Harald Staiger

Summary

Country: Germany

Publications

  1. ncbi request reprint Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:37-41. 2002
  2. ncbi request reprint Serum-free differentiation of 3T3-L1 preadipocytes is characterized by only transient expression of peroxisome proliferator-activated receptor-gamma
    Harald Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard Karls University, Tubingen, Germany
    Biochem Biophys Res Commun 296:125-8. 2002
  3. ncbi request reprint Three-dimensional in vitro model of adipogenesis: comparison of culture conditions
    Claudia Fischbach
    Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany
    Tissue Eng 10:215-29. 2004
  4. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
  5. pmc The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies
    Peter Weyrich
    Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, Clinical Chemistry, Department of Internal Medicine, Paul Langerhans Institute Tübingen, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e13980. 2010
  6. pmc Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels
    Anja Böhm
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e34035. 2012
  7. ncbi request reprint Hypomagnesemia and nephrocalcinosis in a patient with two heterozygous mutations in the CLDN16 gene
    Katrin Staiger
    Section of Nephrology and Hypertension, Division of Endocrinology, Department of Internal Medicine, Eberhard Karls University Tubingen, Tubingen Germany
    J Nephrol 20:107-10. 2007
  8. pmc Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3019. 2008
  9. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
  10. pmc Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:3247-52. 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:37-41. 2002
    ..In contrast, in individuals who are already burdened by other genetic factors, this small effect may be very hard to detect...
  2. ncbi request reprint Serum-free differentiation of 3T3-L1 preadipocytes is characterized by only transient expression of peroxisome proliferator-activated receptor-gamma
    Harald Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard Karls University, Tubingen, Germany
    Biochem Biophys Res Commun 296:125-8. 2002
    ..We conclude that maintenance, but not induction, of PPARgamma gene expression in vitro must be achieved by one or more still unknown serum component(s)...
  3. ncbi request reprint Three-dimensional in vitro model of adipogenesis: comparison of culture conditions
    Claudia Fischbach
    Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany
    Tissue Eng 10:215-29. 2004
    ....
  4. ncbi request reprint High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans
    Norbert Stefan
    Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Diabetes Care 30:1173-8. 2007
    ..To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution...
  5. pmc The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies
    Peter Weyrich
    Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, Clinical Chemistry, Department of Internal Medicine, Paul Langerhans Institute Tübingen, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e13980. 2010
    ....
  6. pmc Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels
    Anja Böhm
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e34035. 2012
    ..Therefore, we assessed whether common genetic variation within the SERPINF1 locus contributes to adipose tissue-related prediabetic phenotypes in humans...
  7. ncbi request reprint Hypomagnesemia and nephrocalcinosis in a patient with two heterozygous mutations in the CLDN16 gene
    Katrin Staiger
    Section of Nephrology and Hypertension, Division of Endocrinology, Department of Internal Medicine, Eberhard Karls University Tubingen, Tubingen Germany
    J Nephrol 20:107-10. 2007
    ..Due to their location within the primary structure of Claudin-16, both mutations are suggested to interfere with renal paracellular magnesium conductance...
  8. pmc Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3019. 2008
    ..e., obesity, impaired insulin secretion, and insulin resistance...
  9. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
    ..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
  10. pmc Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:3247-52. 2010
    ..Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/or incretin-induced insulin secretion. Here, we investigated interactions between glycemia and such diabetes risk polymorphisms...
  11. doi request reprint The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    Axel Haupt
    Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:1775-80. 2009
    ..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity...
  12. pmc Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Eberhard Karls University Tubingen, Member of the German Centre for Diabetes Research DZD, Tubingen, Germany
    BMC Med Genet 11:86. 2010
    ..We studied whether these SNPs influence the prediabetic traits insulin resistance, beta-cell dysfunction, or glucose intolerance...
  13. pmc Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 33:405-7. 2010
    ..We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts insulin sensitivity in humans...
  14. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
    ..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate...
  15. pmc Relationships of circulating sex hormone-binding globulin with metabolic traits in humans
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 59:3167-73. 2010
    ..In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes...
  16. pmc The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors
    Anna Maria Ordelheide
    Division of Endocrinology, Department of Internal Medicine, Eberhard Karls University Tübingen and German Center for Diabetes Research DZD eV, Tubingen, Germany
    Exp Diabetes Res 2011:692536. 2011
    ..03). In conclusion, myocyte expression of PPARδ and the adiponectin receptors are highly coordinated, and this might be of relevance for human lipid metabolism in vivo...
  17. pmc No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Otfried Müller Str, 10, 72076 Tubingen, Germany
    BMC Med Genet 11:84. 2010
    ....
  18. doi request reprint Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:1809-11. 2009
    ..02, P = .02, P = .05, and P = .03, respectively). Our data suggest that a common genetic variation within the GPBAR1 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  19. ncbi request reprint Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
    ..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro...
  20. doi request reprint Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity
    Martin Heni
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Member of the German Center for Diabetes Research DZD, Tubingen, Germany
    Obesity (Silver Spring) 19:1004-9. 2011
    ..In the long run, genetic variation within the CD36 locus may contribute to metabolic disease via its effect on body adiposity, but not via an independent effect on insulin sensitivity...
  21. pmc Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen, Germany
    Diabetes 58:1715-20. 2009
    ..This linkage appears to be mediated by altered beta-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ1 single nucleotide polymorphisms (SNPs) on insulin secretion upon different stimuli...
  22. ncbi request reprint Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
    ..009, dominant inheritance model). Therefore, our results suggest that these new obesity SNPs, despite their influence on BMI, are neither associated with a metabolically unfavorable nor with a favorable body composition...
  23. doi request reprint Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes Metab Res Rev 26:200-5. 2010
    ..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans...
  24. pmc Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function
    Silke A Herzberg-Schäfer
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen and Eberhard Karls University Tübingen, Tubingen, Germany
    PLoS ONE 5:e14194. 2010
    ..g., for genetic studies. Here, we evaluated twelve common (or recently introduced) fasting state-/OGTT-derived indices for their suitability to detect genetically determined β-cell dysfunction...
  25. pmc Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3962. 2008
    ....
  26. ncbi request reprint Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism
    Otto Tschritter
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 52:239-43. 2003
    ..This suggests pleiotropic insulin sensitizing effects of adiponectin in humans...
  27. pmc Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 59:747-50. 2010
    ..As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studied the impact of TCF7L2 variants on body composition and weight loss during lifestyle intervention...
  28. doi request reprint Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, University Hospital, Eberhard Karls University Tubingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 98:E1224-9. 2013
    ..Bile acid signaling via farnesoid X receptor (FXR) regulates glucose and lipid levels, fat mass, and hepatic steatosis in animal models...
  29. pmc Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 8:e61903. 2013
    ....
  30. doi request reprint Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 17:1942-5. 2009
    ..Thus, this candidate SNP for human obesity may preferentially affect the accumulation of subcutaneous adipose tissue. Furthermore, the variation near MC4R has no effect on success of weight loss during lifestyle intervention...
  31. doi request reprint RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Metabolism 58:519-24. 2009
    ..In generalized obesity, this genetic effect may be masked by the close association between whole-body obesity and visceral fat mass...
  32. doi request reprint Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
    Karsten Müssig
    Department of Diagnostic Radiology, Division of Endocrinology, University Hospital of Tü bingen, Tubingen, Germany
    J Clin Endocrinol Metab 94:1353-60. 2009
    ..The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver...
  33. doi request reprint Genetic variation within the ANGPTL4 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    Harald Staiger
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    Metabolism 57:637-43. 2008
    ..We conclude that common genetic variation within the ANGPTL4 gene may not play a major role in the development of prediabetic phenotypes in our white population...
  34. doi request reprint In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo
    Anna Maria Ordelheide
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Member of the German Center for Diabetes Research DZD e V, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Clin Invest 41:1323-9. 2011
    ..Therefore, we asked here whether human muscle cell PPARD expression is a determinant of donors' insulin sensitivity...
  35. doi request reprint Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids
    Alexander Krogmann
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    Microvasc Res 81:52-9. 2011
    ..In conclusion, hCAECs express a large panel of inflammatory genes with a series of genes being regulated by palmitate and stearate, but not by UFAs. Thus, SFAs represent potential contributors to vascular inflammation...
  36. pmc Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 2:e832. 2007
    ..However, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed...
  37. ncbi request reprint Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans
    Harald Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Obes Res 11:368-72. 2003
    ..We investigated whether serum concentrations of adiponectin are determined by body fat distribution and compared the findings with leptin...
  38. pmc Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects
    Peter Weyrich
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    BMC Med Genet 10:77. 2009
    ..In this study, we assessed whether common genetic variation within the NR4A3 locus, encoding Nor-1, contributes to the development of prediabetic phenotypes, such as glucose intolerance, insulin resistance, or beta-cell dysfunction...
  39. doi request reprint Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
    Claus Thamer
    Department of Endocrinology, Metabolism, Clinical Chemistry, Nephrology, and Angiology, Medical Clinic, Eberhard Karls University, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:1497-500. 2008
    ..e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI)...
  40. doi request reprint Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine, Tubingen, Germany
    J Cell Mol Med 14:903-13. 2010
    ....
  41. ncbi request reprint Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetes Care 29:853-7. 2006
    ..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
  42. ncbi request reprint Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
    Karsten Müssig
    Division of Endocrinology, Metabolism and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Biochem Biophys Res Commun 335:819-25. 2005
    ....
  43. pmc Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans
    Tina Sartorius
    Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tubingen, Germany
    PLoS ONE 7:e47647. 2012
    ..This variation's impact on insulin sensitivity may be more important since its effect on insulin release vanishes with increasing BMI...
  44. doi request reprint Interscapular fat is strongly associated with insulin resistance
    Claus Thamer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany
    J Clin Endocrinol Metab 95:4736-42. 2010
    ..Whole-body magnetic resonance imaging and spectroscopy offer a unique approach to quantify fat depots in larger cohorts...
  45. doi request reprint Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans
    Konstantinos Kantartzis
    Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, University of Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 17:390-2. 2009
    ..These data indicate that, among circulating forms of adiponectin, HMW is strongly related to ectopic fat, thus possibly representing the form of adiponectin regulating lipid oxidation in liver and skeletal muscle...
  46. ncbi request reprint Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
    Katrin Eitel
    Internal Medicine IV, University of Tubingen, Tubingen, Germany
    Diabetes 52:991-7. 2003
    ..These data suggest that nuclear translocation and kinase activity of PKC-delta are both necessary for saturated fatty acid-induced apoptosis...
  47. pmc Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion
    Martin Heni
    Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e46154. 2012
    ..We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or proinsulin conversion...
  48. pmc Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals
    Katarzyna Linder
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e38224. 2012
    ..It is not known whether a similar genetic impact on the risk of prediabetes (impaired glucose tolerance [IGT] or impaired fasting glycemia [IFG]) exists...
  49. ncbi request reprint Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation
    Katrin Staiger
    Internal Medicine IV, Medical Clinic, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 55:3121-6. 2006
    ..Mechanistically, promotion of HCAEC apoptosis by saturated NEFA requires acyl-CoA formation, IKK, and NFkappaB activation...
  50. doi request reprint Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
    Andreas Peter
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Am J Physiol Endocrinol Metab 295:E339-49. 2008
    ..These findings add a novel aspect to the atheroprotective actions of LXR activators in cardiovascular disease...
  51. ncbi request reprint Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells
    Harald Staiger
    Department of Endocrinology, Metabolism and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Diabetes 53:3209-16. 2004
    ..29, P < 0.05). We show here that the common plasma FFA palmitate induces high levels of IL-6 in CAECs. Furthermore, palmitate correlates with IL-6 in vivo. This points to a potential contribution of palmitate to vascular inflammation...
  52. ncbi request reprint Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism
    Harald Staiger
    Department of Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 53:2195-201. 2004
    ..AdipoR1, but not AdipoR2, expression correlated with insulin secretion. The molecular nature of this link between muscle and beta-cells needs to be further clarified...
  53. pmc Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin
    Robert Wagner
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 6:e23639. 2011
    ..For several of these loci, the mechanism of action in glucose homeostasis is unclear. The objective of the study was to establish metabolic phenotypes for these genetic variants to deliver clues to their pathomechanism...
  54. doi request reprint Effect of insulin detemir, compared to human insulin, on 3T3-L1 adipogenesis
    Anja Böhm
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    Regul Pept 151:160-3. 2008
    ..We conclude that DET displays reduced adipogenity, and this could contribute to DET's weight-sparing effect in vivo...
  55. ncbi request reprint Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1
    Karsten Müssig
    Division of Endocrinology, Metabolism, and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, Tubingen 72076, Germany
    J Biol Chem 280:32693-9. 2005
    ..Because the activation of these kinases does not depend on Shp2, it is concluded that the function of Shp2 is to direct these activated kinases to IRS-1...
  56. pmc Fetuin-A induces cytokine expression and suppresses adiponectin production
    Anita M Hennige
    Department of Internal Medicine, Division of Endocrinology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 3:e1765. 2008
    ....
  57. ncbi request reprint Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes
    Caroline Ketterer
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Metabolism 60:1325-33. 2011
    ..3). In our German population, the common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus...
  58. doi request reprint The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia
    Martin Heni
    Department of Internal Medicine, Eberhard Karls University Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 95:E479-84. 2010
    ..Single-nucleotide polymorphisms (SNPs) within the G6PC2 locus are associated with fasting glucose and insulin secretion. These SNPs are not associated with type 2 diabetes risk...
  59. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  60. ncbi request reprint Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen 72076, Germany
    J Biol Chem 279:23942-52. 2004
    ..We conclude that IL-6 expression may be modulated by the composition of circulating FFA, e.g. by diet, and that skeletal muscle cells could be target cells for IL-6...
  61. pmc Insulin promotes glycogen storage and cell proliferation in primary human astrocytes
    Martin Heni
    Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 6:e21594. 2011
    ..Thus, they may also contribute to cerebral insulin actions. Therefore, we examined whether primary human astrocytes are insulin-responsive and whether their metabolic functions are affected by the hormone...
  62. doi request reprint Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes
    Caroline Ketterer
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, German Center for Diabetes Research DZD, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 89:75-81. 2011
    ..In subjects of European ancestry at increased risk for type 2 diabetes, common variation within the NR1H2 gene impaired insulin secretion, which may facilitate the development of type 2 diabetes...
  63. ncbi request reprint Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action
    Caroline Ketterer
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tubingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen Paul Langerhans Institute Tübingen, Tubingen, Germany German Center for Diabetes Research DZD, Neuherberg, Germany
    Obesity (Silver Spring) 22:925-31. 2014
    ..Furthermore, we wanted to investigate if the identified hits influence weight loss during lifestyle intervention; and study a potential involvement of cerebral insulin action...
  64. ncbi request reprint Pathomechanisms of type 2 diabetes genes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    Endocr Rev 30:557-85. 2009
    ..This favors a beta-cell-centric view on the genetics of type 2 diabetes. The aim of this review is to summarize the current knowledge about the type 2 diabetes risk genes and their variants' pathomechanisms...
  65. doi request reprint Genetic variants in MTNR1B affecting insulin secretion
    Karsten Müssig
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University, Member of the German Centre for Diabetes Research DZD, 72076 Tubingen, Germany
    Ann Med 42:387-93. 2010
    ..This brief review aims to give an overview of how alterations in the melatonin system could contribute to an increased diabetes risk, paying special attention to the role of melatonin receptors in pancreatic beta-cell function...
  66. doi request reprint Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors
    Magnus Wolf
    Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry, and Clinical Chemistry, Department of Internal Medicine, University Tübingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 98:E1137-42. 2013
    ..It is unknown whether the production of acylcarnitines in primary human myotubes obtained from lean, metabolically healthy subjects reflects the fat oxidation in vivo...
  67. pmc Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 7:e50953. 2012
    ..Since this is yet unclear for prostate cancer, we investigated IR isoform composition and IRS balance in prostate cancer compared to benign and tumor adjacent benign prostate tissue and brought this into relation to cell proliferation...
  68. ncbi request reprint Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects: response to Broch et al
    Norbert Stefan
    Diabetes Care 30:e91; author reply e92. 2007
  69. ncbi request reprint Oxygen consumption in undifferentiated versus differentiated adipogenic mesenchymal precursor cells
    Dennis von Heimburg
    Department of Plastic Surgery and Hand Surgery Burn Center, University Hospital of the Aachen University of Technology, Pauwelsstr 30, 52057 Aachen, Germany
    Respir Physiol Neurobiol 146:107-16. 2005
    ....
  70. ncbi request reprint A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance
    Otto Tschritter
    Medizinische Universitatsklinik, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:654-8. 2006
    ..The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed in a variety of tissues including liver and skeletal muscle. In animal models, knockout of Kv1.3 has been found to improve insulin sensitivity and glucose tolerance...
  71. ncbi request reprint [Apoptosis induced by free fatty acids]
    Katrin Eitel
    Medizinische Klinik IV, Universitat Tubingen
    Med Klin (Munich) 98:248-52. 2003
    ..The purpose of this study was to investigate whether the lipoapoptotic effect of FFAs is determined by the degree of saturation and the chain length, and which pathways might be involved...
  72. ncbi request reprint Comparison of viable cell yield from excised versus aspirated adipose tissue
    Dennis von Heimburg
    Department of Plastic Surgery and Hand Surgery, Burn Center, University Hospital, Aachen University of Technology, Aachen, Germany
    Cells Tissues Organs 178:87-92. 2004
    ..If cell isolation is not performed immediately after the operation, liposuction material is clearly the better alternative for storage...