- 14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescenceJulia Schultz
Department of Cardiac Surgery, University of Rostock, Rostock, Germany
Mol Cancer 8:53. 2009..The 14-3-3sigma isoform acts as a tumor suppressor and is often inactivated during tumor development...
- Tumor-promoting role of signal transducer and activator of transcription (Stat)1 in late-stage melanoma growthJulia Schultz
Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany
Clin Exp Metastasis 27:133-40. 2010..Taken together, these data suggest that Stat1 might play a role in late-stage melanoma progression. Interference with the Stat1 pathway could have therapeutic implications for late-stage melanoma patients...
- The functional -443T/C osteopontin promoter polymorphism influences osteopontin gene expression in melanoma cells via binding of c-Myb transcription factorJulia Schultz
Department of Dermatology and Venereology, University of Rostock, Rostock, Germany
Mol Carcinog 48:14-23. 2009..These findings might be a feasible explanation for different OPN expression levels in metastatic tumors and may also have prognostic and therapeutic relevance...
- Dynamical effects of epigenetic silencing of 14-3-3sigma expressionJulio Vera
Systems Biology and Bioinformatics Group, Department of Computer Science, University of Rostock, 18051 Rostock, Germany
Mol Biosyst 6:264-73. 2010....
- MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growthJulia Schultz
Department of Dermatology and Venereology, University of Rostock, 18055 Rostock, Germany
Cell Res 18:549-57. 2008..Taken together, these findings not only point to new regulatory mechanisms of early melanoma development, but also may open avenues for future targeted therapies of this tumor...