Research Topics
Genomes and Genes
| André ScheragSummaryAffiliation: Institute for Medical Informatics, Biometry and Epidemiology; University of Duisburg-Essen Location: Essen, Germany URL: http://www.imibe.de/institut/mitarbeiter/wissenschaft/scherag.php Summary: biostatistics genetic epidemiology genetical statistics clinical trial statistics Publications
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Detail Information
Publications
Lack of association of the genotype in the GNAS Fok I polymorphism and prostate cancerA Eisenhardt
Praxisklinik Urologie Rhein Ruhr, Mulheim an der Ruhr, Germany Andreas Eisenhardt googlemail com
Urol Int 87:80-6. 2011..The Gαs subunit has been considered as an apoptosis factor. In this study the role of GNAS T393C genotypes of the GNAS gene encoding Gαs was analyzed for its influence on the development and progression of prostate cancer...
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexElizabeth K Speliotes
Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
Nat Genet 42:937-48. 2010..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...- Evaluating strategies for marker ranking in genome-wide association studies of complex traitsA Scherag
André Scherag, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Methods Inf Med 49:632-40. 2010..Thus, several methods to sort marker data have been proposed which will be evaluated here... - Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 yearsPeter Rzehak
Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
Obes Facts 3:173-80. 2010..However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity... - Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohortSonali Pechlivanis
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
Arterioscler Thromb Vasc Biol 30:1867-72. 2010.... - Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from BerlinJeannine Sauber
Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Berlin, Germany
Eur J Endocrinol 163:259-64. 2010..In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis... - Elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomyTibor Szarvas
Department of Urology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
Int J Cancer 128:1486-92. 2011..In clinically localized prostate cancer, MMP-7 may provide independent prognostic information, thereby helping to optimize therapy decisions... - Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groupsAndre Scherag
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS Genet 6:e1000916. 2010..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults... - Child and adolescent psychiatric geneticsJohannes Hebebrand
Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
Eur Child Adolesc Psychiatry 19:259-79. 2010..This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry... - Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)Susanne Tan
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 11:12. 2010..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS... - The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in menO Albayrak
Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Germany
J Gerontol A Biol Sci Med Sci 65:219-24. 2010..Thus, our results support the idea that rs17571 confers an increased risk for AD in men but not in women. Further investigation should substantiate the role of gender for AD risk of rs17571... - Procolipase gene: no association with early-onset obesity or fat intakeAnne Kathrin Wermter
Department of Child and Adolescent Psychiatry, University of Marburg, Germany
Obes Facts 2:40-4. 2009..We explored the relationship between genetic variation in CLPS, early-onset obesity and fat intake in humans... - Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesityTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
BMC Med Genet 11:2. 2010..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity... - Biodistribution of (10)B for Boron Neutron Capture Therapy (BNCT) in a mouse model after injection of sodium mercaptoundecahydro-closo-dodecaborate and l-para-boronophenylalanineAndrea Wittig
Department of Radiation Oncology, University Hospital Essen, University Duisburg Essen, University Hospital Essen, Essen, Germany
Radiat Res 172:493-9. 2009..The ratio of the (10)B concentrations in tissues and blood differed significantly for the two compounds depending on the compound combination, which implies a different uptake profile for normal organs... - Lack of association of CD36 SNPs with early onset obesity: a meta-analysis in 9,973 European subjectsHelene Choquet
CNRS UMR8199 Institute of Biology, Pasteur Institute, Lille, France
Obesity (Silver Spring) 19:833-9. 2011..In summary, we were unable to confirm the recently reported association of variants in CD36 with early onset obesity in populations of European ancestry... - Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosaTimo D Müller
Obesity Research Centre, Institute for Metabolic Disease, Division of Endocrinology, Department of Medicine, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
J Psychiatr Res 45:706-11. 2011..031). Based on our results we conclude that genetic variation in GOAT might be implicated in the etiology of AN... - Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survivalPhilip Hilgard
Department for Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
Hepatology 52:1741-9. 2010..Because TTP and survival appear to be comparable to systemic therapy in selected patients with advanced HCC, randomized controlled trials in combination with systemic therapy are warranted... - Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation modelChristian D Fingas
Institute of Physiological Chemistry, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
Liver Transpl 17:650-60. 2011..These results suggest an overall beneficial effect of chloride in HTK-based liver preservation solutions... - Extended longevity of reproductives appears to be common in Fukomys mole-rats (Rodentia, Bathyergidae)Philip Dammann
Department of General Zoology, Institute of Biology, University of Duisburg Essen, Essen, Germany
PLoS ONE 6:e18757. 2011.... - Is there an association between hospital accreditation and patient satisfaction with hospital care? A survey of 37,000 patients treated by 73 hospitalsC Sack
Department of Strategy and Medical Planning, University Hospital Essen, Essen, Germany
Int J Qual Health Care 23:278-83. 2011..It is believed that accreditation positively influence quality of care and patient satisfaction. This survey aims at assessing the relationship between patient satisfaction and accreditation status... - Aquaporin 5 gene promoter--1364A/C polymorphism associated with 30-day survival in severe sepsisMichael Adamzik
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
Anesthesiology 114:912-7. 2011..Therefore, we tested the hypothesis that the AQP5 promoter -1364A/C polymorphism is associated with increased 30-day survival in severe sepsis... - Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsElizabeth K Speliotes
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 7:e1001324. 2011.... - Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle interventionCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Obes Facts 4:67-75. 2011..Association with obesity and increased insulin levels have been reported for two variants (rs17782313 and rs12970134) located downstream of the melanocortin-4 receptor gene (MC4R)... - Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescentsThomas Reinehr
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
Pediatr Diabetes 12:435-41. 2011..The aim of this study was to analyze whether there is an allele-dosage effect on glucose metabolism in overweight children and to explore if changes in glucose metabolism in a lifestyle intervention do also depend on genotype... - Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced diseaseSokratis Trellakis
Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
Int J Cancer 129:2183-93. 2011..In vitro, tumor-derived factors modulate cellular functions of PMNs and increase their inflammatory activity. Thus, the interaction between HNSCC and PMNs may contribute to host-mediated changes in the tumor microenvironment... - Ghrelin, leptin and adiponectin as possible predictors of the hedonic value of odorsSokratis Trellakis
Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
Regul Pept 167:112-7. 2011.... 
Impact of immunosuppressive therapy on hepatitis C infection after renal transplantationA Kahraman
Department of Gastroenterology and Hepatology, University Hospital Essen, Germany
Clin Nephrol 75:16-25. 2011....- Multiscale assessment of treatment efficacy in adults with ADHD: a randomized placebo-controlled, multi-centre study with extended-release methylphenidateWolfgang Retz
Neurocentre, Saarland University Hospital, University of the Saarland, Homburg, Germany
World J Biol Psychiatry 13:48-59. 2012..This trial was performed to test the efficacy and safety of an extended-release formulation of methylphenidate (MPH ER)... - Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysisIvonne Jarick
Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstraße 3, D 35037 Marburg, Germany
Hum Mol Genet 20:840-52. 2011..However, rare CNVs had not been the focus of our study. We conclude that common CNVs are unlikely to contribute substantially to the genetic basis of early-onset extreme obesity... - Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locusAndre Scherag
Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS ONE 5:e13967. 2010..As both exist, functionally relevant mutations and polymorphisms in the MC4R coding region and a robust association downstream of the gene, MC4R is an ideal model to explore synthetic association... - Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groupsCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 10:19. 2009..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies... - Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestryCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 10:14. 2009..We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity... - Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescentsKatja Holter
Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
BMC Med Genet 8:21. 2007..We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents... - The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individualsE H Young
MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
Int J Obes (Lond) 31:1437-41. 2007..Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation... - Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorderRainald Mossner
Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Psychopharmacol 21:833-6. 2007..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD... - Power matters in closing the phenotyping gapCarola W Meyer
Faculty of Biology, Philipps Universitat Marburg, Karl von Frisch Str 8, Marburg, Germany
Naturwissenschaften 94:401-6. 2007..Both will ultimately improve the detectability of novel phenotypes by phenotypic screening... - Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trialsLeopold H J Eberhart
Department of Anaesthesiology and Critical Care Medicine, Philipps University Marburg, Germany
BMC Anesthesiol 6:14. 2006..A quantitative systematic review was performed in order to provide more reliable estimates of the incidence of re-occurring PONV/vomiting after placebo and to help investigators defining a clinically relevant treatment effect... - Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studiesAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
Hum Mol Genet 15:2772-83. 2006..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population... - Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from GermanyAnke Hinney
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
J Clin Endocrinol Metab 91:1761-9. 2006..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals... - Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorderRainald Mossner
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
Int J Neuropsychopharmacol 9:437-42. 2006..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD... - Lack of support for the association between GAD2 polymorphisms and severe human obesityMichael M Swarbrick
Diabetes Center, University of California, San Francisco, California, USA
PLoS Biol 3:e315. 2005.... - Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesityNadine Schäuble
Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
J Nutr 135:1387-92. 2005..244G-->A revealed no transmission disequilibrium. We conclude that the analyzed SNPs in GAL and GALR1 do not play a major role in early onset obesity or dietary fat intake in the obese children and adolescents of our study groups... - The effects of late acquisition of L2 and the consequences of immigration on L1 for semantic and morpho-syntactic language aspectsAndre Scherag
Experimental and Biological Psychology, Philipps University, Marburg, Germany
Cognition 93:B97-108. 2004..The present data suggest that the full acquisition of at least some syntactic functions may be restricted to limited periods in life while semantic and morpho-syntactic functions seem to be relatively inured to loss due to non-use... - Data adaptive interim modification of sample sizes for candidate-gene association studiesAndre Scherag
Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Germany
Hum Hered 56:56-62. 2003..One would therefore wish to reassess the sample size during the course of a study... - Differences between noun and verb processing in a minimal phrase context: a semantic priming study using event-related brain potentialsPatrick Khader
Experimental and Biological Psychology, Philipps University, 35032 Marburg, Germany
Brain Res Cogn Brain Res 17:293-313. 2003.... - Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studiesAndre Scherag
Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Hum Hered 54:210-7. 2002.... - The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsHelen N Lyon
Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
PLoS Genet 3:e61. 2007.... - Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13Susann Friedel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Genet 8:17. 2007..Additionally, we tested for linkage and performed family based association studies at four common variants in the 165 families of our initial genome scan... - [Socioeconomical comparison between treated and untreated candidates for laser refractive surgery in mid-Hesse]W Sekundo
Universitats Augenklinik, Mainz
Klin Monbl Augenheilkd 225:1035-40. 2008..The aim of this study was to explore the possible economic and social differences between patients who decided to undergo laser refractive surgery and those,who did not... - Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosaTimo Dirk Müller
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Child Adolesc Psychiatry Ment Health 2:33. 2008..The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN)... - 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescentsTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
BMC Med Genet 9:85. 2008..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism... - Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumorsRudolf Arnold
Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
Clin Gastroenterol Hepatol 6:820-7. 2008.... - Gene-environment interactions for complex traits: definitions, methodological requirements and challengesAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
Eur J Hum Genet 16:1164-72. 2008..Advantages and disadvantages of different epidemiological study designs are given and sample size requirements are exemplified. These issues as well as a critical appraisal of common methodological concerns are finally discussed... - Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritisAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
BMC Proc 1:S73. 2007..The previously reported R620W single-nucleotide polymorphism was identified using logistic regression, but the haplotype-based methods did not provide any precise location information... - Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008.... - Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic systemSusanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
J Neural Transm 115:1071-8. 2008..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group... - Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humansAnne Kathrin Wermter
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Eur J Hum Genet 16:1126-34. 2008..Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep... - Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexiaSusanne Knoll
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
BMC Cancer 8:85. 2008..We tested if cancer patients that are homo-/heterozygous for the Val103Ile polymorphism are more likely to develop cachexia and/or a loss of appetite than non-carriers of the 103Ile-allele... - No association of sequence variants in the neuropeptide Y2 receptor (NPY2R) gene with early onset obesity in GermansH J Wang
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, PR China
Horm Metab Res 39:840-4. 2007..50). In conclusion, we did not find evidence for an involvement of genetic variation in the NPY2R in early onset obesity in German samples... - Evaluation of the Unified Wilson's Disease Rating Scale (UWDRS) in German patients with treated Wilson's diseaseBarbara Leinweber
Department of Neurology, Philipps University Marburg, Germany
Mov Disord 23:54-62. 2008..54 (CI(95%) 0.40-0.69, P < 0.001). In summary, the UWDRS appears to be a promising tool to assess the disease severity in WD. Its usefulness in clinical research and drug trials should be further addressed... - Pre- and perioperative predictors of short-term clinical outcomes in patients undergoing percutaneous nephrolitholapaxyPeter J Olbert
Department of Urology and Pediatric Urology, Philipps University Medical School, Baldingerstr, 35043 Marburg, Germany
Urol Res 35:225-30. 2007..In addition, patients with lower BMIs might be at higher risk of not being stone free at hospital discharge accompanied by prolonged inpatient treatment... - Association and linkage of allelic variants of the dopamine transporter gene in ADHDS Friedel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Mol Psychiatry 12:923-33. 2007..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p... - Oxygen persufflation as adjunct in liver preservation (OPAL): study protocol for a randomized controlled trialThomas Minor
Surgical Research Division, University Clinic of Surgery, Bonn, Germany
Trials 12:234. 2011..Final analysis will be based on all participants as randomized (intention to treat). TRIAL REGISTRATION: Current Controlled Trials ISRCTN00167887... - Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomasChristoph Bergmann
Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrasse 55, 45127 Essen, Germany
J Transl Med 9:139. 2011....