Andrea Schmitt

Summary

Country: Germany

Publications

  1. ncbi Is brain banking of psychiatric cases valuable for neurobiological research?
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Germany
    Clinics (Sao Paulo) 63:255-66. 2008
  2. ncbi Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats
    Nina Segnitz
    University of Heidelberg, Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Neurochem Int 55:619-28. 2009
  3. ncbi Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
    Nadine Farkas
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    World J Biol Psychiatry 11:556-66. 2010
  4. ncbi Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:565-77. 2012
  5. ncbi Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
    Mario Herrera-Marschitz
    Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, P O Box 70 000, Santiago 7, Chile
    Neurotox Res 19:603-27. 2011
  6. ncbi Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study
    Gregor Habl
    Central Institute of Mental Health, P O Box 12 21 20, 68072 Mannheim, Germany
    J Neural Transm 116:1657-65. 2009
  7. ncbi Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr, Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
    BMC Psychiatry 9:17. 2009
  8. ncbi Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
  9. ncbi Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
    Andrea Schmitt
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008
  10. ncbi Schizophrenia as a disorder of disconnectivity
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S150-4. 2011

Detail Information

Publications41

  1. ncbi Is brain banking of psychiatric cases valuable for neurobiological research?
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Germany
    Clinics (Sao Paulo) 63:255-66. 2008
    ....
  2. ncbi Differential expression of glutamate transporter genes after chronic oral treatment with aripiprazole in rats
    Nina Segnitz
    University of Heidelberg, Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Neurochem Int 55:619-28. 2009
    ..These transcriptional effects exerted by aripiprazole may counteract a glutamatergic deficit state and strengthen the neurotransmission of glutamate with positive consequences on cognitive and negative symptoms of schizophrenia...
  3. ncbi Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
    Nadine Farkas
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    World J Biol Psychiatry 11:556-66. 2010
    ..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia...
  4. ncbi Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:565-77. 2012
    ..It is hypothesized that abnormal expression of these and related genes has a major impact on the pathophysiology of schizophrenia...
  5. ncbi Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
    Mario Herrera-Marschitz
    Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, P O Box 70 000, Santiago 7, Chile
    Neurotox Res 19:603-27. 2011
    ..It is proposed that sentinel proteins can be used as markers for characterising long-term effects of perinatal asphyxia, and as targets for novel therapeutic development and innovative strategies for neonatal care...
  6. ncbi Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study
    Gregor Habl
    Central Institute of Mental Health, P O Box 12 21 20, 68072 Mannheim, Germany
    J Neural Transm 116:1657-65. 2009
    ..However, our study group was small and results should be verified using larger samples...
  7. ncbi Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr, Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
    BMC Psychiatry 9:17. 2009
    ..The superior temporal gyrus is implicated in schizophrenia and executes functions such as the processing of speech, language skills and sound processing...
  8. ncbi Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
    ....
  9. ncbi Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
    Andrea Schmitt
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008
    ..In animal models of ischemia/hypoxia, NRG1 has been shown to act as a therapeutic, neuroprotective agent and should be investigated in more detail in transgenic animal models...
  10. ncbi Schizophrenia as a disorder of disconnectivity
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S150-4. 2011
    ..The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed...
  11. ncbi Reduction of gyrification index in the cerebellar vermis in schizophrenia: a post-mortem study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    World J Biol Psychiatry 12:99-103. 2011
    ..Cerebellar regions have been implicated in the pathophysiology of schizophrenia; however, the GI has not been investigated here so far...
  12. ncbi Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:101-11. 2010
    ..This supports the hypothesis of an abnormal glutamatergic neurotransmission in the right cerebellum in the pathophysiology of schizophrenia...
  13. ncbi Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Neuromolecular Med 14:270-80. 2012
    ....
  14. ncbi Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, D 40629 Düsseldorf, Germany
    J Clin Psychiatry 72:205-18. 2011
    ..The current study was therefore designed to compare prospectively the relapse preventive efficacy of further maintenance treatment and targeted intermittent treatment in patients with ICD-10-diagnosed first-episode schizophrenia...
  15. ncbi Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:126-34. 2009
    ..Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia...
  16. ncbi Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 11:243-50. 2010
    ..However, our study sample was small and results of this exploratory study should be verified in a larger sample...
  17. ncbi Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 12:201-15. 2011
    ..This may be partly ascribed to the origin of the materials (CSF, blood, brain tissue) or to the genes selected for the respective studies. Moreover, in some locations, inflammatory genes may be up-regulated, others may be down-regulated...
  18. ncbi Akathisia and suicidal ideation in first-episode schizophrenia
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J Clin Psychopharmacol 32:694-8. 2012
    ..The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES...
  19. ncbi Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 13:30-8. 2012
    ..To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol...
  20. ncbi Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  21. ncbi Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain
    Nina Segnitz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, P O Box 122120, 68072 Mannheim, Germany
    Psychopharmacology (Berl) 217:127-42. 2011
    ..Within the second-generation antipsychotics, the partial dopaminergic and serotonergic agonist aripiprazole (APZ) was able to counteract the behavioral effects of NMDA-R antagonists...
  22. ncbi Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  23. ncbi Differential effects of long-term treatment with clozapine or haloperidol on GABAA receptor binding and GAD67 expression
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 66:151-7. 2004
    ..However, the reduced GAD67 expression seen in postmortem brains does not appear to reflect drug effects, since our animal model demonstrated increased gene expression...
  24. ncbi Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms
    Andrea Schmitt
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Schizophr Res 80:305-13. 2005
    ..Correlations point to the impact of S100B in neuroplasticity and ageing. Post-mortem studies should clarify the presence of altered S100B function in the brain and its relationship to neuroplastic or neurodegenerative processes...
  25. ncbi Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 122120, D 68072 Mannheim, Germany
    Neurosci Lett 347:81-4. 2003
    ..We hypothesize that glutamate transporter downregulation by neuroleptics increases glutamatergic action at the postsynaptic neuron and thereby may be related to beneficial antipsychotic effects and side effects...
  26. ncbi Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  27. ncbi Predictors of response and remission in the acute treatment of first-episode schizophrenia patients--is it all about early response?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Neuropsychopharmacol 21:370-8. 2011
    ..To evaluate the predictive validity of early response compared to other well-known predictor variables in acutely ill first-episode patients...
  28. ncbi The role of the cerebellum in schizophrenia: from cognition to molecular pathways
    Peyman Yeganeh-Doost
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Clinics (Sao Paulo) 66:71-7. 2011
    ..We discuss the molecular findings in the light of the role of the cerebellum in attention and cognitive deficits in schizophrenia...
  29. ncbi Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Schizophr Res 89:198-210. 2007
    ....
  30. ncbi Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
    ..Dysfunctional N-methyl D-aspartate receptors or modulation of dopaminergic transmission can explain these findings. Nevertheless, the effects of antipsychotic medication still need to be considered...
  31. ncbi Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures
    Mathias Zink
    Central Institute of Mental Health, P O Box 12 21 20, D 68072 Mannheim, Germany
    Alcohol Clin Exp Res 28:1752-7. 2004
    ..To further characterize the influence of chronic ethanol exposure on the developing brain, we assessed the transcriptional and translational regulation of glutamate transporters in a less artificial in vitro system...
  32. ncbi Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits
    Andrea Schmitt
    Central Institute of Mental Health, PO Box 12 21 20, D 68072 Mannheim, Germany
    Neurochem Res 28:235-41. 2003
    ..Because the effects seen in different brain areas clearly vary between haloperidol and clozapine, they may also be responsible for some of the differences in efficacy and side effects...
  33. ncbi Pedophilia: neuropsychological evidence encouraging a brain network perspective
    Heike Tost
    Central Institute of Mental Health, NMR Research in Psychiatry, P O Box 122120, 68072 Mannheim, Germany
    Med Hypotheses 63:528-31. 2004
    ....
  34. ncbi Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence
    Berend Malchow
    Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Georg August University, Germany
    Eur Arch Psychiatry Clin Neurosci 263:3-13. 2013
    ..There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed...
  35. ncbi Altered thalamic membrane phospholipids in schizophrenia: a postmortem study
    Andrea Schmitt
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 56:41-5. 2004
    ..They support the notion of an increased phospholipid breakdown in schizophrenia as a sign for decreased myelination and oligodendrocyte dysfunction...
  36. ncbi Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
    Gerald Stober
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 10:127-55. 2009
    ....
  37. ncbi Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
    ..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity...
  38. ncbi Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  39. ncbi D2 antidopaminergic modulation of frontal lobe function in healthy human subjects
    Heike Tost
    Department of Psychiatry and Psychotherapy, University of Heidelberg, Germany
    Biol Psychiatry 60:1196-205. 2006
    ..Two major neurophysiological models propose segregated functional circuits on the systems level as well as D(1) and D(2) receptor-dependent processing states on the cellular level (two-state model)...
  40. ncbi Huntington's disease: phenomenological diversity of a neuropsychiatric condition that challenges traditional concepts in neurology and psychiatry
    Heike Tost
    Central Institute of Mental Health, University of Heidelberg, Germany
    Am J Psychiatry 161:28-34. 2004
  41. ncbi microRNA-34c is a novel target to treat dementias
    Athanasios Zovoilis
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Gottingen, Germany
    EMBO J 30:4299-308. 2011
    ..Our data suggest that miR-34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34c could be a suitable therapy...