Christine Stadelmann

Summary

Country: Germany

Publications

  1. doi Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications
    Christine Stadelmann
    Institute of Neuropathology, University Medical Centre, Gottingen, Germany
    Curr Opin Neurol 24:224-9. 2011
  2. pmc An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3
    Christina Roebke
    Institut fur Virologie, Gebäude 47, Universitatsklinikum des Saarlandes, 66421 Homburg, Germany
    Retrovirology 7:69. 2010
  3. doi Cortical pathology in multiple sclerosis
    Christine Stadelmann
    Institute of Neuropathology, University Medical Centre, Gottingen, Germany
    Curr Opin Neurol 21:229-34. 2008
  4. doi Interplay between mechanisms of damage and repair in multiple sclerosis
    Christine Stadelmann
    Georg August Universitat Gottingen, Abteilung Neuropathologie, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 255:12-8. 2008
  5. doi Inflammation, demyelination, and degeneration - recent insights from MS pathology
    Christine Stadelmann
    Institute of Neuropathology, University Medical Center, Gottingen, Germany
    Biochim Biophys Acta 1812:275-82. 2011
  6. pmc Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Robert Koch Str 40, 37099, Gottingen, Germany
    Acta Neuropathol 124:411-24. 2012
  7. doi Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions
    Lucas Schirmer
    Department of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    Brain Pathol 23:2-12. 2013
  8. ncbi Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
  9. ncbi Gray matter pathology and multiple sclerosis
    Christiane Wegner
    Institute of Neuropathology, University Medical Centre, Göttingen 37099, Germany
    Curr Neurol Neurosci Rep 9:399-404. 2009
  10. pmc Carcinoma cells misuse the host tissue damage response to invade the brain
    Han Ning Chuang
    Department of Hematology Oncology, University Medical Center, Gottingen, Germany
    Glia 61:1331-46. 2013

Collaborators

Detail Information

Publications48

  1. doi Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications
    Christine Stadelmann
    Institute of Neuropathology, University Medical Centre, Gottingen, Germany
    Curr Opin Neurol 24:224-9. 2011
    ..This has led to the hypothesis that disease mechanisms independent of an adaptive immune response contribute to disease progression and closely resemble neurodegeneration...
  2. pmc An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3
    Christina Roebke
    Institut fur Virologie, Gebäude 47, Universitatsklinikum des Saarlandes, 66421 Homburg, Germany
    Retrovirology 7:69. 2010
    ..We set out to characterize the protein encoded by that ORF...
  3. doi Cortical pathology in multiple sclerosis
    Christine Stadelmann
    Institute of Neuropathology, University Medical Centre, Gottingen, Germany
    Curr Opin Neurol 21:229-34. 2008
    ..Lately, evidence has accumulated that large areas of grey matter are affected in multiple sclerosis patients...
  4. doi Interplay between mechanisms of damage and repair in multiple sclerosis
    Christine Stadelmann
    Georg August Universitat Gottingen, Abteilung Neuropathologie, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 255:12-8. 2008
    ..There is important heterogeneity between patients in terms of the extent of remyelination, which may reflect underlying differences in pathogenetic mechanisms between patients...
  5. doi Inflammation, demyelination, and degeneration - recent insights from MS pathology
    Christine Stadelmann
    Institute of Neuropathology, University Medical Center, Gottingen, Germany
    Biochim Biophys Acta 1812:275-82. 2011
    ..This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS...
  6. pmc Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Robert Koch Str 40, 37099, Gottingen, Germany
    Acta Neuropathol 124:411-24. 2012
    ..Modulation of astrocyte activation may be an attractive therapeutic target to prevent tissue damage in MS...
  7. doi Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions
    Lucas Schirmer
    Department of Neuropathology, University Medical Center Gottingen, Gottingen, Germany
    Brain Pathol 23:2-12. 2013
    ..Furthermore, axonal GAP43+ and Syn+ swellings correlated with prolonged survival after TBI, indicating a sustained regenerative response...
  8. ncbi Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
    ..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain...
  9. ncbi Gray matter pathology and multiple sclerosis
    Christiane Wegner
    Institute of Neuropathology, University Medical Centre, Göttingen 37099, Germany
    Curr Neurol Neurosci Rep 9:399-404. 2009
    ..This review focuses on recent information from pathologic and imaging studies and summarizes our current knowledge on cortical pathology derived from human and experimental studies...
  10. pmc Carcinoma cells misuse the host tissue damage response to invade the brain
    Han Ning Chuang
    Department of Hematology Oncology, University Medical Center, Gottingen, Germany
    Glia 61:1331-46. 2013
    ..Together, our findings point to a detrimental misuse of the glial damage response program by carcinoma cells resistant to glia-induced apoptosis...
  11. pmc Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons
    Shailender Singh
    Department of Neuropathology, University Medical Center, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Acta Neuropathol 125:595-608. 2013
    ..In addition, we show that early MS microglial nodules exhibit both pro- and antiinflammatory phenotypes...
  12. ncbi A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain 129:1972-83. 2006
    ..Our data thus suggest that cortical inflammation is a transient phenomenon, and that remyelination of cortical inflammatory-demyelinating lesions may occur rapidly...
  13. ncbi Effects of interferon-beta-1a on neuronal survival under autoimmune inflammatory conditions
    Muriel B Sättler
    Neurologische Universitatsklinik, Robert Koch Str 40, 37075 Gottingen, Germany
    Exp Neurol 201:172-81. 2006
    ..We conclude that IFN-beta-1a is a suitable candidate to be combined with a directly neuroprotective agent in order to further decrease axonal and neuronal degeneration in MS patients...
  14. doi Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    Christiane Wegner
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    J Neuroimmunol 227:133-43. 2010
    ..Laquinimod might thus protect myelin and axons by decreasing pro-inflammatory cytokines and impairing the migratory capacity of lymphocytes...
  15. doi Substantial early, but nonprogressive neuronal loss in multiple sclerosis (MS) spinal cord
    Lucas Schirmer
    Department of Neuropathology, University Medical Centre Göttingen, Gottingen, Germany
    Ann Neurol 66:698-704. 2009
    ....
  16. ncbi The spectrum of multiple sclerosis: new lessons from pathology
    Wolfgang Bruck
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Curr Opin Neurol 18:221-4. 2005
    ....
  17. doi Wallerian degeneration: a major component of early axonal pathology in multiple sclerosis
    Tomasz Dziedzic
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Brain Pathol 20:976-85. 2010
    ..It may contribute to radiological changes observed in early MS and most likely plays a major role in the development of disability...
  18. doi Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions
    Claudia Wrzos
    Institute of Neuropathology, University Medical Centre Göttingen, Robert Koch Str 40, 37099, Gottingen, Germany
    Acta Neuropathol 127:523-38. 2014
    ....
  19. ncbi Extensive cortical remyelination in patients with chronic multiple sclerosis
    Monika Albert
    Institute of Neuropathology, University of Goettingen, Goettingen, Germany
    Brain Pathol 17:129-38. 2007
    ..Our data confirm the high prevalence of cortical demyelination in chronic MS and imply that the propensity to remyelinate is high in cortical MS lesions...
  20. ncbi Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way
    Tobias Pukrop
    Department of Hematology Oncology, University of Gottingen, Gottingen, Germany
    Glia 58:1477-89. 2010
    ..In conclusion, microglia are critical for the successful colonization of the brain by epithelial cancer cells, suggesting inhibition of proinvasive microglia as a promising antimetastatic strategy...
  21. ncbi Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis
    Simone C Tauber
    Department of Neurology, Georg August University, Gottingen, Germany
    J Neuropathol Exp Neurol 64:806-15. 2005
    ..004). No significant changes in GDNF expression were observed. In conclusion, increased synthesis of BDNF and TrkB suggests a contribution of this neurotrophic factor to neurogenesis after bacterial meningitis...
  22. pmc Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia
    Alonso Barrantes-Freer
    Max Planck Institute of Experimental Medicine, Molecular Biology of Neuronal Signals, AG Oncophysiology, Gottingen
    J Neuropathol Exp Neurol 72:307-24. 2013
    ..Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties...
  23. ncbi Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosis
    Frank K H van Landeghem
    Institute of Neuropathology, Charite, Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Pediatr Res 51:129-35. 2002
    ..There was no significant difference between cases with and without PSN. We conclude that in the developing human brain, cells expressing the Fas receptor may be susceptible to undergoing apoptosis in response to hypoxic-ischemic injury...
  24. pmc Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    J Exp Med 200:1027-38. 2004
    ..This framework will help to understand the endogenous repair capacity of the CNS and to develop therapeutic strategies to support it...
  25. ncbi Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system
    Shin Young Na
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    Brain 131:2353-65. 2008
    ....
  26. ncbi Behavioral testing strategies in a localized animal model of multiple sclerosis
    Bigna S Buddeberg
    Brain Research Institute, University of Zurich and Department Biology Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Neuroimmunol 153:158-70. 2004
    ..Such refined behavioral testing in EAE will be crucial for the analysis of new therapeutic approaches for MS that seek to improve or prevent neurological impairment...
  27. ncbi Remyelination in multiple sclerosis
    Wolfgang Bruck
    Institut für Neuropathologie, Charite, Campus Virchow Klinikum, Humboldt Universitat, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neurol Sci 206:181-5. 2003
    ..The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging...
  28. ncbi Differential regulation of myelin phagocytosis by macrophages/microglia, involvement of target myelin, Fc receptors and activation by intravenous immunoglobulins
    Tanja Kuhlmann
    Department of Neuropathology, Charite, Humboldt Universitat, Berlin, Germany
    J Neurosci Res 67:185-90. 2002
    ..Local factors within the CNS or PNS may affect this process by modulating the surface receptor profile and activation state of the phagocytic cell or the structure of the myelin sheath...
  29. ncbi BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?
    Christine Stadelmann
    Institute for Neuropathology, Charite, Humboldt University, Berlin, Germany
    Brain 125:75-85. 2002
    ....
  30. pmc From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases
    Monique Dubois-Dalcq
    National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, Bethesda, MD 20892 3706, USA
    Brain 131:1686-700. 2008
    ..We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man...
  31. ncbi Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
    ..This pathway may act as an inhibitory feedback aimed to downregulate the deleterious effects of T-cell infiltration in neuroinflammation...
  32. ncbi Remyelination is extensive in a subset of multiple sclerosis patients
    Peter Patrikios
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Brain 129:3165-72. 2006
    ..These results suggest that the variable and patient-dependent extent of remyelination must be considered in the design of future clinical trials aimed at promoting CNS repair...
  33. ncbi Tolerance induction by bone marrow transplantation in a multiple sclerosis model
    Martin M Herrmann
    Hertie Institute for Clinical Brain Research, Department of General Neurology, Experimental Neuroimmunology Laboratory, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Blood 106:1875-83. 2005
    ..Thus, our results indicate potential mechanisms of how BMT may contribute to the improvement of MS and provide a rationale for its application in patients suffering from various autoimmune diseases...
  34. ncbi Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage
    Stefan Nessler
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Brain 130:2186-98. 2007
    ..Taken together, MRI of mouse EAE models with brain lesions provide new insights into lesion pathology and evolution and may prove useful for the in vivo assessment of new therapeutic strategies in MS...
  35. ncbi Multicontrast MRI of remyelination in the central nervous system
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Germany
    NMR Biomed 18:395-403. 2005
    ..With a correct assignment of 95% of all animals examined, the procedure will allow for the survey of new therapeutic approaches aiming at improved remyelination...
  36. ncbi Cortical demyelination and diffuse white matter injury in multiple sclerosis
    Alexandra Kutzelnigg
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Brain 128:2705-12. 2005
    ..With chronicity, diffuse inflammation accumulates throughout the whole brain, and is associated with slowly progressive axonal injury in the NAWM and cortical demyelination...
  37. ncbi Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders
    Thomas Stahnke
    Department of Biology, Molecular Neurobiology, University of Oldenburg, D 26111 Oldenburg, Germany
    J Mol Neurosci 32:25-37. 2007
    ..The data suggest that stress-induced HO-1 initially plays a protective role, while its chronic upregulation, might contribute to oligodendroglial cell death rather than providing protection...
  38. ncbi Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders
    Aixiao Liu
    Department of Neuroscience, R Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 25:737-47. 2005
    ..On one hand, by favoring the migratory phenotype of progenitors, it may promote myelin repair. On the other hand, stathmin in mature OLs may indicate cell stress and possibly affect survival...
  39. ncbi Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
    Estibaliz Capetillo-Zarate
    Department of Neuropathology, University of Bonn, Bonn, Germany
    Brain 129:2992-3005. 2006
    ..The vulnerability of different types of neurons to Abeta, thereby, is presumably related to the complexity of their dendritic morphology...
  40. pmc Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis
    Martin Kerschensteiner
    Brain Research Institute, University of Zurich, and the Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Pathol 164:1455-69. 2004
    ..We believe that this targeted EAE model will become a helpful new tool for the evaluation of therapeutic approaches for MS that attempt to protect axons or support their repair...
  41. ncbi Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases
    Fahmy Aboul-Enein
    Division of Neuroimmunology, Brain Research Institute, University of Vienna, Austria
    J Neuropathol Exp Neurol 62:25-33. 2003
    ..Our data suggest that a hypoxia-like tissue injury may play a pathogenetic role in a subset of inflammatory demyelinating brain lesions...
  42. ncbi Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist--a putative role for substance P in CNS inflammation
    Stefan Nessler
    Clinical Neuroimmunology Group, Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, Marburg, Germany
    J Neuroimmunol 179:1-8. 2006
    ..In summary, our findings suggest that the protective effect of CP96,345 treatment is mediated by stabilization of the blood-brain barrier and suppression of Th1 immunity...
  43. ncbi Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets
    Khairul Bariah Abdul-Majid
    Neuroimmunology Unit, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Neuroimmunol 141:10-9. 2003
    ..We interpret our findings such that in an ontogenic lack of CD4(+) T cells, EAE is mediated by CD8(+) and elevated levels of alphabetaCD4(-)CD8(-) cells, and that CNS damage is partly enacted by the activity of CD8(+) T cells...
  44. ncbi Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis
    Christine Stadelmann
    Brain Research Center, Medical University of Vienna, Vienna, Austria
    Brain 128:979-87. 2005
    ..Due to their neuroprotective effects, the rim of periplaque tissue, where these proteins are expressed, may be resistant to further damage in an expanding lesion and may therefore remain as a layer of preserved myelinated tissue...
  45. ncbi Widespread demyelination in the cerebellar cortex in multiple sclerosis
    Alexandra Kutzelnigg
    Center for Brain Research, Medical University of Vienna, Austria
    Brain Pathol 17:38-44. 2007
    ..Our data identify cortical demyelination as a potential substrate of cerebellar dysfunction in MS...
  46. ncbi Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis
    Ricarda Diem
    Neurologische Universitatsklinik, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Brain 128:375-85. 2005
    ..In contrast, isolated neuronal or axonal protection without clinical benefit was achieved under monotherapy with erythropoietin or methylprednisolone, respectively...
  47. pmc Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
    Stefan Lüth
    Department of Medicine I, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Invest 118:3403-10. 2008
    ..Our findings indicate that autoantigen expression in the liver may generate autoantigen-specific Tregs. Thus, targeting of autoantigens to hepatocytes may be a novel approach to prevention or treatment of autoimmune diseases...
  48. pmc Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
    Dun Zhou
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 103:19057-62. 2006
    ..Overall these findings suggest a pathogenic antibody response to native MOG in a subgroup of MS patients...