Michael Wilhelm

Summary

Affiliation: Social and Environmental Medicine
Country: Germany

Publications

  1. doi request reprint Levels and predictors of urinary nickel concentrations of children in Germany: results from the German Environmental Survey on children (GerES IV)
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 216:163-9. 2013
  2. ncbi request reprint Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 207:69-73. 2004
  3. ncbi request reprint Assessment and management of the first German case of a contamination with perfluorinated compounds (PFC) in the Region Sauerland, North Rhine-Westphalia
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:725-33. 2008
  4. ncbi request reprint Lack of neurodevelopmental adversity by prenatal exposure of infants to current lowered PCB levels: comparison of two German birth cohort studies
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:700-2. 2008
  5. ncbi request reprint Human biomonitoring of cadmium and lead exposure of child-mother pairs from Germany living in the vicinity of industrial sources (hot spot study NRW)
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Trace Elem Med Biol 19:83-90. 2005
  6. doi request reprint Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:142-5. 2009
  7. ncbi request reprint Human biomonitoring studies in North Rhine-Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Int J Hyg Environ Health 210:307-18. 2007
  8. ncbi request reprint Contribution to the evaluation of reference values for PFOA and PFOS in plasma of children and adults from Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 212:56-60. 2009
  9. ncbi request reprint Influence of industrial sources on children's health--hot spot studies in North Rhine Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 210:591-9. 2007
  10. ncbi request reprint New reference value and the background exposure for the PAH metabolites 1-hydroxypyrene and 1- and 2-naphthol in urine of the general population in Germany: basis for validation of human biomonitoring data in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 211:447-53. 2008

Detail Information

Publications67

  1. doi request reprint Levels and predictors of urinary nickel concentrations of children in Germany: results from the German Environmental Survey on children (GerES IV)
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 216:163-9. 2013
    ..With a contribution of 13.8% the urinary creatinine concentration was the most important predictor. No influence of nickel intake via drinking water and second hand smoke exposure was observed...
  2. ncbi request reprint Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 207:69-73. 2004
    ..For aluminium in blood or urine no reference values were derived and the use of human biomonitoring to estimate aluminium exposure in environmental medicine is not recommended...
  3. ncbi request reprint Assessment and management of the first German case of a contamination with perfluorinated compounds (PFC) in the Region Sauerland, North Rhine-Westphalia
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:725-33. 2008
    ..Remediation of the affected area is ongoing and PFC levels in various matrices are still above background levels...
  4. ncbi request reprint Lack of neurodevelopmental adversity by prenatal exposure of infants to current lowered PCB levels: comparison of two German birth cohort studies
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:700-2. 2008
    ..Evidence indicates that exposure to PCB at current exposure levels no longer apparently impair neurodevelopment of infants...
  5. ncbi request reprint Human biomonitoring of cadmium and lead exposure of child-mother pairs from Germany living in the vicinity of industrial sources (hot spot study NRW)
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Trace Elem Med Biol 19:83-90. 2005
    ..Minor associations were also found between Cd in air and Cd in the blood of mothers and between Cd in air and urine of mothers...
  6. doi request reprint Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:142-5. 2009
    ..There was a close association between PFOS and PFOA-plasma levels. From this pilot study there are no indications for an increased exposure to PFCs of residents in Arnsberg in the years 1977-2004 prior to the contamination in 2006...
  7. ncbi request reprint Human biomonitoring studies in North Rhine-Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Int J Hyg Environ Health 210:307-18. 2007
    ..More recent studies suggest that there still is an increased internal exposure to metals, PAH and DNA damaging agents in children and women living very close to industrial sources...
  8. ncbi request reprint Contribution to the evaluation of reference values for PFOA and PFOS in plasma of children and adults from Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 212:56-60. 2009
    ....
  9. ncbi request reprint Influence of industrial sources on children's health--hot spot studies in North Rhine Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 210:591-9. 2007
    ....
  10. ncbi request reprint New reference value and the background exposure for the PAH metabolites 1-hydroxypyrene and 1- and 2-naphthol in urine of the general population in Germany: basis for validation of human biomonitoring data in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 211:447-53. 2008
    ..Therefore, the commission recommends the following upper margins of background exposures for adult non-smokers: 1-naphthol less than 30 microg/l, 2-naphthol less than 20 microg/l...
  11. ncbi request reprint Consumption of homegrown products does not increase dietary intake of arsenic, cadmium, lead, and mercury by young children living in an industrialized area of Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
    Sci Total Environ 343:61-70. 2005
    ..Children living in the industrialized area with a substantial food consumption of own grown vegetables or products from domestic animals products had no increased dietary intake of the metals...
  12. doi request reprint Reassessment of critical lead effects by the German Human Biomonitoring Commission results in suspension of the human biomonitoring values (HBM I and HBM II) for lead in blood of children and adults
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:265-9. 2010
    ..We conclude that any setting of an "effect threshold" for blood lead levels would be arbitrary and therefore unjustified. As a consequence the Commission suspends the HBM values for lead in blood of children and adults...
  13. ncbi request reprint The Duisburg birth cohort study: influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
    Mutat Res 659:83-92. 2008
    ..This study supports the view that the current decreased exposure to PCDD/Fs and PCBs does not impair thyroid function of newborns and neurodevelopment of infants until the age of 24 months...
  14. ncbi request reprint Comparison of arsenic levels in fingernails with urinary As species as biomarkers of arsenic exposure in residents living close to a coal-burning power plant in Prievidza District, Slovakia
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Expo Anal Environ Epidemiol 15:89-98. 2005
    ..It is concluded that As levels in fingernails are a reliable marker of environmental As exposure, and that As concentrations in fingernails reflect the As exposure in a similar manner compared with urinary As(sum) and As species...
  15. ncbi request reprint Dietary intake of lead by children and adults from Germany measured by the duplicate method
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 206:493-503. 2003
    ..week) proposed by the WHO. The median and maximum of the different groups amounted to 7.2-16% and 16-36% of the PTWI, respectively. It is concluded that health risks due to dietary lead intake seem to be low in Germany...
  16. ncbi request reprint PCDD/F and dioxin-like PCB in human blood and milk from German mothers
    Jurgen Wittsiepe
    Ruhr Universtität Bochum, Abteilung für Hygiene, Sozial und Umweltmedizin, Universitatsstrasse 150, D 44801 Bochum, Germany
    Chemosphere 67:S286-94. 2007
    ..4 to 318 ng WHO-TEq (median: 106, arithmetic mean: 118). The actual mean daily exposure of a breastfed infant can be estimated to 131 pg WHO-TEq/kg(body weight)...
  17. doi request reprint Prevalence of nickel sensitization and urinary nickel content of children are increased by nickel in ambient air
    Monika Kasper-Sonnenberg
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitaetsstr 150, 44780 Bochum, Germany
    Environ Res 111:266-73. 2011
    ..4; 95% CI: 1.20-4.48). Ni in ambient air of areas with Ni-emitting factories contributes to internal Ni exposure in residents via inhalation and, furthermore, is a risk factor for the development of Ni sensitization in children...
  18. ncbi request reprint One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:499-504. 2009
    ..The observed decline in PFOA-concentrations indicates a slow elimination in humans. This finding in groups of the general population is in agreement with data on long elimination half-lives observed in occupationally exposed workers...
  19. ncbi request reprint Bioavailability of PCDD/F from contaminated soil in young Goettingen minipigs
    Jurgen Wittsiepe
    Ruhr University Bochum, Department of Hygiene, Social and Environmental Medicine, Universitatsstrasse 150, 44801 Bochum, Germany
    Chemosphere 67:S355-64. 2007
    ..2% (mean: 28.4%). When not considering the bioavailability, the risk by oral uptake of PCDD/F contaminated soil might be overestimated...
  20. doi request reprint Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany
    Boleslaw Marczynski
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Arch Toxicol 83:947-57. 2009
    ..The type of industry contributed to genotoxic DNA damage and DNA damage was not unequivocally associated to PAH on the individual level most likely due to potential contributions of co-exposures...
  21. doi request reprint High levels of 1-hydroxypyrene and hydroxyphenanthrenes in urine of children and adults from Afghanistan
    Hamayon Hemat
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Expo Sci Environ Epidemiol 22:46-51. 2012
    ..We conclude that populations in low-developed countries may be at special risk to increased PAH exposure due to inadequate control of air pollution from car emissions and due to burning of biomass fuels for cooking and household energy...
  22. ncbi request reprint Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany
    Edna Brede
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:217-23. 2010
    ..The decline of PFC levels in plasma of participants from the reference areas reflects the general decrease of human PFC exposure during the very recent years...
  23. ncbi request reprint Prenatal and early life exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls may influence dehydroepiandrosterone sulfate levels at prepubertal age: results from the Duisburg birth cohort study
    Annette Rennert
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 75:1232-40. 2012
    ..Data indicate that PCDD/F and PCB exposure in infancy may influence DHEA-S serum levels in prepubertal children. Increased DHEA-S serum levels are considered to indicate acceleration of the adrenal maturation...
  24. doi request reprint Perfluorinated compounds in fish and blood of anglers at Lake Möhne, Sauerland area, Germany
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, MA 1 33, Ruhr University Bochum, Universitätsstrasse 150, 44801 Bochum, Germany
    Environ Sci Technol 45:8046-52. 2011
    ..The study results strongly suggest that human internal exposure to PFC is distinctly increased by consumption of fish from PFC-contaminated sites...
  25. pmc Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Environ Health Perspect 116:651-7. 2008
    ..40,000 residents in Arnsberg, Germany, had been exposed to drinking water contaminated with perfluorinated compounds (PFCs). Internal exposure of the residents of Arnsberg to six PFCs was assessed in comparison with reference areas...
  26. doi request reprint Determination of bisphenol a in urine from mother-child pairs-results from the duisburg birth cohort study, Germany
    Monika Kasper-Sonnenberg
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 75:429-37. 2012
    ..Only small amounts (less than 16%) were detectable as free (unconjugated) BPA. Analytical reliability is high even at such low levels, provided that external contamination is minimized...
  27. ncbi request reprint Dietary intake of persistent organic pollutants (POPs) by German children using duplicate portion sampling
    Michael Wilhelm
    Institute of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 204:359-62. 2002
    ..4%. However, compared with minimal risk levels (ATSDR), the percentage of dietary intake was much higher, especially for gamma-HCH (based on median intake: 95%), for HCB (23.1%) and for PCB (69%)...
  28. ncbi request reprint Dietary intake of arsenic, mercury and selenium by children from a German North Sea island using duplicate portion sampling
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr Universitat Bochum, Bochum, Germany
    J Trace Elem Med Biol 17:123-32. 2003
    ..3%), whereas the recommended Se intake, fixed at 15-45 microg/day for the 4-7 years-old children, was not reached in 15 out of 48 cases (31.3%)...
  29. ncbi request reprint External and internal exposure to polycyclic aromatic hydrocarbons (PAH) among workers in the production of fire-proof materials - proposal of a biological monitoring guidance value
    Ralf Preuss
    University of Erlangen Nuremberg, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    Int J Hyg Environ Health 209:575-80. 2006
    ..The following BMGVs for the non-smokers of this branch of industry are proposed: for 1-hydroxypyrene 18microg/g creatinine and for the sum of hydroxyphenanthrenes 77microg/g creatinine in urine measured at the end of the shift...
  30. ncbi request reprint Polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and organochlorine pesticides in human blood of pregnant women from Germany
    Jurgen Wittsiepe
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:703-9. 2008
    ..In contrast, these women showed higher blood levels of organochlorine pesticides, indicating that these chemicals are still in use outside Western Europe...
  31. ncbi request reprint The 2005 World Health Organization re-evaluation of TEFs for dioxins and dioxin-like compounds--what are the consequences for German human background levels?
    Jurgen Wittsiepe
    Department of Hygiene, Social and Environmental Medicine, Ruhr Universtity Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Int J Hyg Environ Health 210:335-9. 2007
    ..If similar congener patterns can be assumed for certain matrices, appropriate multiplication factors can be used to convert TEq values of other TEF models sufficiently to WHO 2005 TEq values...
  32. ncbi request reprint Dietary intake of platinum and gold by children from Germany using duplicate portion sampling
    Jurgen Wittsiepe
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    J Trace Elem Med Biol 17:117-22. 2003
    ..No influence of the food consumption behaviour was found for the concentrations in the food duplicates or the dietary intake of Au...
  33. ncbi request reprint Human biomonitoring: state of the art
    Jurgen Angerer
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 210:201-28. 2007
    ..For the evaluation of HBM results the German HBM Commission elaborates reference- and HBM-values...
  34. ncbi request reprint Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int Arch Occup Environ Health 78:355-62. 2005
    ..Furthermore, a control collective from the general population was investigated...
  35. doi request reprint Dietary intake of nickel and zinc by young children--results from food duplicate portion measurements in comparison to data calculated from dietary records and available data on levels in food groups
    Jurgen Wittsiepe
    Ruhr Universitat Bochum, Abteilung für Hygiene, Sozial und Umweltmedizin, Universitatsstrasse 150, D 44801 Bochum, Germany
    J Trace Elem Med Biol 23:183-94. 2009
    ..Health risks are especially given with regard to the influence of nickel intake by food on dermatitis for nickel-sensitive individuals...
  36. ncbi request reprint Low serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) in children and adults from Afghanistan
    Hamayon Hemat
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Sci Total Environ 408:3493-5. 2010
    ..5 (PFOA) and 3.0 microg/l (PFHxS). All PFOS and PFOA concentrations in drinking water were below LOQ (PFOA 0.03 microg/l and PFOS 0.015 microg/l). It is concluded that exposure to PFCs also occurs in Afghanistan but on a very low level...
  37. ncbi request reprint Revised and new reference values for some persistent organic pollutants (POPs) in blood for human biomonitoring in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 206:223-9. 2003
    ..3 microgram/l for beta-HCH, 0.3 microgram/l for HCB and 0.7 microgram/l for DDE. In comparison with the former evaluation the revised reference values for PCB, beta-HCH and HCB levels in blood were reduced especially for younger adults...
  38. ncbi request reprint Occurrence of perfluorinated compounds (PFCs) in drinking water of North Rhine-Westphalia, Germany and new approach to assess drinking water contamination by shorter-chained C4-C7 PFCs
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:224-32. 2010
    ..3 microg/l and perfluoroheptanesulfonate (PFHpS) 0.3 microg/l. For all PFCs the long-term lowest maximal quality goal (general precautionary value, PVg) in drinking water is set to -0.1 microg/l...
  39. ncbi request reprint Dietary intake of cadmium by children and adults from Germany using duplicate portion sampling
    Michael Wilhelm
    Institute of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Sci Total Environ 285:11-9. 2002
    ..3-55.7% and 62.7-120.7 respectively of the PTWI. We therefore conclude, that the cadmium exposure of the population needs to be reduced in order to minimize the risk of adverse health effects related to this metal...
  40. ncbi request reprint Detection and quantification of human bocavirus in river water
    Ibrahim Ahmed Hamza
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    J Gen Virol 90:2634-7. 2009
    ..Therefore, the present study suggests that river water could play a role in the spread of HBoV. However, further work should be done to determine the actual risk of infection via surface water...
  41. doi request reprint Evaluation of pepper mild mottle virus, human picobirnavirus and Torque teno virus as indicators of fecal contamination in river water
    Ibrahim Ahmed Hamza
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Water Res 45:1358-68. 2011
    ..Whereas, the high excretion level and dissemination of PMMoV in human sewage and river water suggest that PMMoV could be a promising indicator of fecal pollution in surface water...
  42. doi request reprint Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in blood samples of occupationally exposed workers from a transformer recycling plant in Dortmund, Germany-initial findings
    Jurgen Wittsiepe
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    J Toxicol Environ Health A 75:423-8. 2012
    ..Compared to the most recent studies on German background levels of adults, elevated concentrations of up to 71.6 pg WHO(2005)-TEq/g(lipid base) were found for 8 participants, and for individual PCDF congeners for 15 participants...
  43. doi request reprint Methods to detect infectious human enteric viruses in environmental water samples
    Ibrahim Ahmed Hamza
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 214:424-36. 2011
    ..Techniques for rapid detection of infectious viruses such as fluorescence microscopy and automated flow cytometry have also been suggested to assess virus infectivity in water samples...
  44. ncbi request reprint Chemical and microbiological parameters as possible indicators for human enteric viruses in surface water
    Lars Jurzik
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:210-6. 2010
    ..We conclude that neither TCPP nor any other chemical or microbiological parameter can be used as a reliable indicator for the presence of enteric viruses in river water...
  45. ncbi request reprint Pilot study on the naphthalene exposure of German adults and children by means of urinary 1- and 2-naphthol levels
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Hyg Environ Health 207:441-5. 2004
    ..2 microg/g creatinine (non-smoking adults) and 23.5 microg/g creatinine (young children). It is concluded that 1- and 2-naphthol levels in urine are suitable for human biomonitoring of the naphthalene exposure in environmental medicine...
  46. ncbi request reprint Prevalence of respiratory symptoms in school children and salivary IgA--an epidemiological study in a rural area of Northrhine-Westphalia, Germany
    Juergen Hoelzer
    Institut fuer Hygiene, Sozial und Umweltmedizin, Department for Hygiene, Environmental and Social Medicine, Ruhr University Bochum, Universitaetsstrasse 150, D 44801 Bochum, Germany
    Int J Hyg Environ Health 205:309-19. 2002
    ..4 (SD (standard deviation) 35.1, median: 53.7) mg/l in children aged 6-8 years and 83.4 (SD 39.0, median: 76.3) mg/l in children aged 12-15 years. No significant association between salivary immunoglobulins and wheezing was detected...
  47. doi request reprint Levels of phthalate metabolites in urine among mother-child-pairs - results from the Duisburg birth cohort study, Germany
    Monika Kasper-Sonnenberg
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 215:373-82. 2012
    ..Further analyses are ongoing to study long-term phthalate exposure and the associations with puberty outcome in these children...
  48. ncbi request reprint Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes
    Friederike Lemm
    Abteilung für Hygiene, Sozial und Umweltmedizin, Ruhr Universitat Bochum, Bochum, Germany
    Int J Hyg Environ Health 207:325-35. 2004
    ....
  49. ncbi request reprint A comparative study of chemically induced DNA damage in isolated nasal mucosa cells of humans and rats assessed by the alkaline comet assay
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, MA 1 33, Ruhr University Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:936-46. 2008
    ..78 mM). NDELA induced a marked concomitant cytotoxicity. For EPI (LEC(human) and LEC(rat): 0.097 mM) and EDB (LEC(human): 0.195, LEC(rat): 0.048 mM), pronounced interindividual differences were observed in human samples...
  50. ncbi request reprint Comparison of soil Pb in vitro bioaccessibility and in vivo bioavailability with Pb pools from a sequential soil extraction
    Bernd Marschner
    Department of Soil Science and Soil Ecology, Geographical Institute, Ruhr University Bochum, Universitaetsstrasse 150, 44780 Bochum, Germany
    Environ Sci Technol 40:2812-8. 2006
    ..These results indicate that reductive processes in the intestine may be more relevant for Pb absorption than the initial solubilization in the acidic stomach...
  51. doi request reprint Colonization of patients and contamination of the patients' environment by MRSA under conditions of single-room isolation
    Ute Rohr
    Department of Hygiene, Social and Environmental Medicine, Universitatsstr 150, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:209-15. 2009
    ..3; 95% confidence interval, 7.7-20). It is concluded that MRSA patients without colonization of the groin have a relatively low risk of environmental spread of MRSA and thus a reduced risk of transmission...
  52. ncbi request reprint The European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results
    Birgit Karin Schindler
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum IPA, Bochum, Germany PROOF ACS GmbH, Hamburg, Germany
    Int J Hyg Environ Health 217:653-61. 2014
    ..The procedure described here, that has shown its success, can be used as a blueprint for future transnational, multicentre HBM projects. ..
  53. ncbi request reprint Development of a Luminex assay for the simultaneous detection of human enteric viruses in sewage and river water
    Ibrahim A Hamza
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany Electronic address
    J Virol Methods 204:65-72. 2014
    ..Results suggest that the multiplex Luminex assay could be a reliable method for the simultaneous detection of viral pathogens in wastewater. ..
  54. doi request reprint Determination of polychlorinated biphenyls and organochlorine pesticides in small volumes of human blood by high-throughput on-line SPE-LVI-GC-HRMS
    Jurgen Wittsiepe
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstrase 150, D 44801 Bochum, Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 945:217-24. 2014
    ..Under clean laboratory air conditions, these values may be improved. This method is recommended when high throughput is desirable and/or only small amounts of material are available, such as during studies involving children. ..
  55. ncbi request reprint Quality test of the MicroSeq D2 LSU Fungal Sequencing Kit for the identification of fungi
    Peter Rozynek
    Research Institute for Occupational Medicine of the Institutions for Statutory Accident Insurance and Prevention BGFA, Institute at the Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 207:297-9. 2004
    ..Five samples could not be identified. It is concluded that the identification of fungi by molecular biological method needs to be improved. This can partly be reached by expanding the fungal DNA-sequence datasets...
  56. doi request reprint Detection of human viruses in rivers of a densly-populated area in Germany using a virus adsorption elution method optimized for PCR analyses
    Ibrahim Ahmed Hamza
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Federal Republic of Germany
    Water Res 43:2657-68. 2009
    ....
  57. ncbi request reprint Risk potentials for humans of original and remediated PAH-contaminated soils: application of biomarkers of effect
    Peter H Roos
    Institute of Occupational Physiology, University of Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicology 205:181-94. 2004
    ..This concerns, for example, the identification of the suitable animal model, the identification of biomarkers for other contaminants and concepts to transpose the in vivo data to in vitro technologies or to mathematical modelling...
  58. ncbi request reprint Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..This study was done to evaluate effects related to the HPG axis...
  59. ncbi request reprint Lead concentration in the blood of children and its association with lead in soil and ambient air--trends between 1983 and 2000 in Duisburg
    Ulrich Ranft
    Institut fur Umweltmedizinische Forschung, an der Heirnrich Heine Universität Düsseldorf, Dusseldorf, Germany
    J Toxicol Environ Health A 71:710-5. 2008
    ..The results of the study were used for a local risk assessment and the definition of action values for Pb in soil...
  60. ncbi request reprint New biomarkers of occupational exposure to polycyclic aromatic hydrocarbons
    Albrecht Seidel
    Biochemisches Institut für Umweltcarcinogene Prof Dr Gernot Grimmer Stiftung, Grosshansdorf, Germany
    J Toxicol Environ Health A 71:734-45. 2008
    ..57. With a doubling of P, 1-OHP rose by 1.31 and DiOHP by 1.27. P is predominantly metabolized into 1-OHP, whereas PHE is metabolized equally into OHPHE and PHED. Thus metabolites of PHE were found as reliable biomarkers for PAH exposure...
  61. ncbi request reprint Perfluorinated compounds (PFC) hit the headlines : meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology
    Peter H Roos
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 82:57-9. 2008
  62. ncbi request reprint Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH)
    Peter H Roos
    Institut fur Arbeitsphysiologie, AK Biomarker und Fremdstoffwirkungen, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 76:326-34. 2002
    ..This is equally relevant for risk assessment and for selection of a suitable animal model that reflects effects of PAH exposure in humans...
  63. doi request reprint Interdisciplinary activities in environmental toxicology in North Rhine-Westphalia, Germany
    Klaus Golka
    J Toxicol Environ Health A 71:699. 2008
  64. ncbi request reprint DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons
    Thomas Mensing
    Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Institut für Arbeitsmedizin der Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Int J Hyg Environ Health 208:173-8. 2005
    ..g., skin absorption, dietary habits) or interindividual differences in their formation and repair...
  65. ncbi request reprint Occupational exposure to polycyclic aromatic hydrocarbons in German industries: association between exogenous exposure and urinary metabolites and its modulation by enzyme polymorphisms
    Hans Peter Rihs
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Ruhr University of Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Toxicol Lett 157:241-55. 2005
    ..001). OHPhe turned out to be also a suitable biomarker of occupational PAH exposure. The association with ambient PAH exposure and the influence of polymorphisms was more pronounced for OHPhe...
  66. ncbi request reprint Estimation of the dietary intake of acrylamide by German infants, children and adolescents as calculated from dietary records and available data on acrylamide levels in food groups
    Annett Hilbig
    Research Institute of Child Nutrition FKE, Dortmund, Germany
    Int J Hyg Environ Health 207:463-71. 2004
    ..Practical suggestions to lower the risk of acrylamide exposure by food without decreasing the quality of the nutrition in the diet are given...
  67. ncbi request reprint Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect
    Beate Pesch
    BGFA Forschungsinstitut für Arbeitsmedizin der Deatschen Gesetzlichen Unfallversicherung, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Cancer Epidemiol Biomarkers Prev 16:1863-73. 2007
    ..56; 95% confidence interval, 0.47-0.64). Hydroxyphenanthrenes may be recommended as biomarker of occupational PAH exposure, whereas biomarkers of DNA damage in blood did not show a dose-response relation to PAH exposure...