Birgit Schittek

Summary

Country: Germany

Publications

  1. doi request reprint The antimicrobial skin barrier in patients with atopic dermatitis
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Curr Probl Dermatol 41:54-67. 2011
  2. pmc Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression
    Tobias Sinnberg
    Department of Dermatology, Division of Dermatooncology, Eberhard Karls University Tubingen, Liebermeisterstr 25, D 72076, Tubingen, Germany
    BMC Cancer 16:594. 2016
  3. pmc Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
    Birgit Schittek
    Department of Dermatology, Division of Dermatooncology, University of Tubingen, Liebermeisterstr, 25, 72076 Tubingen, Germany
    Mol Cancer 13:231. 2014
  4. doi request reprint The multiple facets of dermcidin in cell survival and host defense
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    J Innate Immun 4:349-60. 2012
  5. ncbi request reprint Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction
    B Schittek
    Section of Dermatologic Oncology, Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Br J Dermatol 141:37-43. 1999
  6. ncbi request reprint The role of antimicrobial peptides in human skin and in skin infectious diseases
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Infect Disord Drug Targets 8:135-43. 2008
  7. ncbi request reprint Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma
    B Schittek
    Section of Dermatologic Oncology, Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Br J Dermatol 141:30-6. 1999
  8. ncbi request reprint The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance
    Birgit Schittek
    Division of Dermatologic Oncology, Department of Dermatology, University of Tubingen, Liebermeisterstrasse 25, D 72076 Tubingen, Germany
    Int J Cancer 120:2110-8. 2007
  9. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
  10. pmc β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance
    Tobias Sinnberg
    Division of Dermatooncology, Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 6:e23429. 2011

Collaborators

Detail Information

Publications49

  1. doi request reprint The antimicrobial skin barrier in patients with atopic dermatitis
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Curr Probl Dermatol 41:54-67. 2011
    ..Increasing AMP expression in AD skin and repairing the skin barrier defect might have a therapeutic effect in AD patients enabling the skin to mount an enhanced response to pathogens...
  2. pmc Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression
    Tobias Sinnberg
    Department of Dermatology, Division of Dermatooncology, Eberhard Karls University Tubingen, Liebermeisterstr 25, D 72076, Tubingen, Germany
    BMC Cancer 16:594. 2016
    ..We previously identified CK1α as a novel tumor suppressor in melanoma and reported that the loss of CK1α leads to increased proliferation and invasive growth of melanoma cells by strong activation of the Wnt/β-catenin signaling pathway...
  3. pmc Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
    Birgit Schittek
    Department of Dermatology, Division of Dermatooncology, University of Tubingen, Liebermeisterstr, 25, 72076 Tubingen, Germany
    Mol Cancer 13:231. 2014
    ..This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis. ..
  4. doi request reprint The multiple facets of dermcidin in cell survival and host defense
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    J Innate Immun 4:349-60. 2012
    ..This review summarizes the evidence gathered until now concerning the expression of dermcidin and the functional relevance of dermcidin-derived peptides...
  5. ncbi request reprint Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction
    B Schittek
    Section of Dermatologic Oncology, Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Br J Dermatol 141:37-43. 1999
    ..MelanA could serve as a sensitive marker in addition to tyrosinase for detecting micrometastases...
  6. ncbi request reprint The role of antimicrobial peptides in human skin and in skin infectious diseases
    Birgit Schittek
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Infect Disord Drug Targets 8:135-43. 2008
    ..The broad spectrum of antimicrobial activity, the low incidence of bacterial resistance and their function as immunomodulatory agents are attractive features of AMPs for their clinical use...
  7. ncbi request reprint Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma
    B Schittek
    Section of Dermatologic Oncology, Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, 72076 Tubingen, Germany
    Br J Dermatol 141:30-6. 1999
    ..MelanA is a sensitive additional marker to tyrosinase in detecting micrometastases using RT-PCR...
  8. ncbi request reprint The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance
    Birgit Schittek
    Division of Dermatologic Oncology, Department of Dermatology, University of Tubingen, Liebermeisterstrasse 25, D 72076 Tubingen, Germany
    Int J Cancer 120:2110-8. 2007
    ..Thus, YB-1 may be a promising molecular target in melanoma therapy...
  9. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
    ..Altogether, L1 plays a critical role in melanoma invasion and progression and offers therapeutic potential in combination with conventional anticancer agents...
  10. pmc β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance
    Tobias Sinnberg
    Division of Dermatooncology, Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 6:e23429. 2011
    ..The differential requirements for beta-catenin signaling in aggressive melanoma versus benign melanocytic cells make beta-catenin a possible new target in melanoma therapy...
  11. doi request reprint The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells
    Heike Niessner
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    J Invest Dermatol 131:468-79. 2011
    ..Together, these findings suggest that the FTI lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells and may therefore represent an effective alternative for melanoma treatment...
  12. doi request reprint Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide
    Tobias Sinnberg
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    J Invest Dermatol 129:1500-15. 2009
    ..These effects were associated with suppression of the antiapoptotic Bcl-2 family protein Mcl-1. These data suggest that inhibition of the PI3K-AKT-mTOR pathway potently increases sensitivity of melanoma cells to chemotherapy...
  13. ncbi request reprint Diagnostic value and prognostic significance of protein S-100beta, melanoma-inhibitory activity, and tyrosinase/MART-1 reverse transcription-polymerase chain reaction in the follow-up of high-risk melanoma patients
    Claus Garbe
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Cancer 97:1737-45. 2003
    ....
  14. ncbi request reprint Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites
    Siegbert Rieg
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Invest Dermatol 126:354-65. 2006
    ..Owing to the durable and abundant presence, DCD-derived peptides contribute to the first line of defense by building a constant barrier that overlies the epithelial skin...
  15. doi request reprint Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity
    Ilknur Senyürek
    Department of Dermatology, University of Tubingen, Germany
    Peptides 31:1468-72. 2010
    ..These data suggest that extracellular matrix components are able to protect the respective tissues from invading pathogens and are part of the host defense response...
  16. doi request reprint MAPK and PI3K/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop
    Tobias Sinnberg
    Department of Dermatology, Division of Dermatooncology, Eberhard Karls University, Tubingen, Germany
    Exp Dermatol 21:265-70. 2012
    ..These data suggest that there is a tightly regulated feedback mechanism regulating YB-1 expression and activation, necessary for proper cell cycle progression of melanoma cells...
  17. pmc Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat
    Maren Paulmann
    Department of Dermatology, Eberhard Karls University Tubingen, 72076 Tubingen, Germany
    J Biol Chem 287:8434-43. 2012
    ..These data allow us for the first time to propose a molecular model for the antimicrobial mechanism of a naturally processed human anionic peptide that is active under the harsh conditions present in human sweat...
  18. ncbi request reprint The natural course of cutaneous melanoma
    Ulrike Leiter
    Department of Dermatology, Division of Dermatologic Oncology, Eberhard Karls University, Tuebingen, Germany
    J Surg Oncol 86:172-8. 2004
    ....
  19. doi request reprint Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth
    Sandeep Dhayade
    Interfakultäres Institut für Biochemie, University of Tubingen, 72076 Tubingen, Germany
    Cell Rep 14:2599-610. 2016
    ..Sildenafil treatment further increases intracellular cGMP concentrations, potentiating activation of this pathway. Collectively, our data identify this cGMP-cGKI pathway as the link between sildenafil usage and increased melanoma risk. ..
  20. doi request reprint Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis
    Tobias Sinnberg
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    Cancer Res 70:6999-7009. 2010
    ..These results show that melanoma cells developed an efficient new mechanism to activate the beta-catenin signaling pathway and define CK1alpha as a novel tumor suppressor...
  21. ncbi request reprint The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    Front Biosci 10:2986-3001. 2005
    ..The results of the research to date indicate that in melanoma both the MAPK and the AKT signaling pathways may represent promising therapeutic targets...
  22. doi request reprint Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells
    Konstantinos G Lasithiotakis
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    J Invest Dermatol 128:2013-23. 2008
    ..Sorafenib combined with rapamycin appears to be a promising strategy for the effective treatment of melanoma and merits clinical investigation...
  23. doi request reprint PTEN regulates IGF-1R-mediated therapy resistance in melanoma
    Jun Wang
    Division of Dermatooncology, Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    Pigment Cell Melanoma Res 28:572-89. 2015
    ..Our data emphasize the crosstalk and therapeutic relevance of microenvironmental and tumor cell-autonomous mechanisms in regulating IGF-1R expression and by this sensitivity toward targeted therapies. ..
  24. doi request reprint Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase
    Corinna Kosnopfel
    Division of Dermatooncology, Department of Dermatology, University of Tubingen, Tubingen, Germany
    Oncotarget 8:35761-35775. 2017
    ..These data suggest that active RSK signalling might be an attractive novel therapeutic target in melanoma with acquired resistance to MAPK pathway inhibitors...
  25. doi request reprint Processing of laminin α chains generates peptides involved in wound healing and host defense
    Ilknur Senyürek
    Division of Dermatooncology, Center for Medical Research, University Medical Clinic, Tubingen, Germany
    J Innate Immun 6:467-84. 2014
    ....
  26. ncbi request reprint Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L
    Daniel Baechle
    Medical and Natural Sciences Research Center, University of Tubingen, Ob dem Himmelreich 7, 72074 Tubingen, Germany
    J Biol Chem 281:5406-15. 2006
    ..Functional analysis indicated that proteolytic processing of DCD-1L by CatD in human sweat modulates the innate immune defense of human skin...
  27. ncbi request reprint Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Germany
    Exp Dermatol 12:296-306. 2003
    ..The described results of the current and previous studies emphasise the key role of FGF-2 in melanoma development and progression, underscoring the promise of FGF-2 as a target for therapy...
  28. pmc Dermcidin-derived peptides show a different mode of action than the cathelicidin LL-37 against Staphylococcus aureus
    Ilknur Senyürek
    Department of Dermatology, University of Tubingen, Liebermeisterstr 25, D 72076 Tubingen, Germany
    Antimicrob Agents Chemother 53:2499-509. 2009
    ..Altogether, these data indicate that the mode of action of DCD-derived peptides is different from that of the cathelicidin LL-37 and that components of the bacterial cell envelope play a role in the antimicrobial activity of DCD...
  29. pmc Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells
    Daniela Beck
    Division of Dermatologic Oncology, Department of Dermatology, University of Tubingen, 72076 Tubingen, Germany
    Sci Signal 6:ra7. 2013
    ..Thus, thapsigargin or other inducers of ER stress may be useful in combination therapies to overcome vemurafenib resistance...
  30. ncbi request reprint Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo
    Siegbert Rieg
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    J Immunol 174:8003-10. 2005
    ..These data indicate that reduced expression of DCD in sweat of patients with AD may contribute to the high susceptibility of these patients to skin infections and altered skin colonization...
  31. doi request reprint Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways
    Ines Wanke
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Invest Dermatol 131:382-90. 2011
    ..These data indicate that commensal and pathogenic microorganisms evolved specific mechanisms to modulate innate immunity of the skin...
  32. doi request reprint Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin
    Philipp Zanger
    Institut fur Tropenmedizin, Eberhard Karls Universitat, 72074 Tubingen, Germany
    J Infect Dis 200:1907-15. 2009
    ..This study aimed to clarify whether their baseline expression influences the propensity of healthy individuals to develop S. aureus-positive skin infections...
  33. ncbi request reprint Detection of dermcidin-derived peptides in sweat by ProteinChip technology
    Thomas Flad
    Section for Transplantation Immunology and Immunohaematology, University of Tuebingen, Waldhoernlestr 22, 72072, Tuebingen, Germany
    J Immunol Methods 270:53-62. 2002
    ..Such studies could reveal valuable new biomarkers for diagnosis and treatment of skin and sweat gland disorders...
  34. doi request reprint Keratinocytes as sensors and central players in the immune defense against Staphylococcus aureus in the skin
    Katharina Bitschar
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    J Dermatol Sci 87:215-220. 2017
    ..aureus in healthy skin and the mechanisms leading to an impaired keratinocyte function in AD patients...
  35. doi request reprint UVA-Irradiation Induces Melanoma Invasion via the Enhanced Warburg Effect
    York Kamenisch
    Department of Dermatology, University Hospital Regensburg, Regensburg, Germany Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    J Invest Dermatol 136:1866-75. 2016
    ..Therefore, we demonstrate in melanoma cells that production of lactic acid, induced by UVA irradiation, increases invasiveness of melanoma cells via expression of tumor-relevant proteases. ..
  36. ncbi request reprint PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo
    Heike Niessner
    Department of Dermatology, University Hospital Tubingen, Eberhard Karls University, Tubingen, Germany
    Clin Cancer Res 22:5818-5828. 2016
    ....
  37. doi request reprint Staphylococcus aureus skin colonization is promoted by barrier disruption and leads to local inflammation
    Ines Wanke
    Department of Dermatology, Eberhard Karls University Tubingen, Tubingen, Germany
    Exp Dermatol 22:153-5. 2013
    ..Our study suggests that skin barrier defects favour S. aureus skin colonization, which is associated with profound cutaneous inflammation...
  38. pmc Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tubingen, Roentgenweg 11, D 72076 Tubingen, Germany
    Breast Cancer Res 13:R28. 2011
    ..These pathways can be activated by growth factors and by exposure to ionizing radiation (IR). So far, however, no studies have been conducted on IR-induced YB-1 phosphorylation...
  39. ncbi request reprint Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy
    Claus Garbe
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University of Tuebingen, Germany
    J Clin Oncol 21:520-9. 2003
    ..To prospectively examine and evaluate the results of follow-up procedures in a large cohort of cutaneous melanoma patients...
  40. pmc Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2
    Philipp Zanger
    Institut fur Tropenmedizin, Eberhard Karls Universitat, Tubingen, Germany
    Infect Immun 78:3112-7. 2010
    ..01) than in the respective baseline groups. This suggests that inducibility of HBD-3 influences the severity of Gram-positive skin infection in vivo. The physiological function of HBD-2 induction in this context remains unclear...
  41. doi request reprint Human commensals producing a novel antibiotic impair pathogen colonization
    Alexander Zipperer
    Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tubingen, 72076 Tubingen, Germany
    Nature 535:511-6. 2016
    ..aureus carriage rate, suggesting that lugdunin or lugdunin-producing commensal bacteria could be valuable for preventing staphylococcal infections. Moreover, human microbiota should be considered as a source for new antibiotics...
  42. pmc Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus
    Patrick Ebner
    Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine, University of Tubingen, Tubingen, Germany
    Infect Immun 84:1672-81. 2016
    ..Finally, the contribution of external FbaA and GAPDH to S. aureus pathogenicity was confirmed in an insect infection model. ..
  43. doi request reprint Y-box binding protein 1--a prognostic marker and target in tumour therapy
    Corinna Kosnopfel
    Department of Dermatology, Division of Dermatooncology, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Eur J Cell Biol 93:61-70. 2014
    ..In this review, we discuss both the role of YB-1 in cancer and specifically in malignant melanoma as well as possible translations into the clinics derived thereof. ..
  44. doi request reprint Anthralin modulates the expression pattern of cytokeratins and antimicrobial peptides by psoriatic keratinocytes
    Julia Holstein
    Department of Dermatology, University Medical Center Tübingen, Eberhard Karls University, Liebermeisterstr 25, D 72076 Tubingen, Germany
    J Dermatol Sci 87:236-245. 2017
    ..While the mode of action of anti-cytokine antibodies is defined, the effects of topical anthralin on psoriatic skin are not fully understood...
  45. pmc A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib
    Tobias Sinnberg
    Department of Dermatology, Division of Dermatooncology, Eberhard Karls University Tubingen, Germany Electronic address
    EBioMedicine 8:132-49. 2016
    ..We further demonstrate that β-catenin interacts with Stat3 after chronic vemurafenib treatment and both together cooperate in the acquisition and maintenance of resistance towards BRAFi. ..
  46. pmc Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes
    Jessica Spreu
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:5100-5. 2010
    ..Thus, we report a unique NKC-encoded receptor-ligand system that may fulfill a dedicated function in the immunobiology of human skin...
  47. ncbi request reprint Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin
    Masamoto Murakami
    Division of Dermatology, University of California San Diego, and VA San Diego Healthcare Center, 92161, USA
    J Invest Dermatol 119:1090-5. 2002
    ..Thus, sweat represents a unique mode of delivery for potent innate immune effector molecules in the absence of inflammation...
  48. ncbi request reprint First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer
    Mike W Helms
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Munster, Germany
    J Pathol 206:366-76. 2005
    ..The definition of this pathway characterizes a new potential target in the molecular treatment of invasive breast cancer...
  49. ncbi request reprint Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression
    Sebastian Tuve
    Center for Cancer Research and Cancer Therapy, Institute of Molecular Biology, University of Essen Medical School, Essen, Germany
    Int J Cancer 108:162-6. 2004
    ..Moreover, increased expression of p73Deltaex2 and p73Deltaex2/3 correlated with high-levels of both TA-p73 and E2F1. Our data suggest a potential function of DeltaTA-p73 splice isoforms in melanoma progression...