C Sommer

Summary

Country: Germany

Publications

  1. ncbi request reprint Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein
    Annette George
    Neurologische Universitätsklinik Würzburg, Germany
    Exp Neurol 188:187-91. 2004
  2. ncbi request reprint Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators
    Yong Chen
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 85:1478-88. 2007
  3. ncbi request reprint A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy
    C Sommer
    Neurologische Klinik der Universität, Wurzburg, Germany
    Neurosci Lett 237:45-8. 1997
  4. ncbi request reprint Is serotonin hyperalgesic or analgesic?
    Claudia Sommer
    Department of Neurology, Neurologische Universitatsklinik, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Curr Pain Headache Rep 10:101-6. 2006
  5. ncbi request reprint Serotonin in pain and analgesia: actions in the periphery
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Mol Neurobiol 30:117-25. 2004
  6. ncbi request reprint [Patient careers. Facial pain and neuralgias]
    C Sommer
    Neurologische Klinik, Universitat Wurzburg
    Schmerz 18:385-91. 2004
  7. ncbi request reprint 147th ENMC international workshop: guideline on processing and evaluation of sural nerve biopsies, 15-17 December 2006, Naarden, The Netherlands
    C Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neuromuscul Disord 18:90-6. 2008
  8. ncbi request reprint Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neurosci Lett 361:184-7. 2004
  9. ncbi request reprint Questionnaire on neuropathic pain: a European neurologist survey
    C Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Neurol Sci 28:136-41. 2007
  10. ncbi request reprint Painful neuropathies
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Neurol 16:623-8. 2003

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein
    Annette George
    Neurologische Universitätsklinik Würzburg, Germany
    Exp Neurol 188:187-91. 2004
    ..These results suggest that changes of the local cytokine network during wallerian degeneration include an early deficiency of the antiinflammatory cytokine IL-10 despite up-regulation at the mRNA level...
  2. ncbi request reprint Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators
    Yong Chen
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neurosci Res 85:1478-88. 2007
    ..Together, these findings reveal novel mechanisms by which the NC system produces analgesia...
  3. ncbi request reprint A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy
    C Sommer
    Neurologische Klinik der Universität, Wurzburg, Germany
    Neurosci Lett 237:45-8. 1997
    ..We conclude that the metalloprotease inhibitor TAPI specifically reduces endoneurial TNF-levels after nerve injury and thereby may diminish neuropathic pain in the CCI-model...
  4. ncbi request reprint Is serotonin hyperalgesic or analgesic?
    Claudia Sommer
    Department of Neurology, Neurologische Universitatsklinik, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Curr Pain Headache Rep 10:101-6. 2006
    ..In the central nervous system, 5-HT is involved in descending inhibition, but facilitatory serotonergic pathways may be functionally more important...
  5. ncbi request reprint Serotonin in pain and analgesia: actions in the periphery
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Mol Neurobiol 30:117-25. 2004
    ..5-HT, acting in combination with other inflammatory mediators, may ectopically excite and sensitize afferent nerve fibers, thus contributing to peripheral sensitization and hyperalgesia in inflammation and nerve injury...
  6. ncbi request reprint [Patient careers. Facial pain and neuralgias]
    C Sommer
    Neurologische Klinik, Universitat Wurzburg
    Schmerz 18:385-91. 2004
    ..A thorough history and examination are crucial to correctly classify these facial pain syndromes...
  7. ncbi request reprint 147th ENMC international workshop: guideline on processing and evaluation of sural nerve biopsies, 15-17 December 2006, Naarden, The Netherlands
    C Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neuromuscul Disord 18:90-6. 2008
  8. ncbi request reprint Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neurosci Lett 361:184-7. 2004
    ..Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory cytokines, interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, with regards to pain and hyperalgesia...
  9. ncbi request reprint Questionnaire on neuropathic pain: a European neurologist survey
    C Sommer
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Neurol Sci 28:136-41. 2007
    ..Antiepileptic and antidepressant drugs were by far the drug classes most used (73%), with 2/3 of the patients reaching at least moderate pain relief...
  10. ncbi request reprint Painful neuropathies
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Neurol 16:623-8. 2003
    ..To summarize the current understanding of clinical assessment, pathophysiology, and treatment of pain in neuropathies, focusing on selected entities in which the understanding of the mechanisms underlying pain has advanced recently...
  11. ncbi request reprint [Etiology and pathophysiology of fibromyalgia syndrome and chronic widespread pain]
    C Sommer
    Neurologische Klinik, Universitat Wurzburg, Wurzburg
    Schmerz 22:267-82. 2008
    ..To write a systematic review on the etiology and pathophysiology of the fibromyalgia syndrome (FMS) and of chronic widespread pain (CWP)...
  12. ncbi request reprint [Pharmacological treatment of fibromyalgia syndrome]
    C Sommer
    Neurologische Klinik, Universitat Wurzburg, Wurzburg
    Schmerz 22:313-23. 2008
    ..An interdisciplinary guideline for the treatment of fibromyalgia syndrome (FMS) and chronic widespread pain (CWP) was developed in cooperation with ten German medical and psychological associations and two patients' self-help organizations...
  13. ncbi request reprint Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy
    C Sommer
    Neurologische Klinik der Universität Würzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Brain Res 913:86-9. 2001
    ..In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment...
  14. ncbi request reprint [Cytokines in neuropathic pain]
    C Sommer
    Neurologische Universitatsklinik, Josef Schneider Strasse 11, 97080 Wurzburg
    Anaesthesist 50:416-26. 2001
    ..Preliminary data from human studies are encouraging insofar as in the future, cytokine inhibition may add to the panel of treatment modalities for neuropathic pain...
  15. ncbi request reprint Etanercept reduces hyperalgesia in experimental painful neuropathy
    C Sommer
    Department of Neurology, University of Wurzburg, Germany
    J Peripher Nerv Syst 6:67-72. 2001
    ..These results suggest the potential of etanercept as a treatment option for patients with neuropathic pain...
  16. ncbi request reprint Macrophage clustering as a diagnostic marker in sural nerve biopsies of patients with CIDP
    C Sommer
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    Neurology 65:1924-9. 2005
    ..The authors previously observed clustering of macrophages around endoneurial blood vessels in sural nerve biopsies from patients with CIDP...
  17. ncbi request reprint Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy
    C Sommer
    Neurologische Klinik der Universität Würzburg, Germany
    Neurosci Lett 270:25-8. 1999
    ..Degeneration of myelinated fibers was not altered by any of the treatment schedules. We conclude that IL-1 may be a mediator of hyperalgesia after nerve lesion...
  18. ncbi request reprint [Determining the diagnosis from the pain pattern. Brief and stabbing or chronic and dull?]
    C Sommer
    Neurologische Universitätsklinik Würzburg
    MMW Fortschr Med 145:30-3. 2003
    ..The Tolosa-Hunt syndrome is presumably caused by a granuloma in the cavernous sinus, and treatment is effected with corticosteroids. Painful craniomandibular dysfunction (CMD) is often misinterpreted as atypical facial pain...
  19. ncbi request reprint Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Lancet 365:1406-11. 2005
    ..Proof of a causal role of the antibodies is still lacking for this and all other antibody-associated paraneoplastic syndromes of the central nervous system...
  20. ncbi request reprint Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Ann Neurol 52:247-50. 2002
    ..These findings indicate a selective degenerative process of the cholinergic sudomotor neurons...
  21. ncbi request reprint Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury
    T Lindenlaub
    Neurologische Klinik, Universitat Wurzburg, Josef Schneider Strasse 11, 97080, Wurzburg, Germany
    Brain Res 866:15-22. 2000
    ..Furthermore, the number of epidermal nerve fibers is not relevant to the magnitude of behavioral hyperalgesia in CCI...
  22. doi request reprint [Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:297-310. 2012
    ....
  23. ncbi request reprint Contralateral cytokine gene induction after peripheral nerve lesions: dependence on the mode of injury and NMDA receptor signaling
    C Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Brain Res Mol Brain Res 136:23-8. 2005
    ..Our study confirms that nerve injury evokes contralateral responses and identifies NMDA-mediated signaling as one underlying mechanism...
  24. doi request reprint Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro
    M Schäfers
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Neuroscience 157:414-23. 2008
    ..Importantly, the effects of individually applied R1 and R2 on injured and adjacent uninjured fibers imply that the role of TNFR2 in the excitation of sensory neurons increases after injury...
  25. doi request reprint [Clinical application of pain-related evoked potentials]
    N Hansen
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    Schmerz 26:8-15. 2012
    ....
  26. doi request reprint Neuroprotection and glutamate attenuation by acetylsalicylic acid in temporary but not in permanent cerebral ischemia
    C Berger
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Exp Neurol 210:543-8. 2008
    ..These results suggest that the neuroprotective effect of ASA is reflected by glutamate attenuation and IL-6 induction even if given after stroke onset, but only if reperfusion is achieved...
  27. ncbi request reprint Mechanical but not painful electrical stimuli trigger TNF alpha release in human skin
    T Eberle
    Department of Neurology, University Medical Centre Mainz, Mainz, Germany
    Exp Neurol 221:246-50. 2010
    ..Our results show that minimal mechanical trauma is sufficient to induce significant TNF-alpha release in the skin. These results may be relevant to the treatment of posttraumatic pain disorders...
  28. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process...
  29. ncbi request reprint The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve
    C Sommer
    Department of Neurology, University of Wurzburg, Germany
    Pain 74:83-91. 1998
    ..We conclude that preemptive treatment with a substance that blocks production of TNF reduces pain-related symptoms and pathologic vascular changes in the chronic constriction injury model of neuropathic pain...
  30. ncbi request reprint Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice
    M Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Neurosci Lett 310:113-6. 2001
    ..We conclude that combined anti-cytokine therapy may be a useful strategy in the treatment of neuropathic pain...
  31. ncbi request reprint Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy
    N Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neurology 74:1806-13. 2010
    ..Small fiber neuropathy (SFN) is a subtype of sensory neuropathy with acral pain and normal findings in routine nerve conduction studies...
  32. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  33. ncbi request reprint Delayed neuroprotective effect of insulin-like growth factor-i after experimental transient focal cerebral ischemia monitored with mri
    W R Schäbitz
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 32:1226-33. 2001
    ..Therefore, in the present study, we evaluated, by applying MRI monitoring, whether a clinically relevant systemic administration of IGF-I can achieve a long-lasting neuroprotective effect...
  34. doi request reprint Lack of the serotonin transporter in mice reduces locomotor activity and leads to gender-dependent late onset obesity
    N Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Int J Obes (Lond) 34:701-11. 2010
    ....
  35. ncbi request reprint Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve
    Annette George
    Neurologische Klinik der Universität, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 192:163-6. 2005
    ..These data indicate that endoneurial TNFR1 and TNFR2 proteins are differentially regulated during Wallerian degeneration...
  36. doi request reprint Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  37. ncbi request reprint Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia
    W R Schäbitz
    Department of Neurology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Stroke 35:992-7. 2004
    ..We explored the effects of these therapies on behavioral recovery and molecular markers of regeneration after experimental ischemia...
  38. doi request reprint Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain
    C Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuroscience 169:463-74. 2010
    ..These findings support the hypothesis of cytokine-dependent pain development in cancer pain. Differential targeting of TNFR activation could be an interesting strategy in bone-cancer-related pain conditions...
  39. ncbi request reprint Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
    W R Schäbitz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 31:2212-7. 2000
    ..In this experiment we studied the effect of intravenous BDNF delivered after focal cerebral ischemia on neurological outcome, infarct size, and expression of proapoptotic and antiapoptotic proteins Bax and Bcl-2, respectively...
  40. ncbi request reprint Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy
    Nurcan Uceyler
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Neurosci Res 84:37-46. 2006
    ..Thus, the P0(+/-) phenotype seems to be protected against VIN-induced neuropathy. The mechanism of this neuroprotection remains elusive...
  41. ncbi request reprint Intraneural injection of interleukin-1beta and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain
    Marek Zelenka
    Department of Neurology, , Josef Schneider Str 11, , Germany
    Pain 116:257-63. 2005
    ..The absence of corresponding morphological changes in nerves supports the concept of a functional effect of the cytokines at these doses...
  42. ncbi request reprint Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    Brain Behav Immun 21:553-60. 2007
    ..MDL-28170, but not (+)-MK-801 inhibited TNF and IL-1beta upregulation one hour after CCI. This leads us to suggest that calpain is one of the earliest mediators of cytokine upregulation in injured peripheral nerves...
  43. ncbi request reprint Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies
    Thies Lindenlaub
    , Josef Schneider Strasse 11, 97080, , Germany
    Acta Neuropathol 105:593-602. 2003
    ..Cytokine immunoreactivity was directly correlated with the degree of axonal degeneration, endoneurial macrophages and epineurial T cells. In VANP and CANP, a higher cytokine content was associated with neuropathic pain...
  44. ncbi request reprint Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein
    Annette George
    Neurologische Klinik der Universität Würzburg, Wurzburg, Germany
    Neurosci Lett 372:215-9. 2004
    ..IHC revealed prominent TNF-immunoreactivity in many epineurial macrophages on days 0.5 to 3 after crush injury. These data indicate that TNF protein is early and transiently upregulated at the site of peripheral nerve trauma...
  45. ncbi request reprint Selective increase of tumour necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Eur J Neurosci 17:791-804. 2003
    ..Spared myelinated fibres with intact sensory functions but upregulated TNF expression may contribute to behavioural changes observed after nerve injury...
  46. ncbi request reprint Tumor necrosis factor-alpha (TNF) regulates the expression of ICAM-1 predominantly through TNF receptor 1 after chronic constriction injury of mouse sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Acta Neuropathol 104:197-205. 2002
    ..Our data support the hypothesis that TNF regulates the expression of ICAM-1 predominantly through TNFR1...
  47. ncbi request reprint The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling
    C Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    J Neuroimmunol 149:77-83. 2004
    ..Our study indicates that the mode of nerve injury influences the extent of cytokine expression, and identifies NMDA-mediated signaling as one mechanism of cytokine induction in peripheral nerves...
  48. ncbi request reprint Partial sciatic nerve transection as a model of neuropathic pain: a qualitative and quantitative neuropathological study
    T Lindenlaub
    Neurologische Klinik, Universitat Wurzburg, Josef Schneider Strasse 11, 97080, Wurzburg, Germany
    Pain 89:97-106. 2000
    ..Also, the importance of regeneration in the termination of hyperalgesia can convincingly be shown in this model...
  49. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  50. ncbi request reprint T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
    ..Our study supports the notion that T cells and T-cell-derived cytokines contribute to the inflammatory response after peripheral nerve injury...
  51. ncbi request reprint Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..Thus, blocking TRPV1 might be a way to reduce morphine tolerance...
  52. doi request reprint Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
    Heidrun H Krämer
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz 55101, Germany
    Neurobiol Dis 35:177-83. 2009
    ..These findings resemble human 'cold' CRPS and suggest that ET 1 plays an important role in the pathogenesis of CRPS with nerve injury...
  53. ncbi request reprint Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 22:536-45. 2002
    ..Our results suggest that anterograde transport of TNF plays a major role in the early neuronal response to peripheral nerve injury at sites distal to the cell body...
  54. ncbi request reprint Altered pain behavior and regeneration after nerve injury in TNF receptor deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 11:294-303. 2006
    ..Furthermore, the differential action of TNF via each of its receptors should be taken into account when considering clinical trials with TNF inhibitors for pain...
  55. doi request reprint [Etiology and pathophysiology of fibromyalgia syndrome]
    C Sommer
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:259-67. 2012
    ....
  56. ncbi request reprint Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1
    C Sommer
    Neurologische Klinik, Universitat Wurzburg, Josef Schneider Strasse 11, Wurzburg, 97080, Germany
    Exp Neurol 151:138-42. 1998
    ..Neutralizing antibodies to TNFR2 had no effect. We conclude that TNFR1, but not TNFR2, is mediating thermal hyperalgesia and mechanical allodynia after nerve injury...
  57. ncbi request reprint Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndrome
    C Wessig
    Department of Neurology, University of Wurzburg, Germany
    Neurology 61:195-8. 2003
    ..Later, the encephalopathy progressed rapidly and the patient died. Binding studies and the detection of autoantibodies in the patient's CNS as well as the treatment response suggest a pathogenic role of the anti-amphiphysin antibodies...
  58. ncbi request reprint A functional serotonin transporter gene polymorphism is associated with migraine with aura
    M Marziniak
    Department of Neurology, University of Wurzburg, Germany
    Neurology 64:157-9. 2005
    ..001). This indicates that the 5-HTT may be involved in the polygenic etiology of migraine with aura...
  59. ncbi request reprint Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter
    Florian Palm
    Department of Neurology, University of Wurzburg, Neurologische Klinik der Universität, D 97080 Wurzburg, Germany
    Eur J Pain 12:790-7. 2008
    ..Human variants of the 5-HTT genotypes might be part of the factors determining the extent of nerve injury and hyperalgesia in inflammation...
  60. doi request reprint [Fabry disease : diagnosis and treatment]
    N Uceyler
    Neurologische Klinik, Universitatsklinikum Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Deutschland
    Schmerz 26:609-19. 2012
    ..Fabry-associated pain is treated following the principles of analgesic treatment in neuropathic pain conditions, but some special features need to be considered and will be discussed...
  61. ncbi request reprint Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs
    M Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 114:1227-32. 2007
    ..For the first time, our results indicate a role of allelic variation of the 5-HT1A receptor in motion related discomfort in migraineurs and a role of the 5-HT1B receptor polymorphism in headache intensity...
  62. ncbi request reprint [Cytokine regulation and pain. Results of experimental and clinical research]
    N Uceyler
    Neurologische Klinik, Universitat Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Deutschland
    Schmerz 22:652-64. 2008
    ..The following review article summarizes the main data of animal experiments and clinical trials concerning the role of cytokines in pain and the potential importance of cytokine modulation in pain treatment...
  63. doi request reprint Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2+)]i rise in embryonic motoneurons
    C Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Neurobiol Dis 36:191-9. 2009
    ..Thus, anti-amphiphysin antibodies exert a direct effect on GABA signaling, which is likely to contribute to the pathogenesis of SPS...
  64. ncbi request reprint Evaluation of topiramate as an anti-hyperalgesic and neuroprotective agent in the peripheral nervous system
    Stefan Bischofs
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 9:70-8. 2004
    ..In conclusion, we could show moderate anti-hyperalgesic effects but could not prove a neuroprotective effect of TPM in these two rat nerve injury models using electrophysiological and morphometric methods...
  65. ncbi request reprint Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves
    M Samsam
    Neurologische Klinik der Universität Würzburg, Wurzburg, Germany
    J Neurosci Res 67:167-73. 2002
    ..These alterations might be causally linked to the sensory deficits in the absence of profound myelin degeneration in the sensory nerves of the mutants...
  66. ncbi request reprint Epidermal innervation density after partial sciatic nerve lesion and pain-related behavior in the rat
    T Lindenlaub
    Neurologische Klinik, Bayerische Julius Maximilians Universität Würzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Acta Neuropathol 104:137-43. 2002
    ..5-ir Langerhans cells was increased after CCI, and this increase also temporally correlated with the presence of thermal hyperalgesia and mechanical allodynia, supporting a role of Langerhans cells in the generation of pain...
  67. ncbi request reprint Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation
    H H Kramer
    Department of Neurology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Exp Neurol 195:179-84. 2005
    ..Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin. This may be of particular importance for the understanding of pain disorders like migraine or complex regional pain syndrome...
  68. doi request reprint Early cytokine gene expression in mouse CNS after peripheral nerve lesion
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany ueceyler
    Neurosci Lett 436:259-64. 2008
    ..Our results suggest an early cytokine regulation in the CNS after peripheral nerve lesion, which is opposite in direction to that in the periphery and which is partly mediated by the NMDA receptor system...
  69. doi request reprint Cytokine regulation in animal models of neuropathic pain and in human diseases
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neurosci Lett 437:194-8. 2008
    ..Further research is needed for a better understanding of the mechanisms linking altered cytokine profiles to the sensation of pain...
  70. pmc 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg 97080, Germany
    Mol Pain 7:21. 2011
    ..Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds...
  71. doi request reprint [Females with Fabry's disease - an interdisciplinary diagnostic and therapeutic challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Med Klin (Munich) 105:627-34. 2010
    ..This synopsis wants to systematically review the typical organ involvement in female Fabry patients. Moreover, therapy recommendations especially for female patients are discussed...
  72. doi request reprint Department-related tasks and organ-targeted therapy in Fabry disease: an interdisciplinary challenge
    Frank Weidemann
    Department of Medicine, Würzburg University Medical Center, Wurzburg, Wurzburg, Germany
    Am J Med 123:658.e1-658.e10. 2010
    ....
  73. doi request reprint [Division-related function and organ-related therapy in Fabry's disease. An interdisciplinary challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Med Klin (Munich) 104:10-9. 2009
    ....
  74. ncbi request reprint Skin biopsy as a diagnostic tool
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Curr Opin Neurol 21:563-8. 2008
    ..To give an overview of recent data on the use of skin biopsy as a diagnostic tool in neuropathies...
  75. ncbi request reprint Status of immune mediators in painful neuropathies
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Pain Headache Rep 12:159-64. 2008
    ..Specifically, an imbalance between pro- and anti-inflammatory cytokines may contribute to pain generation. A better understanding of the underlying pathophysiology may open new opportunities for the treatment of pain...
  76. ncbi request reprint Skin biopsy as an additional diagnostic tool in non-systemic vasculitic neuropathy
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Germany
    Acta Neuropathol 120:109-16. 2010
    ..Inflammatory cells were very rare in controls. Quantification of inflammatory cells in skin biopsies may thus be a sensitive and specific additional tool for diagnosing NSVN...
  77. ncbi request reprint MDL-28170 has no analgesic effect on CCI induced neuropathic pain in mice
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Molecules 15:3038-47. 2010
    ..This finding implies that local cytokine upregulation after nerve injury alone is only one factor in the induction and maintenance of neuropathic pain...
  78. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  79. doi request reprint Mode of action of cytokines on nociceptive neurons
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Brain Res 196:67-78. 2009
    ..Individual cytokine profiles may be of diagnostic importance in chronic pain states, and, in the future, might guide the choice of treatment...
  80. ncbi request reprint Differential expression patterns of cytokines in complex regional pain syndrome
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Pain 132:195-205. 2007
    ..Sensory testing showed a predominant loss of small fiber-related modalities in the patient group. The shift towards a pro-inflammatory cytokine profile in patients with CRPS suggests a potential pathogenic role in the generation of pain...
  81. ncbi request reprint Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
    Nurcan Uceyler
    Julius Maximilians Universitat, Wurzburg, Germany
    Arthritis Rheum 54:2656-64. 2006
    ..We undertook this study to investigate whether cytokine profiles differ in patients with chronic widespread pain and controls...
  82. ncbi request reprint Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Ann Neurol 57:388-95. 2005
    ....
  83. ncbi request reprint Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing
    Yong Chen
    Department of Neurology, Julius Maximilians University, Wurzburg, Germany
    J Peripher Nerv Syst 11:232-40. 2006
    ..Thus, NC and the ORL1 receptor may be involved in the modulation of neuropathic and inflammatory pain at the level of the primary afferent neuron...
  84. ncbi request reprint Differential expression of cytokines in painful and painless neuropathies
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neurology 69:42-9. 2007
    ..The factors determining why some peripheral neuropathies are painful and others are not are incompletely understood. Pro-inflammatory cytokines have been implicated to play a crucial role in the generation of pain...
  85. ncbi request reprint Partial sciatic nerve transection
    Thies Lindenlaub
    Neurologische Klinik, Universitatskliniken des Saarlandes, Hamburg, Germany
    Methods Mol Med 99:47-53. 2004
    ..PST is easy to perform in rats and mice and leads to reproducible pain-related behavior for 5 wk or longer...
  86. ncbi request reprint Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Exp Neurol 185:160-8. 2004
    ..Nerve-injury- and TNF-induced pain-related behavior seem to be only partly dependent on peripheral prostaglandins...
  87. ncbi request reprint Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Pain 104:579-88. 2003
    ..These findings allow us to speculate that endogenous TNF may play a role in the development of muscle hyperalgesia. Targeting proinflammatory cytokines might be beneficial for the treatment of musculoskeletal pain syndromes...
  88. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  89. doi request reprint Long-term outcome of enzyme-replacement therapy in advanced Fabry disease: evidence for disease progression towards serious complications
    F Weidemann
    Department of Medicine, Divisions of Cardiology and Nephrology, University of Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    J Intern Med 274:331-41. 2013
    ..Thus, the aim of this study was to determine whether ERT in patients with advanced Fabry disease affects progression towards 'hard' clinical end-points in comparison with the natural course of the disease...
  90. ncbi request reprint [Pharmacotherapy of orofacial pain]
    C Sommer
    Neurologische Universitätsklinik Würzburg, Germany
    Schmerz 16:381-8. 2002
    ..Pharmacotherapy of chronic orofacial pain is unsatisfactory. Here we set out to prepare a systematic review of randomized controlled clinical trials (RCTs) on pharmacotherapy of facial pain...
  91. ncbi request reprint Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy
    Mark Obermann
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Pain 138:79-86. 2008
    ..The method of pain-related evoked potential conduction appears to be a sensitive, fast, non-invasive technique for the detection of small-fiber neuropathy and may prove to become a valuable diagnostic asset...
  92. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  93. ncbi request reprint Anticytokine therapy in neuropathic pain management
    Maria Schäfers
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Expert Rev Neurother 7:1613-27. 2007
    ..Agents that specifically target downstream signaling molecules may provide hope for safer and more specific therapies...
  94. ncbi request reprint [Pain drawings of patients with orofacial pain. Comparison of acceptance and gain of information]
    C Geis
    Neurologische Klinik, Universitatsklinikum, Josef Schneider Strasse 11, 97080 Wurzburg, Deutschland
    Schmerz 20:498-508. 2006
    ..The aim of this prospective multicentric study was to compare two different types of pain drawings in terms of acceptance and gain of information in patients with orofacial pain...
  95. ncbi request reprint Hyperparathyroidism in a patient with proximal myotonic myopathy (PROMM)
    C Schneider
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080, Wurzburg, Germany
    Neuromuscul Disord 10:481-3. 2000
    ..She also suffered from primary hyperparathyroidism. A biopsy of the left deltoid muscle showed vacuoles as an unusual histopathological finding...
  96. ncbi request reprint Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine
    M Marziniak
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 111:603-9. 2004
    ..These findings thus indicate that there is no association between the functional MAO-A-LPR and susceptibility to migraine...
  97. ncbi request reprint Increased lipocortin-1 (annexin-1) expression in the sciatic nerve of Lewis rats with experimental autoimmune neuritis
    R Gold
    Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Acta Neuropathol 98:583-9. 1999
    ..By analogy with other immune-mediated disorders, increased lipocortin-1 expression in the inflamed sciatic nerve in EAN may exert immunoregulatory functions in-situ and contribute to the termination of the autoimmune response...
  98. doi request reprint Diagnostic value of sural nerve biopsy in patients with suspected Borrelia neuropathy
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 13:81-91. 2008
    ..None of the findings of this study are disease specific but as a pattern may help support the diagnosis of inflammatory neuropathy in patients with serological evidence for Borrelia infection...
  99. ncbi request reprint Mild experimental autoimmune encephalitis as a tool to induce blood-brain barrier dysfunction
    Michael K Boettger
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    J Neural Transm 117:165-9. 2010
    ..We show that large molecules can readily penetrate the BBB between days 3 and 7 after EAE-induction. This model may be valuable for studying putative pathogenic effects of immunoglobulins in the central nervous system...
  100. ncbi request reprint Musculoskeletal pain in patients with myotonic dystrophy type 2
    Annette George
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Arch Neurol 61:1938-42. 2004
    ..Myotonic dystrophy type 2/proximal myotonic myopathy (DM2/PROMM) is an autosomal dominant multisystem disorder. Musculoskeletal pain is one of its frequent symptoms but also occurs in other chronic noninflammatory muscle disorders (OMD)...
  101. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...