Matthias Selbach

Summary

Country: Germany

Publications

  1. pmc Novel insights into proteomic technologies and their clinical perspective
    Gunnar Dittmar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Genome Med 1:53. 2009
  2. doi request reprint Widespread changes in protein synthesis induced by microRNAs
    Matthias Selbach
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Nature 455:58-63. 2008
  3. doi request reprint Host cell interactome of tyrosine-phosphorylated bacterial proteins
    Matthias Selbach
    Max Planck Institute of Biochemistry, Department Proteomics and Signal Transduction, Am Klopferspitz 18, Martinsried D 82152, Germany
    Cell Host Microbe 5:397-403. 2009
  4. doi request reprint Synthesis and degradation jointly determine the responsiveness of the cellular proteome
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Bioessays 35:597-601. 2013
  5. doi request reprint Global analysis of cellular protein translation by pulsed SILAC
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Proteomics 9:205-9. 2009
  6. ncbi request reprint Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
    Svetlana Lebedeva
    Laboratory of Systems Biology of Gene Regulatory Elements, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell 43:340-52. 2011
  7. pmc Argonaute2 regulates the pancreatic β-cell secretome
    Sudhir G Tattikota
    Max Delbrueck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Proteomics 12:1214-25. 2013
  8. ncbi request reprint Analyzing protein-protein interactions by quantitative mass spectrometry
    Florian E Paul
    Cell Signaling and Mass Spectrometry Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Methods 54:387-95. 2011
  9. doi request reprint Global quantification of mammalian gene expression control
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13092 Berlin, Germany
    Nature 473:337-42. 2011
  10. ncbi request reprint Conservation of mRNA and Protein Expression during Development of C. elegans
    Dominic Grün
    Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Cell Rep 6:565-77. 2014

Collaborators

Detail Information

Publications21

  1. pmc Novel insights into proteomic technologies and their clinical perspective
    Gunnar Dittmar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Genome Med 1:53. 2009
    ..A report on the Proteomic Forum 2009 conference, Berlin, Germany, 29 March to 2 April, 2009...
  2. doi request reprint Widespread changes in protein synthesis induced by microRNAs
    Matthias Selbach
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Nature 455:58-63. 2008
    ..Finally, our data suggest that a miRNA can, by direct or indirect effects, tune protein synthesis from thousands of genes...
  3. doi request reprint Host cell interactome of tyrosine-phosphorylated bacterial proteins
    Matthias Selbach
    Max Planck Institute of Biochemistry, Department Proteomics and Signal Transduction, Am Klopferspitz 18, Martinsried D 82152, Germany
    Cell Host Microbe 5:397-403. 2009
    ..Collectively, our results indicate that tyrosine-phosphorylation sites of bacterial effector proteins have evolved as versatile interaction modules that can recruit a rich repertoire of cellular SH2 domains...
  4. doi request reprint Synthesis and degradation jointly determine the responsiveness of the cellular proteome
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Bioessays 35:597-601. 2013
    ....
  5. doi request reprint Global analysis of cellular protein translation by pulsed SILAC
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Proteomics 9:205-9. 2009
    ..We applied the method to cellular iron homeostasis as a model system and demonstrate that it can confidently identify proteins that are translationally regulated by iron availability...
  6. ncbi request reprint Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
    Svetlana Lebedeva
    Laboratory of Systems Biology of Gene Regulatory Elements, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell 43:340-52. 2011
    ..Additionally, HuR knockdown triggered strong and specific upregulation of miR-7. In summary, we identified thousands of direct and functional HuR targets, found a human miRNA controlled by HuR, and propose a role for HuR in splicing...
  7. pmc Argonaute2 regulates the pancreatic β-cell secretome
    Sudhir G Tattikota
    Max Delbrueck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Proteomics 12:1214-25. 2013
    ..This study specifically addresses the role of Ago2 in the systemic release of proteins from β-cells and highlights the contribution of the microRNA pathway to the function of this cell type...
  8. ncbi request reprint Analyzing protein-protein interactions by quantitative mass spectrometry
    Florian E Paul
    Cell Signaling and Mass Spectrometry Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Methods 54:387-95. 2011
    ..The protocols and background information presented here allow the reader to adapt the generic q-AP-MS strategy for a wide range of biological questions...
  9. doi request reprint Global quantification of mammalian gene expression control
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13092 Berlin, Germany
    Nature 473:337-42. 2011
    ..Quantitative information about all stages of gene expression provides a rich resource and helps to provide a greater understanding of the underlying design principles...
  10. ncbi request reprint Conservation of mRNA and Protein Expression during Development of C. elegans
    Dominic Grün
    Systems Biology of Gene Regulatory Elements, Max Delbrück Center Berlin, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Cell Rep 6:565-77. 2014
    ..Finally, among divergently expressed genes, we identified insulin signaling, a pathway involved in lifespan determination, as a putative target of adaptive evolution. ..
  11. doi request reprint Whole cell proteome regulation by microRNAs captured in a pulsed SILAC mass spectrometry approach
    Olivia A Ebner
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Methods Mol Biol 725:315-31. 2011
    ..Here, we describe how pSILAC in conjunction with shotgun mass spectrometry can assess differences in the protein profile between cells transfected with a microRNA and non-transfected cells...
  12. doi request reprint The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
    Alexander G Baltz
    Max Delbruck Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, 13125 Berlin, Germany
    Mol Cell 46:674-90. 2012
    ..Our observations indicate the presence of a large number of mRNA binders with diverse molecular functions participating in combinatorial posttranscriptional gene-expression networks...
  13. pmc Gene expression: degrade to derepress
    Erik McShane
    Proteome Dynamics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    EMBO J 33:407-8. 2014
    ..These findings reveal that the ubiquitin proteasome system actively regulates transcription. ..
  14. doi request reprint Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors
    Jochen E Welcker
    Developmental Biology Signal Transduction Group, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 140:4947-58. 2013
    ..Our work demonstrates that Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo. ..
  15. pmc In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish
    Elena Cibrián Uhalte
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 7:e40000. 2012
    ..This study provides the foundation for using the analog-sensitive kinase method in the context of complex vertebrate development, physiology, or disease...
  16. doi request reprint Quantitative proteomics reveals subset-specific viral recognition in dendritic cells
    Christian A Luber
    Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Immunity 32:279-89. 2010
    ....
  17. ncbi request reprint Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK)
    Matthias Selbach
    Max Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nat Methods 3:981-3. 2006
    ..We used this screen to identify interaction partners of beta-catenin and Cbl...
  18. ncbi request reprint The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin
    Stefan Moese
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Cell Microbiol 9:1148-61. 2007
    ..We hypothesize that CagA-mediated inactivation of vinculin is a key step in the mechanism by which H. pylori induces damage to the gastric epithelium and represents an important step in disease development...
  19. ncbi request reprint Robust Salmonella metabolism limits possibilities for new antimicrobials
    Daniel Becker
    Max Planck Institute for Infection Biology, Department of Molecular Biology, D 10117 Berlin, Germany
    Nature 440:303-7. 2006
    ..Our comprehensive in vivo analysis thus suggests a shortage of new metabolic targets for broad-spectrum antibiotics, and draws attention to some previously known but unexploited targets...
  20. pmc Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways
    Stefan Moese
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    Infect Immun 72:3646-9. 2004
    ..The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA...
  21. ncbi request reprint Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    Matthias Selbach
    Max Planck Institut für Infektionsbiologie, Abt Molekulare Biologie, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Biol Chem 277:6775-8. 2002
    ....