Schittek B. The antimicrobial skin barrier in patients with atopic dermatitis. Curr Probl Dermatol. 2011;41:54-67 pubmed publisher
..Increasing AMP expression in AD skin and repairing the skin barrier defect might have a therapeutic effect in AD patients enabling the skin to mount an enhanced response to pathogens. ..
Makino E, Gutmann V, Kosnopfel C, Niessner H, Forschner A, Garbe C, et al
. Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs. Cell Death Dis. 2018;9:930 pubmed publisher
..These data suggest that a subgroup of melanoma patients with acquired resistance to MAPKi treatment and low TAp73 expression can benefit from chemotherapy with platinum-based drugs as a second-line therapy. ..
Schittek B, Paulmann M, Senyürek I, Steffen H. The role of antimicrobial peptides in human skin and in skin infectious diseases. Infect Disord Drug Targets. 2008;8:135-43 pubmed
..The broad spectrum of antimicrobial activity, the low incidence of bacterial resistance and their function as immunomodulatory agents are attractive features of AMPs for their clinical use. ..
Schittek B, Sinnberg T. Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis. Mol Cancer. 2014;13:231 pubmed publisher
..This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis. ..
Burian M, Velic A, Matić K, GÃ¼nther S, Kraft B, Gonser L, et al
. Quantitative proteomics of the human skin secretome reveal a reduction in immune defense mediators in ectodermal dysplasia patients. J Invest Dermatol. 2015;135:759-767 pubmed publisher
..The systematic reduction in immune system and defense-related proteins may contribute to the high susceptibility of ED patients to skin infections and altered skin colonization. ..
Burian M, Schittek B. The secrets of dermcidin action. Int J Med Microbiol. 2015;305:283-6 pubmed publisher
Sinnberg T, Wang J, Sauer B, Schittek B. Casein kinase 1? has a non-redundant and dominant role within the CK1 family in melanoma progression. BMC Cancer. 2016;16:594 pubmed publisher
..These data indicate that CK1? has a dominant and non-redundant function in melanoma cells and that the CK1? and ? isoforms are not substantially involved in melanoma progression. ..