Joachim P Schmitt
- Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibitionJoachim P Schmitt
Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
Circulation 119:436-44. 2009..Here, we investigated whether PLN exhibits cardiotoxic effects via mechanisms other than chronic inhibition of SERCA2a by studying a PLN mutant, PLN(R9C), that triggers cardiac failure in humans and mice...
- A new type of ERK1/2 autophosphorylation causes cardiac hypertrophyKristina Lorenz
Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, Wurzburg, Germany
Nat Med 15:75-83. 2009..We propose that specific phosphorylation events on ERK1/2 integrate differing upstream signals (Raf1-MEK1/2 or G protein-coupled receptor-G(q)) to induce cardiac hypertrophy...
- Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signalingKristina Lorenz
Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
Int J Biochem Cell Biol 41:2351-5. 2009..This short review will discuss new mechanistic insights into ERK1/2-dependent development of cardiac hypertrophy and the prospect to translate this knowledge into future therapeutic strategies...