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Genomes and Genes | Thomas M ZollnerSummaryAffiliation: Schering AG Country: Germany Publications
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Publications
Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu modelThomas M Zollner
Department of Dermatology, J W Goethe University of Frankfurt, Frankfurt, Germany
J Clin Invest 109:671-9. 2002..We conclude that inhibition of the proteasome, e.g., by PS-519, is a promising means to treat T cell-mediated disorders such as psoriasis...- Selectin and selectin ligand binding: a bittersweet attractionThomas M Zollner
Corporate Research Business Area Dermatology, Schering AG, Muellerstrasse 178, D 13342 Berlin, Germany
J Clin Invest 112:980-3. 2003.... - Animal models of T-cell-mediated skin diseasesThomas M Zollner
CRBA Dermatology, Schering AG, Berlin, Germany
Bioessays 26:693-6. 2004 - Increased incidence of skin infections in atopy: evidence for an antigen-specific homing defect?Thomas M Zollner
Department of Dermatology, Klinikum der Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Clin Exp Allergy 32:180-5. 2002 - Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion moleculesRalf J Ludwig
Department of Dermatology, J W Goethe University, Frankfurt, Germany
J Invest Dermatol 122:830-6. 2004..This increased rolling is due to the aggregate formation of platelets with leukocytes. We also provide evidence for a potential role of this mechanism in the pathogenesis of chronic inflammatory skin diseases... - Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasisRalf J Ludwig
Department of Dermatology, , Frankfurt am Main, Germany
Cancer Res 64:2743-50. 2004.... - Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammationRalf J Ludwig
Department of Dermatology, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
J Invest Dermatol 125:969-76. 2005..In conclusion, interactions with JAM-B and -C are essential for development of cutaneous inflammation... - Chronic mouse model of TMA-induced contact hypersensitivityClaudia Schneider
TRG Inflammation and Immunology, Bayer Schering Pharma AG, Berlin, Germany
J Invest Dermatol 129:899-907. 2009..Altogether, we present an improved model of mouse T-cell-dependent skin inflammation for AD. We hope this model will enhance the predictive value of animal models for therapeutic treatment of atopic eczema... - Extended DNFB-induced contact hypersensitivity models display characteristics of chronic inflammatory dermatosesLars Rose
Immunotherapy and Antibody Drug Conjugates, Bayer Pharma AG, Berlin, Germany Biomarker Research, Bayer Pharma AG, Berlin, Germany Uterine Fibroid Research, Bayer Pharma AG, Berlin, Germany Endometriosis Research, Bayer Pharma AG, Berlin, Germany Inflammation, Bayer Pharma AG, Berlin, Germany
Exp Dermatol 21:25-31. 2012..Altogether, prolonged DNFB-induced mouse CHS models closely reflect ACD sensitive to glucocorticoids as standard therapy, reveal a more chronic skin inflammation and are responsive to cytokine antagonization... - The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammationArndt J Schottelius
Bayer Schering Pharma AG, Berlin, Germany
J Invest Dermatol 130:481-91. 2010..Our data suggest that MK2, in contrast to its downstream effector molecule, TNF-alpha, has a rather elusive role in T-cell-dependent cutaneous inflammation... - CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivityParham Mirshahpanah
TRG Inflammation and Immunology, Bayer Schering Pharma AG, Berlin, Germany
Exp Dermatol 17:30-4. 2008..We conclude that blocking CCR4 and CCR10 simultaneously, or their ligands, should be beneficial in the treatment of T-cell-mediated skin diseases... - Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinomaKatrin Hirsch
Dept. of Dermatology, , Theodor-Stern-Kai 7, Frankfurt am Main, Germany
J Dtsch Dermatol Ges 3:530-1. 2005..We report the association of eosinophilic cellulitis with adenocarcinoma of the colon. Curative hemicolectomy led to a complete remission, suggesting that underlying malignancies can trigger eosinophilic cellulitis... - Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammationMichael P Schön
Department of Dermatology, Otto von Guericke University, Magdeburg, Germany
Nat Med 8:366-72. 2002..Molecular modeling demonstrated a spatial conformation of efomycines mimicking naturally occurring selectin ligands. Efomycine M might be efficacious in the treatment of human inflammatory disorders through a similar mechanism... - Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasisMarcella Grundmann-Kollmann
Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt, Germany
J Am Acad Dermatol 50:734-9. 2004..The cumulative UV doses were significantly lower in the combination therapy. We conclude that cream PUVA can be used in addition to narrowband UVB for areas that tend to clear less quickly than the rest of the body... - Techniques: species' finest blend--humanized mouse models in inflammatory skin disease researchFrederik H Igney
Schering AG, CRBA Dermatology, Berlin, Germany
Trends Pharmacol Sci 25:543-9. 2004..So, how can mice be humanized, and how can humanized mice be employed in immunology research and drug discovery? In this article, we answer these questions, focusing on T-cell-mediated skin diseases as an example... - The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disordersMichael P Schön
Department of Dermatology, Otto von Guericke University, Magdeburg, Germany
J Invest Dermatol 121:951-62. 2003..Selectively targeting the functions of molecules involved in this interplay promises exciting new therapeutic options for treating inflammatory skin disorders... - Acute neuroinflammation in Lewis rats - a model for acute multiple sclerosis relapsesClaudia Schneider
Bayer Schering Pharma AG, Berlin, Germany
J Neuroimmunol 213:84-90. 2009..Overall, due to its inflammatory character, this model is suggested to be used in early drug discovery particularly directed against acute inflammatory processes... - Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome)Ralf J Ludwig
Department of Dermatology, University of Frankfurt, Frankfurt am Main, Germany
J Am Acad Dermatol 48:S60-1. 2003..Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis... - Shortened treatment duration of glucocorticoid-induced skin atrophy in ratsStefanie Schoepe
Exp Dermatol 20:853-5. 2011..We show here that the treatment duration of rat skin atrophy models might be reduced to 5 days for economical and ethical reasons... - High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal modelsMatthias W Laschke
Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Berlin, Germany
Am J Pathol 176:585-93. 2010..Thus, high-resolution ultrasound imaging represents an important tool for future preclinical small animal studies, which address the pathophysiology of endometriosis and the development of new treatment strategies... - Efomycine M: an inhibitor of selectins?Arne von Bonin
Nat Med 12:873; author reply 873-4. 2006 - Cancer therapy monitoring in xenografts by quantitative analysis of circulating tumor DNATobias M Gorges
Global Biomarker Research, Bayer Pharma AG, Berlin, Germany
Biomarkers 17:498-506. 2012..Circulating tumor DNA (ctDNA) is a promising biomarker in cancer... - Superior nuclear receptor selectivity and therapeutic index of methylprednisolone aceponate versus mometasone furoateParham Mirshahpanah
Research Business Area Dermatology, Berlex Biosciences, Richmond, CA, USA
Exp Dermatol 16:753-61. 2007..The degree to which this observation may translate into a clinical setting requires confirmation... - Targeting leukocyte trafficking to inflamed skin: still an attractive therapeutic approach?Thomas M Zollner
RBA Dermatology, Berlex Biosciences, Richmond, CA 94806, USA
Exp Dermatol 16:1-12. 2007..In this article, we delineate some pros and cons of this approach followed by a brief update on where we stand in the field and where we might move in the future... - The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassayYi Yang Yvonne Li
CRBA Inflammation, RBA Dermatology USA, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA Yvonne
Immunol Lett 117:114-8. 2008.... - Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformisWolfgang Holtmeier
Department of Medicine II, Division of Gastroenterology, University of Frankfurt, Frankfurt am Main, Germany. W.Holtmeier.em.uni-frankfurt.de
Exp Dermatol 11:527-31. 2002..Thus, cutaneous gammadelta T cells are not specifically expanded within the involved skin and are unlikely to be derived from the inflamed duodenum... - The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritisAndrea Glatzel
Institute of Immunology, University of Kiel, Kiel, Germany
J Infect Dis 186:1043-6. 2002..Thus, the responsiveness to Borrelia antigens is not a general property of V delta 1-expressing gamma delta T cells but is largely restricted to V delta 1 gamma delta T cells recruited into the inflamed tissue... - CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis XSoo-Zin Kim
Department of Medicine III, Hematology/Oncology, University Hospital, J.W. Goethe University, Theodor-Stern-Kai 7, 60590 Franfurt/M, Germany
Leuk Lymphoma 44:281-9. 2003..This is the first report demonstrating increased CD15s expression on a CD4+ CD56+ neoplasia, possibly explaining the frequent occurrence of the disease in the skin...