Research Topics
| C P SpeerSummaryCountry: Germany Publications
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Publications
Pre- and postnatal inflammatory mechanisms in chronic lung disease of preterm infantsChristian P Speer
University Children s Hospital Wurzburg, Germany
Paediatr Respir Rev 5:S241-4. 2004....
Neonatal respiratory distress syndrome: an inflammatory disease?Christian P Speer
University Children s Hospital, Wurzburg, Germany
Neonatology 99:316-9. 2011..Whenever surfactant inactivation is suspected, higher or repetitive doses of natural surfactant may help to overcome surfactant inactivation and to restore lung function...- Pulmonary inflammation and bronchopulmonary dysplasiaC P Speer
Department of Pediatrics, University Children s Hospital, Wurzburg, Germany
J Perinatol 26:S57-62; discussion S63-4. 2006..In this condensed review article, the current concepts on the possible role of inflammation in the evolution of bronchopulmonary dysplasia will be summarized... - Inflammation and bronchopulmonary dysplasiaChristian P Speer
University Children s Hospital, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
Semin Neonatol 8:29-38. 2003.... - New insights into the pathogenesis of pulmonary inflammation in preterm infantsC P Speer
University Children s Hospital, Wurzburg, Germany
Biol Neonate 79:205-9. 2001..Inflammation and lung injury most certainly affect normal alveolization and pulmonary vascular development in preterm infants with CLD... - [Significance of nitric oxide inhalation (NO) in preterm infants< 34 weeks of gestation]J Wirbelauer
University Hospital, University Children s Hospital, Josef Schneider Strasse 2, Wurzburg
Klin Padiatr 222:56-61. 2010..Current data of long term neurological outcome of iNO-treated preterm infants do not seem to justify iNO administration. Outside of well designed clinical trials iNO-treatment of preterm infants can currently not be recommended... - Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?W Thomas
University Children s Hospital, Wurzburg, Germany
Neonatology 94:150-9. 2008..However, there is no proof for an effect of erythromycin on BPD. The potential roles for therapies like bombesin-like peptide-blocking antibodies or Clara cell 10-kDa protein have yet to be defined... 
Freeze-thawing of breast milk does not prevent cytomegalovirus transmission to a preterm infantJ Maschmann
Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Arch Dis Child Fetal Neonatal Ed 91:F288-90. 2006..A case of a preterm infant exclusively receiving frozen breast milk from his CMV seropositive mother showed that storage of breast milk for two months at -20 degrees C did not prevent symptomatic postnatal CMV infection...- [Congenital Hyposplenia with multiple additional anomalies: a variant of the Ivemark Syndrome]R Nanan
Kinderklinik der Universität Würzburg
Klin Padiatr 214:299-302. 2002..The case indicates that a common genetic defect might be the cause of this syndrome, which shows a variable expression... - Factor VIII is a positive regulator of platelet functionA Obergfell
Institute of Clinical Biochemistry and Pathobiochemistry, Central Laboratory, Wuerzburg, Germany
Platelets 17:448-53. 2006..We hypothesize that FVIII induced increase in platelet activation might contribute to venous and even arterial thrombus formation in patients with high FVIII levels... - [Congenital skin lesions in occult spinal dysraphism--what is typical?]C Schropp
Universitäts Kinderklinik und Poliklinik, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg
Z Geburtshilfe Neonatol 210:222-7. 2006..In this article, an overview on the main forms of OSD and characteristic skin lesions is given, which can guide the clinician to early diagnosis and appropriate diagnostic work-up and, if necessary, therapeutic intervention... - Cytomegalovirus infection of extremely low-birth weight infants via breast milkJ Maschmann
Department of Neonatology, University of Tubingen, Germany
Clin Infect Dis 33:1998-2003. 2001..Low birth weight and early postnatal virus transmission were risk factors for symptomatic infection. VLBW infants of CMV-seropositive mothers are at high risk of acquiring a symptomatic CMV infection postnatally via breast milk... - Connective tissue growth factor does not affect transforming growth factor-beta 1-induced Smad3 phosphorylation and T lymphocyte proliferation inhibitionS Kunzmann
University Children s Hospital, University of Wurzburg, Wurzburg, Germany
Int Arch Allergy Immunol 147:152-60. 2008..Overall, these data support the hypothesis that CTGF does not act on CD4+ T lymphocytes... - [Inhaled nitric oxide in neonatology: state of the art]J Wirbelauer
Universitäts Kinderklinik, Wurzburg
Z Geburtshilfe Neonatol 208:79-90. 2004..Prophylactic therapy according to a risk profile has not yet proved to be meaningful. An indication for the treatment of preterm neonates of less than 34 weeks of gestation has not yet been confirmed... - [Preterm and term infants with acute respiratory distress syndrome (ARDS): what is the role of surfactant substitution?]J Wirbelauer
Universitäts Kinderklinik Würzburg, Germany
Z Geburtshilfe Neonatol 213:33-41. 2009..Surfactant treatment in preterm infants and term newborns with ARDS-like severe respiratory failure has become part of an individualised treatment strategy in many intensive care units around the world... - [Aseptic meningitis after intrathecal infusion of a parenteral nutrition solution: examples of rare malpositions of central venous catheters in preterm neonates]J Wirbelauer
Universitäts Kinderklinik Würzburg
Z Geburtshilfe Neonatol 208:63-7. 2004..A chest X-ray is usually performed for verification of the position of the catheter. Localization of the tip of the catheter is often very difficult because of its extremely small diameter... - [Leukemoid reaction in extremely immature preterm infants]J Wirbelauer
Universitäts Kinderklinik Würzburg, Neonatologie und neonatologische Intensivmedizin, Wurzburg
Z Geburtshilfe Neonatol 212:165-9. 2008.... - Detection by ELISA of low transferrin levels in bronchoalveolar secretions of preterm infantsC E Gerber
University Children s Hospital, Department of Neonatology, Rümelinstr 23, D 72070, Tubingen, Germany
J Immunol Methods 233:41-5. 2000..48 compared to 0.52 ((microgram/microgram SC), median range) for infants who developed chronic lung disease... - The role of surfactant treatment in preterm infants and term newborns with acute respiratory distress syndromeJ Wirbelauer
University Children s Hospital, Wurzburg, Germany
J Perinatol 29:S18-22. 2009..Newborns with MAS will definitely benefit from a reduced need for extracorporeal membrane oxygenation (ECMO). Clinical experience seems to justify surfactant treatment in neonates with ARDS... - Decreased mRNA expression of G-CSF receptor in cord blood neutrophils of term newborns: regulation of expression by G-CSF and TNF-alphaP Gessler
University Children s Hospital, Department of Neonatology, Tubingen, Germany
Biol Neonate 77:168-73. 2000..Furthermore, G-CSF receptor expression on neutrophils was modified not only by G-CSF itself, but also by TNF-alpha... - Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodelingSteffen Kunzmann
University Children s Hospital, Wurzburg, Germany
J Allergy Clin Immunol 119:1398-407. 2007..TGF-beta and its downstream mediator connective tissue growth factor (CTGF) are playing a key role in these processes, resulting in irreversible airway remodelling... - Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungsSteffen Kunzmann
Department of Pediatrics, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
Am J Physiol Lung Cell Mol Physiol 292:L223-31. 2007..These effects may contribute to the impaired alveolar and pulmonary vascular development that is the hallmark of the new form of BPD... - Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitisJohannes Wirbelauer
University Children s Hospital, University of Wurzburg, Germany
Neonatology 93:257-62. 2008.... - Systemic fetal inflammation and reduced concentrations of macrophage migration inhibitory factor in tracheobronchial aspirate fluid of extremely premature infantsWolfgang Thomas
University Children s Hospital, University of Wurzburg, Wurzburg, Germany
Am J Obstet Gynecol 198:64.e1-6. 2008..We speculated that funisitis, reflecting fetal systemic inflammation, would be associated with higher concentrations of macrophage migration inhibitory factor in airways of extremely premature infants... - Prevention and therapy of bronchopulmonary dysplasia - evidence and clinical practiceWolfgang Thomas
University Children s Hospital, University of Wurzburg, Germany
Zhongguo Dang Dai Er Ke Za Zhi 9:264-77. 2007..The role of erythromycin has not been completely elucidated yet. Innovative strategies like Clara Cell 10 kD protein still have to be assessed in future trials... - Inflammation and bronchopulmonary dysplasia: a continuing storyChristian P Speer
University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
Semin Fetal Neonatal Med 11:354-62. 2006.... - TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytesSteffen Kunzmann
University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Am J Physiol Lung Cell Mol Physiol 291:L747-56. 2006..Monitoring of SP-A preparations for possible TGF-beta1 is essential... - Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn pigletsPer Arne Tølløfsrud
Department of Pediatric Research, National Hospital, Oslo, Oslo, Norway
Biol Neonate 84:330-7. 2003.... - The role of transforming growth factor beta in lung development and diseaseUlrike Bartram
University Children s Hospital, Josef Schnewider Strasse 2, 97080 Wuerzburg, Germany
Chest 125:754-65. 2004..TGFbeta plays a key role in mediating fibrotic tissue remodeling by increasing the production and decreasing the degradation of connective tissue via several mechanisms... - Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspirationPer Arne Tølløfsrud
Department of Pediatric Research, The National Hospital, Oslo, Norway
J Perinat Med 32:78-83. 2004..In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration... - Nuclear factor-kappa B expression in alveolar macrophages of mechanically ventilated neonates with respiratory distress syndromeLei Cao
Department of Pediatrics, Hebei Province People's Hospital, Shijiazhuang, P.R. China
Biol Neonate 86:116-23. 2004..01), and IL-8 (r = 0.81, p < 0.01) in AA. CONCLUSION: There were alterations in NF-kappaB activity in the AM of mechanically ventilated preterm neonates with RDS, mediated by decreased synthesis and increased degradation of IkappaB... - Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitisBoris W Kramer
University Children's Hospital, 97080 Wuerzburg, Germany
Pediatr Res 57:263-9. 2005..This underlines the importance of funisitis as a risk factor for adverse outcome... - Management of infants with bronchopulmonary dysplasia in GermanyWolfgang Thomas
University Children s Hospital, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Early Hum Dev 81:155-63. 2005..Infants with home oxygen need a close follow-up by neonatologists and other specialists. Routine vaccination is recommended from the postnatal age of 3 months onwards... - Decreased expression of angiogenic factors in placentas with chorioamnionitis after preterm birthBoris W Kramer
University Children s Hospital, Wuerzburg, Germany
Pediatr Res 58:607-12. 2005..We speculate that cellular stress and changes in angiogenic homeostasis induced by proinflammatory activation of fetal endothelium in chorioamnionitis may not be limited to the placenta but may also involve other fetal organs... - Chorioamnionitis is associated with increased CD40L expression on cord blood plateletsAna-Gabriela Sitaru
Institute of Clinical Biochemistry and Pathobiochemistry, Central Laboratory, , Germany
Thromb Haemost 94:1219-23. 2005..Neither P-selectin expression on cord blood platelets nor plasma sP-selectin or sCD40L were suitable platelet markers in CA, whereas CD40L was significantly elevated in histologically proven CA... - Heterotaxy syndrome -- asplenia and polysplenia as indicators of visceral malposition and complex congenital heart diseaseUlrike Bartram
University Children s Hospital Wurzburg, Germany
Biol Neonate 88:278-90. 2005.... - Case-control study of symptoms and neonatal outcome of human milk-transmitted cytomegalovirus infection in premature infantsPatrick Neuberger
Department of Neonatology, University Children's Hospital and Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tuebingen, Germany
J Pediatr 148:326-31. 2006..Whether withholding or pasteurizing breast milk is warranted, however, depends on long-term outcome... - Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeletonDaniel G M Molin
Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
Dev Dyn 227:431-44. 2003..The information provided favors novel roles of Tgfbeta1-3 in epicardial development, of Tgfbeta2 in myocardialisation, and of Tgfbeta3 in differentiation of the fibrous structures of the heart... - Postnatally acquired cytomegalovirus infection via breast milk: effects on hearing and development in preterm infantsBrigitte Vollmer
Department of Pediatric Neurology, Children s Hospital, University of Tubingen, Tubingen, Germany
Pediatr Infect Dis J 23:322-7. 2004.... - Legionella waltersii--a novel cause of pneumonia?Corinne König
University Children s Hospital, Wurzburg, Germany
Acta Paediatr 94:1505-7. 2005..Since L. waltersii is not detected by routine laboratory tests, it may be speculated that these bacteria, like other Legionella species, are underestimated as a probable cause of community-acquired pneumonia... - Neonatology. PrefaceDominique Haumont
Neonatology 93:282-3. 2008 - Hirudin treatment for multiple thromboses in a preterm infant with inherited thrombophiliaAlexander Sturm
University Children s Hospital, Wuerzburg, Germany
Blood Coagul Fibrinolysis 18:381-3. 2007..Efficacy and safety issues of hirudin treatment, however, need to be evaluated in randomized trials... - European consensus guidelines on the management of neonatal respiratory distress syndromeDavid Sweet
Regional Neonatal Unit, Royal Maternity Hospital, Belfast, Northern Ireland, UK
J Perinat Med 35:175-86. 2007.... - Rapid detection and quantification of cell free cytomegalovirus by a high-speed centrifugation-based microculture assay: comparison to longitudinally analyzed viral DNA load and pp67 late transcript during lactationKlaus Hamprecht
Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
J Clin Virol 28:303-16. 2003..Conventional tissue culture (TC) and low-speed centrifugation-enhanced microtiter culture methods are not able to detect HCMV from milk during all stages of lactation...