- TCDD induces cell migration via NFATc1/ATX-signaling in MCF-7 cellsAnja Seifert
Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06097 Halle Saale, Germany
Toxicol Lett 184:26-32. 2009..Hypoxia did not promote migration of MCF-7 cells, suggesting that ATX down-stream signaling was inhibited by hypoxia. In conclusion, the TCDD-mediated activation of NFATc1 is suggested to promote cell migration via ATX/LPA-signaling...
- TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditionsAnja Seifert
Department of Pharmacology, Otto von Guericke University, D 39120 Magdeburg, Germany
Int J Oncol 35:417-24. 2009..The combination of inhibition of functional p53 protein and induction of ERalpha signaling could serve as a model for the operational sequence of TCDD effects to prevent cell death and promote breast tumor progression...
- Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia-inducible factor-1 alpha signalingAnja Seifert
Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, D 06097 Halle Saale, Germany
Chem Res Toxicol 21:341-8. 2008..We conclude that PHD2 does not mediate the TCDD-mediated HIF-1 alpha destabilization and does not control the interference of AhR and HIF-1 alpha pathways...