Arnd Heiligenhaus

Summary

Affiliation: St. Franziskus Hospital
Country: Germany

Publications

  1. ncbi [Current cataract surgery for uveitis in childhood]
    A Heiligenhaus
    Uveitis Zentrum, Augenabteilung am St Franziskus Hospital, Hohenzollernring 74, 48145 Münster, Deutschland
    Ophthalmologe 104:572-6. 2007
  2. ncbi Everolimus for the treatment of uveitis refractory to cyclosporine A: a pilot study
    Arnd Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, University of Duisburg Essen, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 251:143-52. 2013
  3. ncbi Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood
    Arnd Heiligenhaus
    University of Duisburg Essen, Muenster, Germany
    Arthritis Care Res (Hoboken) 64:1365-72. 2012
  4. ncbi Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Rheumatol Int 32:1121-33. 2012
  5. ncbi Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, University of Duisburg Essen, Hohenzollernring 74, 48145 Muenster, Germany
    Rheumatology (Oxford) 46:1015-9. 2007
  6. ncbi The eye as a common site for the early clinical manifestation of sarcoidosis
    Arnd Heiligenhaus
    Department of Ophthalmology, Bochum, Germany
    Ophthalmic Res 46:9-12. 2011
  7. ncbi [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database]
    A Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 222:993-1001. 2005
  8. ncbi Influence of dimethylfumarate on experimental HSV-1 necrotizing keratitis
    A Heiligenhaus
    Ophtha Lab, Department of Ophthalmology at St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 242:870-7. 2004
  9. ncbi Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines
    A Heiligenhaus
    Ophtha Lab, Department of Ophthalmology at St Franziskus Hospital, Muenster, Germany
    Clin Exp Immunol 142:180-7. 2005
  10. ncbi [Ocular changes in tropical malaria with cerebral involvement--results from the Blantyre Malaria Project]
    C Hirneiss
    Augenklinik der Ludwig Maximilians Universitat, Munchen
    Klin Monbl Augenheilkd 222:704-8. 2005

Collaborators

Detail Information

Publications90

  1. ncbi [Current cataract surgery for uveitis in childhood]
    A Heiligenhaus
    Uveitis Zentrum, Augenabteilung am St Franziskus Hospital, Hohenzollernring 74, 48145 Münster, Deutschland
    Ophthalmologe 104:572-6. 2007
    ..g. with the use of immunosuppressive drugs or TNF-alpha inhibitors. Postoperatively, the anti-inflammatory medication must be increased and continued for 8-10 weeks...
  2. ncbi Everolimus for the treatment of uveitis refractory to cyclosporine A: a pilot study
    Arnd Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, University of Duisburg Essen, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 251:143-52. 2013
    ..This study investigated the efficacy of everolimus, a potent inhibitor of T lymphocyte proliferation, for treating noninfectious uveitis. The study design was an open-label prospective trial...
  3. ncbi Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood
    Arnd Heiligenhaus
    University of Duisburg Essen, Muenster, Germany
    Arthritis Care Res (Hoboken) 64:1365-72. 2012
    ..To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis...
  4. ncbi Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Rheumatol Int 32:1121-33. 2012
    ..Evidence and recommendations were graded, and an algorithm for anti-inflammatory treatment and final statements confirmed in a Delphi method. An interdisciplinary, evidence-based treatment guideline for JIA uveitis is presented...
  5. ncbi Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, University of Duisburg Essen, Hohenzollernring 74, 48145 Muenster, Germany
    Rheumatology (Oxford) 46:1015-9. 2007
    ..To analyse the prevalence and complications of uveitis and their predictors in a large cohort of patients with juvenile idiopathic arthritis (JIA)...
  6. ncbi The eye as a common site for the early clinical manifestation of sarcoidosis
    Arnd Heiligenhaus
    Department of Ophthalmology, Bochum, Germany
    Ophthalmic Res 46:9-12. 2011
    ..Our purpose was to detect the rate of initial manifestation of sarcoidosis in the eye...
  7. ncbi [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database]
    A Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 222:993-1001. 2005
    ..Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis...
  8. ncbi Influence of dimethylfumarate on experimental HSV-1 necrotizing keratitis
    A Heiligenhaus
    Ophtha Lab, Department of Ophthalmology at St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 242:870-7. 2004
    ..This study was performed to investigate the influence of fumaric acid esters on the course of herpes stromal keratitis (HSK)...
  9. ncbi Improvement of herpetic stromal keratitis with fumaric acid derivate is associated with systemic induction of T helper 2 cytokines
    A Heiligenhaus
    Ophtha Lab, Department of Ophthalmology at St Franziskus Hospital, Muenster, Germany
    Clin Exp Immunol 142:180-7. 2005
    ..This is associated with an improvement of herpetic stromal keratitis and reduced corneal T cell infiltration. DMF did not impair the systemic antiviral response...
  10. ncbi [Ocular changes in tropical malaria with cerebral involvement--results from the Blantyre Malaria Project]
    C Hirneiss
    Augenklinik der Ludwig Maximilians Universitat, Munchen
    Klin Monbl Augenheilkd 222:704-8. 2005
    ..Funduscopy plays a major role for the ophthalmologist in the differential diagnosis because of the characteristic changes...
  11. ncbi [Diagnostic and therapeutic recommendations for mucous membrane pemphigoid of the eye]
    A Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 222:689-703. 2005
    ..Previous studies published before December 2004 have been systematically reviewed for their level of evidence. Consequently, recommendations for patient management are provided...
  12. ncbi Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenetic knowledge of the disease
    Arnd Heiligenhaus
    Department of Ophthalmology at St Franziskus Hospital, University Duisburg Essen, Hohenzollernring 74, 48145, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1531-51. 2010
    ....
  13. ncbi Treatment of severe uveitis associated with juvenile idiopathic arthritis with anti-CD20 monoclonal antibody (rituximab)
    Arnd Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Rheumatology (Oxford) 50:1390-4. 2011
    ..Rituximab (RTX), a chimeric mAb directed against the B-cell marker CD20, was investigated for its anti-inflammatory effect in treating refractory uveitis associated with JIA...
  14. ncbi [Inhibitors of tumour necrosis factor-alpha for the treatment of arthritis and uveitis in childhood]
    A Heiligenhaus
    Uveitis Zentrum, Augenabteilung am St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 224:526-31. 2007
    ..Besides from corticosteroids and immunosuppressive drugs, Tumour necrosis factor-alpha (TNF-alpha) inhibitors are used frequently...
  15. ncbi Azathioprine as a treatment option for uveitis in patients with juvenile idiopathic arthritis
    J C Goebel
    Department of Ophthalmology, Uveitis Center at St Franziskus Hospital, Muenster, Germany
    Br J Ophthalmol 95:209-13. 2011
    ..To investigate the therapeutic value of azathioprine as monotherapy or combined with other immunosuppressive drugs for uveitis in patients with juvenile idiopathic arthritis (JIA)...
  16. ncbi Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis
    Dirk Bauer
    Department of Ophthalmology, Ophtha Lab, St Franziskus Hospital, Muenster, Germany
    Invest Ophthalmol Vis Sci 50:3188-98. 2009
    ..To investigate the effect of human amniotic membrane transplantation (AMT) on T-cell immune response in murine corneas with herpetic stromal keratitis (HSK)...
  17. ncbi Comparison of orbital floor triamcinolone acetonide and oral prednisolone for cataract surgery management in patients with non-infectious uveitis
    Martin Roesel
    Department of Ophthalmology at St Franziskus Hospital, Muenster, University Duisburg Essen, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 248:715-20. 2010
    ..To compare orbital floor triamcinolone acetonide and oral prednisolone in cataract surgery in patients with chronic non-infectious uveitis with regard to visual outcome, postoperative inflammation and macular edema...
  18. ncbi Topical antisense-oligonucleotides targeting IFN-gamma mRNA improve incidence and severity of herpetic stromal keratitis by cytokine specific and sequence unspecific effects
    Susanne Wasmuth
    Ophtha Lab, Department of Ophthalmology, St Franziskus Hospital, Hohenzollenring 74, 48145, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 246:443-51. 2008
    ..Interferon-gamma (IFN-gamma) is known to be involved in the development of this disease. In this study, antisense oligonucleotides targeting IFN-gamma mRNA (IFN-gamma-ASON) were investigated for their effects in experimental HSK...
  19. ncbi Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense
    Dirk Bauer
    Department of Ophthalmology, Ophtha Lab at St Franziskus Hospital, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 244:216-25. 2006
    ..We investigated whether the course of herpetic stromal keratitis (HSK) in BALB/c mice could be altered by topical gene-gun-mediated administration of interleukin (IL)-4 or IL-10 plasmid DNA...
  20. ncbi Subconjunctival antisense oligonucleotides targeting TNF-alpha influence immunopathology and viral replication in murine HSV-1 retinitis
    Jin Li
    Department of Ophthalmology, Ophtha Lab at St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1265-73. 2008
    ..To investigate the role of tumor necrosis factor-alpha (TNF-alpha) in immunopathology and viral replication in the contralateral eye in the von Szily model of herpes simplex virus (HSV)-1 acute retinitis...
  21. ncbi Intravitreal and orbital floor triamcinolone acetonide injections in noninfectious uveitis: a comparative study
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital, University Duisburg Essen, DE 48145 Münster, Germany
    Ophthalmic Res 42:81-6. 2009
    ..To compare the effect of orbital floor (OFTA) or intravitreal (IVTA) administration of triamcinolone acetonide on visual acuity and chronic cystoid macular edema (CME) in patients with uveitis...
  22. ncbi Comparison between intravitreal and orbital floor triamcinolone acetonide after phacoemulsification in patients with endogenous uveitis
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Am J Ophthalmol 147:406-12. 2009
    ..To compare the effect of intravitreal and orbital floor triamcinolone acetonide (TA) on macular edema, visual outcome, and course of postoperative inflammation after cataract surgery in uveitis patients...
  23. ncbi On the influence of neutrophils in corneas with necrotizing HSV-1 keratitis following amniotic membrane transplantation
    Dirk Bauer
    Ophtha Lab, Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Exp Eye Res 85:335-45. 2007
    ....
  24. ncbi Effects of systemic and intravitreal TNF-α inhibition in experimental autoimmune uveoretinitis
    Martin Busch
    Ophtha Lab, Department of Ophthalmology at St Franziskus Hospital, Muenster, Germany
    Invest Ophthalmol Vis Sci 54:39-46. 2013
    ..To investigate the effect of systemic or local TNF-α inhibition with etanercept on experimental autoimmune uveoretinitis (EAU)...
  25. ncbi Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea
    Arnd Heiligenhaus
    Ophtha Lab, Department of Ophthalmology, St Franziskus Hospital, Munster, Germany
    Invest Ophthalmol Vis Sci 46:4079-85. 2005
    ..To study matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the corneas from mice with ulcerative herpes stromal keratitis (HSK) treated with amniotic membrane transplantation (AMT)...
  26. ncbi Favourable outcome after cataract surgery with IOL implantation in uveitis associated with juvenile idiopathic arthritis
    Rafael S Grajewski
    Department of Ophthalmology, University of Cologne, Cologne, Germany
    Acta Ophthalmol 90:657-62. 2012
    ..This study investigated the outcome after minimally invasive surgery with IOL implantation...
  27. ncbi Uveal and capsular biocompatibility of two foldable acrylic intraocular lenses in patients with endogenous uveitis--a prospective randomized study
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital, Muenster, University Duisburg Essen, Duisburg, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1609-15. 2008
    ..To compare a hydrophobic and a hydrophilic acrylic single-piece intraocular lens (IOL) in uveitis patients with respect to biocompatibility and visual outcome...
  28. ncbi Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infection
    Dirk Bauer
    Department of Ophthalmology, University of Essen, Essen, Germany
    Immunology 107:118-28. 2002
    ..This effect is at least in part responsible for the impaired course of herpetic keratitis after macrophage depletion...
  29. ncbi Topical treatment with antisense oligonucleotides targeting tumor necrosis factor-alpha in herpetic stromal keratitis
    Susanne Wasmuth
    Department of Ophthalmology, University of Essen, Essen, Germany
    Invest Ophthalmol Vis Sci 44:5228-34. 2003
    ..This topical treatment mitigates the course of HSK, whereas the systemic antiviral effector functions were not impaired...
  30. ncbi Long-term reduction of laser flare values after trabeculectomy but not after cyclodestructive procedures in uveitis patients
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Hohenzollernring 74, Muenster, Germany
    Int Ophthalmol 31:205-10. 2011
    ..TE significantly reduced postoperative LF values. Higher LF values did not increase the development of new complications in this study, but an increased occurrence of cataract formation was seen in the TE group...
  31. ncbi Pars plana vitrectomy with intravitreal triamcinolone: effect on uveitic cystoid macular oedema and treatment limitations
    Matthias Gutfleisch
    Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring, Muenster, Germany
    Br J Ophthalmol 91:345-8. 2007
    ..To investigate the effect of pars plana vitrectomy (PPV) in combination with intraoperative intravitreal triamcinolone acetonide injection on the course of cystoid macular oedema (CME) in patients with uveitis...
  32. ncbi Intraoperative intraocular triamcinolone injection prophylaxis for post-cataract surgery fibrin formation in uveitis associated with juvenile idiopathic arthritis
    Jin Li
    Department of Ophthalmology, St. Franziskus Hospital, Muenster, Germany
    J Cataract Refract Surg 32:1535-9. 2006
    ....
  33. ncbi Comparison of retinal thickness and fundus-related microperimetry with visual acuity in uveitic macular oedema
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital Muenster, University Duisburg Essen, Germany
    Acta Ophthalmol 89:533-7. 2011
    ..The aim of this study was to compare retinal thickness as measured by optical coherence tomography and photoreceptor function as measured by fundus-related microperimetry with respect to their correlation with visual acuity...
  34. ncbi Intravitreal bevacizumab (avastin) as a treatment for refractory macular edema in patients with uveitis: a pilot study
    Friederike Mackensen
    Interdisciplinary Uveitis Center, Department of Ophthalmology, University of Heidelberg, Germany
    Retina 28:41-5. 2008
    ..As VEGF is involved in the pathomechanisms of inflammation and endothelial dysfunction the authors used bevacizumab as a last resort treatment in patients with persistent uveitic cystoid macular edema (CME)...
  35. ncbi Elevated laser flare values correlate with complicated course of anterior uveitis in patients with juvenile idiopathic arthritis
    Christoph Tappeiner
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Acta Ophthalmol 89:e521-7. 2011
    ..To evaluate the prognostic value of anterior chamber (AC) laser flare (LF) in uveitis associated with juvenile idiopathic arthritis (JIA)...
  36. ncbi Amniotic membrane induces peroxisome proliferator-activated receptor-γ positive alternatively activated macrophages
    Dirk Bauer
    Department of Ophthalmology, Ophtha Lab at St Franziskus Hospital, Muenster, Germany
    Invest Ophthalmol Vis Sci 53:799-810. 2012
    ..Amniotic membrane transplantation (AMT) reportedly improves herpetic stromal keratitis (HSK). Here we studied the role of the amniotic membrane (AM) on macrophages...
  37. ncbi Intravitreal treatment with antisense oligonucleotides targeting tumor necrosis factor-α in murine herpes simplex virus type 1 retinitis
    Rafael S Grajewski
    Department of Ophthalmology, University of Cologne, Cologne, Germany
    Graefes Arch Clin Exp Ophthalmol 250:231-8. 2012
    ..This study investigated whether treatment with intravitreal antisense-oligonucleotides (ASON) targeting TNF-α mRNA affects the progression of herpes simplex virus 1 (HSV-1) retinitis in mice...
  38. ncbi Fundus autofluorescence and spectral domain optical coherence tomography in uveitic macular edema
    Martin Roesel
    Department of Ophthalmology at St Franziskus Hospital, Muenster, University Duisburg Essen, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 247:1685-9. 2009
    ..Cystoid macular edema (CME) is a common vision-limiting complication of uveitis. This study correlated fundus autofluorescence (FAF) and optical coherence tomography (OCT) with visual acuity (VA)...
  39. ncbi [Vision-threatening complications in childhood uveitis]
    A Mingels
    Augenabteilung, St Franziskus Hospital, Munster
    Ophthalmologe 102:477-84. 2005
    ..We analyzed the epidemiologic data and vision-threatening complications in different forms of childhood uveitis...
  40. ncbi Influence of corneal thickness changes during active uveitis on Goldmann applanation and dynamic contour tonometry
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital, Munster, Germany
    Ophthalmic Res 48:38-42. 2012
    ..To compare the influence of central corneal thickness (CCT) during active anterior uveitis and after resolution on intraocular pressure (IOP) measurements by Goldmann applanation tonometry (GAT) and by dynamic contour tonometry (DCT)...
  41. ncbi Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation
    A Heiligenhaus
    Department of Ophthalmology, University of Essen, Germany
    Invest Ophthalmol Vis Sci 42:1969-74. 2001
    ..In this study, the effect of amniotic membrane transplantation (AMT) on corneal wound healing and on inflammation in mice with necrotizing HSK was examined...
  42. ncbi [Amniotic membrane transplantation improves herpetic keratitis by local and not by systemic effects]
    A Heiligenhaus
    Ophtha Lab, Augenabteilung am St Franziskus Hospital, Munster
    Ophthalmologe 100:209-15. 2003
    ..This study investigated whether AMT modulates the T cell response and whether the anti-inflammatory action of AMT is due to local or systemic effects...
  43. ncbi Treatment of HSV-1 stromal keratitis with topical cyclosporin A: a pilot study
    A Heiligenhaus
    Department of Ophthalmology, University of Essen, Germany
    Graefes Arch Clin Exp Ophthalmol 237:435-8. 1999
    ..The purpose of this study was to analyze the efficacy of topically applied cyclosporin A (CsA) in patients with HSV keratitis...
  44. ncbi Smoking complicates the course of non-infectious uveitis
    Martin Roesel
    Department of Ophthalmology at St Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 249:903-7. 2011
    ..The aim of this study was to evaluate the effect of tobacco smoking on uveitis activity and complications of noninfections uveitis and the need for immunosuppressive therapy...
  45. ncbi Uveitis in children
    Manfred Zierhut
    Department of Ophthalmology, University of Tuebingen, Schleichstrasse 12-16, 72976 Tuebingen, Germany
    Int Ophthalmol Clin 45:135-56. 2005
  46. ncbi Prevalence of uveitic secondary glaucoma and success of nonsurgical treatment in adults and children in a tertiary referral center
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Muenster, Germany
    Ocul Immunol Inflamm 17:243-8. 2009
    ..The aim of this study is to compare treatment strategies, the success of topical and systemic therapy, and the need for glaucoma surgery in children and adults with secondary uveitic glaucoma...
  47. ncbi Chronic uveitis in children with and without juvenile idiopathic arthritis: differences in patient characteristics and clinical course
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Muenster, Germany
    J Rheumatol 35:1403-7. 2008
    ..We identified factors that may help to differentiate JIA-associated AU from the more common idiopathic AU (IAU) before the onset of arthritis...
  48. ncbi [Juvenile idiopathic arthritis and uveitis: screening and anti-inflammatory therapy]
    Arnd Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Muenster
    Klin Monbl Augenheilkd 220:738-53. 2003
    ....
  49. ncbi Matrix metalloproteinases (MMP-2 and 9) and tissue inhibitors of matrix metalloproteinases (TIMP-1 and 2) during the course of experimental necrotizing herpetic keratitis
    Yan-Ning Yang
    Department of Ophthalmology, Ophtha-Lab, St Franziskus Hospital, , Germany
    Exp Eye Res 77:227-37. 2003
    ..The ratio of MMPs to TIMPs may be important for the course of necrotizing HSV keratitis. TIMPs might participate in the repair process...
  50. ncbi CD4+ T-cell type 1 and type 2 cytokines in the HSV-1 infected cornea
    A Heiligenhaus
    Department of Ophthalmology, University of Essen, Germany
    Graefes Arch Clin Exp Ophthalmol 237:399-406. 1999
    ..CD4+ T cell subpopulations (type 1, type 2) can be defined by their capabilities of producing different sets of cytokines. This study was performed to determine the role of type 1 and type 2 cytokines in murine HSK...
  51. ncbi Combined phacoemulsification and pars plana vitrectomy: clear corneal versus scleral incisions: prospective randomized multicenter study
    Arnd Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    J Cataract Refract Surg 29:1106-12. 2003
    ....
  52. ncbi Prevalence of parvovirus B19-specific antibodies and of viral DNA in patients with endogenous uveitis
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Hohenzollernring 54, 48145, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 243:999-1004. 2005
    ..We investigated serum and aqueous fluid samples of patients with endogenous uveitis...
  53. ncbi [Secondary glaucoma in childhood uveitis]
    C Heinz
    Augenabteilung am St Franziskus Hospital Münster, Hohenzollernring 74, 48145 Münster
    Ophthalmologe 105:438-44. 2008
    ..Reports on the use of trabeculectomy, goniosurgery, glaucoma drainage devices, and cyclodestructive procedures show higher failure rates than when used for primary open angle glaucoma in adults...
  54. ncbi [Uveitis in juvenile idiopathic arthritis]
    C Heinz
    Augenabteilung am St Franziskus Hospital Münster, Hohenzollernring 74, Munster, Germany
    Z Rheumatol 69:411-8. 2010
    ..The main therapeutic goal is to achieve remission. Management of the typical vision-threatening complications such as cataract, glaucoma, ocular hypotension, and macular edema is particularly challenging...
  55. ncbi Methotrexate for uveitis associated with juvenile idiopathic arthritis: value and requirement for additional anti-inflammatory medication
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Eur J Ophthalmol 17:743-8. 2007
    ..To study the value of methotrexate (MTX) and the requirement for additional anti-inflammatory drugs for the treatment of severe chronic iridocyclitis associated with juvenile idiopathic arthritis (JIA)...
  56. ncbi Transscleral diode laser cyclophotocoagulation as primary surgical treatment for secondary glaucoma in juvenile idiopathic arthritis: high failure rate after short term follow up
    C Heinz
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Hohenzollernring 54, 48145 Muenster, Germany
    Br J Ophthalmol 90:737-40. 2006
    ..To evaluate the success rates of transscleral diode cyclophotocoagulation (TD-CPC) for secondary glaucoma in patients with juvenile idiopathic arthritis (JIA) as primary surgical treatment...
  57. ncbi [Clinical presentation of zoster ophthalmicus]
    M Roesel
    Augenabteilung, St Franziskus Hospital, Munster, Germany
    Klin Monbl Augenheilkd 227:370-4. 2010
    ..In addition to the characteristic dermal lesions and to the postherpetic neuralgia, the clinical appearance may include very different forms of eye involvement...
  58. ncbi [Uveitis in childhood sarcoidosis]
    C Heinz
    Augenabteilung am St Franziskus Hospital Münster
    Klin Monbl Augenheilkd 222:348-52. 2005
    ..Sarcoidosis is a rare cause of uveitis in childhood. Differentiation from other rheumatic diseases may be difficult. We report on five children with uveitis in childhood sarcoidosis and review the previous literature...
  59. ncbi [Corticosteroid therapy and secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis and idiopathic chronic anterior uveitis]
    C Heinz
    Augenabteilung, St Franziskus Hospital, Munster, Germany
    Klin Monbl Augenheilkd 227:413-7. 2010
    ..This study examines the influence of corticosteroid therapy on the incidence of secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis (FHC) and chronic anterior uveitis...
  60. ncbi A three-centre experience with adalimumab for the treatment of non-infectious uveitis
    Bianca Carola Dobner
    Department of Ophthalmology, Interdisciplinary Uveitis Center, University of Heidelberg, Heidelberg 69120, Germany and Department of Ophthalmology, Dietrich Bonhoeffer Klinikum, 17033 Neubrandenburg, Germany
    Br J Ophthalmol 97:134-8. 2013
    ..The aim of this study was to assess the efficacy of adalimumab in patients with active non-infectious uveitis in three different centres...
  61. ncbi Particle-mediated administration of plasmid DNA on corneas of BALB/c mice
    Dirk Bauer
    Department of Ophthalmology, Ophtha Lab, St Franziskus Hospital, Munster, Germany
    Methods Mol Biol 940:215-20. 2013
    ..g., 700 psi). The focal transfection of the cornea to improve corneal disease may be an advantage over other transfection methods in order to avoid unwanted bystander transfection in other compartments of the eye or body...
  62. ncbi Diagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on Clinical Practice in chronic GVHD
    Tina Dietrich-Ntoukas
    Department of Ophthalmology, University Medical Center, Regensburg, Regensburg, Germany
    Cornea 31:299-310. 2012
    ..Ocular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and is often associated with significant morbidity and reduced quality of life...
  63. ncbi Improvement of noninfectious uveitis with fumaric acid esters: results of a pilot study
    Carsten Heinz
    Department of Ophthalmology, St Franziskus-Hospital Muenster, Germany
    Arch Ophthalmol 125:569-71. 2007
  64. ncbi Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Clin Ophthalmol 5:1309-13. 2011
    ..Future studies have to show if these advantages are accompanied by greater clinical efficacy and fewer side effects compared with the classic calcineurin inhibitors...
  65. ncbi [Indication and effect of immunosuppression in patients with scleritis]
    Arnd Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 220:471-80. 2003
    ..The value of immunosuppressive drugs for the therapy of scleritis patients is unclear. The authors investigated the indications and effects of immunosuppression in a group of patients with scleral inflammation...
  66. ncbi Rituximab as a treatment option for refractory endogenous anterior uveitis
    C Tappeiner
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Ophthalmic Res 39:184-6. 2007
    ..To report on anti-CD20 antibody therapy in a patient with uveitis refractive to immunosuppression therapy...
  67. ncbi Hypermotility of an iris-fixated anterior chamber phakic intraocular lens due to nontraumatic iris laxity
    Suphi Taneri
    Center for Refractive Surgery, Eye Department, St Francis Hospital, Munster, Germany
    Eur J Ophthalmol 22:481-4. 2012
    ..Unstable position of iris-fixated pIOLs due to traumatic or nontraumatic disenclavation of the haptic has been described previously...
  68. ncbi Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies
    Anja K Eckstein
    Department of Ophthalmology, Essen University Hospital, Germany
    Acta Ophthalmol Scand 82:291-7. 2004
    ..Suspecting a possible role of autoantibodies specific for TSH receptor (TSHR), we further investigated TSHR expression in the healthy lacrimal gland (LG)...
  69. ncbi Trabeculectomy or modified deep sclerectomy in juvenile uveitic glaucoma
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Hohenzollernring 74, 48145, Muenster, Germany
    J Ophthalmic Inflamm Infect 1:165-70. 2011
    ..The purpose of this study is to report the effectiveness of trabeculectomies (TE) and modified deep sclerectomies (mdS) in a group of patients with juvenile uveitic secondary glaucoma...
  70. ncbi [Amniotic membrane transplantation improves experimental herpetic keratitis. Modulation of matrix metalloproteinase-9]
    A Heiligenhaus
    Augenabteilung am St Franziskus Hospital, Ophtha Lab, Munster
    Ophthalmologe 101:59-65. 2004
    ..Transplantation of human amniotic membrane (AMT) accelerates the healing of experimental ulcerative herpetic keratitis. Here the expression and activity of matrix metalloproteinase (MMP)-9 was studied...
  71. ncbi [Apoptosis in human non-necrotizing stromal herpes simplex keratitis]
    A Heiligenhaus
    Augenabteilung, St Franziskus Hospital, Munster
    Klin Monbl Augenheilkd 217:178-82. 2000
    ..Recently, it has been shown that infection of cells with HSV-1 induces apoptosis. In this study we investigated the presence of apoptotic cell death in keratectomy specimens from patients with HSV-1 stromal keratitis...
  72. ncbi [Effect of intravitreal and orbital floor triamcinolone acetonide injection on intraocular inflammation in patients with active non-infectious uveitis]
    M Roesel
    Augenabteilung, St Franziskus Hospital, Hohenzollernring 74, Munster
    Klin Monbl Augenheilkd 226:110-4. 2009
    ..The aim of this study was to compare the effect of TA on intraocular inflammation after a single intravitreal or orbital floor injection of the drug in patients with non-infectious uveitis...
  73. ncbi [Topical and systemic corticosteroid therapy for uveitis in childhood]
    S R Thurau
    Augenklinik der Ludwig Maximilians Universitat, Munchen
    Klin Monbl Augenheilkd 224:516-9. 2007
    ..Therefore, if treatment is required for extended periods of time it is important to avoid steroid quantities above the Cushing level and to initiate an additional systemic immunosuppressive treatment regimen early...
  74. ncbi Ocular hypertension and glaucoma incidence in patients with scleritis
    Carsten Heinz
    Department of Ophthalmology, St Franziskus Hospital Muenster, Hohenzollernring 74, 48145 Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 251:139-42. 2013
    ..Aim of this study was to identify the incidence and risk factors for OHT and SG with regard to the scleritis form...
  75. ncbi Comparison of two acrylic intraocular lenses with different haptic designs in patients with combined phacoemulsification and pars plana vitrectomy
    A Mingels
    Department of Ophthalmology at St Franziskus Hospital, Muenster, Germany
    Eye (Lond) 21:1379-83. 2007
    ....
  76. ncbi Nodular scleritis in a patient with sarcoidosis
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Br J Ophthalmol 87:507-8. 2003
  77. ncbi Multifocal posterior uveitis in Crohn's disease
    C Tappeiner
    Department of Ophthalmology, At St Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany
    Graefes Arch Clin Exp Ophthalmol 245:457-9. 2007
    ..To report a case of rare posterior eye manifestation of Crohn's disease preceding recurrence of inflammatory bowel disease...
  78. ncbi Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation
    A Heiligenhaus
    Department of Ophthalmology, St Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany
    Br J Ophthalmol 87:1215-9. 2003
    ..To report promoted healing of acute ulcerative and necrotising herpetic keratitis after amniotic membrane transplantation (AMT)...
  79. ncbi Soluble HLA class I and HLA-DR plasma levels in patients with anterior uveitis
    A Heiligenhaus
    St. Franziskus Hospital, Department of Ophthalmology, , Germany
    Tissue Antigens 63:369-75. 2004
    ..The presence of associated systemic diseases in AU patients was related to elevated sHLA-DR levels. Secretion of sHLA-DR in blood differs among the various forms of AU. Systemic immune activation was present in AU but not in FHC...
  80. ncbi Photodynamic therapy for choroidal neovascularization in patients with multifocal choroiditis and panuveitis
    C Gerth
    Department of Ophthalmology, St Franziskus Hospital, Munster, Germany
    Eur J Ophthalmol 16:111-8. 2006
    ..To evaluate the visual benefit of photodynamic therapy (PDT) with verteporfin in patients with choroidal neovascularization (CNV) secondary to multifocal choroiditis and panuveitis over a longer follow-up period...
  81. ncbi [Intraocular pressure related to uveitis]
    U Pleyer
    Universitats Augenklinik, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Ophthalmologe 105:431-7. 2008
    ..Despite the availability of many new medical treatments for both conditions, control of IOP in these patients remains challenging...
  82. ncbi [Cataract surgery in childhood uveitis]
    P Szurman
    Universitats Augenklinik, Department für Augenheilkunde, Eberhard Karls Universitat, Tubingen
    Klin Monbl Augenheilkd 224:532-7. 2007
    ..When these factors are taken into consideration, a timely cataract operation can result in a sustained visual rehabilitation even for children with uveitis...
  83. ncbi ["White dot syndromes" in childhood]
    G Spital
    Augenabteilung am St Franziskus Hospital Münster
    Klin Monbl Augenheilkd 224:500-6. 2007
    ..They were first described a few decades ago and our knowledge about these variable diseases is very limited, especially in regard to their overall incidence and their differential diagnostic relevance in uveitis of childhood...
  84. ncbi [Diagnostics in childhood uveitis: what tests for which uveitis?]
    T Hudde
    Augenklinik Wolfsburg
    Klin Monbl Augenheilkd 224:494-9. 2007
    ..Intraocular inflammation in children differs considerably from that found in adults. Therefore the diagnostic work-up has to be adapted to the age and specific diseases...
  85. ncbi [Uveitis and the aging]
    M Zierhut
    Universitats Augenklinik, Schleichstrasse 12, 72076 Tubingen
    Ophthalmologe 103:765-72. 2006
    ..One of the major complications of uveitis is cataract formation. Keeping in mind the importance of pre- and postoperative treatment, even implantation of an intraocular lens in older patients with uveitis is currently a safe procedure...
  86. ncbi [Juvenile idiopathic arthritis and uveitis: epidemiology including data from a national database]
    K Minden
    Deutsches Rheuma ForschungsZentrum Berlin, Chariteplatz 1, Berlin
    Klin Monbl Augenheilkd 224:469-72. 2007
    ..Due to the usual lack of symptoms the diagnosis of uveitis requires, however, an examination by an ophthalmologist. This should be done immediately after the diagnosis of JIA and repeated in a risk-adapted manner during the follow-up...
  87. ncbi [Do antisense oligonucleotides improve viral immunopathology?]
    S Wasmuth
    Ophtha Lab und Augenabteilung, St Franziskus Hospital, Munster
    Ophthalmologe 102:272-8. 2005
    ..In this study the local administration of antisense oligonucleotides (ASON) targeting TNF-alpha was examined for its usefulness in ameliorating this disease...
  88. ncbi Corneal calcification following intensified treatment with sodium hyaluronate artificial tears
    W Bernauer
    Department of Ophthalmology, University of Zurich, Theaterstrasse 2, CH 8001 Zurich, Switzerland
    Br J Ophthalmol 90:285-8. 2006
    ..To report a potential adverse effect of intensified treatment with sodium hyaluronate artificial tears...
  89. ncbi [EBM analysis: classic DMARDs (disease-modifying antirheumatic drugs) and immunosuppressants in arthritis and uveitis]
    T Niehues
    Zentrum für Kinder und Jugendmedizin, Klinik für Kinder Onkologie, Hämatologie und Klinische Immunologie, Pädiatrische Immunologie und Rheumatologie, Jeffrey Modell Immundefektzentrum Universitätsklinikum Düsseldorf
    Klin Monbl Augenheilkd 224:520-5. 2007
    ..The results with azathioprine are not consistent. Controlled studies which led to the approval of drugs for JIA are also mandatory for uveitis to offer the most effective and safe therapy for children...
  90. ncbi Interferon as a treatment for uveitis associated with multiple sclerosis
    M D Becker
    FEBO, Interdisciplinary Uveitis Center, University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
    Br J Ophthalmol 89:1254-7. 2005
    ..The aim of this pilot study was to evaluate the efficacy of type I interferons (IFN) for the treatment of MS associated uveitis...