Mikael Simons


Country: Germany


  1. Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009;21:575-81 pubmed publisher
    ..Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions...
  2. Kippert A, Fitzner D, Helenius J, Simons M. Actomyosin contractility controls cell surface area of oligodendrocytes. BMC Cell Biol. 2009;10:71 pubmed publisher
    ..See related minireview by Bauer and ffrench-Constant: http://www.jbiol.com/content/8/8/78. ..
  3. Simons M, Lyons D. Axonal selection and myelin sheath generation in the central nervous system. Curr Opin Cell Biol. 2013;25:512-9 pubmed publisher
    ..A thorough understanding of the mechanisms underlying these events is a prerequisite for the design of novel myelin repair strategies in demyelinating and dysmyelinating diseases. ..
  4. Simons M, Snaidero N, Aggarwal S. Cell polarity in myelinating glia: from membrane flow to diffusion barriers. Biochim Biophys Acta. 2012;1821:1146-53 pubmed publisher
    ..Finally, we highlight potential mechanism that may contribute to the assembly of specific lipids within myelin. This article is part of a Special Issue entitled Lipids and Vesicular Transport. ..
  5. Schmitt S, Castelvetri L, Simons M. Metabolism and functions of lipids in myelin. Biochim Biophys Acta. 2015;1851:999-1005 pubmed publisher
    ..We postulate that change in myelin lipid composition might be relevant for our understanding of aging and demyelinating diseases. This article is part of a Special Issue titled Brain Lipids. ..
  6. Cantuti Castelvetri L, Fitzner D, Bosch Queralt M, Weil M, Su M, Sen P, et al. Defective cholesterol clearance limits remyelination in the aged central nervous system. Science. 2018;359:684-688 pubmed publisher
    ..Thus, cholesterol-rich myelin debris can overwhelm the efflux capacity of phagocytes, resulting in a phase transition of cholesterol into crystals and thereby inducing a maladaptive immune response that impedes tissue regeneration. ..
  7. Snaidero N, Mobius W, Czopka T, Hekking L, Mathisen C, Verkleij D, et al. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell. 2014;156:277-90 pubmed publisher
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life. ..
  8. Weil M, Mobius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, et al. Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep. 2016;16:314-322 pubmed publisher
    ..We propose that the aberrant phase transition of MBP molecules from their cohesive to soluble and non-adhesive state is a mechanism triggering myelin breakdown in NMO and possibly in other demyelinating diseases. ..
  9. Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner H, et al. Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep. 2017;18:314-323 pubmed publisher
    ..Our study provides a molecular and structural framework for understanding how myelin maintains its cytoplasm to function as an active axon-glial unit. ..

More Information


  1. Dimou L, Simons M. Diversity of oligodendrocytes and their progenitors. Curr Opin Neurobiol. 2017;47:73-79 pubmed publisher
    ..Because oligodendroglia remain highly responsive to environmental changes, they likely contribute to various neurological and psychiatric diseases. ..