann Institute for Cell and Immunobiology of the Skin, University of Munster, Germany
    Curr Opin Allergy Clin Immunol 7:365-73. 2007
    ..Moreover, structural cells and invading immune cells express neuronal receptors and release mediators which directly communicate with nerve endings in the skin...
  32. ncbi request reprint Case mix measures and diagnosis-related groups: opportunities and threats for inpatient dermatology
    P Hensen
    Department of Dermatology, University of Muenster, Muenster, Germany
    J Eur Acad Dermatol Venereol 19:582-8. 2005
    ..The aim of this study was to examine the impact of application of different DRG systems used in the German healthcare system...
  33. ncbi request reprint Role of vasculature in atopic dermatitis
    Martin Steinhoff
    Department of Dermatology, University Hospital Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    J Allergy Clin Immunol 118:190-7. 2006
    ..Endothelial cells play a pivotal role in the pathophysiology of AD and represent future targets for the treatment of AD...
  34. pmc Tumor immune escape by the loss of homeostatic chemokine expression
    Andor Pivarcsi
    Department of Dermatology, Heinrich Heine University, D 40255 Düsseldorf, Germany
    Proc Natl Acad Sci U S A 104:19055-60. 2007
    ..Collectively, our data identify a mechanism of skin tumors to evade host antitumor immune responses...
  35. ncbi request reprint Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells
    Victoria M Shpacovitch
    Department of Dermatology and Ludwig Boltzmann Institute for Cell and Immunbiology of the Skin, University of Munster, Germany
    J Invest Dermatol 118:380-5. 2002
    ..Thus, proteinase-activated receptor 2 may play an important role in cutaneous inflammation by mediating inflammatory responses on dermal microvascular endothelial cells and activation of nuclear transcription factor kappaB...
  36. ncbi request reprint Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices
    V M Shpacovitch
    Department of Dermatology, University of Munster, Von Esmarch Str 58, 48149 Munster, Germany
    J Leukoc Biol 76:388-98. 2004
    ..Thus, PAR2 may represent a potential therapeutic target for the treatment of diseases involving activated neutrophils...
  37. ncbi request reprint Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis
    T E Scholzen
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 166:1285-91. 2001
    ..Thus, these results indicate that NEP and cutaneous neuropeptides have a significant role in the pathogenesis of ACD...
  38. ncbi request reprint Bodybuilder oleoma
    J Georgieva
    Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, D 14195 Berlin, Germany
    Br J Dermatol 149:1289-90. 2003
  39. ncbi request reprint Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils
    Victoria M Shpacovitch
    Department of Dermatology, IZKF Münster, and Boltzmann Institute for Immunobiology of the Skin, University of Munster, Germany
    Exp Dermatol 16:799-806. 2007
    ....
  40. ncbi request reprint Neuronal control of skin function: the skin as a neuroimmunoendocrine organ
    Dirk Roosterman
    Department of Dermatology, IZKF Münster, Germany
    Physiol Rev 86:1309-79. 2006
    ..A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases...
  41. ncbi request reprint Calcineurin inhibitors for the treatment of atopic dermatitis
    Jan Ehrchen
    University Hospital Munster, Boltzmann Institute for Cell and Immunobiology of the Skin, Department of Dermatology, Munster, Germany
    Expert Opin Pharmacother 9:3009-23. 2008
    ..Therapeutic objectives for AD should be to quickly reduce disease symptoms by targeting pathophysiological pathways, and to provide long-term management by reducing recurrences...
  42. pmc Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
    Dirk Roosterman
    Department of Dermatology, Interdisziplinäres Zentrum für Klinische Forschung Münster, and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:11838-43. 2007
    ..Antagonism of these endosomal processes represents a strategy for inhibiting sustained signaling of receptors, and defects may explain the tachyphylaxis of drugs that are receptor agonists...
  43. ncbi request reprint Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection
    Micha Feld
    Department of Dermatology and Ludwig Boltzmann Institute for Immunobiology of the Skin, University of Munster, Munster, Germany
    J Immunol 180:6903-10. 2008
    ..This effect could be associated with the ability of PAR(2) agonists to enhance IFN-gamma-induced protective effects on human monocytes...
  44. ncbi request reprint Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation
    Tobias Goerge
    Department of Dermatology, Institute of Physiology II, Interdisziplinäres Zentrum für Klinische Forschung Münster, Von Esmarch Strasse 58, 48149 Munster, Germany
    Cancer Res 66:7766-74. 2006
    ..Inhibition of this cross-talk may be a powerful means to prevent tumor-induced ECA and thus thrombotic and inflammatory cell adhesion...
  45. ncbi request reprint Successful treatment of generalized eruptive histiocytoma with PUVA
    H Lan Ma
    Department of Dermatology, University Hospital of Munster, Munster, Germany
    J Dtsch Dermatol Ges 5:131-4. 2007
    ..The lesions resolved completely after 20 PUVA treatments. No relapses occurred. Systemic PUVA therapy represents a promising option for the treatment of GEH...
  46. ncbi request reprint Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
    Martin Steinhoff
    Department of Physiology and Experimental Pathophysiology, University of Erlangen, 91054 Erlangen, Germany
    J Neurosci 23:6176-80. 2003
    ..PAR-2 therefore represents a promising therapeutic target for the treatment of cutaneous neurogenic inflammation and pruritus...
  47. ncbi request reprint Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism
    Cathy Nguyen
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Can J Physiol Pharmacol 81:920-7. 2003
    ..These results implicate PAR2 as an important mediator of intestinal neurogenic inflammation...
  48. ncbi request reprint Neurophysiology of pruritus: interaction of itch and pain
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Kyoto, Japan
    Arch Dermatol 139:1475-8. 2003
    ..Therapeutic antipruritic approaches therefore should target both local inflammation and spinal sensitization of itch processing...
  49. ncbi request reprint Intermedin: a skin peptide that is downregulated in atopic dermatitis
    Friederike Kindt
    Institute for Anatomy and Cell Biology, University of Giessen, Giessen, Germany
    J Invest Dermatol 127:605-13. 2007
    ..These data further point to a role of IMD expressed by pericytes in conferring higher susceptibility of the skin of AD patients to inflammatory stimuli...
  50. ncbi request reprint Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis
    Akihiko Ikoma
    Departments of Dermatology, Kyoto University, Kyoto, Japan
    Arch Dermatol 139:1455-8. 2003
    ..Lowered threshold of neurons (ie, neuronal sensitization) in atopic dermatitis was investigated by testing sensitivity to histamine...
  51. pmc "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:1067-70. 2008
    ..This cycle comprises an "outside-inside-outside" model of AD pathogenesis (Elias et al., in press)...
  52. ncbi request reprint Proteinase-activated receptors: novel signals for peripheral nerves
    Nathalie Vergnolle
    Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
    Trends Neurosci 26:496-500. 2003
    ..New potential roles are suggested for members of the PAR family, highlighting proteinases and their receptors as potential therapeutic targets for diseases associated with PNS activation...
  53. ncbi request reprint Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases
    Kristina Stefansson
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 128:18-25. 2008
    ..The role of KLKs in PAR2 activation in vivo remains to be elucidated...
  54. ncbi request reprint The neurobiology of itch
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Shogin Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Neurosci 7:535-47. 2006
    ..The antagonistic interaction between pain and itch is already exploited in pruritus therapy, and current research concentrates on the identification of common targets for future analgesic and antipruritic therapy...
  55. ncbi request reprint [Persistent plaque on the back and right upper arm. Latent syphilis (lues III) with tubero-ulcero-serpiginous plaque]
    Steffen Emmert
    Abteilung Dermatologie und Venerologie Universitäts Hautklinik, Georg August Universitat Gottingen, Germany
    J Dtsch Dermatol Ges 4:156-9. 2006
  56. ncbi request reprint [Atopic dermatitis. Pathophysiologic background, scientific status quo and therapeutic strategies]
    Tobias Goerge
    Hautklinik des UK Münster
    Med Monatsschr Pharm 28:267-76; quiz 277. 2005
  57. ncbi request reprint Ubiquitin-dependent down-regulation of the neurokinin-1 receptor
    Graeme S Cottrell
    Departments of Surgery and Physiology, University of California, San Francisco, 94143 0660, USA
    J Biol Chem 281:27773-83. 2006
    ..Thus, chronic stimulation with SP induces ubiquitination of the NK(1)R, which mediates its degradation and down-regulation...
  58. pmc Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection
    Marinella Holzhausen
    Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Dr, NW Calgary, T2N 4N1 Alberta, Canada
    Am J Pathol 168:1189-99. 2006
    ..gingivalis infection. We conclude that PAR(2) is activated on P. gingivalis infection, in which it plays an important role in the host inflammatory response...
  59. ncbi request reprint Evaluation of protease-activated receptor 2 in murine models of arthritis
    Nathalie Busso
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Arthritis Rheum 56:101-7. 2007
    ..We undertook this study to explore the importance of PAR-2 activation in 4 murine models of arthritis and to analyze the expression of PAR-2 in human arthritic synovium...
  60. pmc Role for protease activity in visceral pain in irritable bowel syndrome
    Nicolas Cenac
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 117:636-47. 2007
    ..Our study establishes that proteases are released in IBS and that they can directly stimulate sensory neurons and generate hypersensitivity symptoms through the activation of PAR2...
  61. ncbi request reprint Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response
    Nicolas Cenac
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Canada
    Inflamm Bowel Dis 11:792-8. 2005
    ..Moreover, PAR1 expression is increased in biopsies from patients with inflammatory bowel disease, and its activation during TH1-mediated colitis in mice increases all of the hallmarks of inflammation...
  62. pmc A role for proteinase-activated receptor-1 in inflammatory bowel diseases
    Nathalie Vergnolle
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 114:1444-56. 2004
    ....
  63. pmc Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis
    Eric Hyun
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 143:618-25. 2004
    ....
  64. pmc Frontiers in pruritus research: scratching the brain for more effective itch therapy
    Ralf Paus
    Department of Dermatology and Allergy, University of Lubeck, Lubeck, Germany
    J Clin Invest 116:1174-86. 2006
    ....
  65. pmc Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    Benjamin E Padilla
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 179:981-97. 2007
    ..We propose a mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization...