D Schmidt

Summary

Country: Germany

Publications

  1. ncbi request reprint Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsia 45:179-86. 2004
  2. ncbi request reprint What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs?
    Dieter Schmidt
    Arbeitsgruppe Epilepsieforschung Berlin, Berlin, Germany
    Epilepsy Behav 5:627-35. 2004
  3. doi request reprint Drug treatment of epilepsy: options and limitations
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, D 14163 Berlin, Germany
    Epilepsy Behav 15:56-65. 2009
  4. doi request reprint Anti-epileptogenic Clinical Trial Designs in Epilepsy: Issues and Options
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, 14163, Berlin, Germany
    Neurotherapeutics 11:401-11. 2014
  5. doi request reprint Clinical features associated with placebo response in refractory focal epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsy Behav 27:393-8. 2013
  6. ncbi request reprint Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epileptic Disord 14:105-13. 2012
  7. doi request reprint Is incident drug-resistance of childhood-onset epilepsy reversible? A long-term follow-up study
    Matti SillanpAA
    Departments of Public Health and Child Neurology, 20014 Turku University, Turku, Finland
    Brain 135:2256-62. 2012
  8. doi request reprint Evidence-based review on the natural history of the epilepsies
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Curr Opin Neurol 25:159-63. 2012
  9. doi request reprint [Drug treatment of epilepsy]
    D Schmidt
    Arbeitsgruppe Epilepsieforschung, Goethestr 5, 14163, Berlin, Deutschland
    Nervenarzt 83:213-9. 2012
  10. ncbi request reprint How reliable is early treatment response in predicting long-term seizure outcome?
    D Schmidt
    Epilepsy Research Group, Berlin, Goethestrasse 5, D 14163 Berlin, Germany
    Epilepsy Behav 10:588-94. 2007

Detail Information

Publications48

  1. ncbi request reprint Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsia 45:179-86. 2004
    ....
  2. ncbi request reprint What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs?
    Dieter Schmidt
    Arbeitsgruppe Epilepsieforschung Berlin, Berlin, Germany
    Epilepsy Behav 5:627-35. 2004
    ..OXC should be preferred over CBZ and other older AEDs because of its proven efficacy and excellent side effect profile in children, adolescents, and adults with partial seizures...
  3. doi request reprint Drug treatment of epilepsy: options and limitations
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, D 14163 Berlin, Germany
    Epilepsy Behav 15:56-65. 2009
    ..Improved seizure control is likely to reduce the morbidity and increased mortality associated with uncontrolled epilepsy. In this short overview, the options and the limitations of treating patients with epilepsy are briefly summarized...
  4. doi request reprint Anti-epileptogenic Clinical Trial Designs in Epilepsy: Issues and Options
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, 14163, Berlin, Germany
    Neurotherapeutics 11:401-11. 2014
    ....
  5. doi request reprint Clinical features associated with placebo response in refractory focal epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsy Behav 27:393-8. 2013
    ....
  6. ncbi request reprint Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epileptic Disord 14:105-13. 2012
    ..Although more evidence is needed, there is hope on the horizon for antiepileptogenic therapy that works...
  7. doi request reprint Is incident drug-resistance of childhood-onset epilepsy reversible? A long-term follow-up study
    Matti SillanpAA
    Departments of Public Health and Child Neurology, 20014 Turku University, Turku, Finland
    Brain 135:2256-62. 2012
    ..Idiopathic or cryptogenic aetiology is a clinical predictor of reversible drug-resistant epilepsy...
  8. doi request reprint Evidence-based review on the natural history of the epilepsies
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Curr Opin Neurol 25:159-63. 2012
    ..The present review discusses clinically important evidence for unstable remission/relapse patterns and for causes of premature mortality in patients with epilepsy...
  9. doi request reprint [Drug treatment of epilepsy]
    D Schmidt
    Arbeitsgruppe Epilepsieforschung, Goethestr 5, 14163, Berlin, Deutschland
    Nervenarzt 83:213-9. 2012
    ..In one out of three patients, seizure freedom is currently not possible due to drug-resistance, which requires a prompt diagnostic and therapeutic reevaluation of the epilepsy...
  10. ncbi request reprint How reliable is early treatment response in predicting long-term seizure outcome?
    D Schmidt
    Epilepsy Research Group, Berlin, Goethestrasse 5, D 14163 Berlin, Germany
    Epilepsy Behav 10:588-94. 2007
    ..The main conclusion is that response at 6 months is an excellent predictor of response at 12 months...
  11. ncbi request reprint Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsia 46:858-77. 2005
    ....
  12. ncbi request reprint The chance of cure following surgery for drug-resistant temporal lobe epilepsy. What do we know and do we need to revise our expectations?
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, D 14163 Berlin, Germany
    Epilepsy Res 60:187-201. 2004
    ..A randomized controlled trial is needed to determine if, in fact only one in three to four patients with temporal lobe epilepsy undergoing surgery can be considered cured...
  13. doi request reprint Long-term seizure outcome of surgery versus no surgery for drug-resistant partial epilepsy: a review of controlled studies
    Dieter Schmidt
    Epilepsy Research Group Berlin, Germany
    Epilepsia 50:1301-9. 2009
    ....
  14. doi request reprint Outlook: the postictal state--future directions for research
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsy Behav 19:191-2. 2010
    ....
  15. doi request reprint Effect of antiepileptic drugs on the postictal state. A critical overview
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, D 14163 Berlin, Germany
    Epilepsy Behav 19:176-81. 2010
    ....
  16. doi request reprint AED discontinuation may be dangerous for seizure-free patients
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, 14163, Berlin, Germany
    J Neural Transm 118:183-6. 2011
    ..Discontinuation should be avoided in patients with a high risk of seizure recurrence. Given these risks, patients will ultimately have to decide themselves whether they wish to discontinue drug treatment after full informed consent...
  17. doi request reprint Antiepileptic drug discovery: does mechanism of action matter?
    Dieter Schmidt
    Epilepsy Research Group, Berlin, Germany
    Epilepsy Behav 21:342-3. 2011
    ..Developing antiepileptic drugs with antiepileptogenic activity may be a clue to better treatment of presently drug-resistant epilepsy...
  18. ncbi request reprint Recommendations on the clinical use of oxcarbazepine in the treatment of epilepsy: a consensus view
    D Schmidt
    Epilepsy Reseach Group, Goethestrasse 5, D 14163 Berlin, Germany
    Acta Neurol Scand 104:167-70. 2001
    ..In summary, oxcarbazepine is a safe and well tolerated antiepileptic drug for partial epilepsy...
  19. ncbi request reprint [How is oxcarbazepine different from carbamazpine?]
    D Schmidt
    Arbeitsgruppe Epilepsieforschung Berlin
    Nervenarzt 75:153-60. 2004
    ..Oxcarbazepine should be preferred over CBZ and other older AEDs due to its very good efficacy and better side effect profile in children, adolescents, and adults with partial seizures...
  20. ncbi request reprint Gottfried Benn, a German poet-physician, on epilepsy in 1910-1911
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, D 14163 Berlin, Germany
    Arch Neurol 61:140-4. 2004
  21. ncbi request reprint A risk-benefit assessment of therapies for Lennox-Gastaut syndrome
    D Schmidt
    Epilepsy Research Group, Berlin, Germany
    Drug Saf 22:467-77. 2000
    ..These suggestions are based on the best evidence available and do not in any way exclude the use of other treatments if compelling individual risk-benefit considerations apply...
  22. ncbi request reprint [Oxcarbazepine (Trileptal). An effective and well tolerated new drug as first choice in treatment of focal seizures]
    D Schmidt
    Arbeitsgruppe Epilepsieforschung, Berlin
    Nervenarzt 71:849-55. 2000
    ..In addition, OXC has been thoroughly tested in an unusually large clinical development program and been shown to be similarly effective as standard antiepileptic drugs...
  23. ncbi request reprint Proof of principle trials: exploratory open studies
    D Schmidt
    Epilepsy Research Group, Goethe Str 5, 14163, Berlin, Germany
    Epilepsy Res 45:15-8; discussion 19-21. 2001
    ....
  24. ncbi request reprint The clinical impact of new antiepileptic drugs after a decade of use in epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, Berlin, Germany
    Epilepsy Res 50:21-32. 2002
    ..To stimulate the development of even better compounds, the demonstrated benefits and risks of current new AEDs are reviewed...
  25. ncbi request reprint New strategies for the identification of drugs to prevent the development or progression of epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, Berlin, Germany
    Epilepsy Res 50:71-8. 2002
    ..Overall, it was felt that the current preclinical strategies for the discovery and development of new AEDs have to be redefined in order to identify agents that are clearly superior to current medications...
  26. ncbi request reprint Pharmacological overtreatment in epilepsy: mechanisms and management
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, D 14163, Berlin, Germany
    Epilepsy Res 52:3-14. 2002
    ....
  27. ncbi request reprint Strategies to prevent overtreatment with antiepileptic drugs in patients with epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, D 14163, Berlin, Germany
    Epilepsy Res 52:61-9. 2002
    ..To counteract the propensity to overmedication in chronic epilepsy is not easy. Great benefits, without loss of seizure control, are often gained by slowly reducing the overall drug load...
  28. ncbi request reprint A patient with incomplete seizure control during initial monotherapy with carbamazepine
    Dieter Schmidt
    Epilepsy Research Group, Goethestrasse 5, 14163 Berlin, Germany
    Epilepsy Behav 4:S35-8. 2003
  29. ncbi request reprint The impact of temporal lobe surgery on cure and mortality of drug-resistant epilepsy: summary of a workshop
    D Schmidt
    Epilepsy Research Group, Goethestr 5, D 14163 Berlin, Germany
    Epilepsy Res 56:83-4. 2003
    ..Future studies are thus warranted to specifically address the impact of temporal lobe surgery on cure and mortality...
  30. ncbi request reprint How effective is surgery to cure seizures in drug-resistant temporal lobe epilepsy?
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, D 14163 Berlin, Germany
    Epilepsy Res 56:85-91. 2003
    ....
  31. ncbi request reprint Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism
    D Schmidt
    Universitats Augenklinik, Freiburg, Germany
    Eur J Med Res 5:157-64. 2000
    ..The pathogenesis of central retinal artery occlusions (CRAO) varies, depending upon the underlying disease. An embolic origin of an occlusion often occurs...
  32. ncbi request reprint A fluorescein angiographic study of branch retinal artery occlusion (BRAO) - the retrograde filling of occluded vessels
    D Schmidt
    Universitats Augenklinik, D 79106 Freiburg, Germany
    Eur J Med Res 4:491-506. 1999
    ..For assessing the prognosis of a branch retinal artery occlusion (BRAO), examination of the arterial blood flow by fluorescein angiography is necessary...
  33. ncbi request reprint Long-term results of laser treatment for retinal angiomatosis in von Hippel-Lindau disease
    D Schmidt
    Department of Ophthalmology, University of Freiburg, Germany
    Eur J Med Res 5:47-58. 2000
    ..In von Hippel-Lindau disease (VHL), retinal detachment is often a real threat if the retinal angiomas are left untreated. The aim of this trial was to diagnose and treat capillary angiomas early at an asymptomatic stage...
  34. ncbi request reprint Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinical experience
    D Schmidt
    Epilepsy Research Group, Berlin, Germany
    Acta Neurol Scand 111:291-300. 2005
    ..We reviewed the impact of planned discontinuation of antiepileptic drugs (AEDs) in seizure-free patients on seizure recurrence and the seizure outcome of reinstituted treatment...
  35. doi request reprint Antiepileptic drug withdrawal in seizure-free patients
    Dieter Schmidt
    Epilepsy Research Group Berlin, D 14163 Berlin, Germany
    Lancet 372:610-2. 2008
  36. doi request reprint Prophylaxis of recurrent urinary tract infection after renal transplantation by cranberry juice and L-methionine
    N Pagonas
    Department of Nephrology, Charite Campus Benjamin Franklin, Berlin, Germany
    Transplant Proc 44:3017-21. 2012
    ..Data on the efficacy of cranberry and L-methionine, however, are controversial in the general population; there are few data in renal transplant recipients...
  37. ncbi request reprint New horizons in the development of antiepileptic drugs: the search for new targets
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany
    Epilepsy Res 60:77-159. 2004
    ..In this conference review, the current status of antiepileptic therapies is critically assessed, and innovative approaches for future therapies are highlighted...
  38. ncbi request reprint New horizons in the development of antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, Hannover, Germany
    Epilepsy Res 50:3-16. 2002
    ..In this review, the current status of antiepileptic therapies is critically assessed, and innovative approaches for future therapies are highlighted...
  39. ncbi request reprint Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Epilepsia 47:1253-84. 2006
    ..Knowledge of tolerance to AED effects as a mechanism of drug resistance in previous responders is important for patients, physicians, and scientists...
  40. doi request reprint Seizure clustering during drug treatment affects seizure outcome and mortality of childhood-onset epilepsy
    Matti SillanpAA
    Department of Public Health, University of Turku, Turku, Finland
    Brain 131:938-44. 2008
    ..In conclusion, clustering of seizures during treatment, but not prior to treatment, is associated with a poorer long-term seizure and mortality outcome...
  41. ncbi request reprint Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients?
    Christian Hoppe
    Department of Epileptology, University of Bonn Medical Centre, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Seizure 17:327-32. 2008
    ..To evaluate bodyweight gain during pregabalin therapy for epilepsy and the utility of a short counseling program to prevent this side effect...
  42. ncbi request reprint Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study
    Matti SillanpAA
    Department of Public Healthv, DUniversity of Turku, Turku, Finland
    Brain 129:617-24. 2006
    ..One-third will have a poor long-term outcome in terms of persistent seizures after remission or without any remission ever...
  43. doi request reprint Modern management of epilepsy: a practical approach
    Christian E Elger
    Clinic for Epileptology, University Bonn, Bonn, Germany
    Epilepsy Behav 12:501-39. 2008
    ..Potential advances in the management of epilepsy are briefly discussed. This short review summarizes the authors' how-to-do approach to the modern management of people with epilepsy...
  44. ncbi request reprint [Amiodarone treatment and visual prognosis]
    Dieter Schmidt
    Univ Augenklinik Freiburg
    Klin Monbl Augenheilkd 220:774-86. 2003
    ..Up to now, no recommendations exist concerning ophthalmological follow-up examinations at regular intervals of patients treated with amiodarone...
  45. ncbi request reprint Anxiety in patients with epilepsy: systematic review and suggestions for clinical management
    Stefan Beyenburg
    Department of Neurology, Centre Hospitalier de Luxembourg, Rue Barblé 4, L 1210 Luxembourg, Luxembourg
    Epilepsy Behav 7:161-71. 2005
    ..Nevertheless, a practical approach based on the temporal relationship between anxiety and epileptic seizures allows clinicians to consider appropriate treatment strategies to reduce the psychiatric comorbidity in patients with epilepsy...
  46. ncbi request reprint First research on developmental ambloypia due to early deprivation--Hans Berger's experiments in 1900
    Dieter Schmidt
    Perception 34:765-7. 2005
  47. ncbi request reprint Color-coded sonography in suspected temporal arteritis-experiences after 83 cases
    Matthias Reinhard
    Department of Neurology and Clinical Neurophysiology, University of Freiburg, Neurocenter, Breisacherstrasse 64, 79106 Freiburg, Germany
    Rheumatol Int 24:340-6. 2004
    ..Considering the low PPV and high NPV of the clinical criteria defined by the American College of Rheumatology, color-coded sonography is a useful tool in the noninvasive diagnostic workup of temporal arteritis...
  48. pmc New Horizons in the development of antiepileptic drugs: Innovative strategies
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Epilepsy Res 69:183-272. 2006
    ..In this conference review, the current status of antiepileptic therapies under development is critically assessed, and innovative approaches for future therapies are highlighted...