Wolfdieter Springer

Summary

Country: Germany

Publications

  1. ncbi request reprint Regulation of PINK1-Parkin-mediated mitophagy
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Autophagy 7:266-78. 2011
  2. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
  3. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
  4. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010
  5. ncbi request reprint Mechanisms and models of alpha-synuclein-related neurodegeneration
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Curr Neurol Neurosci Rep 6:432-6. 2006
  6. doi request reprint Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways
    Takafumi Hasegawa
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen, Germany
    J Neurochem 105:1700-15. 2008
  7. doi request reprint Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
    Christian L Klein
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    J Neurochem 111:703-15. 2009
  8. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Regulation of PINK1-Parkin-mediated mitophagy
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Autophagy 7:266-78. 2011
    ..This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well...
  2. ncbi request reprint The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
    Sven Geisler
    Laboratory of Functional Neurogenetics, Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Centre for Neurodegenerative Diseases, Tubingen, Germany
    Autophagy 6:871-8. 2010
    ....
  3. doi request reprint PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    Sven Geisler
    Laboratory of Functional Neurogenetics, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Nat Cell Biol 12:119-31. 2010
    ..Thus, our data provide functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease...
  4. doi request reprint Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
    Elena M Cornejo Castro
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    J Neural Transm 117:599-604. 2010
    ..Thus, PD-associated DJ-1 contributes to regulation of innate immunity...
  5. ncbi request reprint Mechanisms and models of alpha-synuclein-related neurodegeneration
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Curr Neurol Neurosci Rep 6:432-6. 2006
    ..These recent findings provided major insights into the molecular mechanisms of alpha-synucleinopathies...
  6. doi request reprint Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways
    Takafumi Hasegawa
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen, Germany
    J Neurochem 105:1700-15. 2008
    ..PD-associated mutations differentially affected the anti-apoptotic signaling of parkin. Thus, parkin contributes to DAergic neuroprotection by suppression of apoptotic stress-activated protein kinase pathways...
  7. doi request reprint Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
    Christian L Klein
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    J Neurochem 111:703-15. 2009
    ..Importantly, our finding of ROCO(LRRK2) fragment-mediated LRRK2 kinase inhibition offers a novel lead for drug design and thus might have important implications for new therapeutic avenues in PD...
  8. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
    ..In conclusion, loss of functional TDP-43 causes HDAC6 downregulation and might thereby contribute to pathogenesis...