Claudia Sommer

Summary

Country: Germany

Publications

  1. pmc New treatment options for fibromyalgia: critical appraisal of duloxetine
    Nurcan Uceyler
    Department of Neurology, University of Würzburg Germany
    Neuropsychiatr Dis Treat 4:525-9. 2008
  2. doi request reprint [Neuropathic pain: pathophysiology, assessment, and therapy]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 27:619-32; quiz 633-4. 2013
  3. doi request reprint [Pain therapy for Fabry's disease]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Deutschland
    Internist (Berl) 54:121-2, 124-30. 2013
  4. doi request reprint [Etiology and pathophysiology of fibromyalgia syndrome]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:259-67. 2012
  5. doi request reprint [Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:297-310. 2012
  6. pmc Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro
    Serena Quarta
    Div Physiology, DPMP, Medical University Innsbruck, Innsbruck, Austria
    Mol Pain 7:73. 2011
  7. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
  8. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
  9. doi request reprint Peripheral Nerve Society Guideline on processing and evaluation of nerve biopsies
    Claudia L Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 15:164-75. 2010
  10. doi request reprint Nerve biopsy in chronic inflammatory neuropathies: in situ biomarkers
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Street 11, Wurzburg, Germany
    J Peripher Nerv Syst 16:24-9. 2011

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc New treatment options for fibromyalgia: critical appraisal of duloxetine
    Nurcan Uceyler
    Department of Neurology, University of Würzburg Germany
    Neuropsychiatr Dis Treat 4:525-9. 2008
    ..As true for other antidepressants further studies are needed to assess the long-term efficacy and safety of duloxetine as an additional pharmacological treatment option in FMS...
  2. doi request reprint [Neuropathic pain: pathophysiology, assessment, and therapy]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 27:619-32; quiz 633-4. 2013
    ..The drugs available include antidepressants, anticonvulsants, opioids, and topical medications. Data from controlled trials and recommendations from guidelines are available...
  3. doi request reprint [Pain therapy for Fabry's disease]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Deutschland
    Internist (Berl) 54:121-2, 124-30. 2013
    ..In addition, medication has to be adjusted to concomitant cardiac and renal involvement in Fabry's disease. This review gives guidance for pain therapy in Fabry's disease based on the available evidence and on experience...
  4. doi request reprint [Etiology and pathophysiology of fibromyalgia syndrome]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:259-67. 2012
    ....
  5. doi request reprint [Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:297-310. 2012
    ....
  6. pmc Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro
    Serena Quarta
    Div Physiology, DPMP, Medical University Innsbruck, Innsbruck, Austria
    Mol Pain 7:73. 2011
    ..Together, the results argue for IL-6 signal transducer gp130 as an essential prerequisite in nociceptors for long-term mechanical hypersensitivity associated with cancer, inflammation and nerve injury...
  7. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
    ..To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features...
  8. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
    ..Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen...
  9. doi request reprint Peripheral Nerve Society Guideline on processing and evaluation of nerve biopsies
    Claudia L Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 15:164-75. 2010
    ..5) Immunohistochemistry, teased fiber analysis, electron microscopy, and morphometry may help clarify the diagnosis in some conditions and should be considered as additional studies...
  10. doi request reprint Nerve biopsy in chronic inflammatory neuropathies: in situ biomarkers
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Street 11, Wurzburg, Germany
    J Peripher Nerv Syst 16:24-9. 2011
    ..More research is needed to establish the diagnostic validity of specific markers and of gene expression studies and to test whether they can distinguish between subtypes of inflammatory neuropathies...
  11. doi request reprint Skin biopsy as a diagnostic tool
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Curr Opin Neurol 21:563-8. 2008
    ..To give an overview of recent data on the use of skin biopsy as a diagnostic tool in neuropathies...
  12. pmc A modified score to identify and discriminate neuropathic pain: a study on the German version of the Neuropathic Pain Symptom Inventory (NPSI)
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    BMC Neurol 11:104. 2011
    ..We hypothesized that the NPSI might also be used to differentiate neuropathic from non-neuropathic pain...
  13. doi request reprint Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  14. doi request reprint Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  15. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  16. ncbi request reprint Differential expression of cytokines in painful and painless neuropathies
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neurology 69:42-9. 2007
    ..The factors determining why some peripheral neuropathies are painful and others are not are incompletely understood. Pro-inflammatory cytokines have been implicated to play a crucial role in the generation of pain...
  17. doi request reprint Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Straße 11, 97080 Wurzburg, Germany
    Neurosci Lett 495:93-7. 2011
    ..Conversely, attenuation of mechanical allodynia in 5-HTT-/- mice may indicate reduced 5-HT-mediated facilitation in the central nervous system...
  18. doi request reprint Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz 55101, Germany
    Neurobiol Dis 35:177-83. 2009
    ..These findings resemble human 'cold' CRPS and suggest that ET 1 plays an important role in the pathogenesis of CRPS with nerve injury...
  19. ncbi request reprint Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy
    Nurcan Uceyler
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Neurosci Res 84:37-46. 2006
    ..Thus, the P0(+/-) phenotype seems to be protected against VIN-induced neuropathy. The mechanism of this neuroprotection remains elusive...
  20. ncbi request reprint Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve
    Annette George
    Neurologische Klinik der Universität, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 192:163-6. 2005
    ..These data indicate that endoneurial TNFR1 and TNFR2 proteins are differentially regulated during Wallerian degeneration...
  21. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process...
  22. ncbi request reprint Intraneural injection of interleukin-1beta and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain
    Marek Zelenka
    Department of Neurology, , Josef Schneider Str 11, , Germany
    Pain 116:257-63. 2005
    ..The absence of corresponding morphological changes in nerves supports the concept of a functional effect of the cytokines at these doses...
  23. doi request reprint Vasculitis-like neuropathy in amyotrophic lateral sclerosis unresponsive to treatment
    Grazia Devigili
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Acta Neuropathol 122:343-52. 2011
    ..ALS(vasc) appears as a neuropathological subtype in ALS+ suggesting immune-mediated disease components but without response to standard immunosuppressive treatment...
  24. pmc Impaired small fiber conduction in patients with Fabry disease: a neurophysiological case-control study
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    BMC Neurol 13:47. 2013
    ..Fabry disease is an inborn lysosomal storage disorder which is associated with small fiber neuropathy. We set out to investigate small fiber conduction in Fabry patients using pain-related evoked potentials (PREP)...
  25. doi request reprint Department-related tasks and organ-targeted therapy in Fabry disease: an interdisciplinary challenge
    Frank Weidemann
    Department of Medicine, Würzburg University Medical Center, Wurzburg, Wurzburg, Germany
    Am J Med 123:658.e1-658.e10. 2010
    ....
  26. doi request reprint Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..Thus, blocking TRPV1 might be a way to reduce morphine tolerance...
  27. ncbi request reprint Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Exp Neurol 185:160-8. 2004
    ..Nerve-injury- and TNF-induced pain-related behavior seem to be only partly dependent on peripheral prostaglandins...
  28. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  29. doi request reprint Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    J Neural Transm 119:981-5. 2012
    ..We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways...
  30. ncbi request reprint Skin biopsy as an additional diagnostic tool in non-systemic vasculitic neuropathy
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Germany
    Acta Neuropathol 120:109-16. 2010
    ..Inflammatory cells were very rare in controls. Quantification of inflammatory cells in skin biopsies may thus be a sensitive and specific additional tool for diagnosing NSVN...
  31. ncbi request reprint T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
    ..Our study supports the notion that T cells and T-cell-derived cytokines contribute to the inflammatory response after peripheral nerve injury...
  32. doi request reprint Small fibers in Fabry disease: baseline and follow-up data under enzyme replacement therapy
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 16:304-14. 2011
    ..We conclude that ERT may improve proximal skin innervation in patients with good renal function, but does not protect small fiber function in men with impaired renal function...
  33. ncbi request reprint MDL-28170 has no analgesic effect on CCI induced neuropathic pain in mice
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Molecules 15:3038-47. 2010
    ..This finding implies that local cytokine upregulation after nerve injury alone is only one factor in the induction and maintenance of neuropathic pain...
  34. ncbi request reprint Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Brain Behav Immun 21:553-60. 2007
    ..MDL-28170, but not (+)-MK-801 inhibited TNF and IL-1beta upregulation one hour after CCI. This leads us to suggest that calpain is one of the earliest mediators of cytokine upregulation in injured peripheral nerves...
  35. doi request reprint Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats
    Niels Hansen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Exp Neurol 239:202-9. 2013
    ..GABAergic dysfunction in supraspinal motor pathways rather than in the spinal cord may lead to motor deficits observed in the rats contrasting observations made in SPS with amphiphysin antibodies...
  36. pmc IL-4 deficiency is associated with mechanical hypersensitivity in mice
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e28205. 2011
    ..We conclude that a lack of IL-4 leads to mechanical sensitivity; the compensatory hyperexpression of analgesic cytokines and opioid receptors after CCI, in turn, protects IL-4 ko mice from enhanced pain behavior after nerve lesion...
  37. doi request reprint Interdisciplinary approach towards female patients with Fabry disease
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Eur J Clin Invest 42:455-62. 2012
    ..Fabry disease (FD) is a rare X-linked lysosomal storage disorder leading to an accumulation of globotriaosylceramides in the lysosomes of various organs...
  38. ncbi request reprint Altered pain behavior and regeneration after nerve injury in TNF receptor deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 11:294-303. 2006
    ..Furthermore, the differential action of TNF via each of its receptors should be taken into account when considering clinical trials with TNF inhibitors for pain...
  39. ncbi request reprint Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators
    Yong Chen
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 85:1478-88. 2007
    ..Together, these findings reveal novel mechanisms by which the NC system produces analgesia...
  40. doi request reprint Small fibre pathology in patients with fibromyalgia syndrome
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Brain 136:1857-67. 2013
    ..All three methods used support the concept of impaired small fibre function in patients with fibromyalgia syndrome, pointing towards a neuropathic nature of pain in fibromyalgia syndrome...
  41. doi request reprint [Females with Fabry's disease - an interdisciplinary diagnostic and therapeutic challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Med Klin (Munich) 105:627-34. 2010
    ..This synopsis wants to systematically review the typical organ involvement in female Fabry patients. Moreover, therapy recommendations especially for female patients are discussed...
  42. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  43. doi request reprint Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine
    Martin Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:1321-5. 2008
    ..Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine...
  44. ncbi request reprint Tumor necrosis factor-alpha (TNF) regulates the expression of ICAM-1 predominantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Acta Neuropathol 104:197-205. 2002
    ..Our data support the hypothesis that TNF regulates the expression of ICAM-1 predominantly through TNFR1...
  45. doi request reprint A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome
    Nurcan Uceyler
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 59:1279-98. 2008
    ..To systematically review the efficacy of treatment of fibromyalgia syndrome (FMS) with antidepressants...
  46. ncbi request reprint Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity
    Mathias Leinders
    Institute of Neuroscience, Group of Neuropharmacology, Universite Catholique de Louvain, Avenue Hippocrate B1 54 10, 1200 Brussels, Belgium Department of Neurology, University of Wurzburg, Josef Schneider Straße 11, 97080 Wurzburg, Germany
    Neurosci Lett 554:146-50. 2013
    ..We therefore conclude that microglia remain partly activated beyond the phase of pain hypersensitivity. Thus, the relation between microglial cells and neuropathic pain outcome is subject to change over time after nerve injury. ..
  47. pmc 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg 97080, Germany
    Mol Pain 7:21. 2011
    ..Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds...
  48. doi request reprint TNF-α in CRPS and 'normal' trauma--significant differences between tissue and serum
    Heidrun H Krämer
    Department of Neurology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany
    Pain 152:285-90. 2011
    ..03). Our results indicate a local but not systemic increase of TNF-alpha in CRPS patients. This increase persists for months after limb trauma and may offer the opportunity for targeted treatment...
  49. doi request reprint Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction
    Michael K Boettger
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    J Neural Transm 117:165-9. 2010
    ..We show that large molecules can readily penetrate the BBB between days 3 and 7 after EAE-induction. This model may be valuable for studying putative pathogenic effects of immunoglobulins in the central nervous system...
  50. ncbi request reprint Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 22:536-45. 2002
    ..Our results suggest that anterograde transport of TNF plays a major role in the early neuronal response to peripheral nerve injury at sites distal to the cell body...
  51. ncbi request reprint Methylprednisolone prevents nerve injury-induced hyperalgesia in neprilysin knockout mice
    Lan He
    Department of Neurology, University Hospital of Wurzburg, Wurzburg, Germany
    Pain 155:574-80. 2014
    ..The results provide evidence that MP reduces CCI-induced hyperalgesia in NEP ko mice, and that this may be related to ET-1 via analgesic actions of ETBR. ..
  52. doi request reprint Disruption of nodal architecture in skin biopsies of patients with demyelinating neuropathies
    Kathrin Doppler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 18:168-76. 2013
    ....
  53. ncbi request reprint Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine
    Martin Marziniak
    Department of Neurology, University of Munster, Munster, Germany
    J Neural Transm 116:815-9. 2009
    ..Our data argue against a major influence of the TPH2 gene promoter region in migraine...
  54. ncbi request reprint Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neurosci Lett 361:184-7. 2004
    ..Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory cytokines, interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, with regards to pain and hyperalgesia...
  55. ncbi request reprint Cerebral blood flow in patients with Fabry disease as measured by Doppler sonography is not different from that in healthy individuals and is unaffected by treatment
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    J Ultrasound Med 31:463-8. 2012
    ..The purpose of this study was to investigate cervical and cerebral blood flow characteristics in patients with Fabry disease at baseline and under enzyme replacement therapy...
  56. ncbi request reprint Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein
    Annette George
    Neurologische Klinik der Universität Würzburg, Wurzburg, Germany
    Neurosci Lett 372:215-9. 2004
    ..IHC revealed prominent TNF-immunoreactivity in many epineurial macrophages on days 0.5 to 3 after crush injury. These data indicate that TNF protein is early and transiently upregulated at the site of peripheral nerve trauma...
  57. doi request reprint Mode of action of cytokines on nociceptive neurons
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Brain Res 196:67-78. 2009
    ..Individual cytokine profiles may be of diagnostic importance in chronic pain states, and, in the future, might guide the choice of treatment...
  58. ncbi request reprint Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing
    Yong Chen
    Department of Neurology, Julius Maximilians University, Wurzburg, Germany
    J Peripher Nerv Syst 11:232-40. 2006
    ..Thus, NC and the ORL1 receptor may be involved in the modulation of neuropathic and inflammatory pain at the level of the primary afferent neuron...
  59. doi request reprint Early cytokine gene expression in mouse CNS after peripheral nerve lesion
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany ueceyler
    Neurosci Lett 436:259-64. 2008
    ..Our results suggest an early cytokine regulation in the CNS after peripheral nerve lesion, which is opposite in direction to that in the periphery and which is partly mediated by the NMDA receptor system...
  60. ncbi request reprint Status of immune mediators in painful neuropathies
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Pain Headache Rep 12:159-64. 2008
    ..Specifically, an imbalance between pro- and anti-inflammatory cytokines may contribute to pain generation. A better understanding of the underlying pathophysiology may open new opportunities for the treatment of pain...
  61. ncbi request reprint Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
    Nurcan Uceyler
    Julius Maximilians Universitat, Wurzburg, Germany
    Arthritis Rheum 54:2656-64. 2006
    ..We undertook this study to investigate whether cytokine profiles differ in patients with chronic widespread pain and controls...
  62. ncbi request reprint Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Ann Neurol 57:388-95. 2005
    ....
  63. ncbi request reprint Is serotonin hyperalgesic or analgesic?
    Claudia Sommer
    Department of Neurology, Neurologische Universitatsklinik, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Curr Pain Headache Rep 10:101-6. 2006
    ..In the central nervous system, 5-HT is involved in descending inhibition, but facilitatory serotonergic pathways may be functionally more important...
  64. ncbi request reprint Partial sciatic nerve transection
    Thies Lindenlaub
    Neurologische Klinik, Universitatskliniken des Saarlandes, Hamburg, Germany
    Methods Mol Med 99:47-53. 2004
    ..PST is easy to perform in rats and mice and leads to reproducible pain-related behavior for 5 wk or longer...
  65. doi request reprint Diagnostic value of sural nerve biopsy in patients with suspected Borrelia neuropathy
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 13:81-91. 2008
    ..None of the findings of this study are disease specific but as a pattern may help support the diagnosis of inflammatory neuropathy in patients with serological evidence for Borrelia infection...
  66. ncbi request reprint Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies
    Thies Lindenlaub
    , Josef Schneider Strasse 11, 97080, , Germany
    Acta Neuropathol 105:593-602. 2003
    ..Cytokine immunoreactivity was directly correlated with the degree of axonal degeneration, endoneurial macrophages and epineurial T cells. In VANP and CANP, a higher cytokine content was associated with neuropathic pain...
  67. doi request reprint Lacosamide has protective disease modifying properties in experimental vincristine neuropathy
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuropharmacology 61:600-7. 2011
    ..Lacosamide may be a promising candidate for preventive treatment of CIPN in patients receiving chemotherapy with vinca alkaloids or platinum drugs...
  68. ncbi request reprint Differential expression patterns of cytokines in complex regional pain syndrome
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Pain 132:195-205. 2007
    ..Sensory testing showed a predominant loss of small fiber-related modalities in the patient group. The shift towards a pro-inflammatory cytokine profile in patients with CRPS suggests a potential pathogenic role in the generation of pain...
  69. ncbi request reprint Evaluation of topiramate as an anti-hyperalgesic and neuroprotective agent in the peripheral nervous system
    Stefan Bischofs
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 9:70-8. 2004
    ..In conclusion, we could show moderate anti-hyperalgesic effects but could not prove a neuroprotective effect of TPM in these two rat nerve injury models using electrophysiological and morphometric methods...
  70. ncbi request reprint Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Pain 104:579-88. 2003
    ..These findings allow us to speculate that endogenous TNF may play a role in the development of muscle hyperalgesia. Targeting proinflammatory cytokines might be beneficial for the treatment of musculoskeletal pain syndromes...
  71. ncbi request reprint Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy
    Mark Obermann
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Pain 138:79-86. 2008
    ..The method of pain-related evoked potential conduction appears to be a sensitive, fast, non-invasive technique for the detection of small-fiber neuropathy and may prove to become a valuable diagnostic asset...
  72. ncbi request reprint Anticytokine therapy in neuropathic pain management
    Maria Schäfers
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Expert Rev Neurother 7:1613-27. 2007
    ..Agents that specifically target downstream signaling molecules may provide hope for safer and more specific therapies...
  73. ncbi request reprint Analysis of myelinated fibers in human skin biopsies of patients with neuropathies
    Kathrin Doppler
    Department of Neurology, Universitatsklinikum Wurzburg, Wurzburg, Germany
    J Neurol 259:1879-87. 2012
    ....
  74. ncbi request reprint A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine
    Rainald Mossner
    Department of Psychiatry, University of Wurzburg, Germany
    Headache 45:132-6. 2005
    ..Objective: The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura...
  75. pmc Systematic review with meta-analysis: cytokines in fibromyalgia syndrome
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    BMC Musculoskelet Disord 12:245. 2011
    ..To perform a systematic review and meta-analysis on cytokine levels in patients with fibromyalgia syndrome (FMS)...
  76. doi request reprint Cytokine regulation in animal models of neuropathic pain and in human diseases
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neurosci Lett 437:194-8. 2008
    ..Further research is needed for a better understanding of the mechanisms linking altered cytokine profiles to the sensation of pain...
  77. ncbi request reprint Musculoskeletal pain in patients with myotonic dystrophy type 2
    Annette George
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Arch Neurol 61:1938-42. 2004
    ..Myotonic dystrophy type 2/proximal myotonic myopathy (DM2/PROMM) is an autosomal dominant multisystem disorder. Musculoskeletal pain is one of its frequent symptoms but also occurs in other chronic noninflammatory muscle disorders (OMD)...
  78. doi request reprint [Division-related function and organ-related therapy in Fabry's disease. An interdisciplinary challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Med Klin (Munich) 104:10-9. 2009
    ....
  79. ncbi request reprint Selective increase of tumour necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Eur J Neurosci 17:791-804. 2003
    ..Spared myelinated fibres with intact sensory functions but upregulated TNF expression may contribute to behavioural changes observed after nerve injury...
  80. ncbi request reprint Painful neuropathies
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Neurol 16:623-8. 2003
    ..To summarize the current understanding of clinical assessment, pathophysiology, and treatment of pain in neuropathies, focusing on selected entities in which the understanding of the mechanisms underlying pain has advanced recently...
  81. ncbi request reprint Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Lancet 365:1406-11. 2005
    ..Proof of a causal role of the antibodies is still lacking for this and all other antibody-associated paraneoplastic syndromes of the central nervous system...
  82. ncbi request reprint Skin biopsy in the management of peripheral neuropathy
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Lancet Neurol 6:632-42. 2007
    ..We also review the association between morphological measures of skin innervation and function and the limits of this method in the aetiological classification of peripheral neuropathies...
  83. ncbi request reprint Serotonin in pain and analgesia: actions in the periphery
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Mol Neurobiol 30:117-25. 2004
    ..5-HT, acting in combination with other inflammatory mediators, may ectopically excite and sensitize afferent nerve fibers, thus contributing to peripheral sensitization and hyperalgesia in inflammation and nerve injury...
  84. ncbi request reprint Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Peptides 27:917-20. 2006
    ..These findings suggest that NEP and ACE do not have additive effects regarding neuropeptide degradation. In contrast, inhibition of ACE seems to augment CGRP catabolism...
  85. pmc Hypervigilance or avoidance of trigger related cues in migraineurs? - a case-control study using the emotional stroop task
    Anne Katrin Puschmann
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    BMC Neurol 11:141. 2011
    ..The aim of the study was to assess attentional biases for negative affective stimuli that might be related to migraine triggers in migraine patients with either few or frequent migraine and healthy controls...
  86. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  87. doi request reprint Human myoblasts modulate the function of antigen-presenting cells
    Nicholas Schwab
    Department of Neurology, University of Wuerzburg, Germany
    J Neuroimmunol 200:62-70. 2008
    ..MB-lysates strongly stimulated MPh phagocytosis. Hypothetically, MB might modulate APC, counterbalancing immune-mediated damage...
  88. ncbi request reprint Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Ann Neurol 52:247-50. 2002
    ..These findings indicate a selective degenerative process of the cholinergic sudomotor neurons...
  89. ncbi request reprint Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:2517-21. 2003
    ..Parallel inhibition of p38 activation and allodynia may represent a clinically relevant therapeutic window. These data suggest a sequential role for TNF and p38 in the induction of neuropathic pain...
  90. pmc TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I
    Ilya Sabsovich
    Physical Medicine and Rehabilitation Service 117, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Pain 137:507-19. 2008
    ....
  91. ncbi request reprint Chronically infused intrathecal morphine in dogs
    Tony L Yaksh
    Department of Anesthesiology, University of California San Diego, La Jolla 92093, USA
    Anesthesiology 99:174-87. 2003
    ..Despite the extensive use of intrathecal morphine infusion for pain, no systematic safety studies exist on its effects in high concentrations. The authors assessed the effects of morphine and clonidine given 28 days intrathecally in dogs...
  92. ncbi request reprint Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies
    Eva Vlckova-Moravcova
    Department of Neurology, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic
    Muscle Nerve 37:50-60. 2008
    ..92. The combined examination of IENFD and SENPD is a highly sensitive and specific diagnostic tool in patients suspected to suffer from painful sensory neuropathies but with normal values on clinical neurophysiological studies...
  93. ncbi request reprint Psychophysics, flare, and neurosecretory function in human pain models: capsaicin versus electrically evoked pain
    Christian Geber
    Klinik und Poliklinik für Neurologie der Universität Mainz, Germany
    J Pain 8:503-14. 2007
    ..The different time courses of pain stimulation (CAP: rapidly decaying pain versus ES: pain plateau) led to different peripheral neurosecretory effects but induced similar central plasticity and hyperalgesia...
  94. ncbi request reprint Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein
    Annette George
    Neurologische Universitätsklinik Würzburg, Germany
    Exp Neurol 188:187-91. 2004
    ..These results suggest that changes of the local cytokine network during wallerian degeneration include an early deficiency of the antiinflammatory cytokine IL-10 despite up-regulation at the mRNA level...
  95. pmc Epidermal innervation in type 1 diabetic patients: a 2.5-year prospective study after simultaneous pancreas/kidney transplantation
    Petr Boucek
    Diabetes and Transplant Centers, Prague, Czech Republic
    Diabetes Care 31:1611-2. 2008
    ..To assess the effect of normoglycemia following simultaneous pancreas/kidney transplantation (SPK) on neurological function and intraepidermal nerve fiber density (IENFD) in patients with type 1 diabetes...
  96. ncbi request reprint Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF
    Bettina K Beyreuther
    Schwarz BioSciences GmbH, Department of Pharmacology Toxicology, Alfred Nobel Str 10, 40789 Monheim, Germany
    Neuropharmacology 52:1312-7. 2007
    ..We could thus demonstrate in a rat model for myalgia that lacosamide effectively reduces muscular hyperalgesia and is somewhat more potent than gabapentin and pregabalin...
  97. ncbi request reprint Small-fibre neuropathy in female Fabry patients: reduced allodynia and skin blood flow after topical capsaicin
    Anette T Moller
    Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark
    J Peripher Nerv Syst 11:119-25. 2006
    ..006) in female Fabry patients. This indicates that female Fabry patients have a significant loss of small-fibre function and demonstrates that it is possible to evaluate this by a non-invasive method...
  98. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  99. pmc Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury
    Doris Schoffnegger
    Center for Brain Research, Department of Neurophysiology, Medical University Vienna, Spitalgasse 4, 1090 Vienna, Austria
    J Physiol 577:869-78. 2006
    ..Thus, a reduced membrane excitability, altered firing patterns or changes in synaptic input of this group of GABAergic neurons in lamina II of the spinal cord dorsal horn are unlikely causes for neuropathic pain...
  100. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...