M Schemann

Summary

Country: Germany

Publications

  1. ncbi request reprint Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
  2. pmc Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor
    Andrea Nemethova
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    PLoS ONE 8:e79264. 2013
  3. pmc Activity of protease-activated receptors in primary cultured human myenteric neurons
    Eva M Kugler
    Human Biology, Technische Universität München Freising, Germany
    Front Neurosci 6:133. 2012
  4. pmc Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice
    François Reichardt
    Professor M Schemann Lehrstuhl für Humanbiologie, Technische Universitat Munchen, Liesel Beckmann Straße 4, 85350 Freising Weihenstephan, Germany
    J Physiol 591:5125-39. 2013
  5. ncbi request reprint Functions and imaging of mast cell and neural axis of the gut
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 144:698-704.e4. 2013
  6. pmc The mast cell degranulator compound 48/80 directly activates neurons
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    PLoS ONE 7:e52104. 2012
  7. doi request reprint Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients
    S Buhner
    Human Biology, Technische Universitat Munchen, Germany
    Neurogastroenterol Motil 24:1134-e572. 2012
  8. doi request reprint Multifunctional mechanosensitive neurons in the enteric nervous system
    Michael Schemann
    Human Biology, TU Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Auton Neurosci 153:21-5. 2010
  9. ncbi request reprint Region-specific effects of STW 5 (Iberogast) and its components in gastric fundus, corpus and antrum
    M Schemann
    Department of Human Biology, Technische Universitat Munchen, 85354 Freising, Germany
    Phytomedicine 13:90-9. 2006
  10. ncbi request reprint Control of gastrointestinal motility by the "gut brain"--the enteric nervous system
    Michael Schemann
    Department of Human Biology, Technische Universitat Munchen, Freising Weihenstephan, Germany
    J Pediatr Gastroenterol Nutr 41:S4-6. 2005

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors
    Klaus Michel
    Department of Human Biology, Technische Universität Munich, Freising, Germany
    Gastroenterology 128:1317-26. 2005
    ..Recently, the neural 5-HT3 receptor received a lot of attention as a possible target in functional bowel diseases. Yet, the 5-HT3 receptor-mediated changes in properties of human enteric neurons is unknown...
  2. pmc Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor
    Andrea Nemethova
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    PLoS ONE 8:e79264. 2013
    ..To this end, we have studied the effect of nicotine on the activation of resident macrophages in a mouse stomach preparation by means of calcium imaging...
  3. pmc Activity of protease-activated receptors in primary cultured human myenteric neurons
    Eva M Kugler
    Human Biology, Technische Universität München Freising, Germany
    Front Neurosci 6:133. 2012
    ..Our study provided further evidence for the prominent role of neuronal PAR1 in the human enteric nervous system...
  4. pmc Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice
    François Reichardt
    Professor M Schemann Lehrstuhl für Humanbiologie, Technische Universitat Munchen, Liesel Beckmann Straße 4, 85350 Freising Weihenstephan, Germany
    J Physiol 591:5125-39. 2013
    ..This questions the common assumption that increased mucosal inflammation and permeability initiate functional disorders in obesity...
  5. ncbi request reprint Functions and imaging of mast cell and neural axis of the gut
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 144:698-704.e4. 2013
    ..Studies of motility and functional gastrointestinal disorders would be feasible without the need for full-thickness biopsy...
  6. pmc The mast cell degranulator compound 48/80 directly activates neurons
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    PLoS ONE 7:e52104. 2012
    ..Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator. With this study we demonstrate that compound 48/80 also directly activates enteric neurons and visceral afferents...
  7. doi request reprint Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients
    S Buhner
    Human Biology, Technische Universitat Munchen, Germany
    Neurogastroenterol Motil 24:1134-e572. 2012
    ..Based on the concept that mucosa-nerve signaling is altered in IBS, we tested in this study whether the nerve sensitizing effect of IBS mucosal biopsy supernatants is more prominent in the submucous than myenteric plexus...
  8. doi request reprint Multifunctional mechanosensitive neurons in the enteric nervous system
    Michael Schemann
    Human Biology, TU Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    Auton Neurosci 153:21-5. 2010
    ..This review summarises the main arguments in favour of this concept, discusses the stimulus modalities, the response patterns and the functional role of mechanosensitive enteric neurons and concludes with identifying future challenges...
  9. ncbi request reprint Region-specific effects of STW 5 (Iberogast) and its components in gastric fundus, corpus and antrum
    M Schemann
    Department of Human Biology, Technische Universitat Munchen, 85354 Freising, Germany
    Phytomedicine 13:90-9. 2006
    ....
  10. ncbi request reprint Control of gastrointestinal motility by the "gut brain"--the enteric nervous system
    Michael Schemann
    Department of Human Biology, Technische Universitat Munchen, Freising Weihenstephan, Germany
    J Pediatr Gastroenterol Nutr 41:S4-6. 2005
    ..This review provides a summary of the ENS circuits that control muscle activity, the main transmitters and neuromodulators involved and the functional implications for the normal and diseased gut...
  11. ncbi request reprint Motor control of the stomach
    M Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Eur Rev Med Pharmacol Sci 12:41-51. 2008
    ..Only the muscle response at the site of distension exhibited an inhibitory response which is usually dominated by the cholinergic excitatory response...
  12. ncbi request reprint Human mast cell mediator cocktail excites neurons in human and guinea-pig enteric nervous system
    M Schemann
    Department of Human Biology, TU Munich, Hochfeldweg 2, D 85350, Freising Weihenstephan, Germany
    Neurogastroenterol Motil 17:281-9. 2005
    ..This study demonstrates immunoneural signalling in the human gut and revealed for the first time that an MCMC released from stimulated human intestinal mast cells induces excitatory actions in the human and guinea-pig ENS...
  13. ncbi request reprint The human enteric nervous system
    M Schemann
    Department of Human Biology, TU Munich, Freising, Germany
    Neurogastroenterol Motil 16:55-9. 2004
    ..Additionally, we review disease associated changes in human ENS properties. Finally, we highlight some research areas that hold special promise in advancing our understanding of the human ENS...
  14. pmc Fast calcium and voltage-sensitive dye imaging in enteric neurones reveal calcium peaks associated with single action potential discharge
    K Michel
    Human Biology, Technische Universitat Munchen, Freising, Germany
    J Physiol 589:5941-7. 2011
    ..Fast [Ca(2+)](i) imaging can be used to directly record single action potentials in enteric neurones. [Ca(2+)](i) peaks required opening of voltage-gated sodium and calcium channels as well as Ca(2+) release from intracellular stores...
  15. doi request reprint Leptin excites enteric neurons of guinea-pig submucous and myenteric plexus
    F Reichardt
    Lehrstuhl für Humanbiologie, Technische Universitat Munchen, Liesel Beckmann Strasse 4, 85350 Freising Weihenstephan, Germany
    Neurogastroenterol Motil 23:e165-70. 2011
    ..An adipocyte-ENS axis is suggested by close apposition between enteric nerves and adipocytes. The aim of this study was to investigate the effects of leptin on guinea-pig submucous and myenteric neurons...
  16. doi request reprint The multi-herbal drug STW 5 (Iberogast) has prosecretory action in the human intestine
    D Krueger
    Department of Human Biology, Technische Universitat Munchen, Munchen, Germany
    Neurogastroenterol Motil 21:1203-e110. 2009
    ..The prosecretory effect is due to increased epithelial Cl(-) fluxes via CFTR and Ca-dependent ClCa channels. STW 5 may be a novel option to treat secretory disorders associated with IBS and constipation...
  17. doi request reprint Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine
    D Krueger
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Neurogastroenterol Motil 25:e530-9. 2013
    ..Various studies, mainly on animal tissues, suggested that its antimuscarinic action is responsible for its spasmolytic effect. However, functional in vitro studies with human tissue have not been performed so far...
  18. ncbi request reprint The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility
    B Hohenester
    Department of Human Biology, Technical University Munich, Munich, Germany
    Neurogastroenterol Motil 16:765-73. 2004
    ....
  19. doi request reprint Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide
    D Krueger
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Neurogastroenterol Motil 22:1224-31, e319-20. 2010
    ....
  20. ncbi request reprint Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system
    Anne Ruhl
    Department of Human Biology, Technical University of Munich, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 490:1-11. 2005
    ..PEPT2-mediated dipeptide transport in enteric glia could contribute to the clearance of neuropeptides in the ENS. In addition, the fluorophore-coupled dipeptide uptake via PEPT2 is a novel vital marker for glial cells in the ENS...
  21. pmc Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum
    Gemma Mazzuoli
    Human Biology, Technische Universitat Munchen, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
    J Physiol 587:4681-94. 2009
    ..The findings call for a revision of current concepts on sensory transmission within the ENS...
  22. doi request reprint Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    Sabine Buhner
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 137:1425-34. 2009
    ..Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons...
  23. ncbi request reprint Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody
    Sebastian Hoff
    Department of Human Biology, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    J Comp Neurol 509:356-71. 2008
    ..This is a comprehensive set of quantitative EGC measures in man and guinea pig that provides a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut...
  24. doi request reprint The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin
    Michael Schemann
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 138:266-74. 2010
    ..Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode of action of GW427353 in human submucous neurons...
  25. ncbi request reprint Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon
    Rudolf Schicho
    Department of Human Biology, Technical University Munich, Munich, Germany
    Gastroenterology 131:1542-52. 2006
    ..Hydrogen sulfide (H(2)S) has been suggested as a novel gasomediator. We explored its unknown neuromodulatory role in human and guinea-pig colon...
  26. ncbi request reprint Cholinergic and noncholinergic innervation of the smooth muscle layers in the bovine abomasum
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Leipzig, Germany
    Anat Rec 267:70-7. 2002
    ..This innervation pattern is different from that in gastric muscle layers in monogastric animals...
  27. ncbi request reprint Cutting-edge technology. III. Imaging and the gastrointestinal tract: mapping the human enteric nervous system
    Michael Schemann
    Department of Physiology, School of Veterinary Medicine, D 30173 Hannover, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G919-25. 2002
    ..The optical mapping made it possible to record from tissues such as human enteric nerves, which were, until now, inaccessible by other techniques...
  28. ncbi request reprint Ruminal muscle of sheep is innervated by non-polarized pathways of cholinergic and nitrergic myenteric neurones
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, An den Tierkliniken 7, 04103 Leipzig, Germany
    Cell Tissue Res 309:347-54. 2002
    ..Neurones expressing the code ChAT/SP might function as excitatory muscle motor neurones, whereas NOS/VIP neurones are likely to act as inhibitory muscle motor neurones...
  29. pmc Intrinsic innervation patterns of the smooth muscle in the rumen and reticulum of lambs
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Germany
    J Anat 204:293-9. 2004
    ..Consequently, intrinsic innervation patterns for the smooth muscle layers in the rumen and reticulum differ from all gastrointestinal regions examined thus far...
  30. ncbi request reprint Calbindin-immunoreactive neurones in the ovine rumen
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Leipzig, Germany
    Anat Rec A Discov Mol Cell Evol Biol 278:528-32. 2004
    ..We conclude that CALB-positive myenteric neurones within the ovine rumen project to the epithelium; however, their functional role remains to be investigated...
  31. ncbi request reprint Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function
    Yasmin Nasser
    Institute for Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 291:G912-27. 2006
    ..Our data suggest that enteric glia are involved in the modulation of enteric neural circuits underlying the regulation of intestinal motility...
  32. ncbi request reprint Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men
    Amelia N Pilichiewicz
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Am J Gastroenterol 102:1276-83. 2007
    ..The effects of Iberogast on the human gastrointestinal tract have not been evaluated...
  33. ncbi request reprint Enteric nervous system
    David Grundy
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Curr Opin Gastroenterol 22:102-10. 2006
    ..Our aim was to provide a synopsis of how the field of enteric neurobiology has advanced during the past year...
  34. ncbi request reprint Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system
    Selim Cellek
    Neurology and Gastrointestinal Centre of Excellence in Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom
    Gastroenterology 133:175-83. 2007
    ..We aimed to investigate the expression of beta(3)-AR in human enteric nervous system and its role in motility and visceral algesia...
  35. ncbi request reprint Virokinin, a bioactive peptide of the tachykinin family, is released from the fusion protein of bovine respiratory syncytial virus
    Gert Zimmer
    Institut fur Virologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    J Biol Chem 278:46854-61. 2003
    ..The viral tachykinin-like peptide represents a novel form of molecular mimicry, which may benefit the virus by affecting the host immune response...
  36. ncbi request reprint Reticular groove and reticulum are innervated by myenteric neurons with different neurochemical codes
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Veterinärmedizinische Fakultät, Universitat Leipzig, Leipzig, Germany
    Anat Rec A Discov Mol Cell Evol Biol 274:917-22. 2003
    ..It is suggested that the specific neurochemical code in combination with a specific morphology leads to a precise regulation of the specialized tasks of the reticulum and reticular groove by subpopulations of myenteric neurons...
  37. pmc Age-associated plasticity in the intrinsic innervation of the ovine rumen
    Helga Pfannkuche
    Veterinär Physiologisches Institut, Universitat Leipzig, Germany
    J Anat 203:277-82. 2003
    ..We conclude that the age-associated changes in neurochemical code of myenteric neurons in the forestomach are related to the adaption of the rumen to different functional properties during development...
  38. ncbi request reprint Enteric nervous system
    David Grundy
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Curr Opin Gastroenterol 23:121-6. 2007
    ..Our aim was to highlight recent advances...
  39. ncbi request reprint Enteric nervous system
    David Grundy
    Department of Biomedical Science, University of Sheffield, UK
    Curr Opin Gastroenterol 21:176-82. 2005
    ..The purpose of this review is to provide a synopsis of how the field of enteric neurobiology has advanced during the past 2 years...
  40. ncbi request reprint Selective activation of human intestinal mast cells by Escherichia coli hemolysin
    Sigrid Krämer
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Stuttgart, Germany
    J Immunol 181:1438-45. 2008
    ..coli. Our data indicate that human intestinal mast cells interact with selected Gram-negative bacteria, establish E. coli Hly as a factor regulating MC effector functions, and argue further for a role of human MCs in innate immunity...