Christoph Stein

Summary

Country: Germany

Publications

  1. ncbi request reprint Attacking pain at its source: new perspectives on opioids
    Christoph Stein
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Klinikum Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Nat Med 9:1003-8. 2003
  2. ncbi request reprint Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells
    Alexander Brack
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Pain 112:229-38. 2004
  3. ncbi request reprint Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Leukoc Biol 79:1022-32. 2006
  4. ncbi request reprint Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    FASEB J 20:2627-9. 2006
  5. pmc Peripheral non-viral MIDGE vector-driven delivery of beta-endorphin in inflammatory pain
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Medizinische Fakultät Charité Campus Benjamin Franklin, Krahmerstrasse 6, D 12207 Berlin, Germany
    Mol Pain 5:72. 2009
  6. pmc Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
    Christian Zöllner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Clin Invest 118:1065-73. 2008
  7. ncbi request reprint Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression
    Alexander Brack
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Klinik fur Anaesthesiologie und operative Intensivmedizin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Pain 108:67-75. 2004
  8. doi request reprint Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue
    Anja Schreiter
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Freie Universitat Berlin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 26:5161-71. 2012
  9. ncbi request reprint CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Brain Behav Immun 21:1021-32. 2007
  10. ncbi request reprint Relative contribution of peripheral versus central opioid receptors to antinociception
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Brain Res 1160:30-8. 2007

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Attacking pain at its source: new perspectives on opioids
    Christoph Stein
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Klinikum Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Nat Med 9:1003-8. 2003
    ....
  2. ncbi request reprint Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells
    Alexander Brack
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Pain 112:229-38. 2004
    ..05, t-test; P>0.05, ANOVA). In summary, in early inflammation peripheral opioid-mediated antinociception is critically dependent on PMN and their recruitment by CXCR2 chemokines...
  3. ncbi request reprint Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Leukoc Biol 79:1022-32. 2006
    ..Thus, PMN seem to be less important in inflammatory hyperalgesia than previously thought...
  4. ncbi request reprint Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    FASEB J 20:2627-9. 2006
    ..These findings demonstrate that, beyond cell recruitment, CXCR2 ligands induce Ca2+-regulated opioid release from PMN and thereby inhibit inflammatory pain in vivo...
  5. pmc Peripheral non-viral MIDGE vector-driven delivery of beta-endorphin in inflammatory pain
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Medizinische Fakultät Charité Campus Benjamin Franklin, Krahmerstrasse 6, D 12207 Berlin, Germany
    Mol Pain 5:72. 2009
    ..Here, we investigated the effects of a nuclear localization sequence (NLS)-coupled MIDGE encoding the beta-endorphin precursor proopiomelanocortin (POMC) on complete Freund's adjuvant-induced inflammatory pain in rats...
  6. pmc Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
    Christian Zöllner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Clin Invest 118:1065-73. 2008
    ....
  7. ncbi request reprint Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression
    Alexander Brack
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Klinik fur Anaesthesiologie und operative Intensivmedizin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Pain 108:67-75. 2004
    ..05, t-test). In summary, antinociception during early inflammation is apparently not limited by the number of opioid-containing leukocytes but by OR availability...
  8. doi request reprint Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue
    Anja Schreiter
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Freie Universitat Berlin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 26:5161-71. 2012
    ..1-5 mM) or by P8B (0.1-10 mM) additionally hindered dynorphin A 1-17 catabolism. Thus, leukocytes and peripheral nerves are important sources of APN and NEP in inflamed tissue, and their blockade promotes peripheral opioid analgesia...
  9. ncbi request reprint CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Brain Behav Immun 21:1021-32. 2007
    ..Taken together, these findings indicate that END and ENK are contained in primary granules of PMN, and that CXCR1/2 ligands induce p38-dependent translocation and release of these opioid peptides to inhibit inflammatory pain...
  10. ncbi request reprint Relative contribution of peripheral versus central opioid receptors to antinociception
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Brain Res 1160:30-8. 2007
    ..Higher dose loperamide-induced antinociception involved also central opioid receptors...
  11. ncbi request reprint Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo
    Nicolle Sitte
    Department of Anesthesiology and Critical Care Medicine, Charite University Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Neuroimmunol 183:133-45. 2007
    ..Semi-nested PCR revealed 8-fold increased exon 2-3 spanning POMC mRNA. Thus, painful inflammation enhances signal sequence-encoding lymphocytic POMC mRNA needed for regulated secretion of functionally active END...
  12. ncbi request reprint Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue
    Waltraud Binder
    Department of Anesthesiology and Critical Care Medicine, Klinikum Benjamin Franklin, Freie Universitat, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Neurosci 20:92-100. 2004
    ..These findings indicate that sympathetic neuron-derived noradrenaline stimulates adrenergic receptors on inflammatory cells to release beta-endorphin, which induces analgesia via activation of peripheral opioid receptors...
  13. ncbi request reprint Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    J Neurosci 26:4350-8. 2006
    ..Exogenous EM-2 in addition to mu-receptors also activates peripheral delta-receptors, which does not involve actions via other opioid peptides...
  14. ncbi request reprint Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain
    Jeannette Endres-Becker
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Mol Pharmacol 71:12-8. 2007
    ..These observations demonstrate an important new mechanism underlying the analgesic efficacy of peripherally acting mu-receptor ligands in inflammatory pain...
  15. ncbi request reprint Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception
    Alexander Brack
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Anesthesiology 101:204-11. 2004
    ..In this study, the role of tissue monocytes/macrophages in hyperalgesia and in peripheral opioid-mediated antinociception was investigated...
  16. pmc Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Br J Pharmacol 142:772-80. 2004
    ..They point to a cautious use of anti-inflammatory treatments applying anti-selectin, anti-alpha(4) and anti-beta(2) strategies because they may impair intrinsic pain inhibition...
  17. doi request reprint Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner
    Viola Spahn
    Charite Universitatsmedizin Berlin, Klinik fur Anaesthesiologie und operative Intensivmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12203, Germany
    Pain 154:598-608. 2013
    ..In summary, our results demonstrate an increased activity of TRPV1 in DRG neurons as a new mechanism contributing to opioid withdrawal-induced hyperalgesia...
  18. ncbi request reprint Different mechanisms of intrinsic pain inhibition in early and late inflammation
    Halina Machelska
    Klinikum Benjamin Franklin, Freie Universitat Berlin, D 12200 Berlin, Germany
    J Neuroimmunol 141:30-9. 2003
    ..Corticotropin-releasing hormone (CRH) is an endogenous trigger of these effects at both stages. These findings indicate that peripheral opioid mechanisms of pain inhibition gain functional relevance with the chronicity of inflammation...
  19. ncbi request reprint Leukocyte-derived opioid peptides and inhibition of pain
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200, Berlin, Germany
    J Neuroimmune Pharmacol 1:90-7. 2006
    ..Future research should elucidate the selective targeting of opioid peptide-containing immune cells to sites of painful tissue injury and the augmentation of opioid peptide and receptor synthesis...
  20. ncbi request reprint Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain
    Alexander Brack
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charité Universitätmedizin, Berlin, Germany
    Anesthesiology 100:149-57. 2004
    ....
  21. ncbi request reprint Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds
    Martin Heurich
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Brain Behav Immun 21:544-52. 2007
    ..These findings suggest that nociceptive but not sympathetic neurons are primarily involved in the attraction of opioid-containing leukocytes during early stages of inflammation...
  22. pmc Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Ann Rheum Dis 66:871-9. 2007
    ..Therefore, the expression of beta-endorphin (END), Met-enkephalin (ENK), and mu and delta opioid receptors (ORs) within synovium of patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA) were examined...
  23. ncbi request reprint Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
    Pain 106:297-307. 2003
    ..Taken together, these findings suggest that in inflammatory pain CRH-induced peripheral antinociception is mediated via both CRH R1 and CRH R2 located on END containing immune cells within inflamed sites...
  24. pmc The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia
    Dinah Nockemann
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    EMBO Mol Med 5:1263-77. 2013
    ..Thus, GIRK channels are indispensable for peripheral opioid analgesia, and their absence in mice has profound consequences for GPCR signalling in peripheral sensory neurons. ..
  25. ncbi request reprint Opioid receptors on peripheral sensory neurons
    Christoph Stein
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Adv Exp Med Biol 521:69-76. 2003
  26. doi request reprint Peripheral mechanisms of opioid analgesia
    Christoph Stein
    Department of Anaesthesiology and Intensive Care Medicine, Charite Campus Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Curr Opin Pharmacol 9:3-8. 2009
    ..Analgesia results from inhibition of sensory neuron excitability and of proinflammatory neuropeptide release...
  27. ncbi request reprint Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200 Berlin, Germany
    Endocrinology 145:1331-41. 2004
    ..Taken together, our results indicate that immune cells express the entire machinery required for POMC processing into functionally active peptides such as END and are able to release these peptides from secretory granules...
  28. ncbi request reprint A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds
    Sarah Heilmann
    Institute for Pharmacy, Freie Universitat Berlin, Berlin, Germany
    Int J Pharm 444:96-102. 2013
    ..In addition, the formulation should not impair wound healing. Hydrogels provide a moist wound environment, which is known to facilitate the healing process...
  29. doi request reprint Fentanyl decreases discharges of C and A nociceptors to suprathreshold mechanical stimulation in chronic inflammation
    Rabih Moshourab
    Department of Anesthesiology and Critical Care Medicine, Freie Universitat Berlin, Charite Campus Benjamin Franklin, Berlin, Germany
    J Neurophysiol 108:2827-36. 2012
    ..Opioid sensitivity of both A- and C-fibers is markedly augmented. This is consistent with an upregulation or enhanced functionality of opioid receptors located at the peripheral terminals of sensitized nociceptors...
  30. ncbi request reprint Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universitat Berlin, D 12200 Berlin, Germany
    J Neurosci 22:5588-96. 2002
    ..Together, these findings indicate that ICAM-1 expressed on vascular endothelium recruits immunocytes containing opioids to promote the local control of inflammatory pain...
  31. pmc Peripheral mechanisms of pain and analgesia
    Christoph Stein
    Department of Anesthesiology and Critical Care Medicine, Charite Campus Benjamin Franklin, Freie Universitat Berlin, Germany
    Brain Res Rev 60:90-113. 2009
    ....
  32. ncbi request reprint Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain
    Mohammed A Shaqura
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Germany
    J Pharmacol Exp Ther 308:712-8. 2004
    ..These findings show that inflammation causes changes in MOP receptor binding and G protein coupling after DAMGO stimulation selectively in primary afferent neurons but did not cause any adaptive changes of MOP receptor in HT or SC...
  33. ncbi request reprint Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing
    Christoph Stein
    Dep of Anesthesiology and Critical Care Medicine, Freie Universitat Berlin, Charite Campus Benjamin Franklin, Berlin, Germany
    Curr Pharm Des 18:6053-69. 2012
    ..Controversial results, methodological issues, implications for pharmacology, and therapeutic prospects for inflammatory diseases and wound healing will be discussed...
  34. pmc JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats
    Melanie Busch-Dienstfertig
    Department of Anesthesiology and Critical Care Medicine, Charite Campus Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Mol Pain 8:83. 2012
    ..Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment such analgesic effects...
  35. doi request reprint Modulation of peripheral sensory neurons by the immune system: implications for pain therapy
    Christoph Stein
    Department of Anesthesiology and Critical Care Medicine, Freie Universitat Berlin, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    Pharmacol Rev 63:860-81. 2011
    ..The ultimate goal is to avoid detrimental side effects of currently available analgesics such as respiratory depression, cognitive impairment, addiction, gastrointestinal bleeding, and thromboembolic complications...
  36. ncbi request reprint Immune mechanisms in pain control
    Halina Machelska
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Anesth Analg 95:1002-8, table of contents. 2002
  37. ncbi request reprint Controlling pain by influencing neurogenic pathways
    Wiebke Puehler
    Department of Anesthesiology and Critical Care Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Rheum Dis Clin North Am 31:103-13, ix. 2005
    ..This article focuses on the role of peripheral opioid receptors in pain control and on novel pharmaceutical concepts for the treatment of patients who suffer from rheumatoid arthritis and other inflammatory pain...
  38. ncbi request reprint Perioperative management of the chronic pain patient
    Andreas Kopf
    Department of Anesthesiology and Intensive Care Medicine, Charité Campus Benjamin Franklin Freie Universität Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Best Pract Res Clin Anaesthesiol 19:59-76. 2005
    ..No differences between specific techniques for post-operative analgesia (e.g. systemic, patient-controlled or regional analgesia) have been shown so far...
  39. doi request reprint Targeting inflammation and wound healing by opioids
    Christoph Stein
    Department of Anesthesiology and Critical Care Medicine, Freie Universitat Berlin, 12200 Berlin, Germany
    Trends Pharmacol Sci 34:303-12. 2013
    ..In contrast to currently available anti-inflammatory agents, opioids have not demonstrated organ toxicity, thus making them interesting candidates for drug development. Few clinical studies have tapped into this potential to date...
  40. doi request reprint Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors
    Cecile Cayla
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Campus Benjamin Franklin, Berlin, Germany
    Anesthesiology 116:448-57. 2012
    ..Because the overall contribution of kinins to painful processes remains unclear, the aim of this study was to analyze pain-related behaviors of mice unable to respond to kinins because of a lack of both B1 and B2 receptors...
  41. ncbi request reprint Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain
    Shaaban A Mousa
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Freie Universitat Berlin, Universitatsklinikum Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    J Neuroimmunol 126:5-15. 2002
    ..Taken together, the upregulation of MOR and of its endogenous ligands endomorphin-1 and endomorphin-2 in immunocytes suggests an involvement of these opioid peptides in the peripheral control of inflammatory pain...
  42. doi request reprint 3D-wound healing model: influence of morphine and solid lipid nanoparticles
    Sarah Küchler
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
    J Biotechnol 148:24-30. 2010
    ..In conclusion, acceleration of wound closure, low cytotoxicity and irritation as well as possible prolonged morphine release make SLN an interesting approach for innovative wound management...
  43. pmc Functional characteristics of the naked mole rat μ-opioid receptor
    Melanie Busch-Dienstfertig
    Department of Anesthesiology and Intensive Care Medicine, Charite Campus Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    PLoS ONE 8:e79121. 2013
    ..In summary, we found minor functional differences between rat and NMR MOR suggesting that other differences e.g. in anatomical distribution of MOR underlie the NMR's extreme reaction to opioids...
  44. ncbi request reprint Modulation of peripheral endogenous opioid analgesia by central afferent blockade
    Thomas K Schmitt
    Klinik für Anästhesiologie und Notfallmedizin, Westpfalzklinikum Kaiserslautern, Germany
    Anesthesiology 98:195-202. 2003
    ..The spinal application of opioid drugs blocks the transmission of nociceptive information from peripheral injury. This study investigates the influence of exogenous spinal opioid analgesia on peripheral endogenous opioid analgesia...
  45. ncbi request reprint Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception
    Heike L Rittner
    Klinik für Anaesthesiologie m S operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Anesthesiology 107:1009-17. 2007
    ..The authors hypothesized that NK1 receptor antagonists impair recruitment of opioid-containing leukocytes and stress-induced antinociception...
  46. ncbi request reprint Intra-articular morphine for inflammatory pain
    Christoph Stein
    Reg Anesth Pain Med 31:496-7. 2006
  47. ncbi request reprint Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation
    Rudolf Likar
    Abteilung für Anaesthesiologie und Intensivmedizin, LKH Klagenfurt, St Veiter Strasse 47, A 9020 Klagenfurt, Austria
    Clin J Pain 23:136-42. 2007
    ....
  48. ncbi request reprint Breaking the pain barrier
    Halina Machelska
    Nat Med 9:1353-4. 2003
  49. ncbi request reprint Potential links between leukocytes and antinociception
    Alexander Brack
    Pain 111:1-2. 2004
  50. ncbi request reprint [Consensus building on "Long-term opioid administration and non-tumor pain"]
    Hardo Sorgatz
    Institut für Psychologie der TUD, Steubenplatz 12, 64293 Darmstadt
    Z Arztl Fortbild Qualitatssich 96:317-23. 2002
  51. pmc Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C
    Tim D Plant
    Institut fur Pharmakologie und Toxikologie, FB Medizin, Philipps Universitat Marburg, Karl von Frisch Str, 1, 35032 Marburg, Germany
    Mol Pain 3:35. 2007
    ..TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released in response to noxious stimuli and during inflammation, is a potential target for the action of ET-1...