Frank Schuettauf

Summary

Country: Germany

Publications

  1. ncbi request reprint Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 47:3573-8. 2006
  2. ncbi request reprint Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model
    Frank Schuettauf
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Vision Res 42:2333-7. 2002
  3. ncbi request reprint Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Schleichstrasse 12, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1157-68. 2007
  4. ncbi request reprint Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension
    Frank Schuettauf
    Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076, Tuebingen, Germany
    Acta Neuropathol 107:352-8. 2004
  5. ncbi request reprint Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity
    Frank Schuettauf
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Curr Eye Res 29:379-86. 2004
  6. ncbi request reprint Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells
    Frank Schuettauf
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Graefes Arch Clin Exp Ophthalmol 243:1036-42. 2005
  7. ncbi request reprint Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Röntgenweg 11, 72076 Tubingen, Germany
    Exp Eye Res 83:1128-34. 2006
  8. ncbi request reprint Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension
    Robert Rejdak
    Department of Pathophysiology of Vision and Neuro ophthalmology, Division of Experimental Opthalmology, University Eye Hospital, Röntgenweg 11, 72076 Tubingen, Germany
    Vision Res 44:655-60. 2004
  9. doi request reprint Tempol protects against intravitreous indocyanine green-induced retinal damage in rats
    Sebastian Thaler
    Centre for Ophthalmology, University of Tubingen, Röntgenweg 11, 72076, Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 250:1597-606. 2012
  10. doi request reprint In vivo toxicity testing of methyl blue and aniline blue as vital dyes for intraocular surgery
    Sebastian Thaler
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Retina 29:1257-65. 2009

Detail Information

Publications29

  1. ncbi request reprint Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 47:3573-8. 2006
    ..To investigate the effect of intravitreal injections of new vital dyes on the retina, the retinal pigment epithelium (RPE) and the choroid in an in vivo rat model...
  2. ncbi request reprint Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model
    Frank Schuettauf
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Vision Res 42:2333-7. 2002
    ..0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension...
  3. ncbi request reprint Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Schleichstrasse 12, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1157-68. 2007
    ..This study examines changes in amino acid levels in the vitreous, and changes in the expression of retinal glutamate transporters and receptors that occur during the progression of this pathology...
  4. ncbi request reprint Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension
    Frank Schuettauf
    Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076, Tuebingen, Germany
    Acta Neuropathol 107:352-8. 2004
    ..However, neovasculogenesis and myelin-like bodies are observed during aging. Therefore, the DBA/2J model requires judicious interpretation as a glaucoma model...
  5. ncbi request reprint Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity
    Frank Schuettauf
    Department of Ophthalmology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Curr Eye Res 29:379-86. 2004
    ..We tested the possibility of delivering these growth factors to retinal ganglion cells via an adeno-associated viral (AAV) vector and tested their efficacy in two models of excitotoxicity...
  6. ncbi request reprint Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells
    Frank Schuettauf
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Graefes Arch Clin Exp Ophthalmol 243:1036-42. 2005
    ..This cytokine is known as novel neurotrophin-1/B-cell-stimulating factor-3 (NNT-1/BSF-3) or cardiotrophin-like cytokine (CLC). It shows neurotrophic as well as B-cell stimulatory effects...
  7. ncbi request reprint Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat
    Frank Schuettauf
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Röntgenweg 11, 72076 Tubingen, Germany
    Exp Eye Res 83:1128-34. 2006
    ..Both citicoline and lithium protect RGC and their axons in vivo against delayed degeneration triggered by the ONC. Retinoprotective action of both drugs may involve an increase in Bcl-2 expression...
  8. ncbi request reprint Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension
    Robert Rejdak
    Department of Pathophysiology of Vision and Neuro ophthalmology, Division of Experimental Opthalmology, University Eye Hospital, Röntgenweg 11, 72076 Tubingen, Germany
    Vision Res 44:655-60. 2004
    ..The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension...
  9. doi request reprint Tempol protects against intravitreous indocyanine green-induced retinal damage in rats
    Sebastian Thaler
    Centre for Ophthalmology, University of Tubingen, Röntgenweg 11, 72076, Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 250:1597-606. 2012
    ..However, ICG can be toxic to retinal cells. Here we evaluate whether tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl), a free radical scavenger, can protect against ICG-induced retinal damage in rats...
  10. doi request reprint In vivo toxicity testing of methyl blue and aniline blue as vital dyes for intraocular surgery
    Sebastian Thaler
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Retina 29:1257-65. 2009
    ..To investigate the biocompatibility of methyl blue and aniline blue as vital dyes for vitreoretinal surgery in an in vivo rat model and to evaluate the effect of these dyes on retinal structure and function...
  11. doi request reprint Neuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load
    Sebastian Thaler
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Exp Eye Res 90:254-60. 2010
    ....
  12. ncbi request reprint A selective method for transfection of retinal ganglion cells by retrograde transfer of antisense oligonucleotides against kynurenine aminotransferase II
    Sebastian Thaler
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Tubingen, Germany
    Mol Vis 12:100-7. 2006
    ..Expression of kynurenine aminotransferase II (KAT II) in RGCs has been well described in the literature. We describe a new method for downregulating cellular KAT II expression via transfection of RGC by retrograde transfer of ODN...
  13. ncbi request reprint Toxicity testing of the VEGF inhibitors bevacizumab, ranibizumab and pegaptanib in rats both with and without prior retinal ganglion cell damage
    Sebastian Thaler
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Acta Ophthalmol 88:e170-6. 2010
    ..To evaluate the effects of intravitreally introduced vascular endothelial growth factor (VEGF) inhibitors in rat eyes with healthy retinal ganglion cells (RGC) and into others with N-methyl-D-aspartate (NMDA)-induced RGC damage...
  14. ncbi request reprint Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration
    Robert Rejdak
    Centre for Ophthalmology, University of Tubingen, Roentgenweg 11, D 72076 Tubingen, Germany
    Pharmacol Rep 63:1324-34. 2011
    ..In the corpora amylacea in the human retina intensive KAT I and II immunoreactivity was demonstrated. In summary, these findings point to the potential involvement of KYNA in the mechanisms of retinal aging and neurodegeneration...
  15. ncbi request reprint Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death
    Frank Schuettauf
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Clin Experiment Ophthalmol 39:545-54. 2011
    ..We studied the involvement of certain caspases in excitotoxic retinal ganglion cell death, which was experimentally induced in Brown Norway Rats by application of the glutamate receptor agonist N-methyl-D-aspartate (NMDA)...
  16. doi request reprint In vivo toxicity study of rhodamine 6G in the rat retina
    Sebastian Thaler
    Centre for Ophthalmology, Division of Experimental Ophthalmology, University of Tubingen, Röntgenweg 11, Tubingen, Germany
    Invest Ophthalmol Vis Sci 49:2120-6. 2008
    ..To investigate the intraocular effect of rhodamine 6G (R6G) on retinal structures and function in an in vivo rat model and to develop an in vivo method for accurate evaluation of new dyes for intraocular surgery...
  17. doi request reprint Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina
    Aysegül Tura
    University Eye Hospital of the Center of Ophthalmology at the Eberhard Karls University of Tübingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:452-61. 2009
    ..To analyze the outcomes of Rho-kinase (ROCK) inhibition on retinal cell survival and glial reactivity under adverse conditions...
  18. ncbi request reprint Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage
    Robert Rejdak
    Department of Pathophysiology of Vision and Neuro ophthalmology, Division of Experimental Ophthalmology, University Eye Hospital, Röntgenweg 11, D 72076, Tubingen, Germany
    Vision Res 43:497-503. 2003
    ..It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases...
  19. pmc Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat--possible involvement of kynurenic acid
    Sebastian Thaler
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1729-35. 2010
    ..Additionally, the influence of ACA and BHB on kynurenic acid (KYNA) production was assessed in vitro in bovine retinal slices...
  20. doi request reprint K(+) currents fail to change in reactive retinal glial cells in a mouse model of glaucoma
    Sylvia Bolz
    Department of Ophthalmology, Institute for Ophthalmic Research, University of Tubingen, Röntgenweg 11, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1249-54. 2008
    ..To investigate the membrane physiology of Müller glial cells from retinae of DBA/2J mice (which develop ocular hypertension) and of C57BL/6 control mice of different ages...
  21. ncbi request reprint Toxicity study of erucylphosphocholine in a rat model
    Frank Schuettauf
    Department of Ophthalmology, Eberhard Karls University, Tubingen, Germany
    Curr Eye Res 30:813-20. 2005
    ..To investigate the effect of intraocular erucylphosphocholine (ErPC) on the retina, the retinal pigment epithelium (RPE), and the choroid in an in vivo rat model...
  22. doi request reprint Experimental evaluation of aniline and methyl blue for intraocular surgery
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Retina 29:1266-73. 2009
    ....
  23. ncbi request reprint Phenytoin blocks retinal ganglion cell death after partial optic nerve crush
    Rita Naskar
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia and Veterans Administration Medical Center, Philadelphia, PA 19104, USA
    Exp Eye Res 74:747-52. 2002
    ..Phenytoin is known to decrease neuronal firing and neurotransmitter release; this may underlie its ability to serve as a neuro-protectant in this experimental paradigm...
  24. doi request reprint Neuroprotective effects of tempol acyl esters against retinal ganglion cell death in a rat partial optic nerve crush model
    Sebastian Thaler
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    Acta Ophthalmol 89:e555-60. 2011
    ..Although tempol is neuroprotective in a rat partial optic nerve crush (PONC) model, relatively high doses are required to exert this effect...
  25. doi request reprint Methyl blue and aniline blue versus patent blue and trypan blue as vital dyes in cataract surgery: capsule staining properties and cytotoxicity to human cultured corneal endothelial cells
    Sebastian Thaler
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany
    J Cataract Refract Surg 37:1147-53. 2011
    ..To evaluate capsule-staining properties and biocompatibility of the triarylmethane dyes methyl blue and aniline blue compared with patent blue and trypan blue on cultured human corneal endothelial cells...
  26. doi request reprint Early electroretinographic features of streptozotocin-induced diabetic retinopathy
    Kei Shinoda
    University Eye Hospital, Tubingen, Germany
    Clin Experiment Ophthalmol 35:847-54. 2007
    ..This study set out to document the early electrophysiological and immunohistochemical changes that occur in the retina of experimentally induced diabetic rats...
  27. ncbi request reprint A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy
    Marcel V Alavi
    Molecular Genetics Laboratory, University Eye Hospital, Tuebingen, Germany
    Brain 130:1029-42. 2007
    ..Mitochondria in these axons showed disorganized cristae structures. All these defects recapitulate crucial features of adOA in humans and therefore document the validity and importance of this model for future research...
  28. ncbi request reprint Expression of kynurenine aminotransferases in the rat retina during development
    Robert Rejdak
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Division of Experimental Ophthalmology, Röntgenweg 11, D 72076 Tubingen, Germany
    Vision Res 44:1-7. 2004
    ..In conclusion, KAT I and II are present in the rat retina during development. The heterogeneity of the KAT developmental profiles possibly reflects a neuromodulatory role in the retinal differentiation...
  29. ncbi request reprint Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations
    Nicole Weisschuh
    Molecular Genetics Laboratory, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 47:3846-52. 2006
    ..To determine the prevalence of FOXC1 and PITX2 mutations and to assess clinical phenotypes in a cohort of German patients with Axenfeld-Rieger malformations...