T Schwarz

Summary

Country: Germany

Publications

  1. doi request reprint Pimecrolimus: a novel treatment for cetuximab-induced papulopustular eruption
    Elisabeth Eiling
    Arch Dermatol 144:1236-8. 2008
  2. ncbi request reprint [Effects of ultraviolet radiation on the immune system]
    Thomas Schwarz
    Hautklinik, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 1:142-50; quiz 151-2. 2003
  3. ncbi request reprint Skin immunity
    T Schwarz
    Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Br J Dermatol 149:2-4. 2003
  4. ncbi request reprint Photoimmunosuppression
    T Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Photodermatol Photoimmunol Photomed 18:141-5. 2002
  5. ncbi request reprint UV light affects cell membrane and cytoplasmic targets
    T Schwarz
    Department of Dermatology, University Munster, Germany
    J Photochem Photobiol B 44:91-6. 1998
  6. ncbi request reprint IL-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesis
    S Beissert
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 167:6232-8. 2001
  7. ncbi request reprint Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation
    S Beissert
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 163:6725-31. 1999
  8. pmc Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    A Mehling
    Ludwig Boltzmann Institute for Cell Biology, Department of Dermatology and Immunology of the Skin, University of Munster, D 49149 Münster, Germany
    J Exp Med 194:615-28. 2001
  9. ncbi request reprint Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage
    M S Labeur
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 162:168-75. 1999
  10. ncbi request reprint CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide
    K Mahnke
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    Adv Exp Med Biol 417:145-59. 1997

Detail Information

Publications99

  1. doi request reprint Pimecrolimus: a novel treatment for cetuximab-induced papulopustular eruption
    Elisabeth Eiling
    Arch Dermatol 144:1236-8. 2008
  2. ncbi request reprint [Effects of ultraviolet radiation on the immune system]
    Thomas Schwarz
    Hautklinik, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 1:142-50; quiz 151-2. 2003
  3. ncbi request reprint Skin immunity
    T Schwarz
    Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Br J Dermatol 149:2-4. 2003
    ..However, the skin does not only function as a mechanical barrier but also uses the immune system for protection. Therefore, the skin is endowed with the capacity to generate immune responses of the innate as well as of the adaptive type...
  4. ncbi request reprint Photoimmunosuppression
    T Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Photodermatol Photoimmunol Photomed 18:141-5. 2002
    ..In the following, some of the basic mechanisms underlying UV-induced immunosuppression will be discussed...
  5. ncbi request reprint UV light affects cell membrane and cytoplasmic targets
    T Schwarz
    Department of Dermatology, University Munster, Germany
    J Photochem Photobiol B 44:91-6. 1998
    ..Recently, we observed that UV can interfere with cytokine signalling and induce apoptosis via direct activation of apoptosis-related surface receptors. These findings will be briefly reviewed in the paper...
  6. ncbi request reprint IL-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesis
    S Beissert
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 167:6232-8. 2001
    ..These data strongly indicate the importance of cis-UCA during photocarcinogenesis and support the concept of counteracting cis-UCA as an alternative strategy to prevent UV-induced skin cancer, possibly via the application of IL-12...
  7. ncbi request reprint Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation
    S Beissert
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 163:6725-31. 1999
    ..Together, these data show that overall B7 engagement directs immune responses toward the Th2 pathway. Moreover, they point out the crucial role of Th1 immune reactions in the protection against photocarcinogenesis...
  8. pmc Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    A Mehling
    Ludwig Boltzmann Institute for Cell Biology, Department of Dermatology and Immunology of the Skin, University of Munster, D 49149 Münster, Germany
    J Exp Med 194:615-28. 2001
    ....
  9. ncbi request reprint Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage
    M S Labeur
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 162:168-75. 1999
    ..The present data support the clinical use of mature, rather than immature, tumor Ag-pulsed dendritic cells as cancer vaccines and identifies CD40L as a potent stimulus to enhance their in vivo Ag-presenting capacity...
  10. ncbi request reprint CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide
    K Mahnke
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    Adv Exp Med Biol 417:145-59. 1997
    ..Thus, M phi and DC cannot be distinguished by flow cytometry using these markers. Moreover, CD14 may be involved in mediating LPS-induced activation of murine DC...
  11. ncbi request reprint Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity
    M Bohm
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 117:132-40. 2001
    ....
  12. ncbi request reprint Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system
    A Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, Germany
    J Immunol 160:4262-70. 1998
    ..The ability of IL-12 to break established tolerance may be due to the prevention of DC death induced by T suppressor cells...
  13. ncbi request reprint Ultraviolet radiation-induced interleukin 6 release in HeLa cells is mediated via membrane events in a DNA damage-independent way
    D Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, D 48149 Munster, Germany
    J Biol Chem 275:15060-6. 2000
    ..These data demonstrate that UV can exert biological effects mainly by affecting cell surface receptors and that this is independent of its ability to induce nuclear DNA damage...
  14. ncbi request reprint Role of epidermal cell-derived alpha-melanocyte stimulating hormone in ultraviolet light mediated local immunosuppression
    T A Luger
    Department of Dermatology, University of Munster, Germany
    Ann N Y Acad Sci 885:209-16. 1999
    ..The therapeutic application of alpha MSH or alpha MSH-derived peptides may prove to be a useful approach for treating inflammatory skin diseases...
  15. ncbi request reprint Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes
    D Kulms
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, , Von-Esmarchstrasse 58, , Germany
    J Biol Chem 276:12849-55. 2001
    ..Because STAT5-mediated IL-2 effects are vital for normal immune functions, inhibition of STAT5 signaling by UV may contribute to its well known immunosuppressive properties...
  16. ncbi request reprint Transfection of immature murine bone marrow-derived dendritic cells with the granulocyte-macrophage colony-stimulating factor gene potently enhances their in vivo antigen-presenting capacity
    C Curiel-Lewandrowski
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 163:174-83. 1999
    ..These results show that GM-CSF gene transfection significantly enhances the capacity of DC to induce primary immune responses in vivo, which might also improve DC-based vaccines currently under clinical investigation...
  17. ncbi request reprint An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 174:5298-305. 2005
    ..Furthermore, CD86-mediated costimulation appears to play a more critical role in the protection against photocarcinogenesis than CD80...
  18. ncbi request reprint Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome
    E Strozyk
    Department of Dermatology, University of Muenster, Muenster, Germany
    Oncogene 25:6239-51. 2006
    ..This may have implications for the role of NF-kappaB in carcinogenesis and for the application of NF-kappaB inhibitors in anticancer therapy...
  19. ncbi request reprint Enhanced photocarcinogenesis in interleukin-12-deficient mice
    Akira Maeda
    Department of Dermatology, University Kiel, Kiel, Germany
    Cancer Res 66:2962-9. 2006
    ..Together, these data indicate that IL-12 deficiency is associated with an increased risk to develop UV-induced skin cancer, implying that endogenous IL-12 may protect from photocarcinogenesis...
  20. ncbi request reprint IL-10 controls ultraviolet-induced carcinogenesis in mice
    Karin Loser
    Department of Dermatology and Interdisciplinary Center of Clinical Research, Interdisziplinäres Zentrum für Klinische Forschung, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    J Immunol 179:365-71. 2007
    ..Moreover, these results point out the crucial role of Th1 responses and UV-induced regulatory T cell function in the protection against UV-induced tumor development...
  21. ncbi request reprint Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells
    Akira Maeda
    Department of Dermatology, University Kiel, Kiel, Germany
    J Immunol 180:3065-71. 2008
    ..However, constant boosting of Treg with Ag doses in the challenging range results in final sensitization that might limit their therapeutic potential...
  22. doi request reprint DNA repair and cytokine responses
    Thomas Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Investig Dermatol Symp Proc 14:63-6. 2009
    ..The mechanisms involved and the biological as well as the potential therapeutic implications of these findings are discussed.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 63-66; doi:10.1038/jidsymp.2009.3...
  23. ncbi request reprint Resistance of human melanoma cells against the death ligand TRAIL is reversed by ultraviolet-B radiation via downregulation of FLIP
    Elke Zeise
    Department of Dermatology, University Munster, Munster, Germany
    J Invest Dermatol 123:746-54. 2004
    ..This study indicates that (i) the expression level and the processing status of FLIP may play a crucial role in determining the sensitivity of melanoma cells towards TRAIL and (ii) expression of FLIP is regulated by UVB...
  24. doi request reprint IL-23 antagonizes UVR-induced immunosuppression through two mechanisms: reduction of UVR-induced DNA damage and inhibition of UVR-induced regulatory T cells
    Sebastian Majewski
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 130:554-62. 2010
    ..IL-23 shares with IL-12 the still unique capacity to restore suppressed immune responses because of its effect on Treg...
  25. ncbi request reprint UV-induced production of immunosuppressive mediators in human skin: prevention by a broadspectrum sunscreen
    D H Kalden
    Ludwig Boltzmann Instute of Cell and Immunobiology of the Skin, University of Munster, Munster, Germany
    Eur J Dermatol 12:XV-XVI. 2002
  26. ncbi request reprint Intracellular persistence of Staphylococcus aureus small-colony variants within keratinocytes: a cause for antibiotic treatment failure in a patient with darier's disease
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Clin Infect Dis 32:1643-7. 2001
    ..The presence of intracellular S. aureus SCVs may protect against host defenses and antibiotic therapy and thus may have contributed to this patient's very prolonged skin infection...
  27. ncbi request reprint [Topical interferon-beta: an additional treatment for ulcerated mycosis fungoides]
    H Stander
    Klinik und Poliklinik für allgemeine Dermatologie, Westfalische Wilhelms Universitat Munster, Von Esmarch Strasse 56, 48149 Munster
    Hautarzt 52:882-4. 2001
    ..This observation suggests topical interferon-beta may be an effective adjuvant strategy to be combined with systemic therapy...
  28. ncbi request reprint Pyodera gangrenosum after aortic valve replacement
    M Rothenburger
    Department of Cardiothoracic Surgery, Westfalian Wilhelms University, Muenster, Germany
    Ann Thorac Surg 71:349-51. 2001
    ..Pyoderma gangrenosum is a potential life-threatening complication that must be considered in patients with severely impaired wound healing after cardiac operation...
  29. ncbi request reprint [G-DRG Version 2004: changes in view of dermatology]
    Peter Hensen
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster, Germany
    J Dtsch Dermatol Ges 2:15-23. 2004
    ..Additionally, the revised classification system versions OPS-301 SGB V and ICD-10-GM 2004 and the German coding standards version 2004 must be appropriately applied for dermatologic purposes...
  30. ncbi request reprint [Disseminated erythematous maculae with central bullae formation. Generalized fixed drug exanthema]
    Stefan Werner Schneider
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 2:143-6. 2004
  31. ncbi request reprint IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Immunol 176:2896-901. 2006
    ..Though being primarily a proinflammatory cytokine through this capacity, IL-18 can also foster an immune response that is suppressed by UV radiation...
  32. ncbi request reprint [DRGs in dermatology: quality of coding and the effects of case mix]
    Peter Hensen
    Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
    J Dtsch Dermatol Ges 1:36-45. 2003
    ..The aim of the study was to determine the effect of controlled documentation on patient clinical data and to ascertain the outcome of calculated DRG-based yields depending on higher coding quality of patient treatment...
  33. ncbi request reprint [Pathomechanisms of the elicitation phase of allergic contact dermatitis]
    Helge Riemann
    Universitätshautklinik Münster
    J Dtsch Dermatol Ges 1:613-9. 2003
    ..Detailed knowledge about the mechanisms of the elicitation phase of ACD is needed in order to develop novel therapeutic approaches...
  34. ncbi request reprint [Therapy of atopic eczema with calcineurin inhibitors]
    Thomas A Luger
    Hautklinik, Universitätsklinikkum Münster, Deutschland
    J Dtsch Dermatol Ges 3:385-91. 2005
  35. ncbi request reprint Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    Karin Loser
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    Nat Med 12:1372-9. 2006
    ..Therefore, environmental stimuli at the skin can rewire the local and systemic immune system by means of RANKL...
  36. ncbi request reprint Embolia cutis medicamentosa following subcutaneous injection of glatiramer acetate
    Viola Harde
    Department of Dermatology, Allergy and Venereology, University of Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 5:1122-3. 2007
    ..ECM can be easily differentiated from the latter by its typical clinical features...
  37. doi request reprint A randomized, double-blind, vehicle-controlled study of 1% pimecrolimus cream in adult patients with perioral dermatitis
    Thomas Schwarz
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Am Acad Dermatol 59:34-40. 2008
    ..Perioral dermatitis (POD) is a common dermatosis without standard therapy...
  38. doi request reprint Langerhans cells are required for UVR-induced immunosuppression
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 130:1419-27. 2010
    ..This supports the concept that LCs are more important for the downregulation than the induction of immune responses in the skin...
  39. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed in normal skin and cutaneous inflammatory diseases, but not in chronically UV-exposed skin and non-melanoma skin cancer
    Sonja Ständer
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University Clinics Münster, Munster, Germany
    Am J Dermatopathol 27:116-21. 2005
    ..Down-regulation of TRAIL might represent another example of a natural protection mechanism that is eliminated by chronic UV exposure...
  40. ncbi request reprint Independent contribution of three different pathways to ultraviolet-B-induced apoptosis
    Dagmar Kulms
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Münster D 48149, Munster, Germany
    Biochem Pharmacol 64:837-41. 2002
    ..The following review will briefly discuss current aspects of the interplay between the different signaling pathways involved in UVB-induced apoptosis...
  41. ncbi request reprint Role of immunomodulation in diseases responsive to phototherapy
    Stefan Beissert
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Methods 28:138-44. 2002
    ..Most of the effects of both ambient and therapeutic ultraviolet radiation are immunosuppressive in nature...
  42. ncbi request reprint alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Von Esmarch Str 58, D 48149 Munster, Germany
    J Biol Chem 280:5795-802. 2005
    ....
  43. ncbi request reprint Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology and the Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    J Biol Chem 279:6959-66. 2004
    ..Melanocortins such as alpha-MSH may therefore represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders...
  44. pmc Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells
    Stephan Grabbe
    Department of Dermatology, University of Munster, Munster, Germany
    J Clin Invest 109:183-92. 2002
    ..Thus, a dysfunction of T cells, in addition to granulocytes, may contribute to the pathophysiology of leukocyte adhesion deficiency type I, which arises from mutations in the human CD18 gene...
  45. ncbi request reprint Impaired cutaneous immune responses in Thy-1-deficient mice
    S Beissert
    Department of Dermatology, Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Germany
    J Immunol 161:5296-302. 1998
    ..Taken together, these findings demonstrate that a lack of Thy-1 expression does not generally compromise the immune system; however, Thy-1 expression may be involved in the fine-tuning of T cell-mediated immune responses...
  46. ncbi request reprint Mechanisms of UV-induced immunosuppression
    Thomas Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    Keio J Med 54:165-71. 2005
    ..Studies addressing the molecular mechanisms underlying UV-induced immunosuppression will contribute to a better understanding how UV acts as a pathogen but on the other hand can be also used as a therapeutic tool...
  47. ncbi request reprint Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
    ..Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines...
  48. ncbi request reprint Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: generation of IL-10 and induction of regulatory T cells
    Akira Maeda
    Department of Dermatology, University Kiel, Kiel, Germany
    J Immunol 181:5956-62. 2008
    ..Together, this may help explain the clinical benefits of ECP in prophylactic, acute, and therapeutic settings...
  49. ncbi request reprint Mechanisms of UV-induced signal transduction
    Dagmar Kulms
    Ludwing Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, Germany
    J Dermatol 29:189-96. 2002
    ..The following review will briefly discuss current aspects of the mechanisms involved in UV-induced signal transduction...
  50. doi request reprint The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption
    Regine Gläser
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 129:641-9. 2009
    ..coli. This indicates that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin...
  51. doi request reprint Infrared radiation confers resistance to UV-induced apoptosis via reduction of DNA damage and upregulation of antiapoptotic proteins
    Christian Jantschitsch
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 129:1271-9. 2009
    ..As, however, IR reduces UV-induced DNA damage, the balance between these two effects may be important. Thus, in vivo carcinogenesis studies are required to define the role of IR and its interaction with UV in photocarcinogenesis...
  52. ncbi request reprint New insight into immunosuppression and treatment of autoimmune diseases
    M Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    Clin Exp Rheumatol 24:S67-71. 2006
    ..However, there is urgent need for specific immunointervention and further therapeutic options, especially for patients with autoimmune diseases in life-threatening situations and for non-responders to standard immunosuppression...
  53. ncbi request reprint Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1)
    D Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, D 48149 Munster, Germany
    Cell Death Differ 9:598-608. 2002
    ..These data suggest that disruption of the cytoskeleton causes apoptosis via activation of CD95 and enhances UV-induced apoptosis, possibly via aiding receptor clustering...
  54. ncbi request reprint IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines
    Y Aragane
    Ludwig Boltzmann Institute for Cellbiology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Immunol 153:5366-72. 1994
    ..Thus, one may speculate that keratinocytes via this capacity may influence the fate of Th-mediated immune responses, favoring Th1 responses by enhanced production of IL-12 or Th2 responses by reduced IL-12 release...
  55. ncbi request reprint Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Allergy Clin Immunol 124:R19-28. 2009
    ..Because pimecrolimus improved the epidermal barrier and did not cause atrophy, it might be more suitable for long-term treatment of AD...
  56. ncbi request reprint Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells
    Agatha Schwarz
    Department of Dermatology, University Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    J Immunol 178:877-86. 2007
    ..v. injection. This finding shows that the migratory behavior can be reprogrammed by tissue-specific DC and may have input on strategies trying to use Treg not only for the prevention but also for the treatment of immune-mediated diseases...
  57. ncbi request reprint NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis
    Birgit Poppelmann
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    J Biol Chem 280:15635-43. 2005
    ..Taken together, elucidation of the molecular mechanisms underlying IL-1-mediated enhancement of UVB-induced apoptosis revealed that NFkappaB does not exclusively act in an antiapoptotic fashion but may also mediate proapoptotic effects...
  58. doi request reprint The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions
    Paula Velasco
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 129:2022-30. 2009
    ..Our results indicate that TSP-1 downregulates cutaneous delayed-type hypersensitivity reactions by acting on several distinct pathways mediating skin inflammation...
  59. ncbi request reprint Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells
    Akira Maeda
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, Munster, Germany
    J Immunol 174:5968-76. 2005
    ..Transfer activity was lost when cells were depleted of CD4(+) or CD25(+) subpopulations. These data suggest that photopheresis exerts its immunomodulatory effects via the induction of Ag-specific regulatory T cells...
  60. pmc Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, D 48149 Munster, Germany
    J Exp Med 201:173-9. 2005
    ..These data identify a new mechanism by which IL-12 can restore immune responses and also demonstrate a link between DNA repair and the prevention of UV-induced immunosuppression by IL-12...
  61. doi request reprint UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype
    Agatha Schwarz
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 130:1914-21. 2010
    ..Together, this indicates that activated UVR-Treg can alter APCs in such a way that they lose their sensitizing capacity but in turn induce Treg. Thus, UVR-Tregs switch APCs from a stimulatory to a regulatory phenotype...
  62. ncbi request reprint Molecular determinants of UV-induced immunosuppression
    Agatha Schwarz
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    Exp Dermatol 11:9-12. 2002
    ..Hence, it is tempting to speculate that the activity of IL-12 to reduce UV-induced immunosuppression may be due at least partially to this new biological activity of IL-12...
  63. ncbi request reprint DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way
    Dagmar Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, Germany
    Oncogene 21:5844-51. 2002
    ..This indicates that DNA damage, death receptor activation and ROS formation contribute to UVB-induced apoptosis in an essential and independent way...
  64. doi request reprint Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Allergy Clin Immunol 123:1124-33. 2009
    ..It is essential that drugs applied to patients with AD restore the impaired epidermal barrier to prevent sensitization by environmental allergens...
  65. ncbi request reprint Phototherapy: how does UV work?
    Michael Weichenthal
    Department of Dermatology, University Kiel, Kiel, Germany
    Photodermatol Photoimmunol Photomed 21:260-6. 2005
    ..Another major mechanism is the induction of immunosuppression. This review primarily focuses on recent advances in photoimmunology which will contribute to the further understanding how phototherapy acts...
  66. doi request reprint Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis
    J M Jensen
    Department of Dermatology, University of Kiel, Germany
    Allergy 67:413-23. 2012
    ..We recently showed that betamethasone valerate (BM) although clinically more efficient impaired skin barrier repair in contrast to pimecrolimus in AD...
  67. doi request reprint Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12
    Agatha Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    Photochem Photobiol 84:350-5. 2008
    ..Hence the previously reported UV-protective effects of GTP appear to be mediated in human cells via IL-12, most likely through induction of DNA repair...
  68. doi request reprint Eczematous malignant melanoma: a wolf in sheep's clothing
    Cornelius Mensing
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Onkologie 32:206-8. 2009
    ..The clinical diagnosis of amelanotic melanoma is still a challenge...
  69. ncbi request reprint Molecular mechanisms involved in UV-induced apoptotic cell death
    Dagmar Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Munster, Munster, Germany
    Skin Pharmacol Appl Skin Physiol 15:342-7. 2002
    ..The following review will briefly discuss current aspects of the interplay between the different signaling pathways involved in UV-induced apoptosis...
  70. doi request reprint The dark and the sunny sides of UVR-induced immunosuppression: photoimmunology revisited
    Thomas Schwarz
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 130:49-54. 2010
    ..Thus, suppression of the adaptive and induction of the innate immune system by UVR may be components of a physiological protection process. These insights might have effect on the future recommendations for daily sun protection...
  71. ncbi request reprint Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15
    Karin Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Eur J Immunol 34:2022-31. 2004
    ..Together, our results show that overexpression of IL-15 in the epidermis enhances both innate and adaptive cutaneous immunity...
  72. ncbi request reprint Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    J Immunol 172:1036-43. 2004
    ..v. injection, because they obviously do not migrate into the skin...
  73. doi request reprint Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    Jurgen Harder
    Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 130:1355-64. 2010
    ..Thus, a disturbed skin barrier may trigger AMP induction in AD and psoriasis. The functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis...
  74. doi request reprint Multiple skin metastases of malignant melanoma with unusual clinical and histopathologic features in an immunosuppressed patient
    Friederike Egberts
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany
    J Am Acad Dermatol 58:880-4. 2008
    ..The atypical clinical and histopathologic appearance of the melanocytic lesions as well as the course of disease may have been influenced by the immunosuppression...
  75. doi request reprint Multiple squamous cell carcinomas in junctional epidermolysis bullosa: a surgical challenge
    Eva Beatrice Mohr
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Dermatol Surg 34:1131-6. 2008
  76. ncbi request reprint Treatment of severe lichen planus with mycophenolate mofetil
    Uta Frieling
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    J Am Acad Dermatol 49:1063-6. 2003
    ..Mycophenolate mofetil was well tolerated and induced complete remission in 2 patients, and substantial improvement in the third patient...
  77. ncbi request reprint Novel anti-inflammatory properties of the angiogenesis inhibitor vasostatin
    Rainer Huegel
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 127:65-74. 2007
    ..These results reveal a previously unrecognized anti-inflammatory property of the angiogenesis inhibitor vasostatin, and suggest that vasostatin is a potential candidate drug for the treatment of inflammation...
  78. doi request reprint Melanocytic schwannoma of the cutaneous and subcutaneous tissues: three cases and a review of the literature
    Katharina C Kaehler
    Department of Dermatology, University of Kiel, Kiel, Germany
    Melanoma Res 18:438-42. 2008
    ..Owing to the lack of clinical trials, we recommend that patients be treated according to the existing guidelines for melanoma...
  79. ncbi request reprint 20 years after--milestones in molecular photobiology
    Dagmar Kulms
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Germany
    J Investig Dermatol Symp Proc 7:46-50. 2002
    ....
  80. ncbi request reprint Regulatory T cells
    Stefan Beissert
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 126:15-24. 2006
    ..Detailed knowledge about the phenotype and mode of action of these cells will significantly increase our understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies...
  81. ncbi request reprint The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression
    Nicole Rockel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Dusseldorf, Germany
    J Immunol 179:3604-12. 2007
    ..Thus, similar to nucleotide excision repair, taurine uptake is critically involved in photoprotection of the skin...
  82. ncbi request reprint Involvement of dectin-2 in ultraviolet radiation-induced tolerance
    Yoshinori Aragane
    Department of Dermatology, Kinki University School of Medicine, Osaka, Japan
    J Immunol 171:3801-7. 2003
    ..Moreover, sDec2-reactive T cells appear to represent the regulatory T cells responsible for mediating UV-induced tolerance...
  83. ncbi request reprint [Ultraviolet radiation--immune response]
    Thomas Schwarz
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 3:S11-8. 2005
    ....
  84. doi request reprint 25 years of UV-induced immunosuppression mediated by T cells-from disregarded T suppressor cells to highly respected regulatory T cells
    Thomas Schwarz
    Department of Dermatology and Allergology, Christian Albrechts University Kiel, Kiel, Germany
    Photochem Photobiol 84:10-8. 2008
    ....
  85. ncbi request reprint IL-12 breaks dinitrothiocyanobenzene (DNTB)-mediated tolerance and converts the tolerogen DNTB into an immunogen
    Helge Riemann
    Department of Dermatology, UCHSC at Fitzsimons, Aurora, CO 80010, USA
    J Immunol 175:5866-74. 2005
    ....
  86. ncbi request reprint Biological effects of UV radiation on keratinocytes and Langerhans cells
    Thomas Schwarz
    Department of Dermatology and Allergology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Exp Dermatol 14:788-9. 2005
  87. ncbi request reprint NF-kappaB and cytokines
    Dagmar Kulms
    Department of Cell Biology and Immunology, University of Stuttgart, D 70569 Stuttgart, Germany
    Vitam Horm 74:283-300. 2006
    ..This cross talk needs to be taken into account when developing strategies targeting NF-kappaB for anticancer therapy...
  88. ncbi request reprint [Topical skin therapy with glucocorticoids--therapeutic index]
    Thomas Luger
    Universitäts Hautklinik Münster
    J Dtsch Dermatol Ges 2:629-34. 2004
  89. ncbi request reprint Recommendation: daily sun protection in the prevention of chronic UV-induced skin damage
    Peter Elsner
    J Dtsch Dermatol Ges 5:166-73. 2007
  90. ncbi request reprint Impact of carbon coating on the restenosis rate after stenting of atherosclerotic renal artery stenosis
    Thomas Zeller
    Department of Angiology, Herz Zentrum Bad Krozingen, Germany
    J Endovasc Ther 12:605-11. 2005
    ..To investigate the impact of carbofilm coating and low-profile rapid exchange stent devices on the restenosis rate after stent-angioplasty of atherosclerotic renal artery stenosis (RAS)...
  91. ncbi request reprint [UV-induced regulatory T cells]
    Thomas Schwarz
    Klinik fur Dermatologie, Venerologie und Allergologie, Christian Albrechts Universitat zu Kiel
    J Dtsch Dermatol Ges 3:504-10. 2005
    ..The further characterisation of these cells will determine whether they can be applied in the future therapeutically with the ultimate aim to induce specific immunosuppression...
  92. ncbi request reprint UVA1 therapy for sclerodermic graft-versus-host disease of the skin
    Hartmut Ständer
    J Am Acad Dermatol 46:799-800. 2002
  93. ncbi request reprint Cytokines and chemokines in human autoimmune skin disorders
    Dorothee Nashan
    Ludwig Boltzmann Institute for Cell Biology and Inmmunobiology of the Skin, Department of Dematology, University of Munster, Germany
    Adv Exp Med Biol 520:221-36. 2003
  94. ncbi request reprint [Clinical aspects and pathogenesis of UV-induced pigmentary disorders]
    Jean Paul Ortonne
    Hautklinik, Hôpital L Archet 2, Nizza, Frankreich
    J Dtsch Dermatol Ges 1:274-84. 2003
    ..Artificial UV irradiation (UVA, PUVA) can also induce pigmentary disorders, including lentigines. Since the therapeutic options for UV-induced pigmentary changes are limited consequent protection as a prophylactic measure is recommended...
  95. ncbi request reprint Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma
    Youn H Kim
    Multidisciplinary Cutaneous Lymphoma Program, Stanford Comprehensive Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305, USA
    Blood 109:4655-62. 2007
    ..The treatment was well tolerated with no dose-related toxicity other than the targeted depletion of peripheral T cells. A pivotal study has been initiated based on these findings...
  96. ncbi request reprint Filaggrin R501X and 2282del4 mutations are not associated with chronic plaque-type psoriasis in a German cohort
    Michael Weichenthal
    J Invest Dermatol 127:1535-7. 2007
  97. ncbi request reprint Percutaneous rotational and aspiration atherectomy in infrainguinal peripheral arterial occlusive disease: a multicenter pilot study
    Thomas Zeller
    Department of Angiology, Heart Centre Bad Krozingen, Germany
    J Endovasc Ther 14:357-64. 2007
    ..To report a safety and efficacy study of the first rotational aspiration atherectomy system (Pathway PV) for the treatment of arterial lesions below the femoral bifurcation...
  98. doi request reprint VIPER-2: a prospective, randomized single-center comparison of 2 different closure devices with a hemostatic wound dressing for closure of femoral artery access sites
    Aljoscha Rastan
    Abteilung Angiologie, Herz Zentrum Bad Krozingen, Südring 15, Bad Krozingen, Germany
    J Endovasc Ther 15:83-90. 2008
    ..To report the outcome of a prospective randomized safety and performance trial of 2 access site closure devices versus a wound dressing...
  99. ncbi request reprint Regulatory T cells induced by ultraviolet radiation
    Thomas Schwarz
    Department of Dermatology and Allergology, Christian Albrechts University of Kiel, Kiel, Germany
    Int Arch Allergy Immunol 137:187-93. 2005
    ..Further characterization of these cells will determine whether they can be applied therapeutically in the future with the ultimate aim to induce specific immunosuppression...