André Scherag

Summary

Affiliation: Institute for Medical Informatics, Biometry and Epidemiology; University of Duisburg-Essen
Location: Essen, Germany
URL: http://www.imibe.de/institut/mitarbeiter/wissenschaft/scherag.php
Summary:
biostatistics
genetic epidemiology
genetical statistics
clinical trial statistics

Publications

  1. doi request reprint Evaluating strategies for marker ranking in genome-wide association studies of complex traits
    A Scherag
    André Scherag, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Methods Inf Med 49:632-40. 2010
  2. doi request reprint Lack of association of the genotype in the GNAS Fok I polymorphism and prostate cancer
    A Eisenhardt
    Praxisklinik Urologie Rhein Ruhr, Mulheim an der Ruhr, Germany Andreas Eisenhardt googlemail com
    Urol Int 87:80-6. 2011
  3. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
  4. doi request reprint Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years
    Peter Rzehak
    Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Obes Facts 3:173-80. 2010
  5. doi request reprint Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort
    Sonali Pechlivanis
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
    Arterioscler Thromb Vasc Biol 30:1867-72. 2010
  6. doi request reprint Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin
    Jeannine Sauber
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Endocrinol 163:259-64. 2010
  7. doi request reprint Elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomy
    Tibor Szarvas
    Department of Urology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Int J Cancer 128:1486-92. 2011
  8. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
  9. doi request reprint Child and adolescent psychiatric genetics
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:259-79. 2010
  10. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010

Collaborators

Detail Information

Publications67

  1. doi request reprint Evaluating strategies for marker ranking in genome-wide association studies of complex traits
    A Scherag
    André Scherag, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Methods Inf Med 49:632-40. 2010
    ..Thus, several methods to sort marker data have been proposed which will be evaluated here...
  2. doi request reprint Lack of association of the genotype in the GNAS Fok I polymorphism and prostate cancer
    A Eisenhardt
    Praxisklinik Urologie Rhein Ruhr, Mulheim an der Ruhr, Germany Andreas Eisenhardt googlemail com
    Urol Int 87:80-6. 2011
    ..The Gαs subunit has been considered as an apoptosis factor. In this study the role of GNAS T393C genotypes of the GNAS gene encoding Gαs was analyzed for its influence on the development and progression of prostate cancer...
  3. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  4. doi request reprint Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years
    Peter Rzehak
    Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Obes Facts 3:173-80. 2010
    ..However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity...
  5. doi request reprint Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort
    Sonali Pechlivanis
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
    Arterioscler Thromb Vasc Biol 30:1867-72. 2010
    ....
  6. doi request reprint Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin
    Jeannine Sauber
    Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Eur J Endocrinol 163:259-64. 2010
    ..In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis...
  7. doi request reprint Elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomy
    Tibor Szarvas
    Department of Urology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Int J Cancer 128:1486-92. 2011
    ..In clinically localized prostate cancer, MMP-7 may provide independent prognostic information, thereby helping to optimize therapy decisions...
  8. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
    ..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults...
  9. doi request reprint Child and adolescent psychiatric genetics
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:259-79. 2010
    ..This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry...
  10. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
    ..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS...
  11. doi request reprint The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men
    O Albayrak
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Germany
    J Gerontol A Biol Sci Med Sci 65:219-24. 2010
    ..Thus, our results support the idea that rs17571 confers an increased risk for AD in men but not in women. Further investigation should substantiate the role of gender for AD risk of rs17571...
  12. doi request reprint Procolipase gene: no association with early-onset obesity or fat intake
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Obes Facts 2:40-4. 2009
    ..We explored the relationship between genetic variation in CLPS, early-onset obesity and fat intake in humans...
  13. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
    ..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity...
  14. doi request reprint Biodistribution of (10)B for Boron Neutron Capture Therapy (BNCT) in a mouse model after injection of sodium mercaptoundecahydro-closo-dodecaborate and l-para-boronophenylalanine
    Andrea Wittig
    Department of Radiation Oncology, University Hospital Essen, University Duisburg Essen, University Hospital Essen, Essen, Germany
    Radiat Res 172:493-9. 2009
    ..The ratio of the (10)B concentrations in tissues and blood differed significantly for the two compounds depending on the compound combination, which implies a different uptake profile for normal organs...
  15. doi request reprint Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjects
    Helene Choquet
    CNRS UMR8199 Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 19:833-9. 2011
    ..In summary, we were unable to confirm the recently reported association of variants in CD36 with early onset obesity in populations of European ancestry...
  16. doi request reprint Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa
    Timo D Müller
    Obesity Research Centre, Institute for Metabolic Disease, Division of Endocrinology, Department of Medicine, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    J Psychiatr Res 45:706-11. 2011
    ..031). Based on our results we conclude that genetic variation in GOAT might be implicated in the etiology of AN...
  17. doi request reprint Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival
    Philip Hilgard
    Department for Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Hepatology 52:1741-9. 2010
    ..TTP was 10.0 months, whereas the median overall survival was 16.4 months. No lung or visceral toxicity was observed. The most frequently observed adverse events was a transient fatigue-syndrome...
  18. doi request reprint Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation model
    Christian D Fingas
    Institute of Physiological Chemistry, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
    Liver Transpl 17:650-60. 2011
    ..These results suggest an overall beneficial effect of chloride in HTK-based liver preservation solutions...
  19. pmc Extended longevity of reproductives appears to be common in Fukomys mole-rats (Rodentia, Bathyergidae)
    Philip Dammann
    Department of General Zoology, Institute of Biology, University of Duisburg Essen, Essen, Germany
    PLoS ONE 6:e18757. 2011
    ....
  20. doi request reprint Is there an association between hospital accreditation and patient satisfaction with hospital care? A survey of 37,000 patients treated by 73 hospitals
    C Sack
    Department of Strategy and Medical Planning, University Hospital Essen, Essen, Germany
    Int J Qual Health Care 23:278-83. 2011
    ..It is believed that accreditation positively influence quality of care and patient satisfaction. This survey aims at assessing the relationship between patient satisfaction and accreditation status...
  21. doi request reprint Aquaporin 5 gene promoter--1364A/C polymorphism associated with 30-day survival in severe sepsis
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
    Anesthesiology 114:912-7. 2011
    ..Therefore, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated with increased 30-day survival in severe sepsis...
  22. pmc Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    Elizabeth K Speliotes
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Genet 7:e1001324. 2011
    ....
  23. doi request reprint Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Obes Facts 4:67-75. 2011
    ..Association with obesity and increased insulin levels have been reported for two variants (rs17782313 and rs12970134) located downstream of the melanocortin-4 receptor gene (MC4R)...
  24. doi request reprint Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Pediatr Diabetes 12:435-41. 2011
    ..The aim of this study was to analyze whether there is an allele-dosage effect on glucose metabolism in overweight children and to explore if changes in glucose metabolism in a lifestyle intervention do also depend on genotype...
  25. doi request reprint Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease
    Sokratis Trellakis
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:2183-93. 2011
    ..In vitro, tumor-derived factors modulate cellular functions of PMNs and increase their inflammatory activity. Thus, the interaction between HNSCC and PMNs may contribute to host-mediated changes in the tumor microenvironment...
  26. doi request reprint Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odors
    Sokratis Trellakis
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Regul Pept 167:112-7. 2011
    ....
  27. ncbi request reprint Impact of immunosuppressive therapy on hepatitis C infection after renal transplantation
    A Kahraman
    Department of Gastroenterology and Hepatology, University Hospital Essen, Germany
    Clin Nephrol 75:16-25. 2011
    ....
  28. pmc Multiscale assessment of treatment efficacy in adults with ADHD: a randomized placebo-controlled, multi-centre study with extended-release methylphenidate
    Wolfgang Retz
    Neurocentre, Saarland University Hospital, University of the Saarland, Homburg, Germany
    World J Biol Psychiatry 13:48-59. 2012
    ..This trial was performed to test the efficacy and safety of an extended-release formulation of methylphenidate (MPH ER)...
  29. pmc Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
    Ivonne Jarick
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstraße 3, D 35037 Marburg, Germany
    Hum Mol Genet 20:840-52. 2011
    ..However, rare CNVs had not been the focus of our study. We conclude that common CNVs are unlikely to contribute substantially to the genetic basis of early-onset extreme obesity...
  30. pmc Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus
    Andre Scherag
    Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS ONE 5:e13967. 2010
    ..As both exist, functionally relevant mutations and polymorphisms in the MC4R coding region and a robust association downstream of the gene, MC4R is an ideal model to explore synthetic association...
  31. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
    ..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies...
  32. pmc Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:14. 2009
    ..We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity...
  33. pmc Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents
    Katja Holter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    BMC Med Genet 8:21. 2007
    ..We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents...
  34. pmc The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
    E H Young
    MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Int J Obes (Lond) 31:1437-41. 2007
    ..Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation...
  35. ncbi request reprint Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 21:833-6. 2007
    ..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD...
  36. ncbi request reprint Power matters in closing the phenotyping gap
    Carola W Meyer
    Faculty of Biology, Philipps Universitat Marburg, Karl von Frisch Str 8, Marburg, Germany
    Naturwissenschaften 94:401-6. 2007
    ..Both will ultimately improve the detectability of novel phenotypes by phenotypic screening...
  37. pmc Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trials
    Leopold H J Eberhart
    Department of Anaesthesiology and Critical Care Medicine, Philipps University Marburg, Germany
    BMC Anesthesiol 6:14. 2006
    ..A quantitative systematic review was performed in order to provide more reliable estimates of the incidence of re-occurring PONV/vomiting after placebo and to help investigators defining a clinically relevant treatment effect...
  38. ncbi request reprint Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
    ..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population...
  39. ncbi request reprint Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:1761-9. 2006
    ..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals...
  40. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  41. pmc Lack of support for the association between GAD2 polymorphisms and severe human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California, USA
    PLoS Biol 3:e315. 2005
    ....
  42. ncbi request reprint Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity
    Nadine Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    J Nutr 135:1387-92. 2005
    ..244G-->A revealed no transmission disequilibrium. We conclude that the analyzed SNPs in GAL and GALR1 do not play a major role in early onset obesity or dietary fat intake in the obese children and adolescents of our study groups...
  43. ncbi request reprint The effects of late acquisition of L2 and the consequences of immigration on L1 for semantic and morpho-syntactic language aspects
    Andre Scherag
    Experimental and Biological Psychology, Philipps University, Marburg, Germany
    Cognition 93:B97-108. 2004
    ..The present data suggest that the full acquisition of at least some syntactic functions may be restricted to limited periods in life while semantic and morpho-syntactic functions seem to be relatively inured to loss due to non-use...
  44. ncbi request reprint Data adaptive interim modification of sample sizes for candidate-gene association studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Germany
    Hum Hered 56:56-62. 2003
    ..One would therefore wish to reassess the sample size during the course of a study...
  45. ncbi request reprint Differences between noun and verb processing in a minimal phrase context: a semantic priming study using event-related brain potentials
    Patrick Khader
    Experimental and Biological Psychology, Philipps University, 35032 Marburg, Germany
    Brain Res Cogn Brain Res 17:293-313. 2003
    ....
  46. ncbi request reprint Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Hum Hered 54:210-7. 2002
    ....
  47. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  48. pmc Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
    Susann Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Genet 8:17. 2007
    ..Additionally, we tested for linkage and performed family based association studies at four common variants in the 165 families of our initial genome scan...
  49. doi request reprint [Socioeconomical comparison between treated and untreated candidates for laser refractive surgery in mid-Hesse]
    W Sekundo
    Universitats Augenklinik, Mainz
    Klin Monbl Augenheilkd 225:1035-40. 2008
    ..The aim of this study was to explore the possible economic and social differences between patients who decided to undergo laser refractive surgery and those,who did not...
  50. pmc Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Child Adolesc Psychiatry Ment Health 2:33. 2008
    ..The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN)...
  51. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    ..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism...
  52. doi request reprint Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors
    Rudolf Arnold
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
    Clin Gastroenterol Hepatol 6:820-7. 2008
    ....
  53. doi request reprint Gene-environment interactions for complex traits: definitions, methodological requirements and challenges
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
    Eur J Hum Genet 16:1164-72. 2008
    ..Advantages and disadvantages of different epidemiological study designs are given and sample size requirements are exemplified. These issues as well as a critical appraisal of common methodological concerns are finally discussed...
  54. pmc Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    BMC Proc 1:S73. 2007
    ..The previously reported R620W single-nucleotide polymorphism was identified using logistic regression, but the haplotype-based methods did not provide any precise location information...
  55. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  56. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 115:1071-8. 2008
    ..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group...
  57. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  58. ncbi request reprint Pre- and perioperative predictors of short-term clinical outcomes in patients undergoing percutaneous nephrolitholapaxy
    Peter J Olbert
    Department of Urology and Pediatric Urology, Philipps University Medical School, Baldingerstr, 35043 Marburg, Germany
    Urol Res 35:225-30. 2007
    ..In addition, patients with lower BMIs might be at higher risk of not being stone free at hospital discharge accompanied by prolonged inpatient treatment...
  59. ncbi request reprint Evaluation of the Unified Wilson's Disease Rating Scale (UWDRS) in German patients with treated Wilson's disease
    Barbara Leinweber
    Department of Neurology, Philipps University Marburg, Germany
    Mov Disord 23:54-62. 2008
    ..54 (CI(95%) 0.40-0.69, P < 0.001). In summary, the UWDRS appears to be a promising tool to assess the disease severity in WD. Its usefulness in clinical research and drug trials should be further addressed...
  60. ncbi request reprint No association of sequence variants in the neuropeptide Y2 receptor (NPY2R) gene with early onset obesity in Germans
    H J Wang
    Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, PR China
    Horm Metab Res 39:840-4. 2007
    ..50). In conclusion, we did not find evidence for an involvement of genetic variation in the NPY2R in early onset obesity in German samples...
  61. pmc Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
    Susanne Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    BMC Cancer 8:85. 2008
    ..We tested if cancer patients that are homo-/heterozygous for the Val103Ile polymorphism are more likely to develop cachexia and/or a loss of appetite than non-carriers of the 103Ile-allele...
  62. doi request reprint Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Eur J Hum Genet 16:1126-34. 2008
    ..Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep...
  63. pmc Study protocol of Prednisone in episodic Cluster Headache (PredCH): a randomized, double-blind, placebo-controlled parallel group trial to evaluate the efficacy and safety of oral prednisone as an add-on therapy in the prophylactic treatment of episodic c
    Dagny Holle
    Department of Neurology, University Hospital Essen, Hufelandstrase 55, 45122 Essen, Germany
    BMC Neurol 13:99. 2013
    ..This study will assess the efficacy and safety of oral prednisone as an add-on therapy to verapamil and compare it to a monotherapy with verapamil in the initial prophylactic treatment of a cluster episode...
  64. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
    ..Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation...
  65. pmc Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study
    Sonali Pechlivanis
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
    BMC Med Genet 14:23. 2013
    ..Here we examine the association between single nucleotide polymorphisms (SNPs) integrated on Metabochip and coronary artery calcification (CAC), a valid risk factor for CHD, in an unselected, population-based German cohort...
  66. pmc Oxygen persufflation as adjunct in liver preservation (OPAL): study protocol for a randomized controlled trial
    Thomas Minor
    Surgical Research Division, University Clinic of Surgery, Bonn, Germany
    Trials 12:234. 2011
    ....
  67. pmc Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas
    Christoph Bergmann
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrasse 55, 45127 Essen, Germany
    J Transl Med 9:139. 2011
    ....