Mikael Simons

Summary

Country: Germany

Publications

  1. doi request reprint Exosomes--vesicular carriers for intercellular communication
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Curr Opin Cell Biol 21:575-81. 2009
  2. doi request reprint Axonal selection and myelin sheath generation in the central nervous system
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Curr Opin Cell Biol 25:512-9. 2013
  3. doi request reprint Cell polarity in myelinating glia: from membrane flow to diffusion barriers
    Mikael Simons
    Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Biochim Biophys Acta 1821:1146-53. 2012
  4. ncbi request reprint Wrapping it up: the cell biology of myelination
    Mikael Simons
    Centre for Biochemistry and Molecular Cell Biology, Humboldltallee 23, 37073 Gottingen, Germany
    Curr Opin Neurobiol 17:533-40. 2007
  5. pmc Actomyosin contractility controls cell surface area of oligodendrocytes
    Angelika Kippert
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    BMC Cell Biol 10:71. 2009
  6. ncbi request reprint Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis
    Mikael Simons
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Cell Sci 119:4381-9. 2006
  7. pmc Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin
    Dirk Fitzner
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    EMBO J 25:5037-48. 2006
  8. pmc Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system
    Mostafa Bakhti
    Cellular Neuroscience, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 110:3143-8. 2013
  9. pmc Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS Biol 11:e1001577. 2013
  10. pmc Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 172:937-48. 2006

Collaborators

Detail Information

Publications37

  1. doi request reprint Exosomes--vesicular carriers for intercellular communication
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Curr Opin Cell Biol 21:575-81. 2009
    ..Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions...
  2. doi request reprint Axonal selection and myelin sheath generation in the central nervous system
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Curr Opin Cell Biol 25:512-9. 2013
    ..A thorough understanding of the mechanisms underlying these events is a prerequisite for the design of novel myelin repair strategies in demyelinating and dysmyelinating diseases. ..
  3. doi request reprint Cell polarity in myelinating glia: from membrane flow to diffusion barriers
    Mikael Simons
    Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Biochim Biophys Acta 1821:1146-53. 2012
    ..Finally, we highlight potential mechanism that may contribute to the assembly of specific lipids within myelin. This article is part of a Special Issue entitled Lipids and Vesicular Transport...
  4. ncbi request reprint Wrapping it up: the cell biology of myelination
    Mikael Simons
    Centre for Biochemistry and Molecular Cell Biology, Humboldltallee 23, 37073 Gottingen, Germany
    Curr Opin Neurobiol 17:533-40. 2007
    ..These sequential processes create the special lipid and protein composition necessary for myelin to perform its insulating function during nerve conduction...
  5. pmc Actomyosin contractility controls cell surface area of oligodendrocytes
    Angelika Kippert
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    BMC Cell Biol 10:71. 2009
    ..To form myelin oligodendrocytes expand and wrap their plasma membrane multiple times around an axon. How is this expansion controlled?..
  6. ncbi request reprint Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis
    Mikael Simons
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Cell Sci 119:4381-9. 2006
    ..These interconnections at multiple levels show how neurons and glia cooperate to build a complex network during development...
  7. pmc Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin
    Dirk Fitzner
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    EMBO J 25:5037-48. 2006
    ..We propose that this mechanism is essential for myelin to perform its insulating function during nerve conduction...
  8. pmc Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system
    Mostafa Bakhti
    Cellular Neuroscience, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 110:3143-8. 2013
    ..We suggest that loss of electrostatic cell-surface repulsion uncovers weak and unspecific attractive forces in the bilayer that bring the extracellular surfaces of a membrane into close contact over long distances...
  9. pmc Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS Biol 11:e1001577. 2013
    ..These results provide a key mechanism in myelin membrane biogenesis with implications for disabling demyelinating diseases of the central nervous system...
  10. pmc Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 172:937-48. 2006
    ..The release of myelin membrane from LEs/Ls by neuronal signals may represent a mechanism to control myelin membrane growth...
  11. doi request reprint Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  12. ncbi request reprint Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells
    Angelika Kippert
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    J Neurosci 27:3560-70. 2007
    ..We suggest that Rho inactivation is required to trigger plasma membrane specialization in oligodendrocytes...
  13. doi request reprint Central nervous system myelin: structure, synthesis and assembly
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, Gottingen, Germany
    Trends Cell Biol 21:585-93. 2011
    ..Such insight will be essential in designing new therapeutic strategies to promote remyelination in demyelinating disorders such as multiple sclerosis...
  14. doi request reprint Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons
    Anja Schneider
    Centre for Biochemistry and Molecular Cell Biology, Department of Psychiatry and Psychotherapy, University of Gottingen, 37073 Gottingen, Germany
    J Neurosci 28:2874-82. 2008
    ..Together, our data suggest that cholesterol/flotillin-dependent clustering of APP may stimulate the internalization into a specialized clathrin-dependent endocytosis pathway to promote amyloidogenic processing...
  15. pmc Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling
    Angelika Kippert
    Centre for Biochemistry and Molecular Cell Biology, University of Göttingen Humboldtallee 23, Gottingen, Germany
    BMC Neurosci 9:40. 2008
    ..Differentiation of oligodendrocytes to myelin-forming cells requires the downregulation of RhoA GTPase activity...
  16. pmc Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
    Chieh Hsu
    Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Cell Biol 189:223-32. 2010
    ..These findings provide a basis for understanding the biogenesis and function of exosomes in the central nervous system...
  17. pmc Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease
    Katrin Strauss
    Max Planck Institute for Experimental Medicine, Goettingen, Germany
    J Biol Chem 285:26279-88. 2010
    ..Furthermore, we suggest that secretion of cholesterol by exosomes contributes to maintain cellular cholesterol homeostasis...
  18. pmc Self-segregation of myelin membrane lipids in model membranes
    Larisa Yurlova
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Biophys J 101:2713-20. 2011
    ..Taken together, our findings suggest that oligodendrocytes exploit the potential of lipids to self-segregate to generate a highly ordered membrane for electrical insulation of axons...
  19. doi request reprint Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis
    Natalia Manrique-Hoyos
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Ann Neurol 71:227-44. 2012
    ..To investigate the impact of single or repeated episodes of reversible demyelination on long-term locomotor performance and neuroaxonal integrity, and to analyze the myelin proteome after remyelination and during aging...
  20. doi request reprint Cholesterol and myelin biogenesis
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Subcell Biochem 51:489-508. 2010
    ..In this review we will summarize the role of cholesterol in myelin biogenesis in the central and peripheral nervous system...
  21. pmc Targeted ablation of oligodendrocytes triggers axonal damage
    Aniket Ghosh
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 6:e22735. 2011
    ..The models used in this study provide valuable systems for the investigation of therapeutic strategies to prevent axonal or neuronal damage...
  22. doi request reprint Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium
    Schanila Nawaz
    Max Planck Institute of Experimental Medicine, University of Gottingen, D 37075 Gottingen, Germany
    J Neurosci 29:4794-807. 2009
    ..Together, these results establish that PIP2 is an essential determinant for stable membrane binding of MBP and provide a novel link between glial phosphoinositol metabolism and MBP function in development and disease...
  23. pmc Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles
    Mostafa Bakhti
    Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Biol Chem 286:787-96. 2011
    ..We propose that neurons control the secretion of autoinhibitory oligodendroglial-derived exosomes to coordinate myelin membrane biogenesis...
  24. pmc Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice
    Nora Hagemeyer
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Mol Med 18:628-35. 2012
    ..These findings underscore the value of future therapeutic strategies for multiple sclerosis based on EPO or EPO variants...
  25. doi request reprint Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
    Dirk Fitzner
    Max Planck Institute for Experimental Medicine, Hermann Rein Str, D 37075 Gottingen, Germany
    J Cell Sci 124:447-58. 2011
    ..By designating the capacity for macropinocytosis and antigen presentation to distinct cells, degradation and immune function might be assigned to different subtypes of microglia...
  26. doi request reprint Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue
    Nicolas Snaidero
    Max Planck Institute of Experimental Medicine, Cellular Neuroscience, Hermann Rein Strasse, 3, 37075 Gottingen, Germany Department of Neurology, University of Gottingen, Robert Koch Strasse, 40, 37075 Gottingen, Germany
    Cell 156:277-90. 2014
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life...
  27. pmc A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons
    Aniket Ghosh
    Max Planck Institute for Experimental Medicine, Gottingen, Germany Department of Neurology, University of Gottingen, Gottingen, Germany
    PLoS Genet 9:e1003980. 2013
    ..Supplementing sphingosine into the diet rescued the neuropathy in flies. Thus, our RNAi study in Drosophila identifies a key role of ceramide phosphoethanolamine in wrapping of axons by glia. ..
  28. ncbi request reprint Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons
    Anja Schneider
    Center for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Neurobiol Dis 23:573-7. 2006
    ..These results suggest a key role for cholesterol in aggregation of Abeta...
  29. doi request reprint Control of oligodendroglial cell number by the miR-17-92 cluster
    Holger Budde
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Development 137:2127-32. 2010
    ..Together, these results suggest that the miRNA pathway is essential in determining oligodendroglial cell number and that the miR-17-92 cluster is crucial in this process...
  30. doi request reprint Myelin architecture: zippering membranes tightly together
    Mostafa Bakhti
    Max Planck Institute of Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Cell Mol Life Sci 71:1265-77. 2014
    ..Unveiling the mechanisms of myelin membrane assembly at the cytoplasmic and extracelluar sites may help to understand how the myelin bilayers are disrupted and destabilized in the different demyelinating diseases. ..
  31. doi request reprint Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia
    Jörg Scheffel
    Institute of Neuropathology, University of Gottingen, Gottingen, Germany
    Glia 60:1930-43. 2012
    ..Finally, subsets rather than a uniform population of microglia may assemble the reactive phenotypes in responses during infection, injury, and rebuilding, warranting consideration in experimental manipulation and therapeutic strategies...
  32. pmc Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations
    Schanila Nawaz
    III Physikalisches Institut, Faculty of Physics, Georg August Universitat Gottingen, Gottingen, Germany
    PLoS ONE 7:e45297. 2012
    ..The combination of both techniques allows the investigation of single cells at small and large indentations and enables the separation of their viscous and elastic components...
  33. ncbi request reprint A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany, University of Gottingen, 37075 Gottingen, Germany
    Dev Cell 21:445-56. 2011
    ..This system might have evolved in oligodendrocytes in order to generate an anisotropic membrane organization that facilitates the assembly of highly insulating lipid-rich membranes...
  34. pmc Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies
    Dirk Fitzner
    Max Planck Institute for Experimental Medicine, Hermann Rein Str 3, Gottingen, Germany
    Curr Neuropharmacol 8:305-15. 2010
    ..Here, we discuss disease mechanisms and treatment strategies for chronic progressive MS...
  35. ncbi request reprint Palmitoylation is a sorting determinant for transport to the myelin membrane
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strausse 3, 72076 Tubingen, Germany
    J Cell Sci 118:2415-23. 2005
    ..Thus, we conclude that palmitoylation is a sorting determinant for transport to the myelin membrane...
  36. ncbi request reprint Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Biol Chem 279:55833-9. 2004
    ..In summary, our data provide evidence that axonal damage in EAE and possibly MS is linked to tau pathology...
  37. pmc Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease
    Mikael Simons
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Cell Biol 157:327-36. 2002
    ..We propose that these accumulations perturb the process of myelination and impair the viability of oligodendrocytes...