Bernhard B Singer

Summary

Country: Germany

Publications

  1. pmc Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells
    Bernhard B Singer
    Institute of Anatomy, University Hospital Essen, Essen, Germany
    PLoS ONE 5:e8747. 2010
  2. pmc Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog
    Robert Kammerer
    Tumor Immunology Laboratory, LIFE Center, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr, 23, 81377 Munich, Germany
    BMC Evol Biol 7:196. 2007
  3. ncbi request reprint CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes
    Bernhard B Singer
    Institut fur Biochemie und Molekularbiologie, Campus Benjamin Franklin, Charite, Berlin, Germany
    Eur J Immunol 35:1949-59. 2005
  4. ncbi request reprint The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38
    Esther Klaile
    Institut fur Biochemie und Molekularbiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin Dahlem D 14195, Germany
    J Biol Chem 282:26629-40. 2007
  5. ncbi request reprint CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration
    Esther Klaile
    Institut fur Biochemie und Molekularbiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, 14195 Berlin, Germany
    J Cell Sci 118:5513-24. 2005
  6. pmc Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behavior
    Harrison T Muturi
    Institute of Anatomy, University Hospital Essen, Essen, Germany
    PLoS ONE 8:e74654. 2013
  7. ncbi request reprint Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells
    Mario M Müller
    Institut fur Biochemie und Molekularbiologie, Charite Universitatsmedizin Berlin, Berlin Dahlem, Germany
    Blood 105:3925-34. 2005
  8. doi request reprint CEACAM1 expression in oligodendrocytes of the developing rat brain shows a spatiotemporal relation to myelination and is altered in a model of encephalopathy of prematurity
    Sebastian Prager
    Department of Pediatrics 1, Neonatology, University Hospital Essen, Essen, Germany
    Dev Neurosci 35:226-40. 2013
  9. pmc Cold storage of rat hepatocyte suspensions for one week in a customized cold storage solution--preservation of cell attachment and metabolism
    Gesine Pless-Petig
    Institut fur Physiologische Chemie, Universitatsklinikum Essen, Essen, Germany
    PLoS ONE 7:e40444. 2012
  10. doi request reprint A new tool for the transfection of corneal endothelial cells: calcium phosphate nanoparticles
    Jun Hu
    Institute of Anatomy, Essen University Hospital, 45147 Essen, Germany
    Acta Biomater 8:1156-63. 2012

Collaborators

Detail Information

Publications22

  1. pmc Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells
    Bernhard B Singer
    Institute of Anatomy, University Hospital Essen, Essen, Germany
    PLoS ONE 5:e8747. 2010
    ....
  2. pmc Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog
    Robert Kammerer
    Tumor Immunology Laboratory, LIFE Center, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr, 23, 81377 Munich, Germany
    BMC Evol Biol 7:196. 2007
    ..Since little is known about the CEA gene family in other lineages of placental mammals, we expected to gain new insights into the evolution of the rapidly diverging CEA family by analyzing the CEA family of the dog...
  3. ncbi request reprint CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes
    Bernhard B Singer
    Institut fur Biochemie und Molekularbiologie, Campus Benjamin Franklin, Charite, Berlin, Germany
    Eur J Immunol 35:1949-59. 2005
    ..These findings provide evidence that CEACAM1 influences the resolution of inflammation by prolonging the survival of rat granulocytes...
  4. ncbi request reprint The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38
    Esther Klaile
    Institut fur Biochemie und Molekularbiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin Dahlem D 14195, Germany
    J Biol Chem 282:26629-40. 2007
    ....
  5. ncbi request reprint CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration
    Esther Klaile
    Institut fur Biochemie und Molekularbiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, 14195 Berlin, Germany
    J Cell Sci 118:5513-24. 2005
    ..Together, our data demonstrate a novel mechanism for how CEACAM1-L regulates cell migration via its interaction with filamin A...
  6. pmc Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behavior
    Harrison T Muturi
    Institute of Anatomy, University Hospital Essen, Essen, Germany
    PLoS ONE 8:e74654. 2013
    ..All together, our data demonstrate that MV-bound forms of CEACAMs play important roles in intercellular communication processes, which can modulate immune response, tumor progression, metastasis and angiogenesis...
  7. ncbi request reprint Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells
    Mario M Müller
    Institut fur Biochemie und Molekularbiologie, Charite Universitatsmedizin Berlin, Berlin Dahlem, Germany
    Blood 105:3925-34. 2005
    ..Taken together, our results suggest that transmembrane CEACAM1-L expressed on endothelial cells is implicated in the activation phase of angiogenesis by affecting the cytoskeleton architecture and integrin-mediated signaling...
  8. doi request reprint CEACAM1 expression in oligodendrocytes of the developing rat brain shows a spatiotemporal relation to myelination and is altered in a model of encephalopathy of prematurity
    Sebastian Prager
    Department of Pediatrics 1, Neonatology, University Hospital Essen, Essen, Germany
    Dev Neurosci 35:226-40. 2013
    ....
  9. pmc Cold storage of rat hepatocyte suspensions for one week in a customized cold storage solution--preservation of cell attachment and metabolism
    Gesine Pless-Petig
    Institut fur Physiologische Chemie, Universitatsklinikum Essen, Essen, Germany
    PLoS ONE 7:e40444. 2012
    ..Based on previous studies with adherent cells, we here assessed cold storage injury in rat hepatocyte suspensions and aimed to find a cold storage solution that preserves viability, attachment ability and functionality of these cells...
  10. doi request reprint A new tool for the transfection of corneal endothelial cells: calcium phosphate nanoparticles
    Jun Hu
    Institute of Anatomy, Essen University Hospital, 45147 Essen, Germany
    Acta Biomater 8:1156-63. 2012
    ..In summary, CaP-NP are suitable tools for the transfection of corneal endothelial cells. As CaP-NP induce little apoptosis these nanoparticles offer a safe alternative to viral transfection agents...
  11. ncbi request reprint The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells
    Philippe Dje N'guessan
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Infect Dis 195:1651-60. 2007
    ..Thus, M. catarrhalis-induced apoptosis of pulmonary epithelial cells may contribute to the development of COPD and emphysema...
  12. ncbi request reprint Pro-angiogenic properties of orosomucoid (ORM)
    Ster Irmak
    Institute of Anatomy, University Hospital Essen, Hufelandstr 55, D 45147 Essen, Germany
    Exp Cell Res 315:3201-9. 2009
    ..Taken together, our results let assume that ORM has pro-angiogenic properties and supports the angiogenic effect of VEGF-A. Thus, ORM seems to be involved in the regulation of angiogenesis...
  13. doi request reprint Endothelial and hematopoietic progenitor cells (EPCs and HPCs): hand in hand fate determining partners for cancer cells
    Suleyman Ergun
    Institute of Anatomy, University Hospital Essen, Hufelandstr 55, 45147, Essen, Germany
    Stem Cell Rev 4:169-77. 2008
    ..This review attempts to bring these systemic and local players of postnatal vasculogenesis together and to highlight their role in tumor growth and mestastasis...
  14. pmc Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses
    Bernhard B Singer
    Institute of Anatomy, University Hospital, University Duisburg Essen, Essen, Germany
    PLoS ONE 9:e94106. 2014
    ..Our results suggest a new mechanism by which granulocytes reduce pro-inflammatory immune responses in human airways via secretion of CEACAM8 in neutrophil-driven bacterial infections. ..
  15. doi request reprint Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancer
    Tibor Szarvas
    Department of Urology, University Hospital of Essen, Essen, Germany
    BJU Int 107:1069-73. 2011
    ..To assess the presence of matrix metalloproteinase (MMP)-7 in urine samples of patients with bladder cancer and to investigate the correlation between MMP-7 urine concentration and clinicopathological variables...
  16. ncbi request reprint Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1
    Nerbil Kilic
    Internal Medicine, Department of Hematology Oncology Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Blood 110:4223-33. 2007
    ..CEACAM1-induced signaling effects appear to be dependent on the presence of tyrosine residues in the CEACAM1 cytoplasmic domain...
  17. ncbi request reprint Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation
    Inka Scheffrahn
    Department of Cell and Molecular Biology, Medical Nobel Institute, Box 285, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Exp Cell Res 307:427-35. 2005
    ....
  18. ncbi request reprint Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution
    Robert Kammerer
    Tumor Immunology Laboratory, Department of Urology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 23, Munich D 81377, Germany
    Gene 339:99-109. 2004
    ..This is consistent with the notion that CEACAM1 serves or has served as a pathogen receptor in cattle...
  19. ncbi request reprint CEACAM1 is a potent regulator of B cell receptor complex-induced activation
    Gediminas Greicius
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden
    J Leukoc Biol 74:126-34. 2003
    ..Anti-CEACAM1 induced phosphorylation of c-Jun N-terminal kinase (stress-activated protein kinase) but did not activate the extracellular signal-regulated kinase or p38 mitogen-activated protein kinases...
  20. ncbi request reprint Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells
    Björn Obrink
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Ann N Y Acad Sci 971:597-607. 2002
    ....
  21. ncbi request reprint Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes
    Bernhard B Singer
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Immunol 168:5139-46. 2002
    ..We demonstrated that CEACAM1 and CEACAM8 are physically associated in human granulocytes. The CEACAM1/CEACAM8 complex in human cells might accordingly play a similar role as CEACAM1-L/CEACAM1-S dimers known to occur in rat cells...
  22. doi request reprint CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells
    Hortense Slevogt
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Nat Immunol 9:1270-8. 2008
    ..Our results identify a CEACAM1-dependent immune-evasion strategy...