Renate B Schnabel

Summary

Country: Germany

Publications

  1. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
  2. doi request reprint Sex differences in noninvasive vascular function in the community
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center, Hamburg Eppendorf, Hamburg, Germany
    J Hypertens 31:1437-46; discussion 1446. 2013
  3. pmc Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study
    Choumous Kallel
    INSERM UMR, Aix Marseille Universite, France
    BMC Med Genet 13:103. 2012
  4. doi request reprint Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study
    Renate B Schnabel
    University Heart Center, Department of General and Interventional Cardiology, Martinistr 52, 20246 Hamburg, Germany
    Hypertension 60:288-95. 2012
  5. pmc Atrial fibrillation: its prevalence and risk factor profile in the German general population
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany
    Dtsch Arztebl Int 109:293-9. 2012
  6. pmc Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Clin Chem 58:113-26. 2012
  7. doi request reprint Noninvasive vascular function measurement in the community: cross-sectional relations and comparison of methods
    Renate B Schnabel
    Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Circ Cardiovasc Imaging 4:371-80. 2011
  8. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
  9. doi request reprint Can we predict the occurrence of atrial fibrillation?
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cardiol 35:5-9. 2012
  10. ncbi request reprint Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 45:1631-7. 2005

Detail Information

Publications42

  1. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  2. doi request reprint Sex differences in noninvasive vascular function in the community
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center, Hamburg Eppendorf, Hamburg, Germany
    J Hypertens 31:1437-46; discussion 1446. 2013
    ..The relation of noninvasive vascular function to sex, sex hormones, and reproductive history in the general population is little understood...
  3. pmc Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study
    Choumous Kallel
    INSERM UMR, Aix Marseille Universite, France
    BMC Med Genet 13:103. 2012
    ..Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE)...
  4. doi request reprint Multiple endothelial biomarkers and noninvasive vascular function in the general population: the Gutenberg Health Study
    Renate B Schnabel
    University Heart Center, Department of General and Interventional Cardiology, Martinistr 52, 20246 Hamburg, Germany
    Hypertension 60:288-95. 2012
    ..Whether determination of blood biomarkers helps to better understand vascular pathology and may provide prognostic information needs to be investigated in future studies...
  5. pmc Atrial fibrillation: its prevalence and risk factor profile in the German general population
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany
    Dtsch Arztebl Int 109:293-9. 2012
    ..Atrial fibrillation (AF) is an increasingly common problem in primary care, but little is known about its prevalence and the distribution of AF risk factors in the general population...
  6. pmc Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
    Clin Chem 58:113-26. 2012
    ..In most cases, however, these groundbreaking observations have not yet been accompanied by clinically applicable tools for risk prediction, diagnosis, or therapeutic interventions...
  7. doi request reprint Noninvasive vascular function measurement in the community: cross-sectional relations and comparison of methods
    Renate B Schnabel
    Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Circ Cardiovasc Imaging 4:371-80. 2011
    ..A direct comparison of the different methods and their relation to classical cardiovascular risk factors in a large cohort is missing...
  8. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    ..The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated...
  9. doi request reprint Can we predict the occurrence of atrial fibrillation?
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cardiol 35:5-9. 2012
    ..Despite a relevant public-health impact, knowledge on risk prediction and primary prevention of AF is still limited today. There are no conflicts of interest to disclose...
  10. ncbi request reprint Glutathione peroxidase-1 and homocysteine for cardiovascular risk prediction: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 45:1631-7. 2005
    ..This prospective study was designed to evaluate the effect of joint determination of two important contrary biomarkers--homocysteine and glutathione peroxidase (GPx)-1--on cardiovascular risk stratification...
  11. doi request reprint Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Eur Heart J 29:649-57. 2008
    ..Data in patients with manifest coronary artery disease (CAD) are scant stimulating the investigation of the association of adiponectin concentrations and cardiovascular outcome in a prospective CAD cohort...
  12. ncbi request reprint B-type natriuretic peptide and the risk of cardiovascular events and death in patients with stable angina: results from the AtheroGene study
    Renate Schnabel
    Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 47:552-8. 2006
    ..The aim of this study was to assess the predictive value of the cardiac hormone B-type natriuretic peptide (BNP) for long-term outcome in a large cohort of stable angina patients...
  13. doi request reprint Multiple marker approach to risk stratification in patients with stable coronary artery disease
    Renate B Schnabel
    Department of Medicine II, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Eur Heart J 31:3024-31. 2010
    ..multimarker approaches for risk prediction in coronary artery disease have remained inconsistent. We assessed multiple biomarkers representing distinct pathophysiological pathways in relation to cardiovascular events in stable angina...
  14. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  15. doi request reprint Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study
    Philipp S Wild
    Department of Medicine II, Institute for Clinical Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    Circ Cardiovasc Imaging 3:604-13. 2010
    ..This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods...
  16. pmc Validation of an atrial fibrillation risk algorithm in whites and African Americans
    Renate B Schnabel
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Arch Intern Med 170:1909-17. 2010
    ..We sought to validate a recently published risk algorithm for incident atrial fibrillation (AF) in independent cohorts and other racial groups...
  17. doi request reprint Association of MR-proadrenomedullin with cardiovascular risk factors and subclinical cardiovascular disease
    Johannes Tobias Neumann
    Department of General and Interventional Cardiology, Hamburg University Heart Center, Martinistrase 52, 20246 Hamburg, Germany
    Atherosclerosis 228:451-9. 2013
    ..Therefore, we aimed to determine the distribution of MR-proADM in the general population and to reveal potential associations of MR-proADM with cardiovascular risk factors and measures of subclinical cardiovascular disease...
  18. doi request reprint Midregional proadrenomedullin for prediction of cardiovascular events in coronary artery disease: results from the AtheroGene study
    Philipp S Wild
    Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany
    Clin Chem 58:226-36. 2012
    ..We evaluated the prognostic impact of MR-proADM in a cohort of patients with symptomatic coronary artery disease according to their clinical presentation...
  19. pmc P wave duration and risk of longitudinal atrial fibrillation in persons ≥ 60 years old (from the Framingham Heart Study)
    Jared W Magnani
    Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Cardiol 107:917-921.e1. 2011
    ..In conclusion, maximum P wave duration at the upper fifth percentile was associated with long-term AF risk in an elderly community-based cohort. P wave duration is an electrocardiographic endophenotype for AF...
  20. pmc Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study
    Joao D Fontes
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 228:217-23. 2013
    ..We sought to analyze clinical factors associated with change in inflammation in the community...
  21. pmc Insulin resistance and atrial fibrillation (from the Framingham Heart Study)
    Joao D Fontes
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 109:87-90. 2012
    ..18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF...
  22. doi request reprint Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
    ..Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction...
  23. pmc The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations
    Renate B Schnabel
    NHLBIs Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circ Cardiovasc Genet 2:229-37. 2009
    ..In the family-based Framingham Heart Study, we investigated heritability and candidate gene associations of systemic inflammatory biomarkers...
  24. pmc Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Study, Framingham, Mass, USA
    Circulation 121:200-7. 2010
    ..Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial...
  25. ncbi request reprint Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease
    Christoph R Sinning
    Department of Medicine II, University Medical Centre Johannes Gutenberg University, Mainz, Germany
    Circ J 75:1184-91. 2011
    ..Procalcitonin (PCT) is an established biomarker for the diagnosis of sepsis. Evidence is growing that PCT concentration correlates with the extent of atherosclerosis and prognosis in patients with coronary artery disease (CAD)...
  26. pmc A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease
    Philipp S Wild
    Department of Medicine II, University Medical Center Mainz, Germany
    Circ Cardiovasc Genet 4:403-12. 2011
    ..We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD)...
  27. pmc Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study
    Edith Lubos
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
    Atherosclerosis 209:271-7. 2010
    ..We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis...
  28. doi request reprint Cystatin C and cardiovascular mortality in patients with coronary artery disease and normal or mildly reduced kidney function: results from the AtheroGene study
    Till Keller
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Eur Heart J 30:314-20. 2009
    ..Cystatin C is a promising marker to reliably mirror renal function. The role of cystatin C in patients with coronary artery disease (CAD) and normal or mildly reduced kidney function is the subject of current investigation...
  29. pmc Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study
    Renate B Schnabel
    Framingham Heart Study, Framingham, MA, USA Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
    Lancet 373:739-45. 2009
    ..We aimed to develop a risk score to predict individuals' absolute risk of developing the condition, and to provide a framework for researchers to assess new risk markers...
  30. pmc Depression in atrial fibrillation in the general population
    Renate B Schnabel
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    PLoS ONE 8:e79109. 2013
    ..Initial evidence suggests that depressive symptoms are more frequent in patients with atrial fibrillation. Data from the general population are limited...
  31. doi request reprint Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study
    Stergios Tzikas
    Department of Medicine 2, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Clin Chem Lab Med 51:1125-33. 2013
    ..The aim of the present study was to describe the distribution of a contemporary MR-proANP assay in a large population-representative sample and to evaluate the association with prevalent cardiac diseases and cardiovascular risk factors...
  32. pmc P-wave indices: derivation of reference values from the Framingham Heart Study
    Jared W Magnani
    Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA
    Ann Noninvasive Electrocardiol 15:344-52. 2010
    ..Reference values for P-wave indices, providing cut points for their classification and interpretation, have not yet been established and are essential toward facilitating clinical application and comparison between studies...
  33. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  34. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  35. pmc Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators
    Renate B Schnabel
    National Heart, Lung, and Blood Institute and Boston University Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702 5827, USA
    Blood 115:5289-99. 2010
    ..We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications...
  36. pmc Differential associations of depressive symptom dimensions with cardio-vascular disease in the community: results from the Gutenberg health study
    Matthias Michal
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 8:e72014. 2013
    ..They rather emphasize a close interplay with life-style factors and with a family history of MI. ..
  37. doi request reprint Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project
    Stefan Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Circulation 121:2388-97. 2010
    ..We report results from 2 cohorts in such a continuing study...
  38. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  39. doi request reprint High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort
    Tanja Zeller
    Clinic for General and Interventional Cardiology, University Heart Centre Hamburg, Hamburg, Germany
    Eur Heart J 35:271-81. 2014
    ..Our aim was to test the prediction and clinical applicability of high-sensitivity assayed troponin I for incident cardiovascular events in a general middle-aged European population...
  40. pmc Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    Emelia J Benjamin
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:879-81. 2009
    ..19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15))...
  41. pmc Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
    ....
  42. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI...