H Schunkert

..e., direct percutaneous coronary intervention (PCI)) has thus far not been investigated...

..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...

..ABSTRACT (ARB), in essential hypertensive patients not adequately controlled by amlodipine monotherapy...

..Special consideration is given to the association of MI risk with genetic variants in the hemostatic system...

..c.) enalaprilat during primary angioplasty in acute myocardial infarction...

..Due to the increased risk of major bleeding, for each patient the decision of anticoagulation and antiplatelet therapy must be tightly correlated to the individual benefit-risk ratio...

..However, it is unclear as to which of these changes is most critical in the development of congestive heart failure, and this may vary by etiology...

..We sought to develop a prognostic lesion classification based on simple angiographic parameters, lesion length and reference diameter that predicts differential outcome in patients undergoing intracoronary radiation...

..Thus, our data suggest that specific haplotypes of the ghrelin ligand and its receptor act epistatically to affect susceptibility or tolerance to MI and/or CAD...

..Mechanistically, inferior procedural results, as well as exaggerated neointimal proliferation, are, quantitatively, equally important in this process...

..Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction...

..Furthermore, clinically relevant issues that are not clearly covered by recommendations or guidelines like thienopyridines after coronary interventions in patients on chronic oral anticoagulation are also addressed...

..The purpose of this study was to investigate the association of central sleep apnea (CSA) and baroreflex sensitivity (BRS) after acute myocardial infarction...

..Ideally, near-fields and ventricular far-fields ought to be distinguished by beat-to-beat template analysis of the atrial signal. A prerequisite is that atrial signals are stable under different conditions...

..This study investigated whether a combination of MTH with primary percutaneous coronary intervention (PCI) is feasible, safe, and potentially beneficial in patients after cardiac arrest due to acute myocardial infarction...

..However, the strategy for individualized risk prediction by incorporation of new biomarkers in established scores has so far proven to be more difficult than at first hoped...

..In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either...

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..Particular attention is paid in this context to the relation between diastolic blood pressure values and cardiovascular endpoints, which displays a j-shaped curve with the lowest risk at levels between 70 and 90 mmHg...

..This review article will focus on congestive heart failure as a complex trait and will discuss the impact of new technology (genome wide association studies) on the elucidation of common genetic risk factors for congestive heart failure...

..The aim of the present study was to further investigate the association of the IL-6 -174 G/C allele status with specific end organ damage, i.e. myocardial infarction in large population-based samples...

..Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD...

..Waist circumference (WC), given its association with multiple risk factors, is an easy to use tool for initial assessment of cardiovascular risk, but its predictive validity in primary care has not been assessed...

..Thus, we investigated the influence of patient comorbidity, implantation strategy, operator experience, antiplatelet therapy, and anticoagulation therapy on hematoma rate...

..The present study aimed to investigate the impact of the functionally relevant T8590C polymorphism of this gene on blood pressure and the prevalence of hypertension in MI patients...

..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)...

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..These data suggest that common variants in the GHSR region are associated with parameters of LVM and geometry independent of blood pressure and body mass in the general population and, thus, may be involved in the pathogenesis of LVH...

..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC...

..The results of next generation CBL systems combining a dedicated specific CBL design with DES surfaces are to be awaited...

..Thus, we hypothesized that genetic variants within LPIN1 are associated with traits of the metabolic syndrome...

..Such algorithm provides the rational for preprocedural risk stratification and efficient use of resources...

..This study investigates conditions affecting CAC severity in patients with coronary artery disease (CAD) undergoing coronary angiography...

..The frequency and potential differences between patients with apical ("typical") and midventricular ("atypical") ballooning have not been described...

..c.) application of enalaprilat (EN) as an adjunct to direct primary coronary intervention (PCI) on QT dynamics in the acute phase of MI...

..We examined the effects of sleep stages on QT dynamicity and tested the hypothesis of a differential effect of sleep stage on the QT/RR relationship after recent MI, versus in healthy controls (HC)...

..In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results...

..The pathophysiology and long-term prognosis of the transient left ventricular dysfunction syndrome (LVDS, Tako-Tsubo cardiomyopathy) is largely unknown...

..Moreover, we studied if beta-blocker related changes of these cytokines correspond to changes in left ventricular (LV) function and exercise capacity...

..07 to 0.14 +/- 0.09). In patients undergoing successful direct PCI for AMI, treatment with carvedilol, in contrast to metoprolol, was associated with a significant decrease in QT-RR slopes, suggesting greater cardiac electrical stability...

..Moreover, multiple epidemiological observations as to pathophysiologically relevant topics of heart and vascular diseases could be studied in extraordinary details...

..Thus, preventive measures and optimal treatment are mandatory and should be among the main targets of early management of patients with chronic renal disease...

..These different patterns of recovery of reflex versus tonic cardiac autonomic control after MI need to be considered when risk stratifying post-MI patients...

..Nevertheless, the exact mechanisms of these physiological alterations are not entirely understood...

..These data offer new insights into effects of a broader antiadrenergic therapy on autonomic reflexes in the acute phase of AMI...

..Nevertheless, some of the measures used have thus far not been analyzed regarding gender differences in a large group of healthy subjects. Furthermore, new parameters might give further insight...

..This study was conducted to assess presynaptic adrenergic alterations in the dysfunctional myocardium of patients with TLVAB...

..Insulin therapy increased both PAP(1) activity and lipin mRNA expression in diabetic patients. We conclude that suppression of cardiac PAP(1) activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart...

..This study provides evidence that genetic variants in the ACE2 gene may be associated with left ventricular mass, SWT and left ventricular hypertrophy in hemizygous men...

..We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy...

..We studied the relationship between changes in body composition and changes in blood pressure levels...

..We examined the effects of low doses of intracoronary (i.c.) enalaprilat (EN) as an adjunct to direct percutaneous coronary interventions (PCI) on reperfusion VA in the acute phase of myocardial infarction (MI)...

..Here, the authors report and discuss a case of a patient with tako-tsubo cardiomyopathy triggered by adrenaline injection after a wasp sting...

..We have therefore measured macrophage cholesterol efflux in 142 normolipidemic subjects undergoing coronary angiography...

..deltaHR) due to BRS. HR then decreases (3.deltaHR), which is also attributable to BRS. Thus far, however, few data are available regarding the interdependence of these variables...

..The biphasic (Bi) waveform is more effective than the monophasic (Mo) waveform in CV of AF. Whether these waveforms have different effects on autonomic modulation early after CV is unknown...

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..It is thus necessary to perform a comprehensive analysis of complex polygenic diseases, such as myocardial infarction, including both, established cardiovascular risk factors and genomic data...

..The impact of these polymorphisms on cardiovascular risk is poorly understood...

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..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...

..Cutoff concentrations have to be chosen according to renal function to optimize the predictive value of NT-proBNP...

..To test our hypotheses, we performed two large case-control association analyses of individuals from the German MI Family Study...

..Its efficacy in long-segment ISR, where conventional interventional strategies have poor outcome rates, is particularly noteworthy...

..4, 95% confidence interval 1.5 to 13.0, p = 0.007). Thus, the MS strongly predicts cardiac morbidity and mortality in healthy patients with a family background of CAD...

..QT dynamicity is an independent predictor of SCD in post-MI patients. However, the effects of diabetes on QT dynamicity in patients with MI have not been described...

..We conclude that the CFH-Y402H variant has no relevant risk-modifying effect in our population...

..These variants are unlikely to play a significant role in populations of European origin...

..Furthermore, significant LVD can be virtually ruled out in symptomatic and asymptomatic outpatients after myocardial infarction at below-threshold concentrations...

..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...

..These findings indicate that the 9 bp insertion/deletion polymorphism of the BK B2 receptor gene is neither related to the prevalence of MI nor to left ventricular function after MI...

..Renal dysfunction is a potential cause of elevated marker concentrations in the absence of LVD, and cut-off concentrations should be stratified according to renal function...

..In contrast, some features of coronary morphology, such as distal disease, do not appear to be markedly influenced by heritable factors...

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..This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke...

..Both the stronger expression of BNP and the better correlation with LV function provide the molecular basis for a diagnostic superiority of NT-proBNP in clinical LV dysfunction and heart failure...

..However, mechanisms regulating transcription of the human GNAQ gene encoding the Gq protein are unknown and single-nucleotide polymorphisms have not been reported...

..In the future, the development of new techniques in non-invasive diagnostic tests such as contrast echocardiography, computer tomography and cardiac magnetic resonance imaging will extend the diagnostic spectrum of heart failure...

..A prerequisite for further improvement is a better understanding of the underlying pathophysiologic mechanisms responsible for postoperative myocardial stunning. In this report, we analyzed the role of apoptosis in myocardial stunning...