C P Speer

Summary

Country: Germany

Publications

  1. ncbi request reprint Pre- and postnatal inflammatory mechanisms in chronic lung disease of preterm infants
    Christian P Speer
    University Children s Hospital Wurzburg, Germany
    Paediatr Respir Rev 5:S241-4. 2004
  2. doi request reprint Surfactant therapy: past, present and future
    Christian P Speer
    University Children s Hospital, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Early Hum Dev 89:S22-4. 2013
  3. ncbi request reprint Pulmonary inflammation and bronchopulmonary dysplasia
    C P Speer
    Department of Pediatrics, University Children s Hospital, Wurzburg, Germany
    J Perinatol 26:S57-62; discussion S63-4. 2006
  4. ncbi request reprint Inflammation and bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Semin Neonatol 8:29-38. 2003
  5. doi request reprint Neonatal respiratory distress syndrome: an inflammatory disease?
    Christian P Speer
    University Children s Hospital, Wurzburg, Germany
    Neonatology 99:316-9. 2011
  6. ncbi request reprint New insights into the pathogenesis of pulmonary inflammation in preterm infants
    C P Speer
    University Children s Hospital, Wurzburg, Germany
    Biol Neonate 79:205-9. 2001
  7. doi request reprint [Significance of nitric oxide inhalation (NO) in preterm infants< 34 weeks of gestation]
    J Wirbelauer
    University Hospital, University Children s Hospital, Josef Schneider Strasse 2, Wurzburg
    Klin Padiatr 222:56-61. 2010
  8. doi request reprint Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?
    W Thomas
    University Children s Hospital, Wurzburg, Germany
    Neonatology 94:150-9. 2008
  9. doi request reprint [Leukemoid reaction in extremely immature preterm infants]
    J Wirbelauer
    Universitäts Kinderklinik Würzburg, Neonatologie und neonatologische Intensivmedizin, Wurzburg
    Z Geburtshilfe Neonatol 212:165-9. 2008
  10. pmc Freeze-thawing of breast milk does not prevent cytomegalovirus transmission to a preterm infant
    J Maschmann
    Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arch Dis Child Fetal Neonatal Ed 91:F288-90. 2006

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Pre- and postnatal inflammatory mechanisms in chronic lung disease of preterm infants
    Christian P Speer
    University Children s Hospital Wurzburg, Germany
    Paediatr Respir Rev 5:S241-4. 2004
    ....
  2. doi request reprint Surfactant therapy: past, present and future
    Christian P Speer
    University Children s Hospital, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Early Hum Dev 89:S22-4. 2013
    ..Whenever indicated, surfactant should be administered as early as possible in the course of the RDS. ..
  3. ncbi request reprint Pulmonary inflammation and bronchopulmonary dysplasia
    C P Speer
    Department of Pediatrics, University Children s Hospital, Wurzburg, Germany
    J Perinatol 26:S57-62; discussion S63-4. 2006
    ..In this condensed review article, the current concepts on the possible role of inflammation in the evolution of bronchopulmonary dysplasia will be summarized...
  4. ncbi request reprint Inflammation and bronchopulmonary dysplasia
    Christian P Speer
    University Children s Hospital, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Semin Neonatol 8:29-38. 2003
    ....
  5. doi request reprint Neonatal respiratory distress syndrome: an inflammatory disease?
    Christian P Speer
    University Children s Hospital, Wurzburg, Germany
    Neonatology 99:316-9. 2011
    ..Whenever surfactant inactivation is suspected, higher or repetitive doses of natural surfactant may help to overcome surfactant inactivation and to restore lung function...
  6. ncbi request reprint New insights into the pathogenesis of pulmonary inflammation in preterm infants
    C P Speer
    University Children s Hospital, Wurzburg, Germany
    Biol Neonate 79:205-9. 2001
    ..Inflammation and lung injury most certainly affect normal alveolization and pulmonary vascular development in preterm infants with CLD...
  7. doi request reprint [Significance of nitric oxide inhalation (NO) in preterm infants< 34 weeks of gestation]
    J Wirbelauer
    University Hospital, University Children s Hospital, Josef Schneider Strasse 2, Wurzburg
    Klin Padiatr 222:56-61. 2010
    ..Current data of long term neurological outcome of iNO-treated preterm infants do not seem to justify iNO administration. Outside of well designed clinical trials iNO-treatment of preterm infants can currently not be recommended...
  8. doi request reprint Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?
    W Thomas
    University Children s Hospital, Wurzburg, Germany
    Neonatology 94:150-9. 2008
    ..However, there is no proof for an effect of erythromycin on BPD. The potential roles for therapies like bombesin-like peptide-blocking antibodies or Clara cell 10-kDa protein have yet to be defined...
  9. doi request reprint [Leukemoid reaction in extremely immature preterm infants]
    J Wirbelauer
    Universitäts Kinderklinik Würzburg, Neonatologie und neonatologische Intensivmedizin, Wurzburg
    Z Geburtshilfe Neonatol 212:165-9. 2008
    ....
  10. pmc Freeze-thawing of breast milk does not prevent cytomegalovirus transmission to a preterm infant
    J Maschmann
    Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arch Dis Child Fetal Neonatal Ed 91:F288-90. 2006
    ..A case of a preterm infant exclusively receiving frozen breast milk from his CMV seropositive mother showed that storage of breast milk for two months at -20 degrees C did not prevent symptomatic postnatal CMV infection...
  11. ncbi request reprint Factor VIII is a positive regulator of platelet function
    A Obergfell
    Institute of Clinical Biochemistry and Pathobiochemistry, Central Laboratory, Wuerzburg, Germany
    Platelets 17:448-53. 2006
    ..We hypothesize that FVIII induced increase in platelet activation might contribute to venous and even arterial thrombus formation in patients with high FVIII levels...
  12. ncbi request reprint [Congenital skin lesions in occult spinal dysraphism--what is typical?]
    C Schropp
    Universitäts Kinderklinik und Poliklinik, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg
    Z Geburtshilfe Neonatol 210:222-7. 2006
    ..In this article, an overview on the main forms of OSD and characteristic skin lesions is given, which can guide the clinician to early diagnosis and appropriate diagnostic work-up and, if necessary, therapeutic intervention...
  13. doi request reprint Connective tissue growth factor does not affect transforming growth factor-beta 1-induced Smad3 phosphorylation and T lymphocyte proliferation inhibition
    S Kunzmann
    University Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Int Arch Allergy Immunol 147:152-60. 2008
    ..Overall, these data support the hypothesis that CTGF does not act on CD4+ T lymphocytes...
  14. doi request reprint [Preterm and term infants with acute respiratory distress syndrome (ARDS): what is the role of surfactant substitution?]
    J Wirbelauer
    Universitäts Kinderklinik Würzburg, Germany
    Z Geburtshilfe Neonatol 213:33-41. 2009
    ..Surfactant treatment in preterm infants and term newborns with ARDS-like severe respiratory failure has become part of an individualised treatment strategy in many intensive care units around the world...
  15. ncbi request reprint [Inhaled nitric oxide in neonatology: state of the art]
    J Wirbelauer
    Universitäts Kinderklinik, Wurzburg
    Z Geburtshilfe Neonatol 208:79-90. 2004
    ..Prophylactic therapy according to a risk profile has not yet proved to be meaningful. An indication for the treatment of preterm neonates of less than 34 weeks of gestation has not yet been confirmed...
  16. ncbi request reprint Cytomegalovirus infection of extremely low-birth weight infants via breast milk
    J Maschmann
    Department of Neonatology, University of Tubingen, Germany
    Clin Infect Dis 33:1998-2003. 2001
    ..Low birth weight and early postnatal virus transmission were risk factors for symptomatic infection. VLBW infants of CMV-seropositive mothers are at high risk of acquiring a symptomatic CMV infection postnatally via breast milk...
  17. ncbi request reprint [Congenital Hyposplenia with multiple additional anomalies: a variant of the Ivemark Syndrome]
    R Nanan
    Kinderklinik der Universität Würzburg
    Klin Padiatr 214:299-302. 2002
    ..The case indicates that a common genetic defect might be the cause of this syndrome, which shows a variable expression...
  18. ncbi request reprint [Aseptic meningitis after intrathecal infusion of a parenteral nutrition solution: examples of rare malpositions of central venous catheters in preterm neonates]
    J Wirbelauer
    Universitäts Kinderklinik Würzburg
    Z Geburtshilfe Neonatol 208:63-7. 2004
    ..A chest X-ray is usually performed for verification of the position of the catheter. Localization of the tip of the catheter is often very difficult because of its extremely small diameter...
  19. ncbi request reprint Detection by ELISA of low transferrin levels in bronchoalveolar secretions of preterm infants
    C E Gerber
    University Children s Hospital, Department of Neonatology, Rümelinstr 23, D 72070, Tubingen, Germany
    J Immunol Methods 233:41-5. 2000
    ..48 compared to 0.52 ((microgram/microgram SC), median range) for infants who developed chronic lung disease...
  20. doi request reprint The role of surfactant treatment in preterm infants and term newborns with acute respiratory distress syndrome
    J Wirbelauer
    University Children s Hospital, Wurzburg, Germany
    J Perinatol 29:S18-22. 2009
    ..Newborns with MAS will definitely benefit from a reduced need for extracorporeal membrane oxygenation (ECMO). Clinical experience seems to justify surfactant treatment in neonates with ARDS...
  21. ncbi request reprint Decreased mRNA expression of G-CSF receptor in cord blood neutrophils of term newborns: regulation of expression by G-CSF and TNF-alpha
    P Gessler
    University Children s Hospital, Department of Neonatology, Tubingen, Germany
    Biol Neonate 77:168-73. 2000
    ..Furthermore, G-CSF receptor expression on neutrophils was modified not only by G-CSF itself, but also by TNF-alpha...
  22. ncbi request reprint The role of transforming growth factor beta in lung development and disease
    Ulrike Bartram
    University Children s Hospital, Josef Schnewider Strasse 2, 97080 Wuerzburg, Germany
    Chest 125:754-65. 2004
    ..TGFbeta plays a key role in mediating fibrotic tissue remodeling by increasing the production and decreasing the degradation of connective tissue via several mechanisms...
  23. ncbi request reprint Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling
    Steffen Kunzmann
    University Children s Hospital, Wurzburg, Germany
    J Allergy Clin Immunol 119:1398-407. 2007
    ..TGF-beta and its downstream mediator connective tissue growth factor (CTGF) are playing a key role in these processes, resulting in irreversible airway remodelling...
  24. ncbi request reprint Prevention and therapy of bronchopulmonary dysplasia - evidence and clinical practice
    Wolfgang Thomas
    University Children s Hospital, University of Wurzburg, Germany
    Zhongguo Dang Dai Er Ke Za Zhi 9:264-77. 2007
    ..The role of erythromycin has not been completely elucidated yet. Innovative strategies like Clara Cell 10 kD protein still have to be assessed in future trials...
  25. ncbi request reprint Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets
    Per Arne Tølløfsrud
    Department of Pediatric Research, National Hospital, Oslo, Oslo, Norway
    Biol Neonate 84:330-7. 2003
    ....
  26. doi request reprint Systemic fetal inflammation and reduced concentrations of macrophage migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infants
    Wolfgang Thomas
    University Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Am J Obstet Gynecol 198:64.e1-6. 2008
    ..We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of macrophage migration inhibitory factor in airways of extremely premature infants...
  27. ncbi request reprint Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs
    Steffen Kunzmann
    Department of Pediatrics, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L223-31. 2007
    ..These effects may contribute to the impaired alveolar and pulmonary vascular development that is the hallmark of the new form of BPD...
  28. ncbi request reprint Nuclear factor-kappa B expression in alveolar macrophages of mechanically ventilated neonates with respiratory distress syndrome
    Lei Cao
    Department of Pediatrics, Hebei Province People s Hospital, Shijiazhuang, P R China
    Biol Neonate 86:116-23. 2004
    ..In preterm infants with immature lungs, this mechanism is not yet fully understood, therefore we investigated this mechanism in mechanically ventilated neonates with respiratory distress syndrome (RDS)...
  29. ncbi request reprint Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis
    Johannes Wirbelauer
    University Children s Hospital, University of Wurzburg, Germany
    Neonatology 93:257-62. 2008
    ....
  30. ncbi request reprint Decreased expression of angiogenic factors in placentas with chorioamnionitis after preterm birth
    Boris W Kramer
    University Children s Hospital, Wuerzburg, Germany
    Pediatr Res 58:607-12. 2005
    ..We speculate that cellular stress and changes in angiogenic homeostasis induced by proinflammatory activation of fetal endothelium in chorioamnionitis may not be limited to the placenta but may also involve other fetal organs...
  31. ncbi request reprint Chorioamnionitis is associated with increased CD40L expression on cord blood platelets
    Ana Gabriela Sitaru
    Institute of Clinical Biochemistry and Pathobiochemistry, Central Laboratory, University of Wurzburg, Germany
    Thromb Haemost 94:1219-23. 2005
    ..Neither P-selectin expression on cord blood platelets nor plasma sP-selectin or sCD40L were suitable platelet markers in CA, whereas CD40L was significantly elevated in histologically proven CA...
  32. ncbi request reprint TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytes
    Steffen Kunzmann
    University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Am J Physiol Lung Cell Mol Physiol 291:L747-56. 2006
    ..Monitoring of SP-A preparations for possible TGF-beta1 is essential...
  33. ncbi request reprint Management of infants with bronchopulmonary dysplasia in Germany
    Wolfgang Thomas
    University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Early Hum Dev 81:155-63. 2005
    ..Infants with home oxygen need a close follow-up by neonatologists and other specialists. Routine vaccination is recommended from the postnatal age of 3 months onwards...
  34. ncbi request reprint Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis
    Daniela D'Alquen
    University Children s Hospital, 97080 Wuerzburg, Germany
    Pediatr Res 57:263-9. 2005
    ..This underlines the importance of funisitis as a risk factor for adverse outcome...
  35. ncbi request reprint Inflammation and bronchopulmonary dysplasia: a continuing story
    Christian P Speer
    University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Semin Fetal Neonatal Med 11:354-62. 2006
    ....
  36. ncbi request reprint Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
    Per Arne Tølløfsrud
    Department of Pediatric Research, The National Hospital, Oslo, Norway
    J Perinat Med 32:78-83. 2004
    ..In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration...
  37. ncbi request reprint Heterotaxy syndrome -- asplenia and polysplenia as indicators of visceral malposition and complex congenital heart disease
    Ulrike Bartram
    University Children s Hospital Wurzburg, Germany
    Biol Neonate 88:278-90. 2005
    ....
  38. ncbi request reprint Legionella waltersii--a novel cause of pneumonia?
    Corinne König
    University Children s Hospital, Wurzburg, Germany
    Acta Paediatr 94:1505-7. 2005
    ..Further sequencing of Legionella DNA led to the identification of Legionella waltersii. This Legionella species has never been described as a human pathogen before...
  39. ncbi request reprint Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton
    Daniel G M Molin
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 227:431-44. 2003
    ..The information provided favors novel roles of Tgfbeta1-3 in epicardial development, of Tgfbeta2 in myocardialisation, and of Tgfbeta3 in differentiation of the fibrous structures of the heart...
  40. ncbi request reprint Neonatology. Preface
    Dominique Haumont
    Neonatology 93:282-3. 2008
  41. ncbi request reprint Rapid detection and quantification of cell free cytomegalovirus by a high-speed centrifugation-based microculture assay: comparison to longitudinally analyzed viral DNA load and pp67 late transcript during lactation
    Klaus Hamprecht
    Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    J Clin Virol 28:303-16. 2003
    ..Conventional tissue culture (TC) and low-speed centrifugation-enhanced microtiter culture methods are not able to detect HCMV from milk during all stages of lactation...
  42. ncbi request reprint Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infants
    Brigitte Vollmer
    Department of Pediatric Neurology, Children s Hospital, University of Tubingen, Tubingen, Germany
    Pediatr Infect Dis J 23:322-7. 2004
    ....
  43. ncbi request reprint European consensus guidelines on the management of neonatal respiratory distress syndrome
    David Sweet
    Regional Neonatal Unit, Royal Maternity Hospital, Belfast, Northern Ireland, UK
    J Perinat Med 35:175-86. 2007
    ....
  44. ncbi request reprint Hirudin treatment for multiple thromboses in a preterm infant with inherited thrombophilia
    Alexander Sturm
    University Children s Hospital, Wuerzburg, Germany
    Blood Coagul Fibrinolysis 18:381-3. 2007
    ..Efficacy and safety issues of hirudin treatment, however, need to be evaluated in randomized trials...
  45. ncbi request reprint Case-control study of symptoms and neonatal outcome of human milk-transmitted cytomegalovirus infection in premature infants
    Patrick Neuberger
    Department of Neonatology, University Children s Hospital and Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tuebingen, Germany
    J Pediatr 148:326-31. 2006
    ..Over a period of 8.5 years, we compared infants infected postnatally with CMV with noninfected controls to determine whether CMV infection transmitted through breast milk poses serious acute risks...