Thomas Sommer


Country: Germany


  1. Pfeiffer A, Stephanowitz H, Krause E, Volkwein C, Hirsch C, Jarosch E, et al. A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins. J Biol Chem. 2016;291:12195-207 pubmed publisher
    ..Our data support a model in which the balanced activities of Pdi1 and Htm1 are crucial determinants for the efficient removal of misfolded secretory glycoproteins. ..
  2. von Delbrück M, Kniss A, Rogov V, Pluska L, Bagola K, Lohr F, et al. The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation. Mol Cell. 2016;62:918-928 pubmed publisher
    ..Disrupting this mechanism results in dysfunction of the ERAD pathway by a delayed turnover of substrates. ..
  3. Weber A, Cohen I, Popp O, Dittmar G, Reiss Y, Sommer T, et al. Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase. Mol Cell. 2016;63:827-39 pubmed publisher
    ..Such stepwise ubiquitylation reactions most likely represent a more general cellular phenomenon that extends the versatility yet sustains the specificity of the Ub conjugation system. ..
  4. Mehnert M, Sommermeyer F, Berger M, Kumar Lakshmipathy S, Gauss R, Aebi M, et al. The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins. Mol Biol Cell. 2015;26:185-94 pubmed publisher
    ..Our data imply a function of Scj1 in the removal of malfolded proteins from the receptor Hrd3, which facilitates their delivery to downstream-acting components like Der1. ..