Manu Sharma

Summary

Country: Germany

Publications

  1. pmc Integrative pathway-based approach for genome-wide association studies: identification of new pathways for rheumatoid arthritis and type 1 diabetes
    Finja Büchel
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
    PLoS ONE 8:e78577. 2013
  2. pmc A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
    Manu Sharma
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and DZNE German Center for Neurodegenerative Diseases, Tubingen, Hoppe Seyler Str 3, Tubingen 72076, Germany
    J Med Genet 49:721-6. 2012
  3. pmc Large-scale replication and heterogeneity in Parkinson disease genetic loci
    Manu Sharma
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 79:659-67. 2012
  4. pmc Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease
    Albert Rosenberger
    Georg August University Gottingen, Medical School, Department of Genetic Epidemiology, Germany
    BMC Genet 8:44. 2007
  5. doi request reprint Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
    Manu Sharma
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tuebingen, Germany
    Neurobiol Aging 32:2108.e1-5. 2011
  6. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
  7. ncbi request reprint The transcription factor PITX3 is associated with sporadic Parkinson's disease
    Julia Fuchs
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neurobiol Aging 30:731-8. 2009
  8. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
  9. doi request reprint No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Otfried Muller Strasse 27, 72076, Tuebingen, Germany
    Neurobiol Aging 32:551.e1-4. 2011
  10. pmc Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis
    Lena F Burbulla
    DZNE, German Center for Neurodegenerative Diseases, Tubingen, Germany
    Hum Mol Genet 19:4437-52. 2010

Detail Information

Publications13

  1. pmc Integrative pathway-based approach for genome-wide association studies: identification of new pathways for rheumatoid arthritis and type 1 diabetes
    Finja Büchel
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
    PLoS ONE 8:e78577. 2013
    ..These results provide new leads to understand the molecular underpinnings of these diseases. The developed software herein used is available at http://www.cogsys.cs.uni-tuebingen.de/software/GWASPathwayIdentifier/index.htm...
  2. pmc A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
    Manu Sharma
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and DZNE German Center for Neurodegenerative Diseases, Tubingen, Hoppe Seyler Str 3, Tubingen 72076, Germany
    J Med Genet 49:721-6. 2012
    ..Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive...
  3. pmc Large-scale replication and heterogeneity in Parkinson disease genetic loci
    Manu Sharma
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 79:659-67. 2012
    ..The extent to which these genetic effects are consistent across different populations is unknown...
  4. pmc Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease
    Albert Rosenberger
    Georg August University Gottingen, Medical School, Department of Genetic Epidemiology, Germany
    BMC Genet 8:44. 2007
    ..An application to Parkinson's disease is given. Because we had to use secondary data a meta analysis based on original summary values would be desirable...
  5. doi request reprint Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
    Manu Sharma
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tuebingen, Germany
    Neurobiol Aging 32:2108.e1-5. 2011
    ..However, taking the initial mapping of the PARK3 into account, the role of a population-specific effect warrants consideration in future studies...
  6. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
    ..This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide...
  7. ncbi request reprint The transcription factor PITX3 is associated with sporadic Parkinson's disease
    Julia Fuchs
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neurobiol Aging 30:731-8. 2009
    ..004) with PD. The C-allele appears to be a recessive risk allele with an estimated population frequency of 83%. An allele-dependent dysregulation of PITX3 expression might contribute to the susceptibility to PD...
  8. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
    ....
  9. doi request reprint No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Otfried Muller Strasse 27, 72076, Tuebingen, Germany
    Neurobiol Aging 32:551.e1-4. 2011
    ..Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population...
  10. pmc Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis
    Lena F Burbulla
    DZNE, German Center for Neurodegenerative Diseases, Tubingen, Germany
    Hum Mol Genet 19:4437-52. 2010
    ..Our results support the role of this mitochondrial chaperone in neurodegeneration and underscore the concept of impaired mitochondrial protein quality control in PD...
  11. doi request reprint Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities
    Florian Mittag
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
    Hum Mutat 33:1708-18. 2012
    ..The used software is available at http://www.ra.cs.uni-tuebingen.de/software/MACLEAPS/...
  12. doi request reprint Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease
    Manu Sharma
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Neurobiol Aging 30:1706-9. 2009
    ..In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population...
  13. doi request reprint Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
    Oliver Rothfuss
    Department for Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Hum Mol Genet 18:3832-50. 2009
    ..Our data indicate a novel role for parkin in directly supporting mitochondrial function and protecting mitochondrial genomic integrity from oxidative stress...