Mathias Schmidt

Summary

Country: Germany

Publications

  1. doi request reprint Suitability of ivy extract for the treatment of paediatric cough
    M Schmidt
    Herbresearch Germany, Wartbergweg 15, D 86874 Mattsies, Germany
    Phytother Res 26:1942-7. 2012
  2. ncbi request reprint Saffron in phytotherapy: pharmacology and clinical uses
    Mathias Schmidt
    Herbresearch Germany, Tussenhausen, Germany
    Wien Med Wochenschr 157:315-9. 2007
  3. ncbi request reprint St. John's wort: role of active compounds for its mechanism of action and efficacy
    Veronika Butterweck
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32608, USA
    Wien Med Wochenschr 157:356-61. 2007
  4. ncbi request reprint Willow bark extract: the contribution of polyphenols to the overall effect
    Adolf Nahrstedt
    Institut für Pharmazeutische Biologie und Phytochemie, Universitat Munster, Germany
    Wien Med Wochenschr 157:348-51. 2007
  5. ncbi request reprint Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
    Mathias Schmidt
    ALTANA Pharma AG, Therapeutic Area Oncology, Byk Gulden Strasse 2, Konstanz, Germany
    Drug Resist Updat 10:162-81. 2007
  6. ncbi request reprint Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells
    Mathias Schmidt
    Therapeutic Area Oncology, ALTANA Pharma AG, Byk Gulden Str 2, D 78467 Konstanz, Germany
    Mol Cancer Ther 5:809-17. 2006
  7. ncbi request reprint Hepatotoxicity from Cimicifuga racemosa? Recent Australian case report not sufficiently substantiated
    Michael Thomsen
    J Altern Complement Med 9:337-40. 2003
  8. ncbi request reprint Are kavalactones the hepatotoxic principle of kava extracts? The pitfalls of the glutathione theory
    Mathias Schmidt
    J Altern Complement Med 9:183-7; author reply 187-8. 2003
  9. ncbi request reprint HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
    Christiane Knuefermann
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA
    Oncogene 22:3205-12. 2003
  10. ncbi request reprint EGF receptor targeting in therapy-resistant human tumors
    Mathias Schmidt
    Byk Gulden, Lomberg Chemische Fabrik GmbH, Byk Gulden Strasse 2, Konstanz, Germany
    Drug Resist Updat 5:11-8. 2002

Collaborators

  • Mohamed T Khayyal
  • V Butterweck
  • John Mendelsohn
  • Adolf Nahrstedt
  • Michael Thomsen
  • Christiane Knuefermann
  • Thomas Beckers
  • Zhen Fan
  • Ling Wu
  • Bolin Liu
  • Weidong Jin
  • Yang Lu
  • Gordon B Mills
  • Ke Liang
  • Angelika M Burger
  • Herwig Pongratz
  • Siavosh Mahboobi
  • Markus Frieser
  • Thomas Reissmann
  • Jorg Hockemeyer
  • Harald Hufsky
  • Udo Vanhoefer
  • Heinz H Fiebig

Detail Information

Publications12

  1. doi request reprint Suitability of ivy extract for the treatment of paediatric cough
    M Schmidt
    Herbresearch Germany, Wartbergweg 15, D 86874 Mattsies, Germany
    Phytother Res 26:1942-7. 2012
    ..Five adverse events classified as mild and non-serious were reported (1.9%). In conclusion, ivy leaf extract in the form of syrup and of cough drops was confirmed as an effective and safe treatment of cough in children...
  2. ncbi request reprint Saffron in phytotherapy: pharmacology and clinical uses
    Mathias Schmidt
    Herbresearch Germany, Tussenhausen, Germany
    Wien Med Wochenschr 157:315-9. 2007
    ..Antidepressant effects were found in vivo and in clinical pilot studies. Saffron extracts thus have the potential to make a major contribution to rational phytotherapy...
  3. ncbi request reprint St. John's wort: role of active compounds for its mechanism of action and efficacy
    Veronika Butterweck
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32608, USA
    Wien Med Wochenschr 157:356-61. 2007
    ..Although there are some open questions, the bulk of data suggests that several groups of active compounds are contributing to the antidepressant efficacy of the plant extract...
  4. ncbi request reprint Willow bark extract: the contribution of polyphenols to the overall effect
    Adolf Nahrstedt
    Institut für Pharmazeutische Biologie und Phytochemie, Universitat Munster, Germany
    Wien Med Wochenschr 157:348-51. 2007
    ..All in vivo and in vitro models studied pointed to relevant contributions of the fraction of polyphenols and flavonoids. The single compounds or their combinations responsible for the effect remain to be elucidated...
  5. ncbi request reprint Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
    Mathias Schmidt
    ALTANA Pharma AG, Therapeutic Area Oncology, Byk Gulden Strasse 2, Konstanz, Germany
    Drug Resist Updat 10:162-81. 2007
    ..It is expected that this "next generation" of anti-mitotic drugs will be as successful as the classical anti-microtubule drugs, while avoiding some of the adverse side effects...
  6. ncbi request reprint Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells
    Mathias Schmidt
    Therapeutic Area Oncology, ALTANA Pharma AG, Byk Gulden Str 2, D 78467 Konstanz, Germany
    Mol Cancer Ther 5:809-17. 2006
    ..It was found that the differential electrophoretic mobility of cdc25c can serve as a reliable molecular marker to track inhibition of Plk1 by small-molecule inhibitors within a cell...
  7. ncbi request reprint Hepatotoxicity from Cimicifuga racemosa? Recent Australian case report not sufficiently substantiated
    Michael Thomsen
    J Altern Complement Med 9:337-40. 2003
  8. ncbi request reprint Are kavalactones the hepatotoxic principle of kava extracts? The pitfalls of the glutathione theory
    Mathias Schmidt
    J Altern Complement Med 9:183-7; author reply 187-8. 2003
  9. ncbi request reprint HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
    Christiane Knuefermann
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA
    Oncogene 22:3205-12. 2003
    ....
  10. ncbi request reprint EGF receptor targeting in therapy-resistant human tumors
    Mathias Schmidt
    Byk Gulden, Lomberg Chemische Fabrik GmbH, Byk Gulden Strasse 2, Konstanz, Germany
    Drug Resist Updat 5:11-8. 2002
    ..In human breast carcinomas, the presence of EGFR correlates with lack of response towards anti-estrogen therapy suggesting the concomitant inhibition of both the receptors for estrogen and EGF to improve breast cancer therapy...
  11. ncbi request reprint 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors
    Thomas Beckers
    ASTA Medica Oncology, D 60314 Frankfurt Main, Germany
    Cancer Res 62:3113-9. 2002
    ..4 days at 400 mg/kg. Therefore, D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources...
  12. ncbi request reprint Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins
    Mathias Schmidt
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Paul Ehrlich Strasse 42 44, D 60596 Frankfurt am Main, Germany
    Int J Cancer 97:349-56. 2002
    ....