Claus Scheidereit

Summary

Country: Germany

Publications

  1. ncbi request reprint IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
    Claus Scheidereit
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Oncogene 25:6685-705. 2006
  2. doi request reprint A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell 40:63-74. 2010
  3. pmc The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1
    Daniel Krappmann
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell Biol 24:6488-500. 2004
  4. doi request reprint A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation
    Michael Stilmann
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell 36:365-78. 2009
  5. ncbi request reprint Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, FG Dörken, D 13125 Berlin, Germany
    Blood 106:4287-93. 2005
  6. ncbi request reprint NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
    Ruth Schmidt-Ullrich
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Development 133:1045-57. 2006
  7. ncbi request reprint Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo
    Christian Freund
    Franz Volhard Clinic, Department of Cardiology, HELIOS Klinikum Berlin, Charité Campus Berlin Buch, Berlin, Germany
    Circulation 111:2319-25. 2005
  8. pmc Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Exp Med 196:605-17. 2002
  9. pmc Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation
    Sebastian Tegethoff
    Cell Growth and Differentiation Program, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Mol Cell Biol 23:2029-41. 2003
  10. doi request reprint Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
    Armin Rehm
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 125:2367-74. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
    Claus Scheidereit
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Oncogene 25:6685-705. 2006
    ..Finally, IKK is engaged in cross talk with other pathways and confers functions independently of NF-kappaB...
  2. doi request reprint A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell 40:63-74. 2010
    ..Our data indicate that exported SUMOylated IKKγ acts as a substrate. IKKγ monoubiquitination is a prerequisite for genotoxic IKK and NF-κB activation, but also promotes cytokine signaling...
  3. pmc The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1
    Daniel Krappmann
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell Biol 24:6488-500. 2004
    ..Thus, our data illustrate that NF-kappaB orchestrates immediate-early effects of LPS signaling and controls secondary AP-1 activation to mount an appropriate biological response...
  4. doi request reprint A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation
    Michael Stilmann
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell 36:365-78. 2009
    ..Activated PARP-1 and a PARBM in PIASy are required to trigger IKKgamma SUMOylation, which in turn permits IKK and NF-kappaB activation, as well as NF-kappaB-regulated resistance to apoptosis...
  5. ncbi request reprint Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, FG Dörken, D 13125 Berlin, Germany
    Blood 106:4287-93. 2005
    ..Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL...
  6. ncbi request reprint NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
    Ruth Schmidt-Ullrich
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Development 133:1045-57. 2006
    ..The strongly decreased number of hair follicles observed in c(IkappaBalphaDeltaN) mice compared with tabby mice, indicates that additional signals, such as TROY, must regulate NF-kappaB activity in specific hair follicle subtypes...
  7. ncbi request reprint Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo
    Christian Freund
    Franz Volhard Clinic, Department of Cardiology, HELIOS Klinikum Berlin, Charité Campus Berlin Buch, Berlin, Germany
    Circulation 111:2319-25. 2005
    ..Currently, the net effect on cardiac remodeling in vivo under common stress stimuli is unclear...
  8. pmc Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Exp Med 196:605-17. 2002
    ..The gene profile underscores a central role of NF-kappaB in the pathogenesis of HD and potentially of other tumors with constitutive NF-kappaB activation...
  9. pmc Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation
    Sebastian Tegethoff
    Cell Growth and Differentiation Program, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Mol Cell Biol 23:2029-41. 2003
    ..These data thus suggest that IKKgamma tetramerization enforces a spatial positioning of two kinase dimers to facilitate transautophosphorylation and activation...
  10. doi request reprint Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
    Armin Rehm
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 125:2367-74. 2009
    ..Furthermore, we suggest that low-abundance expression of CCR7 and CXCR5 may hinder lymphoma cells from nodal dissemination...
  11. ncbi request reprint Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta
    Amina El Jamali
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    FASEB J 18:1096-8. 2004
    ..Transient hypoxia may contribute to cardiac hypertrophy in ischemic heart disease independent of cardiac workload...
  12. doi request reprint It takes two to tango: IκBs, the multifunctional partners of NF-κB
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Immunol Rev 246:59-76. 2012
    ..Thus, IκB and NF-κB/Rel family proteins establish a complex interrelationship that allows modulated NF-κB-dependent transcription, tailored to the physiological environment...
  13. ncbi request reprint Striking back at the activator: how IkappaB kinase terminates antigen receptor responses
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Sci STKE 2007:pe19. 2007
    ..IKK triggers Bcl10 degradation by the ubiquitin-proteasome system through phosphorylation of Bcl10 at other sites. Thus, inactivation through negative feedback mechanisms is an intrinsic property of the TCR-induced NF-kappaB pathway...
  14. ncbi request reprint Regulation of vascular smooth muscle cell proliferation: role of NF-kappaB revisited
    Felix B Mehrhof
    Medizinische Klinik mit Schwerpunkt Kardiologie, Universitatsklinikum Charite, Campus Virchow Klinikum, Berlin, Germany
    Circ Res 96:958-64. 2005
    ..They further provide genetic evidence for a cell-type restricted requirement of NF-kappaB in the control of cellular proliferation...
  15. ncbi request reprint Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
    Franziska Jundt
    Charite, Robert Rossle Klinik, Humboldt University of Berlin, Germany
    Blood 99:3060-2. 2002
    ..Our study identifies PU.1 deficiency as a recurrent defect in HRS cells that might contribute to their impairment of immunoglobulin transcription...
  16. pmc The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay
    Seda Çöl Arslan
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e26069. 2011
    ....
  17. ncbi request reprint Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, FG Dörken, Robert Rossle Str 10, D 13125 Berlin, Germany
    Blood 102:1028-34. 2003
    ..We conclude that inhibition of NF-kappaB contributes to arsenic-induced apoptosis. Furthermore, pharmacologic inhibition of the IKK/NF-kappaB activity might be a powerful treatment option for Hodgkin lymphoma...
  18. ncbi request reprint Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Biol Chem 282:32311-9. 2007
    ..Thus, the present data denote Hsp90-Cdc37 as a transiently acting essential regulatory component of IKK signaling...
  19. pmc Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism
    Benjamin Mordmuller
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    EMBO Rep 4:82-7. 2003
    ..Thus, both LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome...
  20. pmc Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
    Stephan Mathas
    Max Delbrück Center for Molecular Medicine and Universitätsklinikum Charité, Robert Rossle Klinik, Humboldt University, Lindenberger Weg 80, D 13125 Berlin
    EMBO J 21:4104-13. 2002
    ..Together, these data suggest an important role of AP-1 in lymphoma pathogenesis...
  21. pmc A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways
    Daniel Krappmann
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13122 Berlin, Germany
    EMBO Rep 6:321-6. 2005
    ..Furthermore, Ub conjugation targets upstream signalling mediators as well as nuclear NF-kappaB for post-inductive degradation to limit the duration of signalling...
  22. ncbi request reprint Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  23. ncbi request reprint Inhibition of NF-kappaB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis
    Mira Choi
    Division of Nephrology, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt Univertsity of Berlin, Wiltbergstrasse 50, 13122 Berlin, Germany
    Blood 102:2259-67. 2003
    ..This strategy may help in controlling various cellular functions even in short-lived, transfection-resistant primary human cells...
  24. ncbi request reprint A dual role for Ikk alpha in tooth development
    Atsushi Ohazama
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London Bridge, London SE1 9RT, United Kingdom
    Dev Cell 6:219-27. 2004
    ..Changes in Notch1, Notch2, Wnt7b, and Shh expression found in incisor epithelium of Ikk alpha mutants suggest that this NF-kappa B-independent function is mediated by Notch/Wnt/Shh signaling pathways...
  25. ncbi request reprint Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation
    Meike Broemer
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin, Germany
    Oncogene 23:5378-86. 2004
    ..Together, these results define a dual requirement for Hsp90 as a regulator of NF-kappaB signaling by its general involvement in IKK activation and by its role in IKK homeostasis...
  26. pmc Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation
    Andrea Oeckinghaus
    GSF National Research Center for Environment and Health, Institute of Toxicology, Neuherberg, Germany
    EMBO J 26:4634-45. 2007
    ..Thus, our data demonstrate that induced Malt1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing TCR signals to the canonical NF-kappaB pathway...
  27. ncbi request reprint The effect of fever-like temperatures on neutrophil signaling
    Birgit Salanova
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Germany
    FASEB J 19:816-8. 2005
    ..The effect could protect circulating neutrophils from TNF-alpha activation, while not interfering with activation of adherent neutrophils. Fever could make neutrophils more parsimonious...
  28. ncbi request reprint Purification and characterization of the human elongator complex
    Nicola A Hawkes
    Mechanisms of Gene Transcription Laboratory, Imperial Cancer Research Fund Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire, EN6 3LD, United Kingdom
    J Biol Chem 277:3047-52. 2002
    ..Mutations in IKAP can result in the severe human disorder familial dysautonomia, raising the possibility that this disease might be due to compromised Elongator function and therefore could be a transcription disorder...