Martin Spiecker

Summary

Country: Germany

Publications

  1. ncbi request reprint Heart failure in elderly patients
    Martin Spiecker
    Department of Cardiology, Marien Hospital Marl, Hervester Strasse 57, 45768 Marl, Germany
    Exp Gerontol 41:549-51. 2006
  2. pmc Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2
    Martin Spiecker
    Department of Medicine II Cardiology, St Josef Hospital, University of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Circulation 110:2132-6. 2004
  3. ncbi request reprint Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids
    Martin Spiecker
    Department of Medicine II, St Josef Hospital, Bochum Gudrunstrasse 56 44791 Bochum, Germany
    Arch Biochem Biophys 433:413-20. 2005
  4. pmc The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile
    Jan Borgel
    Department of Cardiology, St, Josef Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    BMC Cardiovasc Disord 8:41. 2008
  5. ncbi request reprint Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease
    Martin Spiecker
    Department of Medicine II, St Josef Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Trends Cardiovasc Med 16:204-8. 2006
  6. ncbi request reprint Doppler echocardiographic prediction of recurrent atrial fibrillation following cardioversion
    Martin Spiecker
    Heart and Vascular Center Bochum, Department of Medicine II Cardiology, St Josef Hospital, University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Int J Cardiol 113:161-6. 2006
  7. ncbi request reprint Comparison of endothelial function in patients with metabolic syndrome on bezafibrate or atorvastatin therapy
    Christoph Hanefeld
    Heart and Vascular Center Bochum, Department of Medicine II, St Josef Hospital, University of Bochum, Germany
    Cardiovasc Drugs Ther 19:153-5. 2005
  8. ncbi request reprint Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells
    Martin Spiecker
    Department of Medicine II, University of Bochum, Bochum, Germany
    Mol Pharmacol 62:856-63. 2002
  9. ncbi request reprint Cloning of CYP2J2 gene and identification of functional polymorphisms
    Lorraine M King
    Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 61:840-52. 2002
  10. ncbi request reprint Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study
    Horst Neubauer
    Clinic of Cardiology and Angiology, Ruhr University, Bochum, Germany
    Eur Heart J 24:1744-9. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Heart failure in elderly patients
    Martin Spiecker
    Department of Cardiology, Marien Hospital Marl, Hervester Strasse 57, 45768 Marl, Germany
    Exp Gerontol 41:549-51. 2006
    ..However, randomized trials evaluating the efficacy of specific therapies in heart failure with normal LVEF are still missing...
  2. pmc Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2
    Martin Spiecker
    Department of Medicine II Cardiology, St Josef Hospital, University of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Circulation 110:2132-6. 2004
    ..The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks...
  3. ncbi request reprint Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids
    Martin Spiecker
    Department of Medicine II, St Josef Hospital, Bochum Gudrunstrasse 56 44791 Bochum, Germany
    Arch Biochem Biophys 433:413-20. 2005
    ..Thus, CYP2J2 and its derived arachidonic acid metabolites may play important roles in regulating vascular function under normal and pathophysiological conditions...
  4. pmc The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile
    Jan Borgel
    Department of Cardiology, St, Josef Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    BMC Cardiovasc Disord 8:41. 2008
    ..In the present study, we investigated the influence of this polymorphism on survived myocardial infarction in two study groups of patients with on average high cardiovascular risk profile...
  5. ncbi request reprint Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease
    Martin Spiecker
    Department of Medicine II, St Josef Hospital Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Trends Cardiovasc Med 16:204-8. 2006
    ..A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease...
  6. ncbi request reprint Doppler echocardiographic prediction of recurrent atrial fibrillation following cardioversion
    Martin Spiecker
    Heart and Vascular Center Bochum, Department of Medicine II Cardiology, St Josef Hospital, University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Int J Cardiol 113:161-6. 2006
    ..Measuring atrial mechanical function is of interest to determine the individual risk of thromboembolism and the risk of recurrent AF...
  7. ncbi request reprint Comparison of endothelial function in patients with metabolic syndrome on bezafibrate or atorvastatin therapy
    Christoph Hanefeld
    Heart and Vascular Center Bochum, Department of Medicine II, St Josef Hospital, University of Bochum, Germany
    Cardiovasc Drugs Ther 19:153-5. 2005
  8. ncbi request reprint Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells
    Martin Spiecker
    Department of Medicine II, University of Bochum, Bochum, Germany
    Mol Pharmacol 62:856-63. 2002
    ..We propose that inhibition of NF-kappaB dependent gene transcription contributes to the anti-inflammatory effects of tranilast...
  9. ncbi request reprint Cloning of CYP2J2 gene and identification of functional polymorphisms
    Lorraine M King
    Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 61:840-52. 2002
    ..Insofar as CYP2J2 products have effects in the cardiovascular system, we speculate that these variants may be functionally relevant...
  10. ncbi request reprint Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study
    Horst Neubauer
    Clinic of Cardiology and Angiology, Ruhr University, Bochum, Germany
    Eur Heart J 24:1744-9. 2003
    ..Since certain lipophilic statins (i.e. simvastatin, atorvastatin, lovastatin) are a substrate of CYP3A4, we were interested in potential drug interactions between clopidogrel and statins...