Harald Scherk

Summary

Country: Germany

Publications

  1. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
  2. pmc No change to grey and white matter volumes in bipolar I disorder patients
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:345-9. 2008
  3. doi Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder
    H Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    Acta Psychiatr Scand 117:283-8. 2008
  4. doi Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
  5. doi SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
  6. ncbi Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    Arch Gen Psychiatry 64:442-55. 2007
  7. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
  8. ncbi Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
  9. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
  10. doi Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    World J Biol Psychiatry 10:524-30. 2009
    ....
  2. pmc No change to grey and white matter volumes in bipolar I disorder patients
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:345-9. 2008
    ..The aim of this study was to investigate grey and white matter volumes in a large sample of patients with bipolar I disorder...
  3. doi Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder
    H Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    Acta Psychiatr Scand 117:283-8. 2008
    ..Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent...
  4. doi Cortical neurochemistry in euthymic patients with bipolar I disorder
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, 37075 Goettingen, Germany
    World J Biol Psychiatry 10:285-94. 2009
    ..The aim of this study was to re-investigate prefrontal and anterior cingulate neurochemistry in a sample of euthymic patients with bipolar I disorder...
  5. doi SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
    ..The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus...
  6. ncbi Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Goettingen, Germany
    Arch Gen Psychiatry 64:442-55. 2007
    ..Meta-analyses addressing the use of SGAs in the treatment of acute mania are lacking...
  7. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  8. ncbi Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  9. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
    ..In conclusion, prefrontal hypogyrification in OCD patients may be a structural correlate of the impairment in executive function of this patient group and may point to a neurodevelopmental origin of this disease...
  10. doi Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009
    ..In conclusion, these results may suggest a cognitive endophenotype in schizophrenia and underline the role of the prefrontal cortex in schizophrenic pathophysiology...
  11. doi CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia
    Claudia Wolf
    Department of Psychiatry and Psychotherapy, Center for Translational Research in Systems Neuroscience and Psychiatry, Georg August University Gottingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 264:93-102. 2014
    ....
  12. doi Hippocampal integrity and neurocognition in first-episode schizophrenia: A multidimensional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 15:188-99. 2014
    ..Disturbed verbal memory functions in FE-SZ might be linked specifically to hippocampal function. ..
  13. doi Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder
    Oliver Gruber
    Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Hum Brain Mapp 31:115-25. 2010
    ..This pathophysiological abnormality appears to be a trait marker in bipolar disorders that can be observed even in the euthymic state and that seems to be largely independent of task performance and medication...
  14. ncbi Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  15. ncbi Effects of antipsychotics on brain structure
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany
    Curr Opin Psychiatry 19:145-50. 2006
    ..This review highlights the recent findings of different effects of typical and atypical antipsychotics on brain structure...
  16. doi Correlation between amygdala volume and age in bipolar disorder - a systematic review and meta-analysis of structural MRI studies
    Juliana Usher
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Germany
    Psychiatry Res 182:1-8. 2010
    ..A meta-regression analysis revealed a positive correlation between mean age and amygdala volume in patients with BD. We speculate that amygdala volume is reduced at the onset of the disease and increases with age...
  17. ncbi Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
    ..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn...
  18. ncbi Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  19. doi [Development of the evidence-based S3 guideline for diagnosis and therapy of bipolar disorders]
    Andrea Pfennig
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinik kum Carl Gustav Carus, Technische Universitat Dresden
    Nervenarzt 79:500-4. 2008