N Stefan

Summary

Country: Germany

Publications

  1. doi request reprint Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
  2. pmc Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic Fatty liver
    Rainer Lehmann
    Corresponding author Norbert Stefan
    Diabetes Care 36:2331-8. 2013
  3. pmc Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Eberhard Karls University Tubingen, Member of the German Centre for Diabetes Research DZD, Tubingen, Germany
    BMC Med Genet 11:86. 2010
  4. pmc Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    BMC Med Genet 10:77. 2009
  5. pmc No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Otfried Müller Str, 10, 72076 Tubingen, Germany
    BMC Med Genet 11:84. 2010
  6. pmc SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    BMC Med Genet 9:100. 2008
  7. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
  8. ncbi request reprint C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Obes Res 12:679-83. 2004
  9. ncbi request reprint Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
  10. ncbi request reprint Lifestyle intervention in individuals with normal versus impaired glucose tolerance
    S Schafer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Eur J Clin Invest 37:535-43. 2007

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. doi request reprint Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
    ..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist...
  2. pmc Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic Fatty liver
    Rainer Lehmann
    Corresponding author Norbert Stefan
    Diabetes Care 36:2331-8. 2013
    ....
  3. pmc Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Eberhard Karls University Tubingen, Member of the German Centre for Diabetes Research DZD, Tubingen, Germany
    BMC Med Genet 11:86. 2010
    ..We studied whether these SNPs influence the prediabetic traits insulin resistance, beta-cell dysfunction, or glucose intolerance...
  4. pmc Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    BMC Med Genet 10:77. 2009
    ..In this study, we assessed whether common genetic variation within the NR4A3 locus, encoding Nor-1, contributes to the development of prediabetic phenotypes, such as glucose intolerance, insulin resistance, or beta-cell dysfunction...
  5. pmc No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Otfried Müller Str, 10, 72076 Tubingen, Germany
    BMC Med Genet 11:84. 2010
    ....
  6. pmc SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention--the TULIP Study
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    BMC Med Genet 9:100. 2008
    ..To investigate the relevance of SIRT1 for human metabolism and caloric restriction, we analyzed SIRT1 genetic variants in respect to the outcome of a controlled lifestyle intervention in Caucasians at risk for type 2 diabetes...
  7. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    ..To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution...
  8. ncbi request reprint C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Obes Res 12:679-83. 2004
    ..We investigated whether this polymorphism contributed to the variability in obesity in our population from southern Germany and whether it was associated with insulin sensitivity of lipolysis and/or glucose disposal...
  9. ncbi request reprint Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
    ..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro...
  10. ncbi request reprint Lifestyle intervention in individuals with normal versus impaired glucose tolerance
    S Schafer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Eur J Clin Invest 37:535-43. 2007
    ..It is currently unknown whether it has beneficial effects on metabolism to a similar extent, in individuals with normal glucose tolerance (NGT) compared to individuals with IGT...
  11. ncbi request reprint Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetes Care 29:853-7. 2006
    ..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
  12. ncbi request reprint Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
    N Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Diabetologia 48:2282-91. 2005
    ..The aim of this study was to investigate whether genetic variants of the genes encoding ADIPOR1 and ADIPOR2 play a role in human metabolism...
  13. ncbi request reprint Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  14. doi request reprint Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
    N Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 51:648-56. 2008
    ..It is imperative for the assembly of VLDL particles, which transport triacylglycerol (TG) from liver to adipose tissue and other sites. We aimed to determine the role of hepatic SCD1 activity in human glucose and lipid metabolism...
  15. doi request reprint [Nonalcoholic steatohepatitis. Predictor and consequence of diabetes]
    N Stefan
    Abteilung für Endokrinologie, Diabetologie, Vaskuläre Medizin, Nephrologie und Klinische Chemie, Innere Medizin, Universitätsklinik Tübingen, Mitglied des Deutschen Zentrums für Diabetesforschung DZD e V, Tubingen
    Internist (Berl) 52:389-94. 2011
    ..The precise investigation of mechanisms involved will deliver new knowledge which may be important for the prevention and therapy of these diseases...
  16. doi request reprint Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase
    N Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetologia 54:7-9. 2011
    ..Among several enzymes that regulate the fate of hepatic lipids, adipose triacylglycerol lipase (ATGL) is of interest. This article briefly summarises novel information about the impact of ATGL in this process...
  17. pmc Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 33:405-7. 2010
    ..We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts insulin sensitivity in humans...
  18. doi request reprint [Individualized prevention of type 2 diabetes]
    N Stefan
    Heisenberg Stipendium der Deutschen Forschungsgemeinschaft, Universitätsklinik Tübingen, Otfried Muller Str 10, 72076 Tubingen
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 52:677-82. 2009
    ..Meanwhile, several genetic and phenotypic markers have been identified, which can help predict the success of the lifestyle intervention, allowing for a more effective individualized prevention of type 2 diabetes...
  19. ncbi request reprint Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
    J Clin Endocrinol Metab 90:4238-43. 2005
    ..Liver fat predicts insulin resistance in humans. So far, there is not much information on genetic determinants of liver fat. Hepatic lipase is a liver-specific enzyme that regulates lipid metabolism...
  20. ncbi request reprint New imaging techniques of fat, muscle and liver within the context of determining insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Horm Res 64:38-44. 2005
    ..This may allow a search for new candidate genes for type 2 diabetes mellitus and identify, at an early stage, individuals at risk for decline in insulin sensitivity...
  21. doi request reprint The risk allele load accelerates the age-dependent decline in beta cell function
    A Haupt
    Medical Clinic, Department of Internal Medicine IV Diabetology, Endocrinology, Nephrology, Angiology, and Clinical Chemistry, Eberhard Karls University, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    Diabetologia 52:457-62. 2009
    ..In the present study we examined the effect of these genes' risk alleles on the age-dependent decline in insulin secretion...
  22. ncbi request reprint Genetic determinants of insulin action in polycystic ovary syndrome
    M Haap
    Department of Endocrinology, Metabolism and Clinical Chemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 113:275-81. 2005
    ..There is an association of T2 D with several polymorphisms in candidate genes related to insulin resistance. However, there is limited information about the association of these polymorphisms with PCOS...
  23. doi request reprint Variation in the FTO gene influences food intake but not energy expenditure
    A Haupt
    Department of Internal Medicine, Division of Diabetology, Endocrinology, Nephrology and Angiology, Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:194-7. 2009
    ..Our data suggest that the increased body weight in carriers of the risk allele of FTO SNP rs8050136 is a consequence of increased food intake, but not of impaired energy expenditure...
  24. ncbi request reprint Role of AMP-activated protein kinase gamma 3 genetic variability in glucose and lipid metabolism in non-diabetic whites
    P Weyrich
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    Diabetologia 50:2097-106. 2007
    ..We also investigated whether genetic variance in PRKAG3 is associated with glucose and/or lipid metabolism in non-diabetic whites...
  25. doi request reprint Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
    K Kirchhoff
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 51:597-601. 2008
    ..We investigated whether these polymorphisms are also associated with impaired proinsulin to insulin conversion...
  26. ncbi request reprint A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6alpha gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids
    P Weyrich
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 48:669-74. 2005
    ....
  27. doi request reprint Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content
    A Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Otfried Müller Street 10, Tubingen, Germany
    Int J Obes (Lond) 36:774-82. 2012
    ..We investigated the relationships of the SNPs with hepatic APOC3 expression and hypothesized that visceral obesity may modulate the effects of these SNPs on liver fat and insulin sensitivity (IS)...
  28. doi request reprint AHSG gene variation is not associated with regional body fat distribution--a magnetic resonance study
    K Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:432-7. 2009
    ..0432), none of the SNPs was associated with regional fat distribution. Common genetic variation within AHSG does not appear to influence regional body fat distribution, but may affect whole-body adiposity in humans...
  29. doi request reprint A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
    S A Schafer
    Department of Internal Medicine, Division of Endocrinology, University Hospital of Tubingen, Tubingen, Germany
    Diabetologia 52:1075-82. 2009
    ..We aimed to investigate the effect of a common WFS1 single-nucleotide polymorphism on several aspects of insulin secretion...
  30. ncbi request reprint Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study
    J Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    MAGMA 18:128-37. 2005
    ....
  31. doi request reprint Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction
    K Rittig
    Department of Endocrinology, University of Tubingen, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    Diabetologia 51:2093-9. 2008
    ..Based on this, the aim of the present study was to test whether PVAT around conduit arteries (i.e. the brachial artery) influences NO bioavailability, expressed as flow-mediated dilation (FMD), or insulin sensitivity in humans in vivo...
  32. doi request reprint Effects of a lifestyle intervention in metabolically benign and malign obesity
    K Kantartzis
    Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Member of the Deutsches Zentrum für Diabetesforschung, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetologia 54:864-8. 2011
    ..In the present study we investigated whether a lifestyle intervention is sufficient to place obese insulin-resistant (OIR) individuals in a position where the possible metabolic consequences are similar to those for MHO individuals...
  33. ncbi request reprint Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetologia 47:1303-5. 2004
    ..In the present study we tested whether plasma adiponectin concentrations influence changes in insulin sensitivity induced by a short-term dietary intervention in humans...
  34. pmc Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
    S A Schafer
    Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    Diabetologia 50:2443-50. 2007
    ..We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms...
  35. doi request reprint High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
    K Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Gut 58:1281-8. 2009
    ..However, for a similar weight loss, there is a large variability in the change in liver fat. We hypothesised that cardiorespiratory fitness may predict the response to the intervention...
  36. doi request reprint The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention
    K Müssig
    Department of Internal Medicine IV Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 53:504-9. 2010
    ..We hypothesised that K121Q may predict the success of lifestyle intervention in terms of improvement of insulin sensitivity...
  37. doi request reprint The impact of liver fat vs visceral fat in determining categories of prediabetes
    K Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 53:882-9. 2010
    ....
  38. doi request reprint The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    Axel Haupt
    Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:1775-80. 2009
    ..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity...
  39. ncbi request reprint Endothelial NO-synthase intron 4 polymorphism is associated with disturbed in vivo nitric oxide production in individuals prone to type 2 diabetes
    K Rittig
    Department of Endocrinology and Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Horm Metab Res 40:13-7. 2008
    ..Due to the high prevalence and the relatively strong effect, this polymorphism might help to identify subjects at increased risk for atherosclerosis associated with overweight and insulin resistance...
  40. ncbi request reprint Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene
    N Stefan
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:1143-8. 2001
    ..8). In conclusion, these results provide evidence that the Pro12Ala polymorphism in the PPAR-gamma2 gene might be involved in a differential regulation of insulin secretion in response to increased FFAs in humans...
  41. doi request reprint Reducing visceral adipose tissue mass is essential for improving endothelial function in type 2 diabetes prone individuals
    K Rittig
    Department of Endocrinology and Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Otfried Müller Straße 10, 72076 Tubingen, Germany
    Atherosclerosis 212:575-9. 2010
    ..Consequently, we hypothesized that during a lifestyle intervention specifically a decrease in VAT, rather than TAT, is associated with improved ED and vascular adhesion molecules in type 2 diabetes prone subjects...
  42. ncbi request reprint Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:2161-3. 2001
    ..This may be entirely different with specific haplotype combinations...
  43. ncbi request reprint Association of serum phosphate levels with glucose tolerance, insulin sensitivity and insulin secretion in non-diabetic subjects
    M Haap
    Department of Endocrinology, Metabolism, Pathobiochemistry, Vascular Medicine and Nephrology, University of Tubingen, Tubingen, Germany
    Eur J Clin Nutr 60:734-9. 2006
    ..Hypophosphatemia is associated with impaired glucose tolerance and insulin resistance in primary hyperparathyroidism. However, little is known about the association between serum phosphate and glucose metabolism in healthy subjects...
  44. doi request reprint The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
    Clin Sci (Lond) 116:531-7. 2009
    ..This finding may be important in the prevention and treatment of insulin resistance and Type 2 diabetes in subjects with fatty liver...
  45. ncbi request reprint High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  46. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  47. ncbi request reprint Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
    ..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
  48. pmc Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:2616-23. 2009
    ..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance...
  49. doi request reprint Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians
    P Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:83-7. 2009
    ..As both high fat diet and obesity contribute to insulin resistance, we investigated whether genetic variability of CLPS associates with metabolic traits in non-diabetic humans at diabetes risk...
  50. ncbi request reprint Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction
    M Stumvoll
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:1235-9. 2001
    ..This strongly argues against the hypothesis that defective processing of proinsulin to insulin represents a major component of the beta-cell dysfunction in IGT...
  51. ncbi request reprint Plasma homocysteine concentrations in young individuals at increased risk of type 2 diabetes are associated with subtle differences in glomerular filtration rate but not with insulin resistance
    S A Schafer
    Department of Endocrinology, Diabetology, Nephrology, Angiology, and Clinical Chemistry, University Hospital of Internal Medicine, University of Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 114:306-9. 2006
    ..However, plasma homocysteine levels were related to subtle differences in kidney function at this early stage...
  52. doi request reprint High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
    O Tschritter
    Department of Internal Medicine IV, University Hospital, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 55:175-82. 2012
    ..This study aimed to test whether cerebral insulin sensitivity facilitates reduction of body weight and body fat by lifestyle intervention in humans...
  53. ncbi request reprint Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis
    K Staiger
    Department of Internal Medicine, University of Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:6707-13. 2005
    ..Whether adiponectin affects insulin secretion and beta-cell apoptosis and whether plasma adiponectin is associated with beta-cell function in humans is under investigation...
  54. doi request reprint Apelin serum levels are not associated with early atherosclerosis or fat distribution in young subjects with increased risk for type 2 diabetes
    K Rittig
    Department of Internal Medicine, Division of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 119:358-61. 2011
    ..We conclude that apelin serum levels do not add further information on the cardiovascular-, or diabetes risk pattern in a diabetes prone population...
  55. doi request reprint Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 16:1969-72. 2008
    ..In conclusion, despite an association with BMI and whole body fat distribution, variation in the FTO locus has no effect on the success of a lifestyle intervention program...
  56. doi request reprint Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes Metab Res Rev 26:200-5. 2010
    ..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans...
  57. ncbi request reprint Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population
    H Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabet Med 24:817-22. 2007
    ..We set out to determine whether genetic variation within the APPL locus (encoding APPL1) contributes to insulin resistance, changes in lipid metabolism or inflammatory parameters in a healthy White population...
  58. ncbi request reprint Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala
    Otto Tschritter
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Metabolism 52:778-83. 2003
    ..Because PPARgamma(2) is mainly expressed in adipose tissue, one of the main regulatory effects of the polymorphism may well be the more efficient suppression of (possibly intra-abdominal) lipolysis...
  59. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  60. doi request reprint Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:1809-11. 2009
    ..02, P = .02, P = .05, and P = .03, respectively). Our data suggest that a common genetic variation within the GPBAR1 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  61. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  62. doi request reprint Diagnostic value of hemoglobin A1c for type 2 diabetes mellitus in a population at risk
    A Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 119:234-7. 2011
    ..5%) we investigated its use as screening parameter for diabetes in a cohort at increased risk for the disease...
  63. doi request reprint Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia
    S Herzberg-Schäfer
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University, Tubingen, Germany
    Diabetes Obes Metab 14:85-90. 2012
    ..We speculate that the response or the non-response to therapy with GLP1 analogues and/or dipeptidyl peptidase-4 (DPP-IV) inhibitors is critically dependent on GLP1 resistance...
  64. doi request reprint The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition
    G Silbernagel
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:113-8. 2009
    ..The L162V single nucleotide polymorphism in PPARA is suggested to play an important role in the pathogenesis of type 2 diabetes, obesity, and body fat composition. However, clinical evidence is controversial...
  65. ncbi request reprint The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
    M Stumvoll
    Medical Clinic, Department of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
    Diabetes 50:882-5. 2001
    ..It is possible that this polymorphism causes insulin resistance at the level of the beta-cell and contributes to the polygenic etiology of type 2 diabetes...
  66. doi request reprint mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action
    J Koska
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health DHHS, Phoenix, AZ, USA
    Int J Obes (Lond) 33:842-50. 2009
    ..To determine whether the mRNA concentrations of inflammation response genes in isolated adipocytes and in cultured preadipocytes are related to adipocyte size and in vivo insulin action in obese individuals...
  67. doi request reprint Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
    Claus Thamer
    Department of Endocrinology, Metabolism, Clinical Chemistry, Nephrology, and Angiology, Medical Clinic, Eberhard Karls University, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:1497-500. 2008
    ..e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI)...
  68. ncbi request reprint Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 85:55-61. 2007
    ..01). In conclusion, subjects carrying the T allele of SNP usf1s1 and the A allele of SNP usf1s2 have a higher antilipolytic insulin sensitivity. Moreover, both SNPs may interact with the -514C > T SNP in LIPC to determine liver fat...
  69. ncbi request reprint Plasma adiponectin concentrations in children: relationships with obesity and insulinemia
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    J Clin Endocrinol Metab 87:4652-6. 2002
    ....
  70. pmc Distribution of subcutaneous fat predicts insulin action in obesity in sex-specific manner
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, Arizona, USA
    Obesity (Silver Spring) 16:2003-9. 2008
    ....
  71. ncbi request reprint Plasma adiponectin levels are not associated with fat oxidation in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Obes Res 10:1016-20. 2002
    ..To test the hypothesis that low adiponectin is associated with low fat oxidation in humans...
  72. doi request reprint Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
    ..009, dominant inheritance model). Therefore, our results suggest that these new obesity SNPs, despite their influence on BMI, are neither associated with a metabolically unfavorable nor with a favorable body composition...
  73. pmc Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen, Germany
    Diabetes 58:1715-20. 2009
    ..This linkage appears to be mediated by altered beta-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ1 single nucleotide polymorphisms (SNPs) on insulin secretion upon different stimuli...
  74. pmc Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3962. 2008
    ....
  75. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  76. doi request reprint Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans
    H Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:21-7. 2009
    ..Thus, these NEFA species may represent specific determinants of plasma interleukin-8...
  77. doi request reprint RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:519-24. 2009
    ..In generalized obesity, this genetic effect may be masked by the close association between whole-body obesity and visceral fat mass...
  78. doi request reprint Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity
    Michael Boettcher
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Magn Reson Imaging 29:1340-5. 2009
    ..To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined...
  79. doi request reprint Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
    Karsten Müssig
    Department of Diagnostic Radiology, Division of Endocrinology, University Hospital of Tü bingen, Tubingen, Germany
    J Clin Endocrinol Metab 94:1353-60. 2009
    ..The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver...
  80. ncbi request reprint Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetes Care 27:2726-9. 2004
  81. doi request reprint Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    Metabolism 57:637-43. 2008
    ..We conclude that common genetic variation within the ANGPTL4 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  82. doi request reprint Interscapular fat is strongly associated with insulin resistance
    Claus Thamer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany
    J Clin Endocrinol Metab 95:4736-42. 2010
    ..Whole-body magnetic resonance imaging and spectroscopy offer a unique approach to quantify fat depots in larger cohorts...
  83. ncbi request reprint Adiponectin--its role in metabolism and beyond
    N Stefan
    Clinical Nutrition and Metabolism Section, NIDDK, NIH, Phoenix, Arizona 85016, USA
    Horm Metab Res 34:469-74. 2002
    ..This suggests that adiponectin may reflect PPAR-gamma activity in vivo. Finally, reversal or alleviation of hypoadiponectinemia may represent a target for development of drugs improving insulin sensitivity and glucose tolerance...
  84. ncbi request reprint The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Int J Obes Relat Metab Disord 26:1629-32. 2002
    ..These findings are consistent with a role of the Gln223Arg polymorphism in reducing peripheral and central leptin binding to the LEPR in humans. However, these effects do not seem to have a major impact on adiposity in this population...
  85. ncbi request reprint Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 53:663-71. 2004
    ..However, the hyperinsulinemia of this population does not appear to be due to increased vagal input to pancreatic beta-cells...
  86. ncbi request reprint The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry, and Clinical Chemistry, Eberhard Karls University of Tubingen, Tubingen, Germany
    Clin Chem 52:1934-42. 2006
    ..Adiposity may also affect the relationship of adiponectin concentrations with serum lipid profile; markers of inflammation, atherosclerosis, and endothelial function; and ectopic fat accumulation...
  87. pmc Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies
    Bjorn Friedrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e3506. 2008
    ..Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans...
  88. ncbi request reprint Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism
    Harald Staiger
    Department of Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 53:2195-201. 2004
    ..AdipoR1, but not AdipoR2, expression correlated with insulin secretion. The molecular nature of this link between muscle and beta-cells needs to be further clarified...
  89. ncbi request reprint High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Obesity (Silver Spring) 15:531-8. 2007
    ..We studied changes in these two fat depots during weight loss and analyzed whether VAT and LF at baseline predict the response to lifestyle intervention...
  90. pmc Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 2:e832. 2007
    ..However, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed...
  91. pmc Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:747-50. 2010
    ..As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studied the impact of TCF7L2 variants on body composition and weight loss during lifestyle intervention...
  92. ncbi request reprint Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Am J Clin Nutr 87:295-302. 2008
    ....
  93. ncbi request reprint [Gene-environment interactions in the pathogenesis and prevention of type 2 diabetes mellitus]
    A Fritsche
    Abt Innere Medizin IV, Universitatsklinikum Tubingen
    Internist (Berl) 48:669-70, 672, 674-5. 2007
    ..This review summarizes the genetic and environmental factors which influence the risk for type 2 diabetes and their interactions, and determine the success of prevention programs...
  94. pmc Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:3247-52. 2010
    ..Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/or incretin-induced insulin secretion. Here, we investigated interactions between glycemia and such diabetes risk polymorphisms...
  95. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
    ..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate...
  96. doi request reprint Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Radiology 257:353-63. 2010
    ....
  97. ncbi request reprint Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Magn Reson Med 55:913-7. 2006
    ..Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease...
  98. doi request reprint Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen Germany
    Clin Chem 55:2113-20. 2009
    ..Additionally, we further evaluated commonly used fatty acid ratios [elongase, de novo lipogenesis, and Delta5 and Delta6 desaturase] in plasma VLDL and hepatic lipid fractions...
  99. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  100. doi request reprint (1)H MR spectroscopy of skeletal muscle, liver and bone marrow
    Jürgen Machann
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Radiol 67:275-84. 2008
    ..Adapted (1)H spectroscopic techniques allow a semi-quantitative analysis of bone marrow composition...
  101. ncbi request reprint A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance
    Otto Tschritter
    Medizinische Universitatsklinik, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:654-8. 2006
    ..The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed in a variety of tissues including liver and skeletal muscle. In animal models, knockout of Kv1.3 has been found to improve insulin sensitivity and glucose tolerance...