Jens Schrader

Summary

Country: Germany

Publications

  1. ncbi request reprint Applied biocatalysis for the synthesis of natural flavour compounds--current industrial processes and future prospects
    J Schrader
    Karl Winnacker Institute, DECHEMA e V, Theodor Heuss Allee 25, 60486 Frankfurt Main, Germany
    Biotechnol Lett 26:463-72. 2004
  2. pmc Identification of a Caldariomyces fumago mutant secreting an inactive form of chloroperoxidase lacking the heme group and N-glycans
    Sonja Hüttmann
    DECHEMA Research Institute, Frankfurt am Main, Germany
    PLoS ONE 8:e67857. 2013
  3. doi request reprint Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria
    Jens Schrader
    Karl Winnacker Institut, Biochemical Engineering, Theodor Heuss Allee 25, 60486 Frankfurt, Germany
    Trends Biotechnol 27:107-15. 2009
  4. doi request reprint P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system
    Hendrik Schewe
    DECHEMA e V, Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 83:849-57. 2009
  5. doi request reprint Oxidation of fatty aldehydes to fatty acids by Escherichia coli cells expressing the Vibrio harveyi fatty aldehyde dehydrogenase (FALDH)
    Markus Buchhaupt
    Biochemical Engineering, DECHEMA Research Institute, Theodor Heuss Allee 25, 60486 Frankfurt am Main, Germany
    World J Microbiol Biotechnol 29:569-75. 2013
  6. doi request reprint Integrated bioprocess for the stereospecific production of linalool oxides from linalool with Corynespora cassiicola DSM 62475
    Sebastian Bormann
    Biochemical Engineering, DECHEMA Research Institute, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    J Ind Microbiol Biotechnol 39:1761-9. 2012
  7. doi request reprint Over-expression of chloroperoxidase in Caldariomyces fumago
    Markus Buchhaupt
    DECHEMA eV, Biochemical Engineering, Frankfurt am Main, Germany
    Biotechnol Lett 33:2225-31. 2011
  8. doi request reprint Enzymatic production and in situ separation of natural β-ionone from β-carotene
    Christoph Nacke
    DECHEMA Research Institute, Biochemical Engineering, Theodor Heuss Allee 25, 60486 Frankfurt, Germany
    J Ind Microbiol Biotechnol 39:1771-8. 2012
  9. doi request reprint Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase
    Markus Buchhaupt
    Biochemical Engineering, DECHEMA eV, Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 93:159-68. 2012
  10. doi request reprint Fungal biotransformation of (+/-)-linalool
    Marco Antonio Mirata
    DECHEMA e V, Karl Winnacker Institut, Biochemical Engineering, PO Box 150104, D 60061 Frankfurt Main, Germany
    J Agric Food Chem 56:3287-96. 2008

Collaborators

  • Markus Buchhaupt
  • Karl Dieter Entian
  • Mark Helm
  • Christian Peifer
  • Julia A Vorholt
  • Wilfried Schwab
  • Frank Hollmann
  • Gerhard Sandmann
  • M M W Etschmann
  • Ulrich Krings
  • Achim Marx
  • Dirk Holtmann
  • Hendrik Schewe
  • Frank Sonntag
  • Bjoern Arne Kaup
  • Christoph Nacke
  • Marco Antonio Mirata
  • Sonja Hüttmann
  • Isabell Schmidt
  • Michael Pescheck
  • Martin Schilling
  • Svenja Kochius
  • Sebastian Bormann
  • Fenja Kaehne
  • Claudia Ley
  • Klaus Michael Mangold
  • Matthias Wüst
  • G A Tuskan
  • Z Ding
  • Anders O Magnusson
  • Markus Hümbelin
  • Chao Jin
  • Sören Gassel
  • John Buckingham
  • Ralf Günter Berger
  • Bianca Brauer
  • Armin Mosandl
  • Kristina Ehrich
  • Frauke Patett
  • Umberto Piantini
  • P M Coutinho
  • A Groover
  • P Richardson
  • D R Nelson
  • S Ralph
  • M Gribskov
  • D Blaudez
  • Y Van de Peer
  • U Kalluri
  • C Douglas
  • R R Bhalerao
  • F Sterky
  • M Campbell
  • K Ritland
  • D Goodstein
  • A Siddiqui
  • O Nilsson
  • S Degroeve
  • S Lucas
  • V Pereda
  • R P Bhalerao
  • C Kelleher
  • M Marra
  • B Segerman
  • B Hamberger
  • M Jones-Rhoades
  • C Rinaldi
  • A Brun
  • L Gunter
  • A Salamov
  • W Huang
  • J Kangasjärvi
  • K Nieminen
  • E Uberbacher
  • G Sandberg
  • S Wessler
  • J Ehlting
  • S Jansson
  • Y Lou
  • A Kohler
  • P Unneberg
  • C J Tsai
  • J Chapman
  • A Brunner
  • J Grimwood
  • B Dirks
  • P Locascio
  • B Henrissat
  • S Covert
  • U Hellsten

Detail Information

Publications34

  1. ncbi request reprint Applied biocatalysis for the synthesis of natural flavour compounds--current industrial processes and future prospects
    J Schrader
    Karl Winnacker Institute, DECHEMA e V, Theodor Heuss Allee 25, 60486 Frankfurt Main, Germany
    Biotechnol Lett 26:463-72. 2004
    ....
  2. pmc Identification of a Caldariomyces fumago mutant secreting an inactive form of chloroperoxidase lacking the heme group and N-glycans
    Sonja Hüttmann
    DECHEMA Research Institute, Frankfurt am Main, Germany
    PLoS ONE 8:e67857. 2013
    ..After removing N-linked oligosaccharides from wild type CPO a protein band at 38-40 kDa was detected. Our results reveal that the mutant protein lacks the heme group as well as the N-glycans. ..
  3. doi request reprint Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria
    Jens Schrader
    Karl Winnacker Institut, Biochemical Engineering, Theodor Heuss Allee 25, 60486 Frankfurt, Germany
    Trends Biotechnol 27:107-15. 2009
    ..This review highlights the potential of these bacteria for the development of economically competitive bioprocesses based on methanol as an alternative carbon source, bringing together biological, technical and economic considerations...
  4. doi request reprint P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system
    Hendrik Schewe
    DECHEMA e V, Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 83:849-57. 2009
    ....
  5. doi request reprint Oxidation of fatty aldehydes to fatty acids by Escherichia coli cells expressing the Vibrio harveyi fatty aldehyde dehydrogenase (FALDH)
    Markus Buchhaupt
    Biochemical Engineering, DECHEMA Research Institute, Theodor Heuss Allee 25, 60486 Frankfurt am Main, Germany
    World J Microbiol Biotechnol 29:569-75. 2013
    ..The whole cell catalyst with the high broad range FALDH activity described here is an important biotechnological module for lipid biotransformation processes, especially the shortening of fatty acids...
  6. doi request reprint Integrated bioprocess for the stereospecific production of linalool oxides from linalool with Corynespora cassiicola DSM 62475
    Sebastian Bormann
    Biochemical Engineering, DECHEMA Research Institute, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    J Ind Microbiol Biotechnol 39:1761-9. 2012
    ..Process optimisation increased productivity to 920 mg l⁻¹ day⁻¹ in a bioreactor with an overall product concentration of 4.600 mg l⁻¹ linalool oxides...
  7. doi request reprint Over-expression of chloroperoxidase in Caldariomyces fumago
    Markus Buchhaupt
    DECHEMA eV, Biochemical Engineering, Frankfurt am Main, Germany
    Biotechnol Lett 33:2225-31. 2011
    ..The highest CPO activity from the bioreactor cultivation was 3,236 U ml(-1). This is the highest value reported so far...
  8. doi request reprint Enzymatic production and in situ separation of natural β-ionone from β-carotene
    Christoph Nacke
    DECHEMA Research Institute, Biochemical Engineering, Theodor Heuss Allee 25, 60486 Frankfurt, Germany
    J Ind Microbiol Biotechnol 39:1771-8. 2012
    ....
  9. doi request reprint Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase
    Markus Buchhaupt
    Biochemical Engineering, DECHEMA eV, Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 93:159-68. 2012
    ..The whole cell catalyst containing LOX and HPL enzyme activity described here can be a promising approach towards a highly efficient microbial green note synthesis process...
  10. doi request reprint Fungal biotransformation of (+/-)-linalool
    Marco Antonio Mirata
    DECHEMA e V, Karl Winnacker Institut, Biochemical Engineering, PO Box 150104, D 60061 Frankfurt Main, Germany
    J Agric Food Chem 56:3287-96. 2008
    ..day linalool oxides, Corynespora cassiicola DSM 62485 was identified as a novel highly stereoselective linalool transforming biocatalyst showing the highest productivity reported so far...
  11. doi request reprint Folding reporter tags can deliver misleading results upon chaperone coexpression
    Christoph Nacke
    DECHEMA e V, Karl Winnacker Institut, Biochemical Engineering Group, Theodor Heuss Allee 25, 60486 Frankfurt Main, Germany
    J Biotechnol 144:268-71. 2009
    ..Incorrect results can be obtained if target protein folding quality is assessed solely based on reporter tag activity. Thus, additional methods for the verification of the obtained results should be performed...
  12. doi request reprint A recombinant α-dioxygenase from rice to produce fatty aldehydes using E. coli
    Fenja Kaehne
    DECHEMA e V Karl Winnacker Institut, Biochemical Engineering, Theodor Heuss Allee 25, 60486 Frankfurt Main, Germany
    Appl Microbiol Biotechnol 90:989-95. 2011
    ..The usage of Triton X 100 improves the conversion rate up to 1 g aldehyde per liter per hour. Easy reuse of the cells was demonstrated by performing a second biotransformation without any loss of biocatalytic activity...
  13. doi request reprint Improved monoterpene biotransformation with Penicillium sp. by use of a closed gas loop bioreactor
    Michael Pescheck
    Biochemical Engineering Group, DECHEMA eV, Karl Winnacker Institut, Frankfurt, Germany
    J Ind Microbiol Biotechnol 36:827-36. 2009
    ..Furthermore, a molar conversion yield of up to 63% was achieved...
  14. ncbi request reprint Microparticle-enhanced cultivation of filamentous microorganisms: increased chloroperoxidase formation by Caldariomyces fumago as an example
    Bjoern Arne Kaup
    DECHEMA e V, Karl Winnacker Institut, Biochemical Engineering Group, Theodor Heuss Allee 25, 60486 Frankfurt, Germany
    Biotechnol Bioeng 99:491-8. 2008
    ..In addition, the novel cultivation method also showed a positive effect on growth characteristics of other filamentous microorganisms proven by the stimulation of single hyphae/cell formation...
  15. doi request reprint Effect of linoleic acids on the release of β-carotene from carotenoid-producing Saccharomyces cerevisiae into sunflower oil
    Frank Sonntag
    DECHEMA Research Institute, Frankfurt am Main, Germany
    J Mol Microbiol Biotechnol 23:233-8. 2013
    ..These findings demonstrate that the effect of the organic solvent should be taken into consideration for further research on in situ extraction of carotenoids...
  16. pmc White mutants of chloroperoxidase-secreting Caldariomyces fumago as superior production strains, revealing an interaction between pigmentation and enzyme secretion
    Markus Buchhaupt
    DECHEMA Research Institute, Frankfurt am Main, Germany
    Appl Environ Microbiol 78:5923-5. 2012
    ..Furthermore, the CPO content increased significantly faster than the wild-type rate, which uncovers possible interactions between pigmentation and enzyme secretion...
  17. ncbi request reprint Improvement of P450(BM-3) whole-cell biocatalysis by integrating heterologous cofactor regeneration combining glucose facilitator and dehydrogenase in E. coli
    Hendrik Schewe
    Biochemical Engineering Group, DECHEMA e V, Karl Winnacker Institut, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    Appl Microbiol Biotechnol 78:55-65. 2008
    ..5 h. The physiological functioning of the heterologous cofactor regeneration system was illustrated by a sevenfold increased alpha-pinene oxide yield in the presence of glucose compared to glucose-free conditions...
  18. doi request reprint Biotechnological production of astaxanthin with Phaffia rhodozyma/Xanthophyllomyces dendrorhous
    Isabell Schmidt
    Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 89:555-71. 2011
    ..rhodozyma for the biotechnological production of astaxanthin in comparison to other natural sources such as the microalga H. pluvialis, other fungi and transgenic plants and to chemical synthesis...
  19. doi request reprint Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically-driven biocatalysis
    Dirk Holtmann
    Biochemical Engineering Group, Karl Winnacker Institut, DECHEMA e V, 60486, Frankfurt am Main, Germany
    Biotechnol Lett 31:765-70. 2009
    ..Repeatedly sweeping the electric potential between -600 and +600 mV versus Ag/AgCl led to enzymatically-catalysed product formation while in the absence of the enzyme no product formed under otherwise identical conditions...
  20. ncbi request reprint Monoterpenes as novel substrates for oxidation and halo-hydroxylation with chloroperoxidase from Caldariomyces fumago
    Bjoern Arne Kaup
    Biochemical Engineering Group, DECHEMA e V, Karl Winnacker Institut, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    Appl Microbiol Biotechnol 73:1087-96. 2007
    ..This is a promising strategy for 'green' terpene chemistry overcoming drawbacks usually associated with cofactor-dependent oxygenases, whole-cell biocatalysts and conventional chemical methods used for terpene conversions...
  21. ncbi request reprint Influence of solubility-enhancing fusion proteins and organic solvents on the in vitro biocatalytic performance of the carotenoid cleavage dioxygenase AtCCD1 in a micellar reaction system
    Martin Schilling
    Biochemical Engineering Group, DECHEMA e V, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    Appl Microbiol Biotechnol 75:829-36. 2007
    ..The results provide a foundation for the development towards the application of carotenoid cleavage dioxygenases as in vitro biocatalysts for the production of norisoprenoids and apocarotenals from carotenoids...
  22. doi request reprint Immobilization of histidine-tagged proteins on electrodes
    Claudia Ley
    Biochemical Engineering Group, Karl Winnacker Institut, DECHEMA e V, Theodor Heuss Allee 25, 60486 Frankfurt am Main, Germany
    Colloids Surf B Biointerfaces 88:539-51. 2011
    ....
  23. ncbi request reprint Thioesterases for ethylmalonyl-CoA pathway derived dicarboxylic acid production in Methylobacterium extorquens AM1
    Frank Sonntag
    DECHEMA Forschungsinstitut, Theodor Heuss Allee 25, 60486, Frankfurt, Germany
    Appl Microbiol Biotechnol 98:4533-44. 2014
    ..Our data demonstrates the biotechnological applicability of the thioesterase YciA and the possibility of EMCP dicarboxylic acid production from methanol using M. extorquens AM1...
  24. ncbi request reprint Partial methylation at Am100 in 18S rRNA of baker's yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification
    Markus Buchhaupt
    DECHEMA Research Institute, Biochemical Engineering, Frankfurt am Main, Germany
    PLoS ONE 9:e89640. 2014
    ..Partial rRNA modification demonstrates a new level of ribosome heterogeneity in eukaryotic cells that might have substantial impact on regulation and fine-tuning of the translation process. ..
  25. ncbi request reprint Quantitative comparison of the signals of an electrochemical bioactivity sensor during the cultivation of different microorganisms
    Dirk Holtmann
    Karl Winnacker Institut der DECHEMA eV, Theodor Heuss Allee 25, 60486, Frankfurt am Main, Germany
    Biotechnol Lett 28:889-96. 2006
    ..07-0.19 mV kJ(-1). Furthermore it was demonstrated that the highest BAS signals could be measured during anaerobic E. coli fermentations, the reason being the formation of electroactive fermentation products, such as formic acid and H(2)...
  26. ncbi request reprint Production of 2-phenylethanol and 2-phenylethylacetate from L-phenylalanine by coupling whole-cell biocatalysis with organophilic pervaporation
    Maria M W Etschmann
    DECHEMA e V, Biochemical Engineering Group, 60486 Frankfurt Main, Germany
    Biotechnol Bioeng 92:624-34. 2005
    ..The medium composition affected the pervaporation efficiency with molasses acting detrimental...
  27. doi request reprint Immobilized redox mediators for electrochemical NAD(P)+ regeneration
    Svenja Kochius
    DECHEMA eV, Karl Winnacker Institut, Frankfurt, Germany
    Appl Microbiol Biotechnol 93:2251-64. 2012
    ..By comparison with other existing regeneration systems, the technical potential and future perspectives of biocatalytic redox reactions based on electrochemically fed immobilized mediators will be assessed...
  28. ncbi request reprint Biotechnological production of 2-phenylethanol
    M M W Etschmann
    DECHEMA e V, Biochemical Engineering Group, Theodor Heuss Allee 25, 60486 Frankfurt am Main, Germany
    Appl Microbiol Biotechnol 59:1-8. 2002
    ..This review describes the microbial production of 2-PE, and also summarizes the chemical syntheses and the market situation...
  29. ncbi request reprint The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)
    G A Tuskan
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Science 313:1596-604. 2006
    ..Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport...
  30. doi request reprint Production of the aroma chemicals 3-(methylthio)-1-propanol and 3-(methylthio)-propylacetate with yeasts
    M M W Etschmann
    Biochemical Engineering Group, Theodor Heuss Allee 25, 60486, Frankfurt am Main, Germany
    Appl Microbiol Biotechnol 80:579-87. 2008
    ..These are the highest concentrations reported up to now for the biocatalytic synthesis of these flavor compounds which are applied in the production of savory aroma compositions such as meat, potato, and cheese flavorings...
  31. ncbi request reprint A minimally invasive approach for efficient gene delivery to rodent hearts
    Z Ding
    Institut für Herz und Kreislaufphysiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Gene Ther 11:260-5. 2004
    ..Our results also suggest that prolongation of viral incubation time is an effective means for achieving highly efficient myocardial gene transduction...
  32. pmc Polar auxin transport in the wood-forming tissues of hybrid aspen is under simultaneous control of developmental and environmental signals
    J Schrader
    Umea Plant Science Centre, Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183 Umea, Sweden
    Proc Natl Acad Sci U S A 100:10096-101. 2003
    ..Our findings collectively demonstrate that trees have developed mechanisms to modulate auxin transport in the vascular meristem in response to developmental and environmental cues...
  33. ncbi request reprint Screening of yeasts for the production of the aroma compound 2-phenylethanol in a molasses-based medium
    M M Etschmann
    Karl Winnacker Institut der DECHEMA e V, Theodor Heuss Allee 25, 60486 Frankfurt Main, Germany
    Biotechnol Lett 25:531-6. 2003
    ..The most productive strains were Kluyveromyces marxianus CBS 600 and CBS 397...
  34. ncbi request reprint An aqueous-organic two-phase bioprocess for efficient production of the natural aroma chemicals 2-phenylethanol and 2-phenylethylacetate with yeast
    M M W Etschmann
    DECHEMA e V, Karl Winnacker Institut, Biochemical Engineering Group, Theodor Heuss Allee 25, 60486, Frankfurt am Main, Germany
    Appl Microbiol Biotechnol 71:440-3. 2006
    ..With Kluyveromyces marxianus CBS 600, 26.5 g/l 2-PE and 6.1 g/l 2-PEAc in the organic phase were obtained, corresponding to space-time yields of 0.33 and 0.08 g/l h, respectively...