Holger Schwender

Summary

Country: Germany

Publications

  1. doi request reprint Imputing missing genotypes with weighted k nearest neighbors
    Holger Schwender
    Statistics, TU Dortmund University, Dortmund, Germany
    J Toxicol Environ Health A 75:438-46. 2012
  2. pmc Rapid testing of SNPs and gene-environment interactions in case-parent trio data based on exact analytic parameter estimation
    Holger Schwender
    TU Dortmund University, 44221 Dortmund, Germany
    Biometrics 68:766-73. 2012
  3. ncbi request reprint Identification of SNP interactions using logic regression
    Holger Schwender
    Department of Statistics, University of Dortmund, 44221 Dortmund, Germany
    Biostatistics 9:187-98. 2008
  4. pmc Testing SNPs and sets of SNPs for importance in association studies
    Holger Schwender
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
    Biostatistics 12:18-32. 2011
  5. pmc Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate
    Terri H Beaty
    School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, Maryland, USA
    Genet Epidemiol 35:469-78. 2011
  6. pmc Examining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans
    Tanda Murray
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Genet Epidemiol 36:392-9. 2012
  7. pmc Fast detection of de novo copy number variants from SNP arrays for case-parent trios
    Robert B Scharpf
    Department of Oncology, Johns Hopkins University, Baltimore, MD, USA
    BMC Bioinformatics 13:330. 2012
  8. doi request reprint Logic regression and its extensions
    Holger Schwender
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Adv Genet 72:25-45. 2010
  9. pmc Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions
    Margaret A Taub
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205 2179, USA
    Genet Epidemiol 36:225-34. 2012
  10. pmc Empirical Bayes analysis of single nucleotide polymorphisms
    Holger Schwender
    Collaborative Research Center 475, Faculty of Statistics, Dortmund University of Technology, 44221 Dortmund, Germany
    BMC Bioinformatics 9:144. 2008

Collaborators

Detail Information

Publications20

  1. doi request reprint Imputing missing genotypes with weighted k nearest neighbors
    Holger Schwender
    Statistics, TU Dortmund University, Dortmund, Germany
    J Toxicol Environ Health A 75:438-46. 2012
    ..Moreover, KNNcatImpute can also be applied to data from genome-wide association studies, as an application to a subset of the HapMap data demonstrates...
  2. pmc Rapid testing of SNPs and gene-environment interactions in case-parent trio data based on exact analytic parameter estimation
    Holger Schwender
    TU Dortmund University, 44221 Dortmund, Germany
    Biometrics 68:766-73. 2012
    ....
  3. ncbi request reprint Identification of SNP interactions using logic regression
    Holger Schwender
    Department of Statistics, University of Dortmund, 44221 Dortmund, Germany
    Biostatistics 9:187-98. 2008
    ....
  4. pmc Testing SNPs and sets of SNPs for importance in association studies
    Holger Schwender
    Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
    Biostatistics 12:18-32. 2011
    ..We show how the proposed procedure can be adapted for testing SNP sets, and how it can be applied to blocks of SNPs in linkage disequilibrium (LD) to overcome problems caused by LD...
  5. pmc Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate
    Terri H Beaty
    School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, Maryland, USA
    Genet Epidemiol 35:469-78. 2011
    ..8. These results emphasize the need to consider G × E interaction when searching for genes influencing risk to complex and heterogeneous disorders, such as nonsyndromic CP...
  6. pmc Examining markers in 8q24 to explain differences in evidence for association with cleft lip with/without cleft palate between Asians and Europeans
    Tanda Murray
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Genet Epidemiol 36:392-9. 2012
    ....
  7. pmc Fast detection of de novo copy number variants from SNP arrays for case-parent trios
    Robert B Scharpf
    Department of Oncology, Johns Hopkins University, Baltimore, MD, USA
    BMC Bioinformatics 13:330. 2012
    ..We evaluate these issues in a study of oral cleft case-parent trios...
  8. doi request reprint Logic regression and its extensions
    Holger Schwender
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Adv Genet 72:25-45. 2010
    ....
  9. pmc Incorporating genotype uncertainties into the genotypic TDT for main effects and gene-environment interactions
    Margaret A Taub
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205 2179, USA
    Genet Epidemiol 36:225-34. 2012
    ..We find that by far the least biased results are obtained when family structure is taken into account and currently recommend this approach in spite of its intense computational requirements...
  10. pmc Empirical Bayes analysis of single nucleotide polymorphisms
    Holger Schwender
    Collaborative Research Center 475, Faculty of Statistics, Dortmund University of Technology, 44221 Dortmund, Germany
    BMC Bioinformatics 9:144. 2008
    ..However, the empirical Bayes analysis of microarrays has only been suggested for binary responses when considering expression values, i.e. continuous predictors...
  11. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
    ..Expression studies support a role for MAFB in palatal development...
  12. doi request reprint Classification with high-dimensional genetic data: assigning patients and genetic features to known classes
    Holger Schwender
    Technische Universitat Dortmund, Fakultat Statistik, Vogelpothsweg 87, Dortmund, Germany
    Biom J 50:911-26. 2008
    ..Finally, we show how the resulting statistical models can be validated...
  13. doi request reprint Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype
    Silvia Selinski
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    Pharmacogenet Genomics 21:673-8. 2011
    ..This procedure represents a facilitation in individualized dosing of NAT2 substrates without losing sensitivity or specificity...
  14. ncbi request reprint A pilot study on the application of statistical classification procedures to molecular epidemiological data
    Holger Schwender
    Department of Statistics, Collaborative Research Centre 475, University of Dortmund, Dortmund, Germany
    Toxicol Lett 151:291-9. 2004
    ..The findings, nevertheless, suggest that SNP data might be useful for the classification of individuals into categories of high or low risk of diseases...
  15. pmc Importance measures for epistatic interactions in case-parent trios
    Holger Schwender
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21218, USA
    Ann Hum Genet 75:122-32. 2011
    ..We illustrate the performance of the novel procedure in simulation studies and in a case study of 461 case-parent trios with autistic children...
  16. pmc Efficient simulation of epistatic interactions in case-parent trios
    Qing Li
    Statistical Genetics Section, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Hum Hered 75:12-22. 2013
    ....
  17. doi request reprint Integrated analysis of copy number alterations and gene expression: a bivariate assessment of equally directed abnormalities
    Martin Schafer
    Collaborative Research Center 475, TU Dortmund University, Dortmund, Germany
    Bioinformatics 25:3228-35. 2009
    ..We employ this approach, based on a modified correlation coefficient and an explorative Wilcoxon test, to find DNA regions of such abnormalities in GE and CN (e.g. underexpressed genes accompanied by a loss of DNA material)...
  18. ncbi request reprint Detecting high-order interactions of single nucleotide polymorphisms using genetic programming
    Robin Nunkesser
    Collaborative Research Center 475, Department of Computer Science, University of Dortmund, Dortmund, Germany
    Bioinformatics 23:3280-8. 2007
    ..This method called GPAS cannot only be used for feature selection, but can also be employed for discrimination...
  19. doi request reprint Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139, Dortmund, Germany
    Arch Toxicol 85:539-54. 2011
    ..In future, besides identifying novel disease-associated rare variants by deep sequencing, it will also be important to understand how the already identified variants interact...
  20. doi request reprint Statistical methods for detecting genetic interactions: a head and neck squamous-cell cancer study
    Katja Ickstadt
    Fakultat Statistik, Collaborative Research Centre 475, Technische Universitat Dortmund, Dortmund
    J Toxicol Environ Health A 71:803-15. 2008
    ....