Guido Seitz

Summary

Country: Germany

Publications

  1. ncbi request reprint In vitro photodynamic therapy of childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Int J Oncol 30:615-20. 2007
  2. ncbi request reprint Establishment of a rhabdomyosarcoma xenograft model in human-adapted mice
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    Oncol Rep 24:1067-72. 2010
  3. doi request reprint Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: a report from the Cooperative Soft Tissue Sarcoma trial CWS-96
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen, Germany
    Pediatr Blood Cancer 56:718-24. 2011
  4. ncbi request reprint Effects of standard chemotherapy on tumor growth and regulation of multidrug resistance genes and proteins in childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Pediatr Surg Int 23:431-9. 2007
  5. ncbi request reprint Laparoscopic cystojejunostomy as a treatment option for pancreatic pseudocysts in children--a case report
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen 72076, Germany
    J Pediatr Surg 41:e33-5. 2006
  6. doi request reprint Imaging of cell trafficking and metastases of paediatric rhabdomyosarcoma
    G Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen, Germany
    Cell Prolif 41:365-74. 2008
  7. ncbi request reprint Visualization of xenotransplanted human rhabdomyosarcoma after transfection with red fluorescent protein
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    J Pediatr Surg 41:1369-76. 2006
  8. ncbi request reprint Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tubingen, Germany
    Biol Neonate 90:247-51. 2006
  9. ncbi request reprint Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    Int J Oncol 36:491-500. 2010
  10. ncbi request reprint Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    J Pediatr Surg 40:1440-5. 2005

Detail Information

Publications42

  1. ncbi request reprint In vitro photodynamic therapy of childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Int J Oncol 30:615-20. 2007
    ..In fibroblasts, PDT was less effective compared to tumor cells. Our data suggest hypericin as a novel tool for visualization and photodynamic therapy of childhood rhabdomyosarcoma...
  2. ncbi request reprint Establishment of a rhabdomyosarcoma xenograft model in human-adapted mice
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    Oncol Rep 24:1067-72. 2010
    ..This model offers a basic tool for further analyzing novel immunotherapeutic approaches in RMS, and could possibly be used in other solid pediatric tumors...
  3. doi request reprint Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: a report from the Cooperative Soft Tissue Sarcoma trial CWS-96
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen, Germany
    Pediatr Blood Cancer 56:718-24. 2011
    ..To analyze the clinical course, treatment modalities, complications and outcome of patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma (BPRMS) treated on the CWS-96 trial...
  4. ncbi request reprint Effects of standard chemotherapy on tumor growth and regulation of multidrug resistance genes and proteins in childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Pediatr Surg Int 23:431-9. 2007
    ..The mechanism of multidrug resistance depends on the tumor subtype. Therefore, further investigations will be required to evaluate multidrug resistance in patients and to investigate new modalities for a reversal of multidrug resistance...
  5. ncbi request reprint Laparoscopic cystojejunostomy as a treatment option for pancreatic pseudocysts in children--a case report
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen 72076, Germany
    J Pediatr Surg 41:e33-5. 2006
    ..The patient was free of complaints after more than 2 years of follow-up. Laparoscopic cystojejunostomy in children with pancreatic pseudocysts may represent an alternative treatment option for large pancreatic pseudocysts...
  6. doi request reprint Imaging of cell trafficking and metastases of paediatric rhabdomyosarcoma
    G Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tuebingen, Germany
    Cell Prolif 41:365-74. 2008
    ..The aim of this study was to establish a preclinical mouse model to study metastases of paediatric rhabdomyosarcoma at the macroscopic and cellular levels, with different imaging methods...
  7. ncbi request reprint Visualization of xenotransplanted human rhabdomyosarcoma after transfection with red fluorescent protein
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    J Pediatr Surg 41:1369-76. 2006
    ..The aims of this study were to establish a DsRed2-transfected human rhabdomyosarcoma (RMS) cell line and to perform a xenotransplantation on nude mice to use imaging as a tool for further basic research studies on this neoplasm...
  8. ncbi request reprint Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Tubingen, Germany
    Biol Neonate 90:247-51. 2006
    ..Several abnormalities may occur in these children, e.g. esophageal atresia (EA), imperforate anus or abdominal wall defects. Correction of EA is often performed as a staged procedure in this group of patients...
  9. ncbi request reprint Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    Int J Oncol 36:491-500. 2010
    ..Reversal of these effects may be achieved by GST inhibitors in part. The GST family represents a promising target for further treatment strategies in childhood RMS...
  10. ncbi request reprint Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    J Pediatr Surg 40:1440-5. 2005
    ..The aim of this study was to evaluate the effects of TNF-alpha on the inflammatory response in NEC by immunoneutralizing TNF-alpha with a selective antibody...
  11. ncbi request reprint In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital Tubingen, Tubingen, Germany
    Oncol Rep 20:1277-82. 2008
    ..4+/-1.6%, p<0.05), proliferative activity and complete apoptosis of all cells in all investigated cell lines. These data show that hypericin might be a useful tool for visualisation and as alternative treatment option in HB and HCC...
  12. ncbi request reprint Optimizing vector application for gene transfer into human hepatoblastoma cells
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Pediatr Surg Int 22:733-42. 2006
    ..Furthermore, enhanced activity of the liver-specific promoters in HUH6 cells compared to HepT1 cells supports the observation of varying biological behavior in histologically differing HB tissues...
  13. doi request reprint Adenovirus-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro
    Steven W Warmann
    Department of Pediatric Surgery, University Children s Hospital Tubingen, Tubingen, Germany
    Pediatr Blood Cancer 53:145-51. 2009
    ....
  14. ncbi request reprint Bcl-2 gene silencing in pediatric epithelial liver tumors
    Steven W Warmann
    Department of Pediatric Surgery, University Children s Hospital Tubingen, Tubingen, Germany
    J Surg Res 144:43-8. 2008
    ..The role of Bcl-2 proteins in these tumors is yet unclear. The purpose of this study was to analyze the influence of Bcl-2 on the chemotherapy resistance of hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC)...
  15. doi request reprint Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells
    Justus Lieber
    Department of Pediatric Surgery, University Children s Hospital, Tubingen, Germany
    Pediatr Blood Cancer 55:1089-95. 2010
    ..In Hepatoblastoma (HB) apoptosis regulation contributes to resistance and therapy failure, therefore we modulated apoptosis sensitivity of HB cells for an improved cytotoxic activity of commonly used drugs...
  16. ncbi request reprint Treatment and outcome of patients suffering from perineal/perianal rhabdomyosarcoma: results from the CWS trials--retrospective clinical study
    Joerg Fuchs
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital, Tuebingen, Germany Department of Pediatric Hematology, Oncology and Immunology, Olgahospital, Stuttgart, Germany Department of Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany Department for Pediatric Hematology and Oncology, University Hospital, Frankfurt Main, Germany Department of Paidopathology, University Hospital, Kiel, Germany Department of Radiotherapy, University Hospital, Muenster, Germany Department of Oncology, University Children s Hospital, Zurich, Switzerland
    Ann Surg 259:1166-72. 2014
    ..To analyze the clinical course, treatment, complications, outcome, and quality of life (QOL) in patients with perineal/perianal rhabdomyosarcoma (PRMS) treated within the CWS-86, -91, -96, and -2002P trials...
  17. doi request reprint Cetuximab promotes immunotoxicity against rhabdomyosarcoma in vitro
    Delia Herrmann
    Department of Pediatric Surgery, University Clinic Tübingen, Germany
    J Immunother 33:279-86. 2010
    ..However, cell dependent cytotoxicity of PBMCs to RMS cells such as Rh30 and RD was enhanced specifically by Cetuximab. These promising Cetuximab effects justify analysis under in vivo conditions using suitable models...
  18. ncbi request reprint New trends in tumor biology: transfection of a human hepatoblastoma cell line with green fluorescent protein
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Pediatr Surg 40:653-7. 2005
    ..The aim of this study was to establish an eGFP-transfected human hepatoblastoma (HB) cell line as tool for further basic research studies...
  19. pmc Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma
    Sorin Armeanu-Ebinger
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital Tubingen, Tubingen, Germany
    PLoS ONE 7:e38223. 2012
    ..HC-AFW1 is the first cell line derived from a paediatric HCC without a background of viral hepatitis or cirrhosis and represents a valuable tool for investigating the biology of and therapeutic strategies for childhood HCC...
  20. doi request reprint Surgical treatment of lung metastases in patients with embryonal pediatric solid tumors: an update
    Joerg Fuchs
    Department of Pediatric Surgery and Pediatric Urology, Children s Hospital, University of Tubingen, Tuebingen, Germany
    Semin Pediatr Surg 21:79-87. 2012
    ..An interdisciplinary approach, including pediatric oncology and radiology, is mandatory in any case...
  21. doi request reprint Differential expression of invasion promoting genes in childhood rhabdomyosarcoma
    Sorin Armeanu-Ebinger
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Int J Oncol 38:993-1000. 2011
    ..Functional evaluation of LMO4 and FOXF1 identified targets of a molecular network for preventing metastatic invasion in RMS...
  22. doi request reprint Surgical management of stem cell transplantation-related complications in children
    Justus Lieber
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital, Tuebingen, Germany
    Pediatr Transplant 16:471-9. 2012
    ..Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results...
  23. ncbi request reprint In vitro gene targeting in human hepatoblastoma
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, Hoppe Seyler Street 3, 72076 Tubingen, Germany
    Pediatr Surg Int 22:16-23. 2006
    ..Additionally, we successfully investigated a model of adenovirus-based suicide gene therapy in HB cell cultures. Our data strongly encourage further studies assessing these alternative treatment approaches...
  24. doi request reprint Differential expression of miRNAs in rhabdomyosarcoma and malignant rhabdoid tumor
    Sorin Armeanu-Ebinger
    Department of Pediatric Surgery and Urology, University Children s Hospital, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Exp Cell Res 318:2567-77. 2012
    ..Despite a comparable high rate of metastatic invasion pediatric RMA and MRT show a different pattern of miRNA expression possibly allowing risk stratification...
  25. ncbi request reprint Proteasome inhibition overcomes TRAIL resistance in human hepatoblastoma cells
    Sorin Armeanu-Ebinger
    Department of Pediatric Surgery, University Children s Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Front Biosci (Elite Ed) 4:2194-202. 2012
    ..FLIP and Bcl-2 contributed to the TRAIL resistance in HB. Overcoming TRAIL resistance in HB by proteasome inhibitors has been identified a possible additive to improve treatment results in HB patients with drug resistant tumors...
  26. ncbi request reprint CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro
    Matthias Pfeiffer
    Department of Pediatric Oncology, University Children s Hospital Tuebingen, Tuebingen, Germany
    Front Biosci (Elite Ed) 3:1456-66. 2011
    ..The inclusion of a NK-based immunotherapy into novel treatment strategies might be a promising alternative especially for advanced tumors...
  27. doi request reprint Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Strahlenther Onkol 187:715-21. 2011
    ..Therefore, a planning study combining organ preserving surgery with three different innovative adjuvant radiotherapy approaches was performed...
  28. ncbi request reprint Extended hepatic resection in advanced hepatoblastoma
    Joerg Fuchs
    Department of Pediatric Surgery, University of Tuebingen, Tuebingen, Germany
    Front Biosci (Elite Ed) 4:462-9. 2012
    ..In this article the authors summarize their own experience with advanced liver resections for HB and give an overview over indications and specifications for the different approaches...
  29. doi request reprint Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors
    Jörg Fuchs
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Surg Oncol 17:323-30. 2008
    ..Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings...
  30. doi request reprint Impact of virtual imaging procedures on treatment strategies in children with hepatic vascular malformations
    Jörg Fuchs
    Department of Pediatric Surgery, University Children s Hospital, University of Tubingen, Tuebingen, Germany
    J Pediatr Gastroenterol Nutr 50:67-73. 2010
    ..Virtual imaging procedures have only rarely been analyzed in pediatric populations. We evaluated the role of CT-based virtual surgery planning in pediatric patients experiencing hepatic vascular malformations (HVM)...
  31. doi request reprint Laparoscopically assisted vaginal pull-through for high urogenital sinus: a new surgical technique
    Jörg Fuchs
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital, Tuebingen, Germany
    Urology 79:1180-3. 2012
    ..To evaluate feasibility and outcome of a laparoscopically assisted vaginal pull through procedure for suprasphincteric high urogenital sinus malformation with hydrometrocolpos and normal external genitalia...
  32. ncbi request reprint Molecular imaging and photodynamic therapy in hepatoblastoma
    Guido Seitz
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Front Biosci (Elite Ed) 4:487-92. 2012
    ..This paper reviews different modalities of molecular imaging, photodynamic diagnosis and photodynamic therapy in childhood hepatoblastoma...
  33. ncbi request reprint Neuroblastoma cells expressing the noradrenaline transporter are destroyed more selectively by 6-fluorodopamine than by 6-hydroxydopamine
    G Seitz
    Children s University Hospital Institutes of Organic Chemistry University of Tübingen, Germany
    J Neurochem 75:511-20. 2000
    ..We demonstrate that 6-FDA cytotoxicity is more specific for cells expressing catecholamine reuptake systems than is 6-OHDA cytotoxicity...
  34. doi request reprint Surgical complications in pediatric surgical oncology
    Steven W Warmann
    Department of Pediatric Surgery and Pediatric Urology, University Children s Hospital Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Pediatr Blood Cancer 59:398-404. 2012
    ..This article highlights background and spectrum as well as management of selected surgical complications during or after surgery for abdominal pediatric solid tumors...
  35. ncbi request reprint Transperineal sonography for determination of the type of imperforate anus
    Hans P Haber
    Department of Pediatric Radiology, University of Tubingen, Hoppe Seyler Str 1, D 72076 Tubingen, Germany
    AJR Am J Roentgenol 189:1525-9. 2007
    ..The distinction is critical in determination of the surgical approach...
  36. ncbi request reprint Follow-up of acute osteomyelitis in children: the possible role of PET/CT in selected cases
    Steven W Warmann
    Department of Pediatric Surgery, University Children s Hospital, 72076 Tubingen, Germany
    J Pediatr Surg 46:1550-6. 2011
    ..We analyzed combined positron emission tomography and multislice computed tomography (PET/CT) for this condition...
  37. doi request reprint Vascular encasement as element of risk stratification in abdominal neuroblastoma
    Steven W Warmann
    University Childrens Hospital, Department of Pediatric Surgery, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Surg Oncol 20:231-5. 2011
    ..Some subgroups of this tumor entity are still subject of discussion regarding surgical approach and radicality. Aim of this study was to analyse a cohort of related patients...
  38. doi request reprint Functional outcome after laparoscopic dismembered pyeloplasty in children
    Philipp O Szavay
    Department of Pediatric Surgery, Children s Hospital, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    J Pediatr Urol 6:359-63. 2010
    ..The aim of this study was to evaluate functional outcome for patients who had undergone a laparoscopic dismembered pyeloplasty...
  39. ncbi request reprint Surgical management of extremely low birth weight infants with neonatal bowel perforation: a single-center experience and a review of the literature
    Carmen Eicher
    Department of Pediatric Surgery and Urology, University Children s Hospital, Tubingen, Germany
    Neonatology 101:285-92. 2012
    ..Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are major causes of morbidity in infants with extremely low birth weight (ELBW)...
  40. doi request reprint Long-term quality-of-life after open and laparoscopic sigmoid colectomy
    Guido Seitz
    Department of Pediatric Surgery, University Hospital, Tubingen, Germany
    Surg Laparosc Endosc Percutan Tech 18:162-7. 2008
    ..Laparoscopic sigmoid colectomy (LSC) is frequently performed for sigmoid diseases with excellent prognosis. We aimed to determine the long-term quality-of-life after open sigmoid colectomy (OSC) compared with LSC...
  41. doi request reprint Efficient in vitro generation of adult multipotent cells from mobilized peripheral blood CD133+ cells
    S Kuci
    University Children s Hospital, Department of Hematology Oncology, University of Tubingen, Tubingen, Germany
    Cell Prolif 41:12-27. 2008
    ..To generate non-haematopoietic tissues from mobilized haematopoietic CD133(+) stem cells...
  42. ncbi request reprint Adult-type hepatocellular carcinoma in the center of a fibrolamellar hepatocellular carcinoma
    Guido Seitz
    Department of Visceral and Transplantation Surgery and the Institute of Pathology, University of Berne, Berne, Switzerland
    Hum Pathol 33:765-9. 2002
    ....