Christoph Schoen

Summary

Country: Germany

Publications

  1. pmc Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome
    Biju Joseph
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e18441. 2011
  2. pmc Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines
    Martin Heisig
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 8, Wurzburg, 97078, Deutschland
    BMC Microbiol 11:163. 2011
  3. ncbi request reprint Living in a changing environment: insights into host adaptation in Neisseria meningitidis from comparative genomics
    Christoph Schoen
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, Bau E1, D 97080 Wurzburg, Germany
    Int J Med Microbiol 297:601-13. 2007
  4. pmc Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 193:2064-5. 2011
  5. doi request reprint Genome flexibility in Neisseria meningitidis
    Christoph Schoen
    Institut für Hygiene und Mikrobiologie, der Universität Würzburg, Josef Schneider Strasse 2, Bau E1, Würzburg 97877, Germany
    Vaccine 27:B103-11. 2009
  6. pmc Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence
    Biju Joseph
    Institute for Hygiene and Microbiology, University of Wurzburg, 97080 Wurzburg, Germany
    J Bacteriol 192:5363-77. 2010
  7. pmc Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:3473-8. 2008
  8. pmc The zinc-responsive regulon of Neisseria meningitidis comprises 17 genes under control of a Zur element
    Marie Christin Pawlik
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    J Bacteriol 194:6594-603. 2012
  9. pmc First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital
    Giuseppe Valenza
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2 E1, 97080 Wurzburg, Germany
    Antimicrob Agents Chemother 54:3493-7. 2010
  10. pmc Genome sequence of a Neisseria meningitidis capsule null locus strain from the clonal complex of sequence type 198
    Sabine Schork
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 194:5144-5. 2012

Collaborators

Detail Information

Publications22

  1. pmc Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome
    Biju Joseph
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e18441. 2011
    ..meningitidis. We combined comparative genome hybridization using microarrays (mCGH) and multilocus sequence typing (MLST) of 29 meningococcal isolates with computational comparison of a subset of seven meningococcal genome sequences...
  2. pmc Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines
    Martin Heisig
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 8, Wurzburg, 97078, Deutschland
    BMC Microbiol 11:163. 2011
    ....
  3. ncbi request reprint Living in a changing environment: insights into host adaptation in Neisseria meningitidis from comparative genomics
    Christoph Schoen
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, Bau E1, D 97080 Wurzburg, Germany
    Int J Med Microbiol 297:601-13. 2007
    ..meningitidis an accidental pathogen. The overall properties of the meningococcal genome are characterized by genomic variability and instability, resulting in increased functional flexibility within this species...
  4. pmc Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 193:2064-5. 2011
    ..Therefore, we sequenced the complete genome of the transformable Neisseria meningitidis serogroup A strain WUE2594...
  5. doi request reprint Genome flexibility in Neisseria meningitidis
    Christoph Schoen
    Institut für Hygiene und Mikrobiologie, der Universität Würzburg, Josef Schneider Strasse 2, Bau E1, Würzburg 97877, Germany
    Vaccine 27:B103-11. 2009
    ..From these studies, N. meningitidis emerges as a paradigm for organisms that use genome variability as an adaptation to changing and thus challenging environments...
  6. pmc Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence
    Biju Joseph
    Institute for Hygiene and Microbiology, University of Wurzburg, 97080 Wurzburg, Germany
    J Bacteriol 192:5363-77. 2010
    ....
  7. pmc Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:3473-8. 2008
    ..meningitidis has emerged as an unencapsulated human commensal from a common ancestor with Neisseria gonorrhoeae and Neisseria lactamica and consecutively acquired the genes responsible for capsule synthesis via horizontal gene transfer...
  8. pmc The zinc-responsive regulon of Neisseria meningitidis comprises 17 genes under control of a Zur element
    Marie Christin Pawlik
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    J Bacteriol 194:6594-603. 2012
    ..The Zur regulon among genes of unknown function comprised genes involved in zinc uptake, tRNA modification, and ribosomal assembly. In summary, this is the first study of the transcriptional response to zinc in meningococci...
  9. pmc First survey of metallo-beta-lactamases in clinical isolates of Pseudomonas aeruginosa in a German university hospital
    Giuseppe Valenza
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2 E1, 97080 Wurzburg, Germany
    Antimicrob Agents Chemother 54:3493-7. 2010
    ....
  10. pmc Genome sequence of a Neisseria meningitidis capsule null locus strain from the clonal complex of sequence type 198
    Sabine Schork
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 194:5144-5. 2012
    ..Here we report the genome sequence of a capsule null locus (cnl) strain of sequence type 198 (ST-198), which is found in half of the reported cases of IMD caused by cnl meningococcal strains...
  11. doi request reprint Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis
    Stephanie Schielke
    University of Wurzburg, Institute of Hygiene and Microbiology, Wurzburg, Germany
    Int J Med Microbiol 301:325-33. 2011
    ..Concluding, we present FarR as an exquisitely specialized, growth phase-dependent, possibly complement-responsive transcriptional regulator in N. meningitidis...
  12. doi request reprint Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells
    Biju Joseph
    Institute for Hygiene and Microbiology, Wurzburg, Germany
    Methods Mol Biol 799:267-93. 2012
    ....
  13. pmc Evaluation of one- and two-color gene expression arrays for microbial comparative genome hybridization analyses in routine applications
    Roland Schwarz
    Department of Bioinformatics, University of Wurzburg, Josef Schneider Str 2, Bau E1, 97080 Wurzburg, Germany
    J Clin Microbiol 48:3105-10. 2010
    ....
  14. doi request reprint Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells
    Alexandra Schubert-Unkmeir
    Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Wurzburg, Germany
    Methods Mol Biol 470:5-27. 2009
    ....
  15. ncbi request reprint Microarray analyses of meningococcal genome composition and gene regulation: a review of the recent literature
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    FEMS Microbiol Rev 31:43-51. 2007
    ..However, harmonization of protocols and tools, as well as central databases are needed to foster the comparability of studies and the integration of knowledge...
  16. doi request reprint O-acetyltransferase gene neuO is segregated according to phylogenetic background and contributes to environmental desiccation resistance in Escherichia coli K1
    Ines L Mordhorst
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Environ Microbiol 11:3154-65. 2009
    ..In contrast, NeuO expression led to a reduced biofilm formation in biofilm positive E. coli K1 isolates. These findings suggest a delicate ecological balance of neuO'on'/'off' switching...
  17. pmc Molecular detection of Campylobacter jejuni as a cause of culture-negative spondylodiscitis
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Clin Microbiol 50:1499-500. 2012
    ..We report a case of culture-negative spondylodiscitis and a psoas abscess due to Campylobacter jejuni in a 68-year-old woman, as revealed by 16S rRNA gene and Campylobacter-specific PCRs from biopsied tissue...
  18. doi request reprint Resistance to tobramycin and colistin in isolates of Pseudomonas aeruginosa from chronically colonized patients with cystic fibrosis under antimicrobial treatment
    Giuseppe Valenza
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Scand J Infect Dis 42:885-9. 2010
    ..To conclude, resistance to tobramycin in P. aeruginosa isolates from CF patients under antimicrobial therapy may occur while colistin resistance remains uncommon...
  19. pmc Transmission of Armillifer armillatus ova at snake farm, The Gambia, West Africa
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Emerg Infect Dis 17:251-4. 2011
    ..Our investigation highlights transmission of infective A. armillatus ova to dogs and, by serologic evidence, also to 1 human, demonstrating a public health concern...
  20. doi request reprint Transposon insertion in a serine-specific minor tRNA coding sequence affects intraperitoneal survival of Haemophilus influenzae in the infant rat model
    Gabriele Gerlach
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, Bau E1, 97080 Wurzburg, Germany
    Int J Med Microbiol 300:218-28. 2010
    ..We speculate that a reduced translation efficiency of several UCC containing mRNAs results in a delay of protein synthesis and consequently in the loss of cellular mechanisms which are necessary for ROS resistance and virulence...
  21. pmc Life-threatening infection caused by daptomycin-resistant Corynebacterium jeikeium in a neutropenic patient
    Christoph Schoen
    Institute for Hygiene and Microbiology, Julius Maximilian University, Wurzburg, Germany
    J Clin Microbiol 47:2328-31. 2009
    ....
  22. pmc Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants
    Jochen Stritzker
    Lehrstuhl für Mikrobiologie am Biozentrum der Universität Würzburg, Wurzburg, Germany
    Infect Immun 72:5622-9. 2004
    ....