Nils Janzen

Summary

Affiliation: Screening-Labor Hannover
Country: Germany

Publications

  1. ncbi request reprint Newborn screening for congenital adrenal hyperplasia: additional steroid profile using liquid chromatography-tandem mass spectrometry
    N Janzen
    Screening Labor Hannover, D 30952 Ronnenberg, Germany
    J Clin Endocrinol Metab 92:2581-9. 2007
  2. doi request reprint UPLC-MS/MS analysis of C5-acylcarnitines in dried blood spots
    Nils Janzen
    Screening Labor Hannover, Hannover, Germany
    Clin Chim Acta 421:41-5. 2013
  3. ncbi request reprint Fast and direct quantification of adrenal steroids by tandem mass spectrometry in serum and dried blood spots
    Nils Janzen
    Screening Laboratory Hannover, c o Box 91 10 09, Hannover D 30430, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 861:117-22. 2008
  4. doi request reprint Energy metabolism in umbilical endothelial cells from preterm and term neonates
    Sabine Illsinger
    Clinic for Paediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    J Perinat Med 39:587-93. 2011
  5. doi request reprint Cyclosporine A: impact on mitochondrial function in endothelial cells
    Sabine Illsinger
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Clin Transplant 25:584-93. 2011
  6. ncbi request reprint Effect of tacrolimus on energy metabolism in human umbilical endothelial cells
    Sabine Illsinger
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Germany
    Ann Transplant 16:68-75. 2011
  7. doi request reprint EDTA in dried blood spots leads to false results in neonatal endocrinologic screening
    Ute Holtkamp
    Screening Labor Hannover, Hannover, Germany
    Clin Chem 54:602-5. 2008
  8. doi request reprint Neonatal screening: identification of children with 11β-hydroxylase deficiency by second-tier testing
    Nils Janzen
    Department of Neuropediatrics, Children s Hospital, Ruhr University of Bochum, Bochum, Germany
    Horm Res Paediatr 77:195-9. 2012
  9. doi request reprint Rapid steroid hormone quantification for congenital adrenal hyperplasia (CAH) in dried blood spots using UPLC liquid chromatography-tandem mass spectrometry
    Nils Janzen
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Steroids 76:1437-42. 2011
  10. doi request reprint Early cataract formation due to galactokinase deficiency: impact of newborn screening
    Nils Janzen
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Arch Med Res 42:608-12. 2011

Detail Information

Publications17

  1. ncbi request reprint Newborn screening for congenital adrenal hyperplasia: additional steroid profile using liquid chromatography-tandem mass spectrometry
    N Janzen
    Screening Labor Hannover, D 30952 Ronnenberg, Germany
    J Clin Endocrinol Metab 92:2581-9. 2007
    ....
  2. doi request reprint UPLC-MS/MS analysis of C5-acylcarnitines in dried blood spots
    Nils Janzen
    Screening Labor Hannover, Hannover, Germany
    Clin Chim Acta 421:41-5. 2013
    ..Metabolic screening including newborn screening requires further differentiation of C5-acylcarnitines in order to separate different metabolic disorders and to detect interferents like pivalic acid originating from antibiotics...
  3. ncbi request reprint Fast and direct quantification of adrenal steroids by tandem mass spectrometry in serum and dried blood spots
    Nils Janzen
    Screening Laboratory Hannover, c o Box 91 10 09, Hannover D 30430, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 861:117-22. 2008
    ..Steroids were measured in MRM mode with electrospray interface (positive ion mode). Validation showed excellent precision, sensitivity, recovery and linearity with coefficients of determination r2>0.992...
  4. doi request reprint Energy metabolism in umbilical endothelial cells from preterm and term neonates
    Sabine Illsinger
    Clinic for Paediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    J Perinat Med 39:587-93. 2011
    ..The aim of this study was to investigate the impact of gestational age on energy metabolism in human umbilical vein endothelial cells (HUVECs) of preterm and term neonates...
  5. doi request reprint Cyclosporine A: impact on mitochondrial function in endothelial cells
    Sabine Illsinger
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Clin Transplant 25:584-93. 2011
    ..Interference of CSA with mitochondrial function may be responsible for these side effects...
  6. ncbi request reprint Effect of tacrolimus on energy metabolism in human umbilical endothelial cells
    Sabine Illsinger
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Germany
    Ann Transplant 16:68-75. 2011
    ..Tacrolimus has a wide spectrum of adverse effects, including neurotoxic and vascular events. Vascular dysfunction due to interference of tacrolimus with mitochondrial function in endothelial cells may contribute to these adverse reactions...
  7. doi request reprint EDTA in dried blood spots leads to false results in neonatal endocrinologic screening
    Ute Holtkamp
    Screening Labor Hannover, Hannover, Germany
    Clin Chem 54:602-5. 2008
    ..Occasionally these samples are contaminated with EDTA, which is often used for anticoagulation. EDTA may interfere with newborn screening tests based on lanthanide fluorescence and thus lead to false-negative or false-positive results...
  8. doi request reprint Neonatal screening: identification of children with 11β-hydroxylase deficiency by second-tier testing
    Nils Janzen
    Department of Neuropediatrics, Children s Hospital, Ruhr University of Bochum, Bochum, Germany
    Horm Res Paediatr 77:195-9. 2012
    ..We describe the additional detection of patients suffering from 11β-hydroxylase deficiency (11-OHD) by second-tier testing...
  9. doi request reprint Rapid steroid hormone quantification for congenital adrenal hyperplasia (CAH) in dried blood spots using UPLC liquid chromatography-tandem mass spectrometry
    Nils Janzen
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Steroids 76:1437-42. 2011
    ..The method is not influenced by cross reactions as found on immunoassay. Analysis of dried blood spots shows that this method is sensitive and fast enough to allow rapid analysis and can therefore improve the newborn screening program...
  10. doi request reprint Early cataract formation due to galactokinase deficiency: impact of newborn screening
    Nils Janzen
    Clinic for Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Arch Med Res 42:608-12. 2011
    ..The aim of this retrospective study was to explore whether GALK-deficiency meets the criteria for neonatal mass screening programs...
  11. ncbi request reprint Newborn screening for hepatorenal tyrosinemia: Tandem mass spectrometric quantification of succinylacetone
    Johannes Sander
    Screening Laboratory, Hannover, Germany
    Clin Chem 52:482-7. 2006
    ..We present our experience with a newly described method for succinylacetone quantification in routine newborn screening...
  12. doi request reprint Monitoring tyrosinaemia type I: Blood spot test for nitisinone (NTBC)
    Johannes Sander
    Screening Laboratory Hannover, Hannover, Germany
    Clin Chim Acta 412:134-8. 2011
    ..We developed a blood spot test to facilitate collection and transport of samples. Furthermore, the test material can be used for determination of other parameters like tyrosine and succinylacetone...
  13. ncbi request reprint Neonatal screening for defects of the mitochondrial trifunctional protein
    Johannes Sander
    Screening Laboratory, Hannover, Postfach 911009, D 30430 Hannover, Germany
    Mol Genet Metab 85:108-14. 2005
    ..Finally, extension of analysis to MTP deficiencies is achieved without additional costs for screening laboratories already using TMS...
  14. ncbi request reprint Neonatal screening for citrullinaemia
    Johannes Sander
    Screeninglabor, 30430 Hannover, Germany
    Eur J Pediatr 162:417-20. 2003
    ..In one child who developed severe hyperammonaemia on the 2nd day of life, sequelae could not be avoided...
  15. doi request reprint A case of 11beta-hydroxylase deficiency detected in a newborn screening program by second-tier LC-MS/MS
    M Peter
    Screening Labor Hannover, Hannover, Germany
    Horm Res 69:253-6. 2008
    ..The objective is to show that the diagnosis of 11beta-hydroxylase deficiency can be done using a dried blood spot from newborn screening...
  16. doi request reprint Preeclampsia and HELLP syndrome: impaired mitochondrial function in umbilical endothelial cells
    Sabine Illsinger
    Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
    Reprod Sci 17:219-26. 2010
    ..Impaired mitochondrial function in HUVEC is associated with PE/HELLP syndrome and may be involved in the pathophysiology of these diseases...
  17. pmc Macro-AST: misleading finding in an adolescent with MCAD-deficiency
    Anibh M Das
    Department of Paediatrics, Hannover Medical School, Hannover, Germany
    BMC Gastroenterol 12:119. 2012
    ..In anabolism, neither clinical symptoms nor biochemical signs of organ dysfunction occur...