Hermann J Schluesener

Summary

Country: Germany

Publications

  1. ncbi request reprint Antimicrobial peptides in the brain: neuropeptides and amyloid
    Hermann Josef Schluesener
    Department of Neuropathology, Division of Immunopathology of the Nervous System, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    Front Biosci (Schol Ed) 4:1375-80. 2012
  2. ncbi request reprint Selection of recombinant phages binding to pathological endothelial and tumor cells of rat glioblastoma by in-vivo display
    Hermann J Schluesener
    Institute of Brain Research, University of Tuebingen, Calwerstrabetae 3D 72076, Germany
    J Neurol Sci 224:77-82. 2004
  3. ncbi request reprint Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury
    Zhiyuan Zhang
    Institute of Brain Research, University of Tubingen, Calwer Str 3, 72076 Tubingen, Germany
    Acta Neuropathol 113:675-82. 2007
  4. doi request reprint Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, Tuebingen, Germany
    Brain Pathol 19:205-13. 2009
  5. ncbi request reprint TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord
    Yanhua Su
    Institute of Brain Research, University of Tuebingen, Germany
    J Neuropathol Exp Neurol 64:991-7. 2005
  6. pmc Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors
    Markus Liebrich
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Arch Immunol Ther Exp (Warsz) 55:41-7. 2007
  7. doi request reprint FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, D 72076 Tuebingen, Germany
    Exp Neurol 210:681-90. 2008
  8. doi request reprint Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Germany
    J Cell Mol Med 13:341-51. 2009
  9. doi request reprint Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Exp Neurol 216:75-82. 2009
  10. ncbi request reprint Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 164:154-60. 2005

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Antimicrobial peptides in the brain: neuropeptides and amyloid
    Hermann Josef Schluesener
    Department of Neuropathology, Division of Immunopathology of the Nervous System, Faculty of Medicine, University of Tuebingen, Tuebingen, Germany
    Front Biosci (Schol Ed) 4:1375-80. 2012
    ....
  2. ncbi request reprint Selection of recombinant phages binding to pathological endothelial and tumor cells of rat glioblastoma by in-vivo display
    Hermann J Schluesener
    Institute of Brain Research, University of Tuebingen, Calwerstrabetae 3D 72076, Germany
    J Neurol Sci 224:77-82. 2004
    ....
  3. ncbi request reprint Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury
    Zhiyuan Zhang
    Institute of Brain Research, University of Tubingen, Calwer Str 3, 72076 Tubingen, Germany
    Acta Neuropathol 113:675-82. 2007
    ..These findings indicate a rather rapid but transient anti-inflammatory effect of dexamethasone in TBI...
  4. doi request reprint Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, Tuebingen, Germany
    Brain Pathol 19:205-13. 2009
    ....
  5. ncbi request reprint TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord
    Yanhua Su
    Institute of Brain Research, University of Tuebingen, Germany
    J Neuropathol Exp Neurol 64:991-7. 2005
    ..These findings suggest an intricate interaction of phylogenetically ancient cellular processes of the innate immune system and regeneration...
  6. pmc Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors
    Markus Liebrich
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Arch Immunol Ther Exp (Warsz) 55:41-7. 2007
    ..Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells...
  7. doi request reprint FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, D 72076 Tuebingen, Germany
    Exp Neurol 210:681-90. 2008
    ..T cell, B cell, and macrophage infiltration and demyelination of sciatic nerves were significantly decreased in FTY720-treated EAN. Therefore, FTY720 might be a potential candidate for treatment of inflammatory neuropathies...
  8. doi request reprint Improved outcome of EAN, an animal model of GBS, through amelioration of peripheral and central inflammation by minocycline
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Germany
    J Cell Mol Med 13:341-51. 2009
    ....
  9. doi request reprint Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Exp Neurol 216:75-82. 2009
    ..These data not only suggests a protective role of Foxp3(+) cells in EAN but also provides a potential way to alter localization of Foxp3(+) cells in vivo...
  10. ncbi request reprint Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 164:154-60. 2005
    ..As injections of TLR ligands can be used to modulate immune activity in the spinal cord, such agents might be tools to modulate local regenerative processes in the spinal cord...
  11. ncbi request reprint Spinal cord glia activation following peripheral polyinosine-polycytidylic acid administration
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
    Neuroreport 16:1495-9. 2005
    ..In sum, our data suggest that repeated peripheral injections of polyinosine-polycytidylic acid might alert the central nervous system through limited activation of microglia and astrocytes...
  12. ncbi request reprint Prolonged lesional expression of RhoA and RhoB following spinal cord injury
    Sabine Conrad
    Institute of Brain Research, D 72076 Tuebingen, Germany
    J Comp Neurol 487:166-75. 2005
    ..The persistent presence of lesional RhoA(+) and RhoB(+) axon/neurite fibers over a period of 4 weeks after injury suggests that Rho inhibition is a putative therapeutic concept also for delayed intervention after SCI...
  13. ncbi request reprint Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    Biochem Biophys Res Commun 349:1156-62. 2006
    ..Thus TLRs and NOD2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation...
  14. ncbi request reprint Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury
    Jan M Schwab
    Institute of Brain Research, Eberhard Karls University of Tuebingen, School of Medicine, Germany
    Glia 47:377-86. 2004
    ....
  15. ncbi request reprint Spinal cord injury-induced immune depression syndrome (SCI-IDS)
    Tino Riegger
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, Tuebingen, Germany
    Eur J Neurosci 25:1743-7. 2007
    ..A deeper understanding of the underlying mechanisms of this novel syndrome might be essential to decrease mortality, costs (time of hospitalization) and to protect the intrinsic neurological recovery potential following SCI...
  16. ncbi request reprint FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury
    Zhiyuan Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Strasse 3, D 72076 Tuebingen, Germany
    J Cell Mol Med 11:307-14. 2007
    ..Our findings show that FTY720 attenuates early accumulation of EMAP-II(+) and MHC-II(+) reactive monocytes following TBI, indicating that FTY720 might be a drug candidate to inhibit brain inflammatory reaction following TBI...
  17. ncbi request reprint Spinal cord injury-induced expression of the antiangiogenic endostatin/collagen XVIII in areas of vascular remodelling
    Christian A Mueller
    Institute of Brain Research, University of Tubingen Medical School, Tubingen, Germany
    J Neurosurg Spine 7:205-14. 2007
    ..In contrast to the emerging knowledge of mechanisms regulating the onset of the postinjury angiogenic response, little is known about counterregulatory signals...
  18. ncbi request reprint Lesional expression of RhoA and RhoB following traumatic brain injury in humans
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Neurotrauma 21:697-706. 2004
    ..As the observed upregulation of RhoA and RhoB was still detectable months after TBI, we speculate that even delayed treatment with Rho inhibitors might be a therapeutic option...
  19. ncbi request reprint Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain
    Jan M Schwab
    Institute of Brain Research, School of Medicine, and Experimental Tissue Engineering, Institute of Anatomy, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Arch Neurol 62:1561-8. 2005
    ..However, the role of RGM in adult central nervous system lesions remains to be clarified...
  20. doi request reprint AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Neuroimmunol 216:59-65. 2009
    ..Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies...
  21. ncbi request reprint Lesional accumulation of P2X4 receptor+ monocytes following experimental traumatic brain injury
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    Exp Neurol 197:252-7. 2006
    ..Our data suggest that P2X4R expression defines a subtype of activated microglia/macrophages involved in the early processes following traumatic brain injury...
  22. ncbi request reprint Uptake, cellular distribution and novel cellular binding proteins of immunostimulatory CpG oligodeoxynucleotides in glioblastoma cells
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mol Cell Biochem 272:35-46. 2005
    ..ODNs binding to these proteins might interfere with the physiological function and thus might cause unwanted effects. Such binding also might influence the uptake efficiency or cellular distribution of therapeutic ODNs...
  23. ncbi request reprint Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 163:120-7. 2005
    ..In conclusion, this is the first demonstration that P2X4R is expressed by microglia in the inflammatory pain...
  24. ncbi request reprint Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, 72076 Tuebingen, Germany
    Acta Neuropathol 115:335-43. 2008
    ..However, dexamethasone treatment did not change the proportion of RhoA+ cells. These observations suggest that dexamethasone has only a transient effect on early leukocyte recruitment...
  25. ncbi request reprint Global hypomethylation defines a sub-population of reactive microglia/macrophages in experimental traumatic brain injury
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, D 72076 Tuebingen, Germany
    Neurosci Lett 429:1-6. 2007
    ..In sum, our data suggest that lesional hypomethylation defines a sub-population of activated microglia/macrophages involved in the early processes following traumatic brain injury...
  26. ncbi request reprint Spinal cord injury induction of lesional expression of profibrotic and angiogenic connective tissue growth factor confined to reactive astrocytes, invading fibroblasts and endothelial cells
    Sabine Conrad
    Institute of Brain Research, University of Tubingen, Medical School, Tubingen, Germany
    J Neurosurg Spine 2:319-26. 2005
    ..The authors investigated the role of a novel profibrotic and angiogenic peptide connective tissue growth factor (CTGF [Hcs24/IGFBP-r2P]) in glial scar formation following spinal cord injury (SCI) in rats...
  27. ncbi request reprint Spinal cord injury-induced expression of the immune-regulatory chemokine interleukin-16 caused by activated microglia/macrophages and CD8+ cells
    Christian A Mueller
    Institute of Brain Research, University of Tubingen Medical School, Germany
    J Neurosurg Spine 4:233-40. 2006
    ..Because cytokines determine the postinjury inflammatory milieu, the authors analyzed the expression of the immunomodulatory chemokine interleukin- 16 (IL- 16) after SCI...
  28. ncbi request reprint Acute but not chronic stimulation of glial cells in rat spinal cord by systemic injection of lipopolysaccharide is associated with hyperalgesia
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, 72076, Tuebingen, Germany
    Acta Neuropathol 112:703-13. 2006
    ..However chronic exposure to LPS can develop a tolerance to mechanical hyperalgesia despite ongoing signs of CNS glial activation...
  29. ncbi request reprint The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 161:68-77. 2005
    ..Therefore PE CpG-ODN containing a 3'-end polyG motif resulting in increased immunostimulatory activity might be promising alternate analogues for studies in the central nervous system...
  30. ncbi request reprint siRNA binding proteins of microglial cells: PKR is an unanticipated ligand
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Cell Biochem 97:1217-29. 2006
    ..Furthermore, both control siRNA and siRNA targeted to beta-actin activated PKR in N9 cells, which suggest that siRNA might cause off-target effects through activation of PKR...
  31. ncbi request reprint Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Cell Mol Med 11:111-9. 2007
    ..The time courses and cellular sources of RhoA together with the functions of RhoA indicate that RhoA may function to facilitate macrophage and T-cell infiltration in EAN and therefore could be a potential therapeutic target...
  32. ncbi request reprint Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM)
    Jan M Schwab
    Institute of Brain Research, Eberhard Karls University Tuebingen, School of Medicine, Calwer Str 3, D 72076 Tuebingen, Germany
    Eur J Neurosci 21:1569-76. 2005
    ..To date, RGM is one of the most potent axonal growth inhibitors identified and present in axonal growth impediments (i) oligodendrocytes; (ii) the plexus choroideus and (iii) components of the developing scar...
  33. ncbi request reprint Experimental strategies to promote spinal cord regeneration--an integrative perspective
    Jan M Schwab
    Institute of Brain Research, Calwer Str 3, University of Tuebingen, Medical School, Calwerstr 3, 72076 Tuebingen, Germany
    Prog Neurobiol 78:91-116. 2006
    ..Here, we line out pre-clinical interventions resulting in improved functional neurological outcome after spinal cord injury and track them on their intended way to bedside...
  34. ncbi request reprint Expression of P2X4 receptor in rat C6 glioma by tumor-associated macrophages and activated microglia
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 152:67-72. 2004
    ..Our results indicate that P2X4R expression defines a distinct subset of tumor-associated macrophages and activated microglia in glioma...
  35. doi request reprint Doxycycline attenuates peripheral inflammation in rat experimental autoimmune neuritis
    Chenju Yi
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, 72076 Tuebingen, Germany
    Neurochem Res 36:1984-90. 2011
    ....
  36. doi request reprint Distinct expression of Tim-3 during different stages of rat experimental autoimmune neuritis
    Zhi Yuan Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Brain Res Bull 86:229-34. 2011
    ..Therefore, Tim3(+) cells might include a distinct macrophage population, which may be involved in anti-inflammatory effect and recovery from EAN...
  37. doi request reprint Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Immunol 183:3081-91. 2009
    ..Therefore, our data demonstrated that Compound A could effectively suppress EAN with reduced side effects by attenuating inflammation, suggesting that Compound A could be a potent candidate for treatment of autoimmune neuropathies...
  38. ncbi request reprint FTY720: a most promising immunosuppressant modulating immune cell functions
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    Mini Rev Med Chem 7:845-50. 2007
    ..FTY720 has been clinically tried for transplantation and multiple sclerosis, showing promising protective effects. This review will summarize potential applications and effects of FTY720...
  39. ncbi request reprint Polyguanosine motif increases cellular oligonucleotide uptake in the brain cortex
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuroreport 17:1579-83. 2006
    ....
  40. ncbi request reprint COX-3--a virtual pain target in humans?
    Jan M Schwab
    Institute of Brain Research, University of Tuebingen, Germany
    FASEB J 17:2174-5. 2003
  41. ncbi request reprint Experimental autoimmune neuritis induces differential microglia activation in the rat spinal cord
    Thomas Beiter
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 160:25-31. 2005
    ..Thus, in rat EAN, a reactive localized and distinct microglial activation correlating with a generalized proliferative response could be observed...
  42. doi request reprint Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model
    Zhi Yuan Zhang
    Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:178-85. 2013
    ..MS-275 also attenuated inflammatory activation of a mouse macrophage cell line in vitro. These results suggest that MS-275 may be a therapeutic option for Alzheimer disease and other neuroinflammatory diseases...
  43. ncbi request reprint Expression and release of CD14 in astrocytic brain tumors
    Martin H Deininger
    Institute of Brain Research, University of Tubingen Medical School, Calwer Str 3, 72076 Tubingen, Germany
    Acta Neuropathol 106:271-7. 2003
    ..These results demonstrate that CD14 is expressed, and more importantly released, from a subset of human glioma cells and infiltrating macrophages/microglial cells that may contribute to immunodepletion observed in these patients...
  44. ncbi request reprint Uptake, intracellular distribution, and novel binding proteins of immunostimulatory CpG oligodeoxynucleotides in microglial cells
    Zhiren Zhang
    Institute of Brain Research, University of Tuebingen, Calwer Street 3, Tuebingen D 72076, Germany
    J Neuroimmunol 160:32-40. 2005
    ..These findings are helpful in understanding the cellular fate of ODN and the nonsequence-specific effects of ODN and for rational design and evaluation of ODN-based therapeutic strategies...
  45. ncbi request reprint Spinal cord injury induces early and persistent lesional P2X4 receptor expression
    Jan M Schwab
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 163:185-9. 2005
    ..Further, P2X4R+ cells coexpressed the intracellular regulators of signalling cascades, COX-1 (>20%), COX-2 (>5%), RhoA (>60%) and RhoB (>10%)...
  46. ncbi request reprint Cyclooxygenases and central nervous system inflammation: conceptual neglect of cyclooxygenase 1
    Jan M Schwab
    Institute of Brain Research, University of Tubingen Medical School, Tubingen, Germany
    Arch Neurol 60:630-2. 2003
  47. ncbi request reprint Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's disease
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen Medical School, D 72076 Tuebingen, Germany
    J Neurosci 22:10621-6. 2002
    ....
  48. ncbi request reprint Galectin-3 labeling correlates positively in tumor cells and negatively in endothelial cells with malignancy and poor prognosis in oligodendroglioma patients
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School Tuebingen, Germany
    Anticancer Res 22:1585-92. 2002
    ..Galectin-3 modulates cell growth, transformation and metastasis in a wide range of neoplasms...
  49. ncbi request reprint Release of regulators of angiogenesis following Hypocrellin-A and -B photodynamic therapy of human brain tumor cells
    Martin H Deininger
    Institute of Brain Research, University of Tubingen, Calwer Strasse 3, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 298:520-30. 2002
    ..However, VEGF release is also induced thus suggesting both favorable and deleterious effects on tumor outgrowth...
  50. ncbi request reprint Infiltrating CD14+ monocytes and expression of CD14 by activated parenchymal microglia/macrophages contribute to the pool of CD14+ cells in ischemic brain lesions
    Rudi Beschorner
    Institute of Brain Research, University of Tubingen Medical School, Calwer Str 3, Germany
    J Neuroimmunol 126:107-15. 2002
    ..5 days and remained elevated until late stages. Early CD14 expression suggests an essential part of CD14 in the acute inflammatory response following stroke...
  51. ncbi request reprint CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury
    Rudi Beschorner
    Institute of Brain Research, University of Tubingen, Medical School, Calwerstr 3, 72076, Germany
    Acta Neuropathol 103:541-9. 2002
    ..In contrast to activated parenchymal microglia/macrophages, resting parenchymal microglial cells lacked CD14. Thus, early CD14 expression constitutes an essential part of the acute inflammatory CNS response following trauma...
  52. ncbi request reprint Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury
    Jan M Schwab
    Institute of Brain Research, University of Tubingen, Medical School, Germany
    J Neurosurg 96:892-9. 2002
    ..The authors report the differential localization of COX-1 in human traumatic brain injury (TBI)...
  53. ncbi request reprint COX-3: just another COX or the solitary elusive target of paracetamol?
    Jan M Schwab
    Institute of Brain Research, Medical School, D 72076, Tubingen, Germany
    Lancet 361:981-2. 2003
  54. ncbi request reprint The allograft inflammatory factor-1 family of proteins
    Martin H Deininger
    Institute of Brain Research, University of Tubingen, Calwer Str 3, D 72076 Tubingen, Germany
    FEBS Lett 514:115-21. 2002
    ..In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed...
  55. ncbi request reprint Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen Medical School, Tuebingen, Germany
    J Mol Neurosci 20:25-30. 2003
    ..These data show that accumulation of COX-1-expressing macrophages/microglial cells and COX-2-expressing neurons might represent important regulatory mechanisms in the complex process of neuronal degeneration in CJD patients...
  56. ncbi request reprint Accumulation of endostatin/collagenXVIII in brains of patients who died with cerebral malaria
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, Tubingen, Germany
    J Neuroimmunol 131:216-21. 2002
    ..Focal accumulation of endostatin/collagenXVIII in granulomas but not in ring hemorrhages of CM brains suggests a novel process that is involved in the destruction of endothelial cells at the time of Dürck's granuloma formation...
  57. doi request reprint HDAC inhibitor MS-275 attenuates the inflammatory reaction in rat experimental autoimmune prostatitis
    Zhi Yuan Zhang
    Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany
    Prostate 72:90-9. 2012
    ..MS-275, a potent histone deacetylase inhibitor, has promising anti-inflammatory activities and might be a new agent in the therapy of prostate inflammation...
  58. ncbi request reprint COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics?
    Jan M Schwab
    Department of Neuropathology, Neuroimmunology, Medical School, Institute of Brain Research, University of Tuebingen, Calwer Str 3, Tuebingen D 72076, Germany
    Prostaglandins Leukot Essent Fatty Acids 69:339-43. 2003
    ..Here, we discuss some of the implications drawn from the identification of additional functional cyclooxygenase members in the generation of bioactive autacoids...
  59. ncbi request reprint Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, Tuebingen D 72076, Germany
    J Neuroimmunol 146:39-45. 2004
    ....
  60. ncbi request reprint Angiogenic proteins in brains of patients who died with cerebral malaria
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Str 3, D 72076 Tubingen, Germany
    J Neuroimmunol 142:101-11. 2003
    ..These data demonstrate the activation of the proangiogenic VEGF signaling cascade in patients with CM, probably reflecting compensatory mechanisms of general and focal brain hypoxia observed in these patients...
  61. ncbi request reprint Nanovesicular vaccines: exosomes
    Xiaobo Li
    Institute of Brain Research, D 72076 Tuebingen, Germany
    Arch Immunol Ther Exp (Warsz) 53:329-35. 2005
    ..Therefore they have been suggested as potential vaccines. Consequently, exosomes have shown considerable anti-tumor effect in several studies and are in phase I clinical trials...
  62. ncbi request reprint Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II
    Christian Andreas Mueller
    Institute of Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
    J Neurotrauma 20:1007-15. 2003
    ..Prolonged accumulation of EMAP II(+), ED1(+) microglia/macrophages suggest a role of EMAP II in the pathophysiology of secondary injury following SCI...
  63. doi request reprint Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury
    Zhiren Zhang
    Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Main Street 30, 400038 Chongqing, People s Republic of China
    Brain Res 1461:102-10. 2012
    ..And further study is necessary to identify functions of these cells in TBI...
  64. ncbi request reprint Binding and uptake of immunostimulatory CpG oligodeoxynucleotides by human neuroblastoma cells
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, D 72076, Tuebingen, Germany
    Oligonucleotides 14:287-98. 2004
    ..These mechanisms might help us to understand the biodistribution of oligo within tumors and might be helpful in evaluating the therapeutic effects of oligonucleotides and rational drug design...
  65. ncbi request reprint Effect of focal cerebral infarctions on lesional RhoA and RhoB expression
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Arch Neurol 60:1245-9. 2003
    ....
  66. ncbi request reprint Identification of peptide sequences that induce the transport of phage across the gastrointestinal mucosal barrier
    Daniel M Duerr
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, D 72076 Tuebingen, Germany
    J Virol Methods 116:177-80. 2004
    ..It is concluded that utilisation of in vivo phage display (IVPD) has provided evidence for a specific peptide-guided transport of undegraded cargo across the intestinal barrier, modelled by M13 phage...
  67. ncbi request reprint Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Calwer Strasse 3, D 72076, Tuebingen, Germany
    Exp Neurol 177:341-6. 2002
    ..Thus, upregulation of EMAP-II by activated monocytes/microglial cells may serve as a sensitive marker of neurotoxic lesions in the rat brain...
  68. doi request reprint Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
    Zhi Yuan Zhang
    Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany
    J Cell Mol Med 17:1566-76. 2013
    ..Our results suggest that Oridonin might be considered a promising therapeutic option for human AD or other neurodegenerative diseases. ..
  69. doi request reprint Nanosilver: application and novel aspects of toxicology
    Jan K Schluesener
    Division of Immunopathology of the Nervous System, Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tuebingen, Germany
    Arch Toxicol 87:569-76. 2013
    ..Amyloid diseases are widespread in humans and a severe health hazard. The known potential of silver to stimulate amyloidosis in rodents will require a timely and balanced evaluation of nanosilvers...
  70. doi request reprint A fraction of stem bark extract of Entada africana suppresses lipopolysaccharide-induced inflammation in RAW 264.7 cells
    Brice Ayissi Owona
    Division of Immunopathology of Nervous System, Department of Neuropathology, Institute of Pathology, University of Tubingen, Germany
    J Ethnopharmacol 149:162-8. 2013
    ..Entada africana is a plant used in African traditional medicine for the treatment of stomachache, fever, liver related diseases, wound healing, cataract and dysentery...
  71. ncbi request reprint Endothelial endostatin release is induced by general cell stress and modulated by the nitric oxide/cGMP pathway
    Martin H Deininger
    Institute of Brain Research, University of Tuebingen Medical School, Calwer Str 3, D 72076 Tuebingen, Germany
    FASEB J 17:1267-76. 2003
    ..These results describe the modulation of endostatin release by the NO signaling cascade and provide important new pharmacological information for the systemic induction of endogenous endostatin release by common NO donor pharmacotherapy...
  72. ncbi request reprint Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis
    Xiao Bo Li
    Institute of Environmental Medicine, Tongji Medical College, Huazhong Science and Technology University, Wuhan City, China
    Arch Immunol Ther Exp (Warsz) 54:51-3. 2006
    ..It is known that cisplatin can induce immunosuppressive effects through inhibition of T cell activity. Therefore we analyzed the anti-inflammatory effects of cisplatin in a rat EAE model...
  73. ncbi request reprint Molecular addresses of tumors: selection by in vivo phage display
    Xiao Bo Li
    MOE Key Lab of Environment and Health, Institute of Environmental Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R China
    Arch Immunol Ther Exp (Warsz) 54:177-81. 2006
    ....
  74. ncbi request reprint Endostatin/collagen XVIII accumulates in patients with traumatic brain injury
    Martin H Deininger
    Department of Neurosurgery, University of Freiburg Medicsal School, Freiburg, Germany
    J Neurotrauma 23:1103-10. 2006
    ..Common NO synthase inhibitor pharmacotherapy with aminoguanidine and L-NAME completely abolished endostatin release from microglial cells, raising hopes of altering endostatin release in vivo...
  75. ncbi request reprint From cell death to neuronal regeneration: building a new brain after traumatic brain injury (J Neuropathol Exp Neurol 2003;62:801-11
    Jan M Schwab
    J Neuropathol Exp Neurol 63:180-1. 2004
  76. ncbi request reprint Advances in SELEX and application of aptamers in the central nervous system
    Yan Yang
    Experimental Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Biomol Eng 24:583-92. 2007
    ..This review presents recent advances in the field of SELEX with special emphasis on applications of aptamers as analytical, diagnostic and therapeutic tools in the central nervous system...