Joachim Spranger

Summary

Country: Germany

Publications

  1. ncbi Adiponectin and protection against type 2 diabetes mellitus
    Joachim Spranger
    Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany
    Lancet 361:226-8. 2003
  2. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
  3. doi The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity
    Ayman M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 94:5093-101. 2009
  4. doi A high normal TSH is associated with the metabolic syndrome
    Stephan Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Clin Endocrinol (Oxf) 72:696-701. 2010
  5. doi Rosiglitazone increases fatty acid Δ9-desaturation and decreases elongase activity index in human skeletal muscle in vivo
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Metabolism 61:108-16. 2012
  6. ncbi Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin
    Knut Mai
    Department of Endocrinology, Diabetes, and Nutrition, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin, Germany
    Am J Physiol Endocrinol Metab 299:E126-30. 2010
  7. doi Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Endocrinol 164:1013-8. 2011
  8. doi Relation between fibroblast growth factor-21, adiposity, metabolism, and weight reduction
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Metabolism 60:306-11. 2011
  9. ncbi Rosiglitazone decreases 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 67:419-25. 2007
  10. pmc Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Berlin, Germany
    Diabetes Care 36:145-9. 2013

Detail Information

Publications48

  1. ncbi Adiponectin and protection against type 2 diabetes mellitus
    Joachim Spranger
    Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany
    Lancet 361:226-8. 2003
    ..3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals...
  2. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  3. doi The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity
    Ayman M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 94:5093-101. 2009
    ..This network is linked to metabolic syndrome and cardiovascular diseases...
  4. doi A high normal TSH is associated with the metabolic syndrome
    Stephan Ruhla
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Clin Endocrinol (Oxf) 72:696-701. 2010
    ..We investigated the associations between TSH and the features and prevalence of the metabolic syndrome in euthyroid German subjects...
  5. doi Rosiglitazone increases fatty acid Δ9-desaturation and decreases elongase activity index in human skeletal muscle in vivo
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Metabolism 61:108-16. 2012
    ..The PPARγ associated phenotypes may be partially explained by an increased Δ9-desaturation and a decreased elongase activity of skeletal muscle...
  6. ncbi Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin
    Knut Mai
    Department of Endocrinology, Diabetes, and Nutrition, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, Berlin, Germany
    Am J Physiol Endocrinol Metab 299:E126-30. 2010
    ..This mechanism might explain the apparent paradox of increased FGF-21 levels in obesity, insulin resistance, and starvation...
  7. doi Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Endocrinol 164:1013-8. 2011
    ..An interaction between testosterone and CAG repeat length (CAG length) with respect to IR has been described in women...
  8. doi Relation between fibroblast growth factor-21, adiposity, metabolism, and weight reduction
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Metabolism 60:306-11. 2011
    ..The finding that moderate weight loss did not induce changes of FGF-21 levels in humans suggests that FGF-21 is not directly regulated by fat mass under those conditions...
  9. ncbi Rosiglitazone decreases 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 67:419-25. 2007
    ..We therefore investigated whether rosiglitazone-induced insulin sensitivity is associated with changes in 11beta-HSD1 activity in different tissues...
  10. pmc Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Berlin, Germany
    Diabetes Care 36:145-9. 2013
    ..Liver-derived fibroblast growth factor (FGF)-21 affects glucose and lipid metabolism. The aim of this study was to analyze the predictive value of FGF-21 on the incidence of T2DM and the metabolic syndrome...
  11. doi Acute hyperinsulinaemia and hyperlipidaemia modify circulating adiponectin and its oligomers
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charité Universitymedicine Berlin, Berlin, Germany
    Clin Endocrinol (Oxf) 71:507-11. 2009
    ..However, obesity is also associated with hyperlipidaemia and the effects of free fatty acids (FFAs) and triglycerides (TG) on circulating adiponectin levels have not yet been investigated...
  12. pmc Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis
    Verena Benz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e37794. 2012
    ..Since these processes are sex-specifically controlled, we investigated sexual dimorphisms in metabolic processes during BW-dynamics (gain-loss-regain)...
  13. doi Retinol-binding protein 4 is associated with insulin resistance, but appears unsuited for metabolic screening in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
    Eur J Endocrinol 158:517-23. 2008
    ..The impact of RBP4 on IR in PCOS and its usability to identify women with metabolic syndrome (MS) or impaired glucose tolerance ((IGT) or diabetes) were investigated...
  14. doi Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes
    Natalia Rudovich
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Nutrition, Campus Benjamin Franklin, Charite University Medicine, Berlin, Germany
    J Mol Med (Berl) 87:1145-51. 2009
    ..This study validates and confirms the association of IDE polymorphisms with T2DM risk in the prospective German cohort and provides novel evidence of influences of IDE genetic variants on insulin metabolism...
  15. ncbi Relation between physiological variation of renal function and carotid intima media thickness in non-diabetic individuals
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Atheroscler Thromb 17:242-8. 2010
    ..We therefore investigated the relation between renal function, established cardiovascular risk factors and carotid intima media thickness in non-diabetic individuals...
  16. ncbi The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 155:127-30. 2006
    ..A polymorphic CAG repeat sequence within the AR gene was reported to modulate its transactivation activity. Therefore, we investigated a putative interaction between testosterone and the CAG repeat length polymorphism with respect to IR...
  17. pmc A1C is associated with intima-media thickness in individuals with normal glucose tolerance
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Berlin, Germany
    Diabetes Care 33:203-4. 2010
    ..However, central markers of glycemic control were not considered. The aim of this study was to identify which marker of glycemic control is most informative with respect to the variation of IMT in individuals with NGT...
  18. doi Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index
    Ayman M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 93:1254-62. 2008
    ..However, the development of highly sensitive and specific GH assays necessitates a critical reevaluation of criteria for diagnosis and follow-up of disease activity...
  19. pmc Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids
    Ozlem Gögebakan
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany
    Diabetes 61:292-300. 2012
    ..This process appears to depend on a modification of 11β-HSD1 activity. In general, the presented data support that GIP has direct and insulin-independent effects on adipose tissue...
  20. pmc Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations
    Antje Fischer-Rosinsky
    Department of Endocrinology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Diabetes and Nutrition, Berlin, Germany
    PLoS ONE 3:e3852. 2008
    ..The suppressor of cytokine signalling 3 (SOCS3) provides a link between cytokine action and their negative consequences on insulin signalling. Thus SOCS3 is a potential candidate gene for type 2 diabetes (T2DM)...
  21. doi Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
    Thomas Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Atherosclerosis 213:549-51. 2010
    ..While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid intima media thickness (IMT) has not been analysed yet...
  22. ncbi Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
    Joachim Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 61:738-46. 2004
    ..The aim of the study was to elucidate determinants of circulating adiponectin levels and to investigate the potential role of adiponectin in insulin resistance in PCOS women...
  23. doi Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid-mediated vasopressin suppression
    Friederike Ufer
    Medical Clinic of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Endocrinol (Oxf) 78:431-7. 2013
    ..However, underlying processes are not well understood. This study aimed to evaluate the mechanism of the modulating effects of glucocorticoids on pAVP and renal water reabsorption...
  24. pmc A distinct metabolic signature predicts development of fasting plasma glucose
    Manuela Hische
    Clinic of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Clin Bioinforma 2:3. 2012
    ..abstract:..
  25. pmc Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1532-8. 2009
    ....
  26. pmc Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors
    Ina Danquah
    Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
    BMC Public Health 12:210. 2012
    ..In this hospital-based study in Kumasi, Ghana, we aimed at characterizing clinical, anthropometric, socio-economic, nutritional and behavioural parameters of DM2 patients and at identifying associated factors...
  27. doi Decision trees as a simple-to-use and reliable tool to identify individuals with impaired glucose metabolism or type 2 diabetes mellitus
    Manuela Hische
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Eur J Endocrinol 163:565-71. 2010
    ..The objective of this study was to create a simple and reliable tool to identify individuals with impaired glucose metabolism (IGM)...
  28. pmc Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis
    Robin Winkler
    Institute of Pharmacology, Department of Endocrinology, Diabetes and Nutrition, Charité Medical University, The Center for Cardiovascular Research, Berlin, Germany
    Diabetes 61:513-23. 2012
    ..Selective pharmacological inhibition of HDAC6 may provide a future therapeutic option against the prodiabetogenic actions of glucocorticoids...
  29. ncbi Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety
    Martin O Weickert
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Br J Nutr 96:795-8. 2006
    ..Postprandial hunger scores were unaffected by the different test meals (P>0.15). Thus, oat- and wheat-fibre consumption result in different postprandial responses of PYY and ghrelin, but interestingly do not differ in satiety effects...
  30. pmc Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1
    Katrin Biedasek
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e16674. 2011
    ..In summary, our data suggest that 11beta-HSD1 controls glucocorticoid-induced protein degradation in human and murine skeletal muscle via regulation of the E3 ubiquitin ligases Atrogin-1 and MuRF-1...
  31. doi Influences of levodopa on adipose tissue and skeletal muscle metabolism in patients with idiopathic Parkinson's disease
    Frauke Adams
    Experimental and Clinical Research Center, A Cooperation with Max Delbrueck Center for Molecular Medicine, Charite Campus Buch, and HELIOS Klinikum, Berlin, Germany
    Eur J Clin Pharmacol 64:863-70. 2008
    ..We assessed systemic and local metabolic responses to levodopa/benserazide in patients with idiopathic Parkinson's disease...
  32. ncbi Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 89:1885-90. 2004
    ....
  33. ncbi IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  34. ncbi The polycystic ovary syndrome per se is not associated with increased chronic inflammation
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam Rehbruecke, Germany
    Eur J Endocrinol 150:525-32. 2004
    ....
  35. ncbi Plasma pyridoxal-5-phosphate and future risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition Potsdam cohort
    Jutta Dierkes
    Institute of Clinical Chemistry and Biochemistry, University Hospital Magdeburg, Magdeburg, Germany
    Am J Clin Nutr 86:214-20. 2007
    ..Retrospective studies indicate that low concentrations of plasma pyridoxal-5-phosphate (PLP) are associated with cardiovascular events; however, few prospective studies of this issue have been conducted...
  36. ncbi Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men
    Matthias Mohlig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Clinical Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 91:964-7. 2006
    ..We therefore investigated whether salicylates reduce lipid-induced insulin resistance in humans by affecting inflammatory pathways as reflected by serum adipocytokines...
  37. ncbi Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...
  38. ncbi Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations
    Inka Lindner
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, Hermann Weigmann Strasse 1, 24103 Kiel, Germany
    Mol Nutr Food Res 49:972-6. 2005
    ..In conclusion, we obtained evidence in two German Caucasian study populations that the variant of the rare CLPS Arg109Cys polymorphism might contribute to increased susceptibility of type 2 diabetes...
  39. ncbi Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Eur J Endocrinol 154:295-301. 2006
    ..This procedure is time-consuming and inconvenient, limiting its general use. Therefore, an easy method is wanted to separate PCOS women with normal from those with potentially abnormal glucose metabolism...
  40. doi Plasma resistin levels and risk of myocardial infarction and ischemic stroke
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    J Clin Endocrinol Metab 93:2647-53. 2008
    ....
  41. ncbi Cereal fiber improves whole-body insulin sensitivity in overweight and obese women
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Diabetes Care 29:775-80. 2006
    ..The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity...
  42. ncbi Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells
    Joachim Spranger
    Dept of Clinical Nutrition, German Institute of Human Nutrition Potsdam, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes 55:141-7. 2006
    ....
  43. ncbi An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes
    Matthias B Schulze
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Epidemiology, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes Care 30:510-5. 2007
    ..We aimed to develop a precise risk score for the screening of large populations for individuals at high risk of developing type 2 diabetes based on noninvasive measurements of major risk factors in German study populations...
  44. ncbi L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Mol Genet Metab 91:278-84. 2007
    ..These results support previous findings in fenofibrate-treated individuals and thereby provide some additional indication of the functional relevance of the FABP1 T94A SNP in hepatic fatty acid and lipid metabolism in humans...
  45. ncbi Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters
    Julia Engl
    Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Obesity (Silver Spring) 15:1172-8. 2007
    ..The aim of the study was to investigate changes of adiponectin isoforms during profound weight loss and its relation to anthropomorphometric and metabolic parameters...
  46. ncbi Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    J Clin Endocrinol Metab 92:3183-8. 2007
    ..On the basis of its chromosomal localization and its role in the synthesis of the antilipolytic compound prostaglandin E(2), the prostaglandin E synthase 2 (PTGES2) is a candidate gene for type 2 diabetes...
  47. ncbi KCNJ11 E23K affects diabetes risk and is associated with the disposition index: results of two independent German cohorts
    Antje Fischer
    Department of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany
    Diabetes Care 31:87-9. 2008
  48. ncbi Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition DIfE, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Eur J Epidemiol 22:429-38. 2007
    ..Consideration of LDL-C beyond smoking, diabetes and hypertension may increase the PAF of MI slightly more than CRP. In contrast, consideration of CRP but not of LDL-C may increase the PAF of stroke beyond these factors...