H Schunkert

Summary

Country: Germany

Publications

  1. ncbi request reprint Accelerated idioventricular rhythm in the post-thrombolytic era: incidence, prognostic implications, and modulating mechanisms after direct percutaneous coronary intervention
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Ann Noninvasive Electrocardiol 10:179-87. 2005
  2. pmc Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 3:e2986. 2008
  3. ncbi request reprint Images in cardiovascular medicine. Focal coronary atherosclerosis proximal to myocardial bridging
    Heribert Schunkert
    Clinic for Internal Medicine II, University of Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Circulation 107:1944. 2003
  4. ncbi request reprint [Reduction of cardiovascular events with lorsartan? The LIFE Study]
    H Schunkert
    Medizinische Klinik II, Universitatsklinikum Lubeck
    Internist (Berl) 44:367-70. 2003
  5. ncbi request reprint [Prehypertension--a definition]
    H Schunkert
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Dtsch Med Wochenschr 131:H17-9. 2006
  6. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
  7. ncbi request reprint [Identification of risk genes for myocardial infarction by genome wide association studies]
    P Linsel-Nitschke
    Universitat zu Lubeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lubeck
    Hamostaseologie 30:230-5. 2010
  8. doi request reprint [Renal denervation a new treatment option in resistant arterial hypertension]
    F Himmel
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck
    Praxis (Bern 1994) 100:1353-60. 2011
  9. ncbi request reprint Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy
    H Schunkert
    Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Medizinische Klinik II, Ratzeburger Allee 160, Luebeck, Germany
    Curr Med Res Opin 25:2655-62. 2009
  10. ncbi request reprint [Acute phase of ischemic stroke. Reduce blood pressure--yes or no?]
    H Schunkert
    Medizinische Klinik II, Universitat zu Lubeck
    MMW Fortschr Med 150:43-5. 2008

Detail Information

Publications100

  1. ncbi request reprint Accelerated idioventricular rhythm in the post-thrombolytic era: incidence, prognostic implications, and modulating mechanisms after direct percutaneous coronary intervention
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Ann Noninvasive Electrocardiol 10:179-87. 2005
    ..e., direct percutaneous coronary intervention (PCI)) has thus far not been investigated...
  2. pmc Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 3:e2986. 2008
    ..Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD...
  3. ncbi request reprint Images in cardiovascular medicine. Focal coronary atherosclerosis proximal to myocardial bridging
    Heribert Schunkert
    Clinic for Internal Medicine II, University of Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Circulation 107:1944. 2003
  4. ncbi request reprint [Reduction of cardiovascular events with lorsartan? The LIFE Study]
    H Schunkert
    Medizinische Klinik II, Universitatsklinikum Lubeck
    Internist (Berl) 44:367-70. 2003
  5. ncbi request reprint [Prehypertension--a definition]
    H Schunkert
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Dtsch Med Wochenschr 131:H17-9. 2006
  6. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  7. ncbi request reprint [Identification of risk genes for myocardial infarction by genome wide association studies]
    P Linsel-Nitschke
    Universitat zu Lubeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lubeck
    Hamostaseologie 30:230-5. 2010
    ..Special consideration is given to the association of MI risk with genetic variants in the hemostatic system...
  8. doi request reprint [Renal denervation a new treatment option in resistant arterial hypertension]
    F Himmel
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck
    Praxis (Bern 1994) 100:1353-60. 2011
    ..Targeting renal sympathetic nerves, percutaneous catheter-based renal denervation is a new therapeutic option for the treatment of resistant arterial hypertension in selected drug resistant patients...
  9. ncbi request reprint Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy
    H Schunkert
    Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Medizinische Klinik II, Ratzeburger Allee 160, Luebeck, Germany
    Curr Med Res Opin 25:2655-62. 2009
    ..ABSTRACT (ARB), in essential hypertensive patients not adequately controlled by amlodipine monotherapy...
  10. ncbi request reprint [Acute phase of ischemic stroke. Reduce blood pressure--yes or no?]
    H Schunkert
    Medizinische Klinik II, Universitat zu Lubeck
    MMW Fortschr Med 150:43-5. 2008
  11. ncbi request reprint [Anticoagulation for secondary prevention: which drug in which situation?]
    J Weil
    Medizinische Klinik II, Universität Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck
    Internist (Berl) 46:1310-7. 2005
    ..Due to the increased risk of major bleeding, for each patient the decision of anticoagulation and antiplatelet therapy must be tightly correlated to the individual benefit-risk ratio...
  12. ncbi request reprint Central sleep apnea is associated with blunted baroreflex sensitivity in patients with myocardial infarction
    Alan Strassburg
    Medizinische Klinik III, Universitätsklinikum Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Int J Cardiol 126:333-9. 2008
    ..The purpose of this study was to investigate the association of central sleep apnea (CSA) and baroreflex sensitivity (BRS) after acute myocardial infarction...
  13. ncbi request reprint Differential outcome after intracoronary radiation therapy is related to a simple classification based on lesion length and reference diameter
    Deepak Jain
    Medizinische Klinik II, Ratzenburger Allee 160, Lubeck, Germany
    J Invasive Cardiol 17:256-61. 2005
    ..We sought to develop a prognostic lesion classification based on simple angiographic parameters, lesion length and reference diameter that predicts differential outcome in patients undergoing intracoronary radiation...
  14. ncbi request reprint Atrial near-field and ventricular far-field analysis by automated signal processing at rest and during exercise
    Frank Eberhardt
    University Hospital Schleswig Holstein, Campus Luebeck, Medicine II, Luebeck, Germany
    Ann Noninvasive Electrocardiol 11:118-26. 2006
    ..Ideally, near-fields and ventricular far-fields ought to be distinguished by beat-to-beat template analysis of the atrial signal. A prerequisite is that atrial signals are stable under different conditions...
  15. ncbi request reprint Thienopyridines in percutaneous coronary interventions: standard procedures and high risk subsets
    Peter W Radke
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Curr Pharm Des 12:1281-6. 2006
    ..Furthermore, clinically relevant issues that are not clearly covered by recommendations or guidelines like thienopyridines after coronary interventions in patients on chronic oral anticoagulation are also addressed...
  16. ncbi request reprint Comparison of coronary restenosis rates in matched patients with versus without diabetes mellitus
    Peter W Radke
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Am J Cardiol 98:1218-22. 2006
    ..Mechanistically, inferior procedural results, as well as exaggerated neointimal proliferation, are, quantitatively, equally important in this process...
  17. ncbi request reprint Genetics and heritability of coronary artery disease and myocardial infarction
    Björn Mayer
    Universitätsklinikum Schleswig Holstein UKSH, Ratzeburger Allee 160, Campus Lubeck, Medizinische Klinik II, 23538 Lubeck, Germany
    Clin Res Cardiol 96:1-7. 2007
    ..Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction...
  18. ncbi request reprint [Pathophysiology of chronic heart failure]
    Joachim Weil
    Universität Schleswig Holstein, Campus Lubeck, Medizinische Klinik II, Lubeck
    Clin Res Cardiol 95:1-15; quiz 16-7. 2006
    ..However, it is unclear as to which of these changes is most critical in the development of congestive heart failure, and this may vary by etiology...
  19. ncbi request reprint Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease
    Andrea Baessler
    Clinic for Internal Medicine II, University of Regensburg Franz Josef Stauss Allee 11, 93053 Regensburg, Germany
    Hum Mol Genet 16:887-99. 2007
    ..Thus, our data suggest that specific haplotypes of the ghrelin ligand and its receptor act epistatically to affect susceptibility or tolerance to MI and/or CAD...
  20. doi request reprint [Risk factor "smoking" : smoking cessation in patients with cardiovascular diseases]
    J Weil
    Medizinische Klinik 2, Universitatsklinik Schleswig Holstein, Campus Lubeck, Lubeck, Deutschland
    Internist (Berl) 53:45-50. 2012
    ..Smoking cessation programs applying a combination of behavior therapy and supporting medical treatment have been demonstrated to be the most effective...
  21. doi request reprint Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction undergoing immediate percutaneous coronary intervention
    Sebastian Wolfrum
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Crit Care Med 36:1780-6. 2008
    ..This study investigated whether a combination of MTH with primary percutaneous coronary intervention (PCI) is feasible, safe, and potentially beneficial in patients after cardiac arrest due to acute myocardial infarction...
  22. doi request reprint Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Clin Sci (Lond) 115:309-15. 2008
    ....
  23. doi request reprint Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 86:1163-70. 2008
    ..In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either...
  24. ncbi request reprint Molecular signatures of cardiovascular disease risk: potential for test development and clinical application
    Heribert Schunkert
    Medicine Clinic II, University of Lubeck, Lubeck, Germany
    Mol Diagn Ther 12:281-7. 2008
    ..However, the strategy for individualized risk prediction by incorporation of new biomarkers in established scores has so far proven to be more difficult than at first hoped...
  25. doi request reprint [Congestive heart failure is a common disease with complex inheritance--new perspectives through genome wide association studies]
    P Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Internist (Berl) 49:405-10, 412. 2008
    ..This review article will focus on congestive heart failure as a complex trait and will discuss the impact of new technology (genome wide association studies) on the elucidation of common genetic risk factors for congestive heart failure...
  26. doi request reprint [Arterial hypertension in patients with coronary artery disease]
    T Graf
    Medizinische Klinik II, Campus Lubeck, Universitatsklinikum Schleswig Holstein, Ratzeburger Allee 160, Lubeck, Germany
    Herz 37:191-7; quiz 198-9. 2012
    ..Particular attention is paid in this context to the relation between diastolic blood pressure values and cardiovascular endpoints, which displays a j-shaped curve with the lowest risk at levels between 70 and 90 mmHg...
  27. ncbi request reprint Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis
    Volkhard Kurowski
    Medical Clinic II, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Chest 132:809-16. 2007
    ..The frequency and potential differences between patients with apical ("typical") and midventricular ("atypical") ballooning have not been described...
  28. ncbi request reprint Evaluation of the dedicated Frontier coronary bifurcation stent: A matched pair analysis with drug-eluting and bare metal stents
    Peter W Radke
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Clin Res Cardiol 97:260-5. 2008
    ..The results of next generation CBL systems combining a dedicated specific CBL design with DES surfaces are to be awaited...
  29. ncbi request reprint Association between arterial pressure and coronary artery calcification
    Björn Mayer
    Medizinische Klinik II, Universitatsklinik Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 25:1731-8. 2007
    ..This study investigates conditions affecting CAC severity in patients with coronary artery disease (CAD) undergoing coronary angiography...
  30. ncbi request reprint Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification
    Zouhair Aherrahrou
    Medizinische Klinik II, University of Luebeck, Luebeck, Germany
    Physiol Genomics 28:203-12. 2007
    ..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC...
  31. ncbi request reprint Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
    Björn Mayer
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 24:1965-70. 2006
    ..The present study aimed to investigate the impact of the functionally relevant T8590C polymorphism of this gene on blood pressure and the prevalence of hypertension in MI patients...
  32. ncbi request reprint Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans
    Silke Wiedmann
    Clinic for Internal Medicine II, University of Regensburg, Regensburg, Germany
    Diabetes 57:209-17. 2008
    ..Thus, we hypothesized that genetic variants within LPIN1 are associated with traits of the metabolic syndrome...
  33. ncbi request reprint Rational use of drug-eluting stents: a comparison of different policies
    Marko Remmel
    Medical Clinic II, University of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Crit Pathw Cardiol 6:85-9. 2007
    ..Such algorithm provides the rational for preprocedural risk stratification and efficient use of resources...
  34. ncbi request reprint Ventricular repolarization dynamics during different sleep stages in the subacute phase of myocardial infarction
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitätsklinikum Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S192-7. 2007
    ..We examined the effects of sleep stages on QT dynamicity and tested the hypothesis of a differential effect of sleep stage on the QT/RR relationship after recent MI, versus in healthy controls (HC)...
  35. ncbi request reprint No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors
    Wolfgang Lieb
    Clinic and Policlinic for Internal Medicine II, University of Luebeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Int J Cardiol 97:205-12. 2004
    ..The aim of the present study was to further investigate the association of the IL-6 -174 G/C allele status with specific end organ damage, i.e. myocardial infarction in large population-based samples...
  36. ncbi request reprint "The artichoke heart": the inverse counterpart of left ventricular apical ballooning
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Resuscitation 72:342-3. 2007
  37. ncbi request reprint Effects of intracoronary low-dose enalaprilat on ventricular repolarization dynamics after direct percutaneous intervention for acute myocardial infarction
    Hendrik Bonnemeier
    Universitat zu Lubeck, Medizinische Klinik II, Lubeck, Germany
    Pacing Clin Electrophysiol 30:631-7. 2007
    ..c.) application of enalaprilat (EN) as an adjunct to direct primary coronary intervention (PCI) on QT dynamics in the acute phase of MI...
  38. ncbi request reprint Modulation of ventricular repolarization in patients with transient left ventricular apical ballooning: a case control study
    Hendrik Bonnemeier
    From the Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    J Cardiovasc Electrophysiol 17:1340-7. 2006
    ....
  39. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
    ..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)...
  40. ncbi request reprint Pocket hematoma after pacemaker or implantable cardioverter defibrillator surgery: influence of patient morbidity, operation strategy, and perioperative antiplatelet/anticoagulation therapy
    Uwe K H Wiegand
    Universitaet zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Chest 126:1177-86. 2004
    ..Thus, we investigated the influence of patient comorbidity, implantation strategy, operator experience, antiplatelet therapy, and anticoagulation therapy on hematoma rate...
  41. doi request reprint The correlation between waist circumference and ESC cardiovascular risk score: data from the German metabolic and cardiovascular risk project (GEMCAS)
    Heribert Schunkert
    Clinic for Internal Medicine II, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Clin Res Cardiol 97:827-35. 2008
    ..Waist circumference (WC), given its association with multiple risk factors, is an easy to use tool for initial assessment of cardiovascular risk, but its predictive validity in primary care has not been assessed...
  42. ncbi request reprint Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic Substudy
    Andrea Baessler
    Clinic for Internal Medicine II, University of Regensburg, Regensburg, Germany
    Hypertension 47:920-7. 2006
    ..These data suggest that common variants in the GHSR region are associated with parameters of LVM and geometry independent of blood pressure and body mass in the general population and, thus, may be involved in the pathogenesis of LVH...
  43. ncbi request reprint [Hypertension and atrial fibrillation. How to ward off an impending stroke]
    U K H Wiegand
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Lubeck
    MMW Fortschr Med 149:43-5. 2007
  44. doi request reprint [Patient care in the acute phase of stress induced cardiomyopathy (Tako-Tsubo cardiomyopathy)--and thereafter?]
    V Kurowski
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Deutschland
    Herz 35:245-50. 2010
    ..The recently reported association between TTC and malignant disorders should prompt tumor screening and subsequent preventive medical checkups in patients affected by TTC...
  45. ncbi request reprint [Kidney insufficiency and cardiovascular disease]
    B Weidtmann
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck
    Internist (Berl) 48:770-8. 2007
    ..Thus, preventive measures and optimal treatment are mandatory and should be among the main targets of early management of patients with chronic renal disease...
  46. ncbi request reprint Cardiovascular phenotypes and functional parameters in the general population--results of the MONICA/KORA studies
    H Schunkert
    Universitatsklinikum Schleswig Holstein, Campus Lubeck, Medizinische Klinik II, Lubeck
    Gesundheitswesen 67:S74-8. 2005
    ..Moreover, multiple epidemiological observations as to pathophysiologically relevant topics of heart and vascular diseases could be studied in extraordinary details...
  47. ncbi request reprint [Antithrombotic treatment of acute coronary syndromes without ST-segment elevation]
    P W Radke
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck
    Dtsch Med Wochenschr 131:S204-7. 2006
  48. ncbi request reprint Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress?
    U Schaefer
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Germany
    J Intern Med 261:188-200. 2007
    ..c.) enalaprilat during primary angioplasty in acute myocardial infarction...
  49. doi request reprint Images in cardiovascular medicine. Brugada-like ECG pattern in severe hypothermia
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Circulation 118:977-8. 2008
  50. ncbi request reprint Carvedilol versus metoprolol in patients undergoing direct percutaneous coronary interventions for myocardial infarction: effects on QT dynamicity
    Hendrik Bonnemeier
    Medizinische Kinik II, Universitat zu Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 28:S217-21. 2005
    ..07 to 0.14 +/- 0.09). In patients undergoing successful direct PCI for AMI, treatment with carvedilol, in contrast to metoprolol, was associated with a significant decrease in QT-RR slopes, suggesting greater cardiac electrical stability...
  51. doi request reprint Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): focus on malignancies
    Christof Burgdorf
    Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Eur J Heart Fail 10:1015-9. 2008
    ..The pathophysiology and long-term prognosis of the transient left ventricular dysfunction syndrome (LVDS, Tako-Tsubo cardiomyopathy) is largely unknown...
  52. ncbi request reprint Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels
    Björn Mayer
    Medizinische Klinik II, Universitatsklinik Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Int J Cardiol 103:182-6. 2005
    ..Moreover, we studied if beta-blocker related changes of these cytokines correspond to changes in left ventricular (LV) function and exercise capacity...
  53. ncbi request reprint Lack of association between the MEF2A gene and myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:185-91. 2008
    ..In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results...
  54. ncbi request reprint Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus
    Christof Burgdorf
    Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany
    Biochem Biophys Res Commun 390:165-70. 2009
    ..Insulin therapy increased both PAP(1) activity and lipin mRNA expression in diabetic patients. We conclude that suppression of cardiac PAP(1) activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart...
  55. ncbi request reprint Gender effects on novel time domain parameters of ventricular repolarization inhomogeneity
    Thomas Timothy Krauss
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 32:S167-72. 2009
    ..Nevertheless, some of the measures used have thus far not been analyzed regarding gender differences in a large group of healthy subjects. Furthermore, new parameters might give further insight...
  56. doi request reprint [Wasp sting, adrenaline injection and acute thoracic pain: an un usual case of stress-induced (tako-tsubo) cardiomyopathy]
    Gesa Geppert
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Med Klin (Munich) 105:246-8. 2010
    ..Here, the authors report and discuss a case of a patient with tako-tsubo cardiomyopathy triggered by adrenaline injection after a wasp sting...
  57. doi request reprint Regional alterations in myocardial sympathetic innervation in patients with transient left-ventricular apical ballooning (Tako-Tsubo cardiomyopathy)
    Christof Burgdorf
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Germany
    J Nucl Cardiol 15:65-72. 2008
    ..This study was conducted to assess presynaptic adrenergic alterations in the dysfunctional myocardium of patients with TLVAB...
  58. pmc Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography
    Patrick Linsel-Nitschke
    Department of Medicine, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Lipids Health Dis 8:14. 2009
    ..We have therefore measured macrophage cholesterol efflux in 142 normolipidemic subjects undergoing coronary angiography...
  59. doi request reprint Variation in body composition determines long-term blood pressure changes in pre-hypertension: the MONICA/KORA (Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Research in the Region of Augsburg) cohort study
    Marcello Ricardo Paulista Markus
    Medical Clinic II, University of Lubeck Medical School, Lubeck, Germany
    J Am Coll Cardiol 56:65-76. 2010
    ..We studied the relationship between changes in body composition and changes in blood pressure levels...
  60. ncbi request reprint No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Clin Sci (Lond) 111:365-72. 2006
    ..We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy...
  61. doi request reprint Effects of gender and aging on differential autonomic responses to orthostatic maneuvers
    Melanie Barantke
    Medizinische Klinik ll, Universitat zu Lubeck, Lubeck, Germany
    J Cardiovasc Electrophysiol 19:1296-303. 2008
    ..Nevertheless, the exact mechanisms of these physiological alterations are not entirely understood...
  62. ncbi request reprint Apical ballooning without apical ballooning
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Eur Heart J 27:2246. 2006
  63. ncbi request reprint Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy
    Wolfgang Lieb
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 84:88-96. 2006
    ..This study provides evidence that genetic variants in the ACE2 gene may be associated with left ventricular mass, SWT and left ventricular hypertrophy in hemizygous men...
  64. ncbi request reprint Coronary artery vasospasm or true transient left ventricular apical ballooning? Differentiation by nuclear imaging
    Christof Burgdorf
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Lubeck, Germany
    J Nucl Cardiol 15:599-603. 2008
  65. ncbi request reprint Low doses of intracoronary enalaprilat suppress reperfusion-associated ventricular arrhythmias after primary percutaneous coronary interventions for acute myocardial infarction
    Hendrik Bonnemeier
    Medizinische Klinik II, Universitätsklinikum Schleswig Holstein Campus Lübeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S160-5. 2007
    ..We examined the effects of low doses of intracoronary (i.c.) enalaprilat (EN) as an adjunct to direct percutaneous coronary interventions (PCI) on reperfusion VA in the acute phase of myocardial infarction (MI)...
  66. ncbi request reprint Changes in heart rate, heart rate variability, and heart rate turbulence during evolving reperfused myocardial infarction
    Jasmin Ortak
    Medizinische Kinik II, Universitat zu Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 28:S227-32. 2005
    ..These different patterns of recovery of reflex versus tonic cardiac autonomic control after MI need to be considered when risk stratifying post-MI patients...
  67. ncbi request reprint Effects of aging on reflex autonomic nervous response induced by orthostatic maneuvers
    Melanie Barantke
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S198-202. 2007
    ..deltaHR) due to BRS. HR then decreases (3.deltaHR), which is also attributable to BRS. Thus far, however, few data are available regarding the interdependence of these variables...
  68. ncbi request reprint Modulation of cardiac autonomic nervous activity early after cardioversion of atrial fibrillation by biphasic waveform
    Jasmin Ortak
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S207-11. 2007
    ..The biphasic (Bi) waveform is more effective than the monophasic (Mo) waveform in CV of AF. Whether these waveforms have different effects on autonomic modulation early after CV is unknown...
  69. ncbi request reprint Carvedilol versus metoprolol in the acute phase of myocardial infarction:
    Hendrik Bonnemeier
    Medizinische Kinik II, Universitat zu Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 28:S222-6. 2005
    ..These data offer new insights into effects of a broader antiadrenergic therapy on autonomic reflexes in the acute phase of AMI...
  70. ncbi request reprint A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Room M0 052, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 59:27-36. 2003
    ....
  71. pmc Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study
    Klaus Stark
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, Regensburg, Germany
    PLoS ONE 3:e1948. 2008
    ..To test our hypotheses, we performed two large case-control association analyses of individuals from the German MI Family Study...
  72. ncbi request reprint Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction
    Marcus Fischer
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Circulation 111:855-62. 2005
    ....
  73. ncbi request reprint Effect of compensated renal dysfunction on approved heart failure markers: direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP
    Andreas Luchner
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Germany
    Hypertension 46:118-23. 2005
    ..Renal dysfunction is a potential cause of elevated marker concentrations in the absence of LVD, and cut-off concentrations should be stratified according to renal function...
  74. ncbi request reprint A comprehensive linkage analysis for myocardial infarction and its related risk factors
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Genet 30:210-4. 2002
    ..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
  75. ncbi request reprint [A threat to cardiovascular risk patients. "Activated renin-angiotensin system promotes end organ damage" (interview by Waldtraud Paukstadt)]
    Heribert Schunkert
    MMW Fortschr Med 146:60. 2004
  76. ncbi request reprint Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction
    Marcus Fischer
    Clinic for Internal Medicine 2, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Clin Sci (Lond) 107:505-11. 2004
    ..These findings indicate that the 9 bp insertion/deletion polymorphism of the BK B2 receptor gene is neither related to the prevalence of MI nor to left ventricular function after MI...
  77. ncbi request reprint Results of intracoronary beta-brachytherapy administered by 60 mm transfer device/radiation source train: a subgroup analysis from the RENO registry
    Deepak Jain
    University of Alabama at Birmingham, Division of Cardiovascular Diseases, Birmingham, AL 35294 0012, USA
    J Invasive Cardiol 16:363-7. 2004
    ..Its efficacy in long-segment ISR, where conventional interventional strategies have poor outcome rates, is particularly noteworthy...
  78. ncbi request reprint Renin angiotensin system and gender differences in the cardiovascular system
    Marcus Fischer
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Cardiovasc Res 53:672-7. 2002
    ....
  79. ncbi request reprint Angiotensin converting enzyme gene polymorphism and myocardial infarction a large association and linkage study
    Stephan R Holmer
    Klinik and Poliklinik für Innere Medizin II, University of Regensburg, 93042 Regensburg, Germany
    Int J Biochem Cell Biol 35:955-62. 2003
    ....
  80. ncbi request reprint Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction
    Stephan R Holmer
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Germany
    Circulation 107:696-701. 2003
    ..The impact of these polymorphisms on cardiovascular risk is poorly understood...
  81. ncbi request reprint [Genetic factors in myocardial infarction--Results from a candidate gene and a genome-wide approach between beta blockers]
    Christian Hengstenberg
    Klinik und Poliklinik fur Innere Medizin II, Universitätsklinik Regensburg, Regensburg, Germany
    Herz 27:649-61. 2002
    ..This is of great importance especially for asymptomatic siblings and children from myocardial infarction patients...
  82. ncbi request reprint Are the benefits of antihypertensive therapy only due to blood pressure reduction?
    Heribert Schunkert
    J Hypertens 20:2095-6; author reply 2096-7. 2002
  83. ncbi request reprint NT-ProBNP in outpatients after myocardial infarction: interaction between symptoms and left ventricular function and optimized cut-points
    Andreas Luchner
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Regensburg, Germany
    J Card Fail 11:S21-7. 2005
    ..It was our objective to reassess this cut-point in outpatients after myocardial infarction...
  84. ncbi request reprint Pharmacotherapy for prehypertension--mission accomplished?
    Heribert Schunkert
    N Engl J Med 354:1742-4. 2006
  85. ncbi request reprint Familial aggregation of left main coronary artery disease and future risk of coronary events in asymptomatic siblings of affected patients
    Marcus Fischer
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, Regensburg, Germany
    Eur Heart J 28:2432-7. 2007
    ....
  86. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  87. ncbi request reprint In transition: from family history into the post-genomic era
    Heribert Schunkert
    Am Heart J 152:204-6. 2006
  88. ncbi request reprint N-terminal pro-brain natriuretic peptide after myocardial infarction: a marker of cardio-renal function
    Andreas Luchner
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat, Regensburg, Germany
    Hypertension 39:99-104. 2002
    ..Cutoff concentrations have to be chosen according to renal function to optimize the predictive value of NT-proBNP...
  89. ncbi request reprint Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations
    Kamil Sedlacek
    Klinik und Poliklinik fur Innere Medizin II, Universitatsklinikum Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    J Mol Med (Berl) 85:997-1004. 2007
    ..These variants are unlikely to play a significant role in populations of European origin...
  90. ncbi request reprint A dream yet to become true
    Heribert Schunkert
    Hypertension 50:39-40. 2007
  91. ncbi request reprint The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors
    Klaus Stark
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, Regensburg, Germany
    Clin Sci (Lond) 113:213-8. 2007
    ..We conclude that the CFH-Y402H variant has no relevant risk-modifying effect in our population...
  92. ncbi request reprint Impact of diabetes on QT dynamicity in patients with and without myocardial infarction: The KORA Family Heart Study
    Wolfgang Lieb
    Medizinische Klinik 2, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Pacing Clin Electrophysiol 30:S183-7. 2007
    ..QT dynamicity is an independent predictor of SCD in post-MI patients. However, the effects of diabetes on QT dynamicity in patients with MI have not been described...
  93. ncbi request reprint The higher, the better? Blood pressure after acute myocardial infarction
    Björn Mayer
    J Hypertens 25:273-4. 2007
  94. ncbi request reprint Association of the metabolic syndrome with early coronary disease in families with frequent myocardial infarction
    Wibke Reinhard
    Klinik und Poliklinik fuer Innere Medizin II, Universitaet Regensburg, Regensburg, Germany
    Am J Cardiol 97:964-7. 2006
    ..4, 95% confidence interval 1.5 to 13.0, p = 0.007). Thus, the MS strongly predicts cardiac morbidity and mortality in healthy patients with a family background of CAD...
  95. ncbi request reprint Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension
    Yalda Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
    Circulation 105:950-5. 2002
    ....
  96. ncbi request reprint Role of apoptosis in myocardial stunning after open heart surgery
    Joachim P Schmitt
    Department of Thoracic and Cardiovascular Surgery, University Medical School, Regensburg, Germany
    Ann Thorac Surg 73:1229-35. 2002
    ..A prerequisite for further improvement is a better understanding of the underlying pathophysiologic mechanisms responsible for postoperative myocardial stunning. In this report, we analyzed the role of apoptosis in myocardial stunning...
  97. ncbi request reprint [Rational diagnosis of chronic heart failure]
    Joachim Weil
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg
    Z Arztl Fortbild Qualitatssich 97:105-12. 2003
    ..In the future, the development of new techniques in non-invasive diagnostic tests such as contrast echocardiography, computer tomography and cardiac magnetic resonance imaging will extend the diagnostic spectrum of heart failure...
  98. ncbi request reprint Head-to-head comparison of BNP and IL-6 as markers of clinical and experimental heart failure: Superiority of BNP
    Christoph M Birner
    Klinik und Poliklinik fur Innere Medizin II, Klinikum der Universitat Regensburg, 93042 Regensburg, Germany
    Cytokine 40:89-97. 2007
    ..Both the stronger expression of BNP and the better correlation with LV function provide the molecular basis for a diagnostic superiority of NT-proBNP in clinical LV dysfunction and heart failure...
  99. ncbi request reprint A locus on chromosome 10 influences C-reactive protein levels in two independent populations
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hum Genet 122:95-102. 2007
    ..This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke...
  100. doi request reprint Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans
    Ulrich H Frey
    Institute of Pharmacogenetics, D 45122 Essen, Germany
    Eur Heart J 29:888-97. 2008
    ..However, mechanisms regulating transcription of the human GNAQ gene encoding the Gq protein are unknown and single-nucleotide polymorphisms have not been reported...