Jens Schittenhelm

Summary

Country: Germany

Publications

  1. ncbi request reprint Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
  2. ncbi request reprint Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:194-210. 2013
  3. ncbi request reprint WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
  4. ncbi request reprint The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Germany
    Clin Neuropathol 27:21-8. 2008
  5. ncbi request reprint Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
  6. doi request reprint Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors
    Jens Schittenhelm
    Institute for Brain Research Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Neuropathology 31:461-7. 2011
  7. doi request reprint Holocord pilocytic astrocytoma--case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Clin Neurol Neurosurg 111:203-7. 2009
  8. doi request reprint Symptomatic intraspinal oncocytic adrenocortical adenoma
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, 72076, Tubingen, Germany
    Endocr Pathol 20:73-7. 2009
  9. ncbi request reprint Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
  10. ncbi request reprint Glioblastoma with granular cell astrocytoma features: a case report and literature review
    J Schittenhelm
    Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany
    Clin Neuropathol 29:323-9. 2010

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
    ....
  2. ncbi request reprint Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:194-210. 2013
    ..016). Together, these data strengthen the rationale for anti-integrin treatment of glial tumors...
  3. ncbi request reprint WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
    ..68, respectively. Therefore, WT1 expression in astrocytes indicates a neoplastic origin and might represent an important diagnostic tool to differentiate reactive from neoplastic astrocytes by immunohistochemistry...
  4. ncbi request reprint The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Germany
    Clin Neuropathol 27:21-8. 2008
    ..Due to the anatomic complexity of the cauda equina, a complete resection can be technically challenging in this region. However, a gross total resection at the primary surgery is the most predictive factor for the outcome...
  5. ncbi request reprint Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
    ..To our knowledge, this is the first reported case of a primary anaplastic ganglioglioma with a small-cell glioblastoma component...
  6. doi request reprint Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors
    Jens Schittenhelm
    Institute for Brain Research Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Neuropathology 31:461-7. 2011
    ..Two AT/RT cases exhibited membranous staining of Kir7.1, indicating a plexus epithelial differentiation of these tumors. The implications of these results on tumor diagnosis are discussed...
  7. doi request reprint Holocord pilocytic astrocytoma--case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Clin Neurol Neurosurg 111:203-7. 2009
    ..Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given...
  8. doi request reprint Symptomatic intraspinal oncocytic adrenocortical adenoma
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, 72076, Tubingen, Germany
    Endocr Pathol 20:73-7. 2009
    ..A view of the literature of these rare but probably underdiagnosed intraspinal tumors is given...
  9. ncbi request reprint Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
    ..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof...
  10. ncbi request reprint Glioblastoma with granular cell astrocytoma features: a case report and literature review
    J Schittenhelm
    Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany
    Clin Neuropathol 29:323-9. 2010
    ..In 35% more than one cerebral lobe was affected. These extended mass effects may explain the worse prognosis despite the relatively bland histology of the granular cell component...
  11. doi request reprint Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, 72076 Tuebingen, Germany
    Neurosurg Rev 31:157-63. 2008
    ..Our review of the literature provides further insights regarding the clinical behavior and different histological types of the lesions as well as the inflammatory changes that can occur in Rathke's cleft cysts...
  12. ncbi request reprint Gliosarcoma with chondroid and osseous differentiation
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:90-4. 2007
    ....
  13. ncbi request reprint Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:383-9. 2007
    ..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
  14. ncbi request reprint WT1 expression increases with malignancy and indicates unfavourable outcome in astrocytoma
    Julian Rauscher
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Clin Pathol 67:556-61. 2014
    ....
  15. doi request reprint Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology
    David Capper
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls Universitat Heidelberg, Germany
    Acta Neuropathol 121:241-52. 2011
    ....
  16. ncbi request reprint Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes
    David Capper
    Department of Neuropathology, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany
    Am J Surg Pathol 34:1199-204. 2010
    ..As IDH mutations are not characteristic of grade IV primary glioblastomas, this antibody cannot differentiate primary glioblastoma from reactive gliosis. Thus, caution has to be taken and a combined panel with other markers is needed...
  17. pmc Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen Tübingen 72076, Germany
    Int J Clin Exp Pathol 6:2719-32. 2013
    ..To evaluate the expression of αv-series integrins in brain metastases. Inhibitors targeting these integrins are being tested for their therapeutic potential...
  18. ncbi request reprint AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry
    Felix Sahm
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Heidelberg, INF 224, 69120, Heidelberg, Germany
    Acta Neuropathol 126:757-62. 2013
    ..We observed strong up-regulation of SFRP1 expression in all meningiomas with AKT1E17K mutation and in HEK293 cells after transfection with mutant AKT1E17K, but not in meningiomas and HEK293 cells lacking this mutation. ..
  19. ncbi request reprint Comparison of three different MR perfusion techniques and MR spectroscopy for multiparametric assessment in distinguishing recurrent high-grade gliomas from stable disease
    Achim Seeger
    Department of Neuroradiology, Eberhard Karls University, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Acad Radiol 20:1557-65. 2013
    ..Magnetic resonance (MR) perfusion techniques and MR spectroscopy (MRS) provide specific physiological information that may allow distinction between recurrent glioma and progression from stable disease...
  20. ncbi request reprint Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach
    David Capper
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Acta Neuropathol 115:249-59. 2008
    ....
  21. doi request reprint CD8(+)/perforin/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia
    Michel Mittelbronn
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathology 30:92-6. 2010
    ....
  22. ncbi request reprint BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression
    Christian Koelsche
    Department of Neuropathology, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany German Cancer Consortium DKTK, CCU Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Brain Pathol 24:221-9. 2014
    ..Combined VE1 positivity and p16 loss represents a frequent immunoprofile of PXA and may therefore constitute an additional diagnostic tool for its differential diagnosis. ..
  23. doi request reprint Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells
    Christian Koelsche
    Department of Neuropathology, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
    Acta Neuropathol 125:891-900. 2013
    ..No cases with an exclusive expression of BRAF V600E in the glial compartment were observed. Thus, using VE1 we identified the neuronal compartment as an essential part of this mixed glioneuronal tumor...
  24. doi request reprint Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors
    Jens Schittenhelm
    Dept of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Am J Clin Pathol 138:85-9. 2012
    ..Specificity and sensitivity of Kir7.1 (both 100%) and EAAT-1 (100% and 91%, respectively) were superior to the values for S-100 (50% and 100%, respectively) and GFAP (50% and 55%, respectively) for distinguishing CPT from ELST...
  25. doi request reprint CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Histopathology 58:739-49. 2011
    ..The aim of this study was to characterize CD133 expression, and the distribution and morphological features of CD133(+) cells, in primary and secondary human central nervous system (CNS) neoplasms...
  26. doi request reprint Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium
    Rudi Beschorner
    Institute for Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 117:667-75. 2009
    ..In conclusion, in contrast to neoplastic CP samples, expression of EAAT-1 is exceptionally rare in non-neoplastic CP. Thus, EAAT-1 is superior to GFAP as a helpful diagnostic tool in CP samples...
  27. ncbi request reprint Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system
    Christian Koelsche
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
    Acta Neuropathol 126:907-15. 2013
    ..0001), but inversely associated with loss of ATRX expression (p < 0.0001) and IDH1/IDH2 mutations (p < 0.0001). TERT promoter mutations are typically found in adult patients and occur in a highly tumor type-associated distribution...
  28. doi request reprint Management of holocord pilocytic astrocytomas in children and adolescents: an update
    Florian H Ebner
    Department of Neurosurgery, Children s Hospital, Eberhard Karl University, Tubingen, Germany
    Pediatr Neurosurg 48:133-40. 2012
    ..Small tumor remnants often remain stable in the due course. In case of unresectable regrowth or recurrence, chemotherapy or radiotherapy are the adjuvant treatment options...
  29. doi request reprint Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation
    Olga Allmendinger
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, D 72076 Tubingen, Germany
    Hum Pathol 43:1289-99. 2012
    ..In summary, our findings indicate that activated leukocyte adhesion molecule expression levels in gliomas are probably linked to other mechanisms than its supposed role as regulator of matrix metalloproteinase 2...
  30. pmc SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    J Immunol 184:4017-24. 2010
    ..Our data suggest a Sp1-dependent regulatory pathway for CD39 during hepatic IP. These studies reveal a novel role of CD39 in hepatic protection and suggest soluble apyrase for the treatment of liver ischemia...
  31. ncbi request reprint Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms
    Jens Schittenhelm
    Institute for Brain Research, Eberhard Karls University, 72076 Tuebingen, Germany
    Folia Neuropathol 48:75-80. 2010
    ..While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas. Furthermore, only very few data are available on CDX2 expression in normal pituitary gland tissue and/or pituitary adenomas...
  32. ncbi request reprint Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients
    Anja Harder
    Institute of Neuropathology, University Hospital Munster, Germany
    Am J Surg Pathol 36:702-9. 2012
    ..Our findings suggest that hybrid neurofibroma/schwannoma represents a common tumor type in schwannomatosis and shows a striking association with neurofibromatoses...
  33. doi request reprint The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress
    Elisabeth Höring
    Laboratory of Molecular Neuro Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Müller Str 27, 72076, Tubingen, Germany
    Acta Neuropathol 124:83-97. 2012
    ....
  34. doi request reprint Mature cerebellar teratoma in adulthood
    Rudi Beschorner
    Institute for Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Neuropathology 29:176-80. 2009
    ..Late clinical manifestation of the tumor in this case is probably due to an acute late-onset hemorrhage within the tumor...
  35. ncbi request reprint Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Germany
    Folia Neuropathol 46:149-53. 2008
    ..In addition, severe spongiosis can be misleading in the histological examination, suggesting the diagnosis of a prion-induced spongiform encephalopathy...
  36. pmc Prognostic value of blood flow measurements using arterial spin labeling in gliomas
    Julia Furtner
    Department of Biomedical Imaging und Image guided Therapy, Medical University of Vienna, Vienna, Austria Department of Neuroradiology, Eberhard Karls University, Tubingen, Germany
    PLoS ONE 9:e99616. 2014
    ..0012) independent of the WHO glioma grade. Quantified mTBF values obtained by ASL offer a new and totally non-invasive marker to prognosticate the EFS, independently on histopathological tumor grading, in patients with gliomas. ..
  37. doi request reprint The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas
    Georgios Pantazis
    1Department of Neuropathology, University of Marburg 2Department of Neuropathology, Edinger Institute Institute of Neurology, Goethe University, Frankfurt Main 3Department of Neuropathology, Ruprecht Karls University of Heidelberg 4Department of Pathology, Klinikum Stuttgart 5Department of Neuropathology, Institute of Pathology and Neuropathology, Eberhard Karls University of Tuebingen, Germany
    Pathology 46:225-9. 2014
    ..With a sensitivity of 100% and a specificity of 97% in the detection of CNS germinomas, UTF1 serves as a new reliable alternative in the diagnostic setting of CNS germ cell tumours...
  38. ncbi request reprint Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1
    Rudi Beschorner
    Institute of Brain Research Neuropathology, Eberhard Karls University, Tuebingen, Germany
    Hum Pathol 37:854-60. 2006
    ..Our findings indicate that EAAT1 immunohistochemistry may be useful in differentiating CPT from metastatic carcinomas...
  39. doi request reprint WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Cancer Biomark 7:73-7. 2010
    ..As WT1 antibodies not only serve as biomarker for cancerous tissue but also are considered for cancer immunotherapy, knowledge of WT1 expression in tumorous and normal peripheral nerve tissue is important for therapeutical purposes...
  40. ncbi request reprint Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Hum Pathol 37:1503-7. 2006
    ..Polymicrogyria can be considered as postmigratory laminar necrosis. Our findings contribute to the pathogenetic understanding of combined hydranencephaly and polymicrogyria...
  41. ncbi request reprint Inflammatory myofibroblastic tumor of the ulnar nerve. Case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tiibingen, Germany
    J Neurosurg 106:1075-9. 2007
    ....
  42. ncbi request reprint Spinal cord compression through extraosseous extension of a vertebral low-grade hemangioendothelioma with histiocytoid differentiation
    M Mittelbronn
    Institute of Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Clin Neuropathol 27:351-6. 2008
    ..Furthermore, the clinical course with a progressive development of a paraparesis due to a hemangioendothelioma is very uncommon...
  43. ncbi request reprint Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue
    G Pantazis
    Institute of Brain Research, University of Tuebingen, Germany
    Clin Neuropathol 29:378-83. 2010
    ..In constellations of highly elevated IgG in CSF and multiple white matter lesions, LCDD should be considered as underlying pathology...
  44. doi request reprint Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: feasibility of the method and initial results
    Sotirios Bisdas
    Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls University, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    Neuroradiology 55:1189-96. 2013
    ..The purpose of this study was to evaluate the feasibility of intravoxel incoherent motion (IVIM) imaging and its value in differentiating the histologic grade among human gliomas...
  45. doi request reprint Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, Center for Inflammation and Hypoxia, University of Tubingen, Germany
    J Immunol 182:3965-8. 2009
    ..Taken together, these studies demonstrate the A2BAR as a novel therapeutic target for protection during gastrointestinal IR injury...
  46. doi request reprint Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein
    Leonille Schweizer
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Heidelberg, INF 224, 69120, Heidelberg, Germany
    Acta Neuropathol 125:651-8. 2013
    ..This immunohistochemical assay may prove valuable for the differentiation of HPC and SFT from other mesenchymal neoplasms...
  47. ncbi request reprint Evidence of ubiquitous in vivo and in vitro expression of pro-apoptotic Smac/DIABLO protein in meningioma cell lines
    Christina Pfister
    Department of Neurosurgery, University of Tubingen, D 72076 Tubingen, Germany
    Oncol Rep 21:1181-8. 2009
    ..These findings indicate no pathological overexpression of survivin in meningiomas as is evident in several other cancer types impeding apoptosis...
  48. doi request reprint Spinal metastasis of endometrial stromal sarcoma: clinicopathological features and management
    Leonardo Moura Batista
    Department of Neurosurgery, University of Tubingen, Eberhard Karls University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Surg Oncol 20:e78-83. 2011
    ..We discuss the histopathological features and the management strategies through an illustrative case of a 77 year-old woman with metastasis to the thoracic spine 13 years after total hysterectomy for ESS...
  49. ncbi request reprint Erythropoietin receptor is expressed in meningiomas and lower levels are associated with tumour recurrence
    O Küster
    Institute of Brain Research, University of Tubingen, Germany
    Neuropathol Appl Neurobiol 35:555-65. 2009
    ..As the EpoR status in human meningiomas is unknown, our aim was to characterize EpoR expression in these tumours...
  50. ncbi request reprint Upregulation of frizzled 9 in astrocytomas
    Z Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 32:615-24. 2006
    ..05). FZD9 is upregulated in astrocytomas, suggesting that FZD9 could be important in the tumorigenesis of human astrocytomas...
  51. doi request reprint The microglial/macrophagic response at the tumour-brain border of invasive meningiomas
    S Grund
    Institute of Brain Research, Univeristy of Tübingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 35:82-8. 2009
    ..The present study was based upon the hypothesis that the microglial/macrophagic response towards brain-invasive meningiomas is dependent on the intactness of the pial-glial basement membrane...
  52. doi request reprint Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells
    D Gramatzki
    Laboratory of Molecular Neuro Oncology, Department of General Neurology and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Oncogene 28:2593-605. 2009
    ....
  53. ncbi request reprint Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 32:525-31. 2006
    ..Destruction of the basement membrane and appearance of SPARC+ spindle cells are not coincident during the course of brain invasion by meningiomas...
  54. doi request reprint Diagnostic value of WT1 in neuroepithelial tumours
    J Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 35:69-81. 2009
    ....
  55. doi request reprint 47-year-old woman with a clival mass
    Rudi Beschorner
    Brain Pathol 18:100-2, 141. 2008