Thomas M Zollner

Summary

Affiliation: Schering AG
Country: Germany

Publications

  1. pmc Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
    Thomas M Zollner
    Department of Dermatology, J W Goethe University of Frankfurt, Frankfurt, Germany
    J Clin Invest 109:671-9. 2002
  2. pmc Selectin and selectin ligand binding: a bittersweet attraction
    Thomas M Zollner
    Corporate Research Business Area Dermatology, Schering AG, Muellerstrasse 178, D 13342 Berlin, Germany
    J Clin Invest 112:980-3. 2003
  3. ncbi request reprint Animal models of T-cell-mediated skin diseases
    Thomas M Zollner
    CRBA Dermatology, Schering AG, Berlin, Germany
    Bioessays 26:693-6. 2004
  4. ncbi request reprint Increased incidence of skin infections in atopy: evidence for an antigen-specific homing defect?
    Thomas M Zollner
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Exp Allergy 32:180-5. 2002
  5. ncbi request reprint Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules
    Ralf J Ludwig
    Department of Dermatology, J W Goethe University, Frankfurt, Germany
    J Invest Dermatol 122:830-6. 2004
  6. ncbi request reprint Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis
    Ralf J Ludwig
    Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Cancer Res 64:2743-50. 2004
  7. ncbi request reprint Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation
    Ralf J Ludwig
    Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 125:969-76. 2005
  8. doi request reprint Chronic mouse model of TMA-induced contact hypersensitivity
    Claudia Schneider
    TRG Inflammation and Immunology, Bayer Schering Pharma AG, Berlin, Germany
    J Invest Dermatol 129:899-907. 2009
  9. doi request reprint Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses
    Lars Rose
    Immunotherapy and Antibody Drug Conjugates, Bayer Pharma AG, Berlin, Germany
    Exp Dermatol 21:25-31. 2012
  10. doi request reprint The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation
    Arndt J Schottelius
    Bayer Schering Pharma AG, Berlin, Germany
    J Invest Dermatol 130:481-91. 2010

Collaborators

Detail Information

Publications29

  1. pmc Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
    Thomas M Zollner
    Department of Dermatology, J W Goethe University of Frankfurt, Frankfurt, Germany
    J Clin Invest 109:671-9. 2002
    ..We conclude that inhibition of the proteasome, e.g., by PS-519, is a promising means to treat T cell-mediated disorders such as psoriasis...
  2. pmc Selectin and selectin ligand binding: a bittersweet attraction
    Thomas M Zollner
    Corporate Research Business Area Dermatology, Schering AG, Muellerstrasse 178, D 13342 Berlin, Germany
    J Clin Invest 112:980-3. 2003
    ....
  3. ncbi request reprint Animal models of T-cell-mediated skin diseases
    Thomas M Zollner
    CRBA Dermatology, Schering AG, Berlin, Germany
    Bioessays 26:693-6. 2004
  4. ncbi request reprint Increased incidence of skin infections in atopy: evidence for an antigen-specific homing defect?
    Thomas M Zollner
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Exp Allergy 32:180-5. 2002
  5. ncbi request reprint Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules
    Ralf J Ludwig
    Department of Dermatology, J W Goethe University, Frankfurt, Germany
    J Invest Dermatol 122:830-6. 2004
    ..This increased rolling is due to the aggregate formation of platelets with leukocytes. We also provide evidence for a potential role of this mechanism in the pathogenesis of chronic inflammatory skin diseases...
  6. ncbi request reprint Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis
    Ralf J Ludwig
    Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Cancer Res 64:2743-50. 2004
    ....
  7. ncbi request reprint Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation
    Ralf J Ludwig
    Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 125:969-76. 2005
    ..In conclusion, interactions with JAM-B and -C are essential for development of cutaneous inflammation...
  8. doi request reprint Chronic mouse model of TMA-induced contact hypersensitivity
    Claudia Schneider
    TRG Inflammation and Immunology, Bayer Schering Pharma AG, Berlin, Germany
    J Invest Dermatol 129:899-907. 2009
    ..Altogether, we present an improved model of mouse T-cell-dependent skin inflammation for AD. We hope this model will enhance the predictive value of animal models for therapeutic treatment of atopic eczema...
  9. doi request reprint Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatoses
    Lars Rose
    Immunotherapy and Antibody Drug Conjugates, Bayer Pharma AG, Berlin, Germany
    Exp Dermatol 21:25-31. 2012
    ..Altogether, prolonged DNFB-induced mouse CHS models closely reflect ACD sensitive to glucocorticoids as standard therapy, reveal a more chronic skin inflammation and are responsive to cytokine antagonization...
  10. doi request reprint The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation
    Arndt J Schottelius
    Bayer Schering Pharma AG, Berlin, Germany
    J Invest Dermatol 130:481-91. 2010
    ..Our data suggest that MK2, in contrast to its downstream effector molecule, TNF-alpha, has a rather elusive role in T-cell-dependent cutaneous inflammation...
  11. ncbi request reprint CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity
    Parham Mirshahpanah
    TRG Inflammation and Immunology, Bayer Schering Pharma AG, Berlin, Germany
    Exp Dermatol 17:30-4. 2008
    ..We conclude that blocking CCR4 and CCR10 simultaneously, or their ligands, should be beneficial in the treatment of T-cell-mediated skin diseases...
  12. ncbi request reprint Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinoma
    Katrin Hirsch
    Dept of Dermatology, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, Germany
    J Dtsch Dermatol Ges 3:530-1. 2005
    ..We report the association of eosinophilic cellulitis with adenocarcinoma of the colon. Curative hemicolectomy led to a complete remission, suggesting that underlying malignancies can trigger eosinophilic cellulitis...
  13. ncbi request reprint Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
    Michael P Schön
    Department of Dermatology, Otto von Guericke University, Magdeburg, Germany
    Nat Med 8:366-72. 2002
    ..Molecular modeling demonstrated a spatial conformation of efomycines mimicking naturally occurring selectin ligands. Efomycine M might be efficacious in the treatment of human inflammatory disorders through a similar mechanism...
  14. ncbi request reprint Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis
    Marcella Grundmann-Kollmann
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Am Acad Dermatol 50:734-9. 2004
    ..To reduce side effects as a result of systemic resorption of psoralens, topical PUVA therapies have been developed and proven to be effective in the treatment of psoriasis...
  15. ncbi request reprint Techniques: species' finest blend--humanized mouse models in inflammatory skin disease research
    Frederik H Igney
    Schering AG, CRBA Dermatology, Berlin, Germany
    Trends Pharmacol Sci 25:543-9. 2004
    ..So, how can mice be humanized, and how can humanized mice be employed in immunology research and drug discovery? In this article, we answer these questions, focusing on T-cell-mediated skin diseases as an example...
  16. ncbi request reprint The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders
    Michael P Schön
    Department of Dermatology, Otto von Guericke University, Magdeburg, Germany
    J Invest Dermatol 121:951-62. 2003
    ..Selectively targeting the functions of molecules involved in this interplay promises exciting new therapeutic options for treating inflammatory skin disorders...
  17. ncbi request reprint Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome)
    Ralf J Ludwig
    Department of Dermatology, University of Frankfurt, Frankfurt am Main, Germany
    J Am Acad Dermatol 48:S60-1. 2003
    ..Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis...
  18. doi request reprint Acute neuroinflammation in Lewis rats - a model for acute multiple sclerosis relapses
    Claudia Schneider
    Bayer Schering Pharma AG, Berlin, Germany
    J Neuroimmunol 213:84-90. 2009
    ..Overall, due to its inflammatory character, this model is suggested to be used in early drug discovery particularly directed against acute inflammatory processes...
  19. doi request reprint Humanised mouse models in drug discovery for skin inflammation
    Frederik H Igney
    Schering AG, CRBA Inflammation, Müllerstr 178, 13342 Berlin, Germany
    Expert Opin Drug Discov 1:53-68. 2006
    ..Here, the authors summarise how mice can be humanised and which humanised models for inflammatory skin diseases exist. Application of these models in drug discovery and their advantages and limitations are discussed...
  20. ncbi request reprint Cancer therapy monitoring in xenografts by quantitative analysis of circulating tumor DNA
    Tobias M Gorges
    Global Biomarker Research, Bayer Pharma AG, Berlin, Germany
    Biomarkers 17:498-506. 2012
    ..Circulating tumor DNA (ctDNA) is a promising biomarker in cancer...
  21. pmc High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Berlin, Germany
    Am J Pathol 176:585-93. 2010
    ..Thus, high-resolution ultrasound imaging represents an important tool for future preclinical small animal studies, which address the pathophysiology of endometriosis and the development of new treatment strategies...
  22. doi request reprint Shortened treatment duration of glucocorticoid-induced skin atrophy in rats
    Stefanie Schoepe
    Exp Dermatol 20:853-5. 2011
    ..We show here that the treatment duration of rat skin atrophy models might be reduced to 5 days for economical and ethical reasons...
  23. ncbi request reprint Efomycine M: an inhibitor of selectins?
    Arne von Bonin
    Nat Med 12:873; author reply 873-4. 2006
  24. doi request reprint The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay
    Yi Yang Yvonne Li
    CRBA Inflammation, RBA Dermatology USA, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA Yvonne
    Immunol Lett 117:114-8. 2008
    ....
  25. ncbi request reprint Targeting leukocyte trafficking to inflamed skin: still an attractive therapeutic approach?
    Thomas M Zollner
    RBA Dermatology, Berlex Biosciences, Richmond, CA 94806, USA
    Exp Dermatol 16:1-12. 2007
    ..In this article, we delineate some pros and cons of this approach followed by a brief update on where we stand in the field and where we might move in the future...
  26. ncbi request reprint Superior nuclear receptor selectivity and therapeutic index of methylprednisolone aceponate versus mometasone furoate
    Parham Mirshahpanah
    Research Business Area Dermatology, Berlex Biosciences, Richmond, CA, USA
    Exp Dermatol 16:753-61. 2007
    ..The degree to which this observation may translate into a clinical setting requires confirmation...
  27. ncbi request reprint The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritis
    Andrea Glatzel
    Institute of Immunology, University of Kiel, Kiel, Germany
    J Infect Dis 186:1043-6. 2002
    ..Thus, the responsiveness to Borrelia antigens is not a general property of V delta 1-expressing gamma delta T cells but is largely restricted to V delta 1 gamma delta T cells recruited into the inflamed tissue...
  28. ncbi request reprint Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis
    Wolfgang Holtmeier
    Department of Medicine II, Division of Gastroenterology, University of Frankfurt, Frankfurt am Main, Germany W Holtmeier em uni frankfurt de
    Exp Dermatol 11:527-31. 2002
    ..Thus, cutaneous gammadelta T cells are not specifically expanded within the involved skin and are unlikely to be derived from the inflamed duodenum...
  29. ncbi request reprint CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X
    Soo Zin Kim
    Department of Medicine III, Hematology Oncology, University Hospital, J W Goethe University, Theodor Stern Kai 7, 60590 Franfurt M, Germany
    Leuk Lymphoma 44:281-9. 2003
    ..This is the first report demonstrating increased CD15s expression on a CD4+ CD56+ neoplasia, possibly explaining the frequent occurrence of the disease in the skin...