- Activity of the Akt-dependent anabolic and catabolic pathways in muscle and liver samples in cancer-related cachexiaThomas L Schmitt
Division of Immunochemistry D020, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
J Mol Med (Berl) 85:647-54. 2007..Our study demonstrates a cachexia-associated loss of Akt-dependent signalling in human skeletal muscle with decreased activity of regulators of protein synthesis and a disinhibition of protein degradation...
- Hydrogen peroxide inhibits activity of the IGF-1 receptor kinaseThomas L Schmitt
Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Redox Rep 11:105-9. 2006..This reciprocal influence of physiologically relevant doses of hydrogen peroxide may have important implications on signal transduction of the closely related receptors for insulin and IGF-1...