Jens Schittenhelm

Summary

Country: Germany

Publications

  1. ncbi Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
  2. ncbi Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:194-210. 2013
  3. ncbi Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, 72076 Tuebingen, Germany
    Neurosurg Rev 31:157-63. 2008
  4. ncbi WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
  5. ncbi Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
  6. ncbi Glioblastoma with granular cell astrocytoma features: a case report and literature review
    J Schittenhelm
    Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany
    Clin Neuropathol 29:323-9. 2010
  7. ncbi Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
  8. ncbi Holocord pilocytic astrocytoma--case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Clin Neurol Neurosurg 111:203-7. 2009
  9. ncbi Symptomatic intraspinal oncocytic adrenocortical adenoma
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, 72076, Tubingen, Germany
    Endocr Pathol 20:73-7. 2009
  10. ncbi Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors
    Jens Schittenhelm
    Institute for Brain Research Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Neuropathology 31:461-7. 2011

Collaborators

Detail Information

Publications44

  1. ncbi Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
    ....
  2. ncbi Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor
    Jens Schittenhelm
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    J Neuropathol Exp Neurol 72:194-210. 2013
    ..016). Together, these data strengthen the rationale for anti-integrin treatment of glial tumors...
  3. ncbi Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, 72076 Tuebingen, Germany
    Neurosurg Rev 31:157-63. 2008
    ..Our review of the literature provides further insights regarding the clinical behavior and different histological types of the lesions as well as the inflammatory changes that can occur in Rathke's cleft cysts...
  4. ncbi WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
    ..68, respectively. Therefore, WT1 expression in astrocytes indicates a neoplastic origin and might represent an important diagnostic tool to differentiate reactive from neoplastic astrocytes by immunohistochemistry...
  5. ncbi Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
    ..To our knowledge, this is the first reported case of a primary anaplastic ganglioglioma with a small-cell glioblastoma component...
  6. ncbi Glioblastoma with granular cell astrocytoma features: a case report and literature review
    J Schittenhelm
    Institute of Brain Research, University Hospital, Eberhard Karls University of Tuebingen, Germany
    Clin Neuropathol 29:323-9. 2010
    ..In 35% more than one cerebral lobe was affected. These extended mass effects may explain the worse prognosis despite the relatively bland histology of the granular cell component...
  7. ncbi Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Mod Pathol 22:1600-11. 2009
    ..Thus, annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof...
  8. ncbi Holocord pilocytic astrocytoma--case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Clin Neurol Neurosurg 111:203-7. 2009
    ..Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given...
  9. ncbi Symptomatic intraspinal oncocytic adrenocortical adenoma
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, 72076, Tubingen, Germany
    Endocr Pathol 20:73-7. 2009
    ..A view of the literature of these rare but probably underdiagnosed intraspinal tumors is given...
  10. ncbi Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors
    Jens Schittenhelm
    Institute for Brain Research Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Neuropathology 31:461-7. 2011
    ..Two AT/RT cases exhibited membranous staining of Kir7.1, indicating a plexus epithelial differentiation of these tumors. The implications of these results on tumor diagnosis are discussed...
  11. ncbi The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Germany
    Clin Neuropathol 27:21-8. 2008
    ..Due to the anatomic complexity of the cauda equina, a complete resection can be technically challenging in this region. However, a gross total resection at the primary surgery is the most predictive factor for the outcome...
  12. ncbi Gliosarcoma with chondroid and osseous differentiation
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:90-4. 2007
    ....
  13. ncbi Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:383-9. 2007
    ..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
  14. ncbi Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology
    David Capper
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls Universitat Heidelberg, Germany
    Acta Neuropathol 121:241-52. 2011
    ....
  15. ncbi Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes
    David Capper
    Department of Neuropathology, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany
    Am J Surg Pathol 34:1199-204. 2010
    ..As IDH mutations are not characteristic of grade IV primary glioblastomas, this antibody cannot differentiate primary glioblastoma from reactive gliosis. Thus, caution has to be taken and a combined panel with other markers is needed...
  16. ncbi CD8(+)/perforin/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia
    Michel Mittelbronn
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathology 30:92-6. 2010
    ....
  17. ncbi Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach
    David Capper
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Acta Neuropathol 115:249-59. 2008
    ....
  18. ncbi Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors
    Jens Schittenhelm
    Dept of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Am J Clin Pathol 138:85-9. 2012
    ..Specificity and sensitivity of Kir7.1 (both 100%) and EAAT-1 (100% and 91%, respectively) were superior to the values for S-100 (50% and 100%, respectively) and GFAP (50% and 55%, respectively) for distinguishing CPT from ELST...
  19. ncbi CD133 expression is associated with small round blue cell tumour morphology in human central nervous system neoplasms
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Histopathology 58:739-49. 2011
    ..The aim of this study was to characterize CD133 expression, and the distribution and morphological features of CD133(+) cells, in primary and secondary human central nervous system (CNS) neoplasms...
  20. ncbi Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium
    Rudi Beschorner
    Institute for Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 117:667-75. 2009
    ..In conclusion, in contrast to neoplastic CP samples, expression of EAAT-1 is exceptionally rare in non-neoplastic CP. Thus, EAAT-1 is superior to GFAP as a helpful diagnostic tool in CP samples...
  21. ncbi Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation
    Olga Allmendinger
    Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tubingen, D 72076 Tubingen, Germany
    Hum Pathol 43:1289-99. 2012
    ..In summary, our findings indicate that activated leukocyte adhesion molecule expression levels in gliomas are probably linked to other mechanisms than its supposed role as regulator of matrix metalloproteinase 2...
  22. ncbi SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, University of Tubingen, Tubingen, Germany
    J Immunol 184:4017-24. 2010
    ..Our data suggest a Sp1-dependent regulatory pathway for CD39 during hepatic IP. These studies reveal a novel role of CD39 in hepatic protection and suggest soluble apyrase for the treatment of liver ischemia...
  23. ncbi Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms
    Jens Schittenhelm
    Institute for Brain Research, Eberhard Karls University, 72076 Tuebingen, Germany
    Folia Neuropathol 48:75-80. 2010
    ..While many neoplasms have been studied, to date, no data is available on CDX2 expression in craniopharyngiomas. Furthermore, only very few data are available on CDX2 expression in normal pituitary gland tissue and/or pituitary adenomas...
  24. ncbi Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients
    Anja Harder
    Institute of Neuropathology, University Hospital Munster, Germany
    Am J Surg Pathol 36:702-9. 2012
    ..Our findings suggest that hybrid neurofibroma/schwannoma represents a common tumor type in schwannomatosis and shows a striking association with neurofibromatoses...
  25. ncbi The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress
    Elisabeth Höring
    Laboratory of Molecular Neuro Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Müller Str 27, 72076, Tubingen, Germany
    Acta Neuropathol 124:83-97. 2012
    ....
  26. ncbi Mature cerebellar teratoma in adulthood
    Rudi Beschorner
    Institute for Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Neuropathology 29:176-80. 2009
    ..Late clinical manifestation of the tumor in this case is probably due to an acute late-onset hemorrhage within the tumor...
  27. ncbi Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Germany
    Folia Neuropathol 46:149-53. 2008
    ..In addition, severe spongiosis can be misleading in the histological examination, suggesting the diagnosis of a prion-induced spongiform encephalopathy...
  28. ncbi Choroid plexus tumors differ from metastatic carcinomas by expression of the excitatory amino acid transporter-1
    Rudi Beschorner
    Institute of Brain Research Neuropathology, Eberhard Karls University, Tuebingen, Germany
    Hum Pathol 37:854-60. 2006
    ..Our findings indicate that EAAT1 immunohistochemistry may be useful in differentiating CPT from metastatic carcinomas...
  29. ncbi WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Cancer Biomark 7:73-7. 2010
    ..As WT1 antibodies not only serve as biomarker for cancerous tissue but also are considered for cancer immunotherapy, knowledge of WT1 expression in tumorous and normal peripheral nerve tissue is important for therapeutical purposes...
  30. ncbi Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Hum Pathol 37:1503-7. 2006
    ..Polymicrogyria can be considered as postmigratory laminar necrosis. Our findings contribute to the pathogenetic understanding of combined hydranencephaly and polymicrogyria...
  31. ncbi Inflammatory myofibroblastic tumor of the ulnar nerve. Case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tiibingen, Germany
    J Neurosurg 106:1075-9. 2007
    ....
  32. ncbi Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high IgG levels in the cerebrospinal fluid as a diagnostic clue
    G Pantazis
    Institute of Brain Research, University of Tuebingen, Germany
    Clin Neuropathol 29:378-83. 2010
    ..In constellations of highly elevated IgG in CSF and multiple white matter lesions, LCDD should be considered as underlying pathology...
  33. ncbi Spinal cord compression through extraosseous extension of a vertebral low-grade hemangioendothelioma with histiocytoid differentiation
    M Mittelbronn
    Institute of Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Clin Neuropathol 27:351-6. 2008
    ..Furthermore, the clinical course with a progressive development of a paraparesis due to a hemangioendothelioma is very uncommon...
  34. ncbi Management of holocord pilocytic astrocytomas in children and adolescents: an update
    Florian H Ebner
    Department of Neurosurgery, Children s Hospital, Eberhard Karl University, Tubingen, Germany
    Pediatr Neurosurg 48:133-40. 2012
    ..Small tumor remnants often remain stable in the due course. In case of unresectable regrowth or recurrence, chemotherapy or radiotherapy are the adjuvant treatment options...
  35. ncbi Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury
    Melanie L Hart
    Department of Anesthesiology and Intensive Care Medicine, Center for Inflammation and Hypoxia, University of Tubingen, Germany
    J Immunol 182:3965-8. 2009
    ..Taken together, these studies demonstrate the A2BAR as a novel therapeutic target for protection during gastrointestinal IR injury...
  36. ncbi Spinal metastasis of endometrial stromal sarcoma: clinicopathological features and management
    Leonardo Moura Batista
    Department of Neurosurgery, University of Tubingen, Eberhard Karls University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Surg Oncol 20:e78-83. 2011
    ..We discuss the histopathological features and the management strategies through an illustrative case of a 77 year-old woman with metastasis to the thoracic spine 13 years after total hysterectomy for ESS...
  37. ncbi Evidence of ubiquitous in vivo and in vitro expression of pro-apoptotic Smac/DIABLO protein in meningioma cell lines
    Christina Pfister
    Department of Neurosurgery, University of Tubingen, D 72076 Tubingen, Germany
    Oncol Rep 21:1181-8. 2009
    ..These findings indicate no pathological overexpression of survivin in meningiomas as is evident in several other cancer types impeding apoptosis...
  38. ncbi The microglial/macrophagic response at the tumour-brain border of invasive meningiomas
    S Grund
    Institute of Brain Research, Univeristy of Tübingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 35:82-8. 2009
    ..The present study was based upon the hypothesis that the microglial/macrophagic response towards brain-invasive meningiomas is dependent on the intactness of the pial-glial basement membrane...
  39. ncbi Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells
    D Gramatzki
    Laboratory of Molecular Neuro Oncology, Department of General Neurology and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Oncogene 28:2593-605. 2009
    ....
  40. ncbi Upregulation of frizzled 9 in astrocytomas
    Z Zhang
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 32:615-24. 2006
    ..05). FZD9 is upregulated in astrocytomas, suggesting that FZD9 could be important in the tumorigenesis of human astrocytomas...
  41. ncbi Erythropoietin receptor is expressed in meningiomas and lower levels are associated with tumour recurrence
    O Küster
    Institute of Brain Research, University of Tubingen, Germany
    Neuropathol Appl Neurobiol 35:555-65. 2009
    ..As the EpoR status in human meningiomas is unknown, our aim was to characterize EpoR expression in these tumours...
  42. ncbi Diagnostic value of WT1 in neuroepithelial tumours
    J Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 35:69-81. 2009
    ....
  43. ncbi Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 32:525-31. 2006
    ..Destruction of the basement membrane and appearance of SPARC+ spindle cells are not coincident during the course of brain invasion by meningiomas...
  44. ncbi 47-year-old woman with a clival mass
    Rudi Beschorner
    Brain Pathol 18:100-2, 141. 2008