M Schaller

Summary

Country: Germany

Publications

  1. doi request reprint [Systemic therapy of rosacea]
    M Schaller
    Universitäts Hautklinik, Eberhard Karls Universitat, Liebermeisterstr 25, 72076, Tubingen, Deutschland
    Hautarzt 64:500-5. 2013
  2. pmc Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans
    Sascha Thewes
    Division FG16 Mycology, Robert Koch Institute, Berlin, Germany
    BMC Microbiol 8:187. 2008
  3. doi request reprint Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection
    Martin Schaller
    Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany
    Med Mycol 47:753-8. 2009
  4. doi request reprint [Characterization of the interaction between Candida albicans and host cells: In vitro model using reconstituted human skin and mucosa]
    M Schaller
    Universitäts Hautklinik Tübingen, Eberhard Karls Universitat Tubingen, Liebermeisterstrasse 25, 72076, Tubingen
    Hautarzt 59:964-70. 2008
  5. ncbi request reprint Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III
    M Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Br J Dermatol 153:66-71. 2005
  6. ncbi request reprint Hydrolytic enzymes as virulence factors of Candida albicans
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Mycoses 48:365-77. 2005
  7. pmc Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia
    Martin Schaller
    Department of Dermatology, Eberhard Karls University, Liebermeisterstr, 25, D 72076 Tuebingen, Germany
    Nat Protoc 1:2767-73. 2006
  8. ncbi request reprint [Candida albicans--interactions with the mucosa and the immune system]
    Martin Schaller
    Department of Dermatology, Eberhard Karls University, Tubingen
    J Dtsch Dermatol Ges 4:328-36; quiz 337-8. 2006
  9. ncbi request reprint Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Frauenlobstr 9 11, D 80337 Munich, Germany
    Microbiology 150:2807-13. 2004
  10. pmc Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis
    Martin Schaller
    Department of Dermatology, Eberhard Karls University Tuebingen, Liebermeisterstrasse 25, 72076 Tuebingen, Germany
    Infect Immun 73:2758-65. 2005

Detail Information

Publications72

  1. doi request reprint [Systemic therapy of rosacea]
    M Schaller
    Universitäts Hautklinik, Eberhard Karls Universitat, Liebermeisterstr 25, 72076, Tubingen, Deutschland
    Hautarzt 64:500-5. 2013
    ..Some forms of rosacea (rosacea fulminans and granulomatous rosacea) may be treated initially with oral corticosteroids. Ophthalmic rosacea is treated topically as well as with tetracyclines or macrolides. ..
  2. pmc Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans
    Sascha Thewes
    Division FG16 Mycology, Robert Koch Institute, Berlin, Germany
    BMC Microbiol 8:187. 2008
    ....
  3. doi request reprint Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection
    Martin Schaller
    Department of Dermatology, University of Tuebingen, 72076 Tuebingen, Germany
    Med Mycol 47:753-8. 2009
    ....
  4. doi request reprint [Characterization of the interaction between Candida albicans and host cells: In vitro model using reconstituted human skin and mucosa]
    M Schaller
    Universitäts Hautklinik Tübingen, Eberhard Karls Universitat Tubingen, Liebermeisterstrasse 25, 72076, Tubingen
    Hautarzt 59:964-70. 2008
    ..Although the most experience is with Candida albicans RHE infections, such model systems can also be used to study infections with other fungi or bacteria...
  5. ncbi request reprint Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III
    M Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Br J Dermatol 153:66-71. 2005
    ..The inflammation in acne vulgaris is widely thought to be induced by an immunological reaction, but the role of Propionibacterium acnes is unclear...
  6. ncbi request reprint Hydrolytic enzymes as virulence factors of Candida albicans
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Mycoses 48:365-77. 2005
    ..In future, prevention and control of Candida infections might be achieved by pharmacological or immunological tools specifically modulated to inhibit virulence factors, e.g. the family of Saps...
  7. pmc Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia
    Martin Schaller
    Department of Dermatology, Eberhard Karls University, Liebermeisterstr, 25, D 72076 Tuebingen, Germany
    Nat Protoc 1:2767-73. 2006
    ..The model requires at least 3 days to be established and can be maintained thereafter for 2-4 days...
  8. ncbi request reprint [Candida albicans--interactions with the mucosa and the immune system]
    Martin Schaller
    Department of Dermatology, Eberhard Karls University, Tubingen
    J Dtsch Dermatol Ges 4:328-36; quiz 337-8. 2006
  9. ncbi request reprint Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Frauenlobstr 9 11, D 80337 Munich, Germany
    Microbiology 150:2807-13. 2004
    ..albicans, as well as the influence of PMNs on C. albicans pathogenesis...
  10. pmc Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis
    Martin Schaller
    Department of Dermatology, Eberhard Karls University Tuebingen, Liebermeisterstrasse 25, 72076 Tuebingen, Germany
    Infect Immun 73:2758-65. 2005
    ..albicans infections at the vaginal mucosa in vivo...
  11. ncbi request reprint Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence
    Martin Schaller
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, Germany
    J Invest Dermatol 118:652-7. 2002
    ....
  12. ncbi request reprint Comparative therapeutic and toxic effects of different povidone iodine (PVP-I) formulations in a model of oral candidosis based on in vitro reconstituted epithelium
    A Bonowitz
    Department of Dermatology and Allergology, Ludwig-Maximilians-University Munich, Frauenlobstr. 9-11, D-80337 Munich, Germany
    J Drug Target 9:75-83. 2001
    ..In conclusion the liposomal PVP-I formulation appeared superior to the conventional ointment formulation because of both less toxicity and better therapeutical effects...
  13. ncbi request reprint Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo
    M Schaller
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, Germany
    J Med Microbiol 50:743-7. 2001
    ..In particular it was localised at the tips of hyphal cells during invasion. These data suggest a different pathogenetic role for Sap1-3 and Sap4-6 during host-fungal interaction...
  14. ncbi request reprint Toxicity and antimicrobial activity of a hydrocolloid dressing containing silver particles in an ex vivo model of cutaneous infection
    M Schaller
    Department of Dermatology and Allergology, University of Munich, Frauenlobstrasse 9 11, DE 80337 Munich, Germany
    Skin Pharmacol Physiol 17:31-6. 2004
    ..We present evidence that delivering silver to infected keratinocytes in a moist healing environment improves the benefit/risk ratio as compared to silver-free wound dressings...
  15. doi request reprint Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia for the study of host-pathogen interactions
    Martin Schaller
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Methods Mol Biol 470:327-45. 2009
    ..It requires at least 3 days to be established and can be maintained thereafter for 2 to 4 days...
  16. ncbi request reprint Induction of nuclear factor- kappa B and c-Jun/activator protein-1 via toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans
    Alexander Roeder
    Department of Dermatology, Ludwig Maximilian University, Munich, Germany
    J Infect Dis 190:1318-26. 2004
    ..albicans demonstrated involvement of the transcription factors nuclear factor- kappa B and c-Jun/activator protein-1 and of the mitogen-activated protein kinases p38, extracellular-related kinase, and c-Jun NH(2)-terminal kinase...
  17. ncbi request reprint Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium
    Hans C Korting
    Department of Dermatology and Allergology, University of Munich, Munich, Germany
    J Med Microbiol 52:623-32. 2003
    ..Furthermore, it could be demonstrated that the lack of Efg1 also caused reduced expression of hyphal-independent SAP genes. Both the EFG1 and the CPH1 gene products are necessary for adequate induction of an immune response...
  18. pmc The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Infect Immun 71:3227-34. 2003
    ..In contrast the vaginopathic potential of mutants lacking SAP3 or SAP4 to SAP6 was not reduced compared to wild-type cells. These data provide further evidence for a crucial role of Sap1 and Sap2 in C. albicans vaginal infections...
  19. ncbi request reprint Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations
    V A Kempf
    Institut fur Medizinische Mikrobiologie, Eberhard Karls Universitat, Elfriede Aulhorn Str 6, D 72076 Tubingen, Germany
    Cell Microbiol 3:623-32. 2001
    ..henselae. Immunohistochemistry for VEGF in specimens from patients with BA or BP revealed increased VEGF expression in vivo. These findings suggest a novel bacteria-dependent mechanism of tumour growth...
  20. ncbi request reprint Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features
    Sabine Gröbner
    Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tubingen, Elfriede Aulhorn Str 6, D 72076, Tubingen, Germany
    Apoptosis 11:1959-68. 2006
    ..However, it has to be resolved if necrosis-like DC death occurs independently from apoptotic events or as an apoptotic epiphenomenon...
  21. ncbi request reprint Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    Klaus Dittmann
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tubingen, 72076 Tubingen, Germany
    J Biol Chem 280:31182-9. 2005
    ..Our data implicate a novel function of the EGFR during DNA repair processes...
  22. ncbi request reprint Multicentric Bowen disease in linear porokeratosis
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karl University Tübingen, Liebermeisterstr 25, 72076 Tubingen, Germany
    Eur J Dermatol 17:439-40. 2007
    ..Here we report a case of linear porokeratosis on the left leg of a 56-year-old man, complicated with two lesions of multicentric Bowen disease...
  23. ncbi request reprint Peroxisome proliferator-activated receptors and their ligands: entry into the post-glucocorticoid era of skin treatment?
    Gunther Weindl
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Drugs 65:1919-34. 2005
    ..Nonetheless, PPARs seem to have significant potential as therapeutic targets in skin inflammatory disorders...
  24. doi request reprint Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654
    Klaus Dittmann
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    FEBS Lett 584:3878-84. 2010
    ..In accordance with that, lack of nuclear EGFR increased residual DNA damage in tumor cells and reduced cellular survival following irradiation. Blockage of nuclear EGFR shuttling may be a new strategy to fight treatment resistance...
  25. ncbi request reprint Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro
    Harald F Langer
    Innere Medizin, Abteilung III, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 27:1463-70. 2007
    ..Thrombotic events and immunoinflammatory processes take place next to each other during vascular remodeling in atherosclerotic lesions. In this study we investigated the interaction of platelets with dendritic cells (DCs)...
  26. ncbi request reprint Early disseminated borreliosis with multiple erythema migrans and elevated liver enzymes: case report and literature review
    Frauke Benedix
    Department of Dermatology, Eberhard Karls University Tubingen
    Acta Derm Venereol 87:418-21. 2007
    ..Dermatologists should keep in mind that early disseminated borreliosis can present with multiple erythema migrans and hepatitis...
  27. pmc Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling
    Gunther Weindl
    Department of Dermatology, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Clin Invest 117:3664-72. 2007
    ....
  28. ncbi request reprint Bartonella henselae inhibits apoptosis in Mono Mac 6 cells
    Volkhard A J Kempf
    Institut fur Medizinische Mikrobiologie und Hygiene, Eberhard Karls Universitat, Tubingen, Germany
    Cell Microbiol 7:91-104. 2005
    ..Our results suggest a new synergistic mechanism in B. henselae pathogenicity by (i) inhibition of host cell apoptosis via activation of NF-kappaB and (ii) induction of host cell VEGF secretion...
  29. doi request reprint PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, Tuebingen, Germany
    DNA Repair (Amst) 7:1746-56. 2008
    ..Likewise, potential of IR-induced XRCC1 expression depends on its basal expression level...
  30. doi request reprint Lysozyme activates Enterococcus faecium to induce necrotic cell death in macrophages
    Sabine Gröbner
    Interfaculty Institute of Microbiology and Infection Medicine, University of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Cell Mol Life Sci 67:3331-44. 2010
    ..Altogether, our results show that enterococci, under specific conditions such as exposure to lysozyme, induce necrotic cell death in macrophages, which might contribute to disseminated infections by these facultative pathogenic bacteria...
  31. pmc The Staphylococcus aureus lipoprotein SitC colocalizes with Toll-like receptor 2 (TLR2) in murine keratinocytes and elicits intracellular TLR2 accumulation
    P Muller
    Department of Microbial Genetics, University of Tubingen, Tubingen, Germany
    Infect Immun 78:4243-50. 2010
    ..The results show that the native lipoprotein SitC-His specifically colocalizes with TLR2, is internalized by host cells, induces proinflammatory cytokines, and triggers intracellular accumulation of TLR2...
  32. ncbi request reprint The secreted aspartic proteinases as a new target in the therapy of candidiasis
    M Bein
    Department of Dermatology, Ludwig Maximilians University, Munich, Germany
    Curr Drug Targets 3:351-7. 2002
    ..Therefore, drugs like the HIV proteinase inhibitors could play an essential role in the treatment of candidiasis in the future, especially if further adapted to this target...
  33. pmc Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi
    C Borelli
    Department of Dermatology and Allergology, Ludwig Maximilians University, Munich, Germany
    Chemotherapy 54:245-59. 2008
    ..In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely...
  34. ncbi request reprint Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects
    G Weindl
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Skin Pharmacol Physiol 17:207-13. 2004
    ..Therefore, ongoing research offers new horizons for the therapeutic use of this glycosaminoglycan which has been regarded as an inert structural component until recently...
  35. ncbi request reprint Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Frauenlobstr 9 11, D 80337 Munich, Germany
    J Med Microbiol 52:247-9. 2003
    ..001). These results point to a multiple effect of this antimycotic agent and might explain the reduced adherence of C. albicans to human epithelial cells at subinhibitory doses...
  36. pmc Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation
    Manfred Kneilling
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Blood 114:1696-706. 2009
    ..As substitution of TNF(-/-) mice with TNF-producing mast cells fully restored DTHR in these mice, signaling of mast cell-derived TNF through TNFR1-expressing ECs is essential for the recruitment of leukocytes into sites of inflammation...
  37. ncbi request reprint Trichophytic Majocchi granuloma mimicking Kaposi sarcoma
    Corinna Brod
    Universitäts Hautklinik, Eberhard Karls Unievrsität Tübingen, Tubingen, Germany
    J Dtsch Dermatol Ges 5:591-3. 2007
    ..Systemic treatment with terbinafine 250 mg per day and topical ciclopirox olamine completely cured the granulomatous skin lesions, and later the nails...
  38. ncbi request reprint Cytokine expression induced by Candida albicans in a model of cutaneous candidosis based on reconstituted human epidermis
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    J Med Microbiol 51:672-6. 2002
    ..These immunomodulatory and morphological similarities might reflect a common pathogenesis factor in both diseases...
  39. pmc Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging
    York Kamenisch
    Department of Dermatology, Eberhard Karls University, D 72076 Tuebingen, Germany
    J Exp Med 207:379-90. 2010
    ....
  40. doi request reprint Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions
    Harald F Langer
    Medical Clini III, Department of Cardiovascular Medicine, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 88:687-99. 2010
    ..In vivo, GPVI-CD133 augments reendothelialization of vascular lesions. Thus, this bifunctional protein could be a potential new therapeutic option for cardiovascular diseases...
  41. ncbi request reprint Infection of human CD34+ progenitor cells with Bartonella henselae results in intraerythrocytic presence of B. henselae
    Tanja Mändle
    Institut fur Medizinische Mikrobiologie und Hygiene, Elfriede Aulhorn Str 6, D 72076, Tubingen, Germany
    Blood 106:1215-22. 2005
    ..Our data provide, for the first time, evidence that a bacterial pathogen is able to infect and persist in differentiating HPCs, and suggest that HPCs might serve as a potential primary niche in Bartonella infections...
  42. ncbi request reprint The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A
    Claudia Borelli
    Department of Dermatology and Allergy, Ludwig Maximilian University of Munich, Frauenlobstr 9 11, 80337 Munich, Germany
    Proteins 68:738-48. 2007
    ..Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme...
  43. doi request reprint [Chronic actinic dermatitis. Therapy with systemic PUVA and mycophenolate mofetil]
    V Lichte
    Universitäts Hautklinik, Universitäts Klinikum Tübingen, Eberhard Karls Universitat, Liebermeisterstr 25, 72076, Tubingen, Deutschland
    Hautarzt 62:539-42. 2011
    ..Since the response was modest, photo-hardening with systemic photochemotherapy (PUVA) was added, producing close to complete recovery within 6 months...
  44. doi request reprint Oxidized LDL-activated platelets induce vascular inflammation
    Karin Daub
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:146-56. 2010
    ..Platelet oxLDL contributes significantly to vascular inflammation and is able to promote atherosclerosis...
  45. ncbi request reprint Toll-like receptors and innate antifungal responses
    Alexander Roeder
    Department of Dermatology, Ludwig Maximilians University, 80337 Munich, Germany
    Trends Microbiol 12:44-9. 2004
    ....
  46. ncbi request reprint [Confluent and reticulated papillomatosis Gougerot-Carteaud successfully treated with minocycline]
    Melitta Löwenstein
    Universitäts Hautklinik, Eberhard Karls Universitat, Tubingen, Germany
    J Dtsch Dermatol Ges 4:556-8. 2006
    ..A 27-year-old patient with typical clinical and histologic features of confluent and reticulated papillomatosis responded well to oral minocycline...
  47. doi request reprint Hereditary progressive mucinous histiocytosis: first report in a male patient
    Christiane Schlegel
    Department of Dermatology, Eberhard Karls University, Liebermeisterstr 25, DE 72076 Tübingen, Germany
    Acta Derm Venereol 90:65-7. 2010
    ....
  48. doi request reprint Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karls University, Liebermeister Strasse, 25, Tuebingen, Germany
    Melanoma Res 19:271-3. 2009
    ..Our case illustrates the necessity of close dermatological surveillance of allograft recipients, to assure an early recognition of any malignant skin tumor and to reduce the risk of systemic metastatic disease...
  49. ncbi request reprint Multisystem Langerhans cell histiocytosis: successful treatment with thalidomide
    Sigrid M C Broekaert
    Department of Dermatology, University of Tubingen, Tubingen, Germany
    Am J Clin Dermatol 8:311-4. 2007
    ..Treatment was started with thalidomide and desmopressin. The skin lesions resolved over 2 months. Over the next 24 months of continued therapy, the cerebral involvement remained stable and the skin lesions did not recur...
  50. ncbi request reprint Toll-like receptors as key mediators in innate antifungal immunity
    Alexander Roeder
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Med Mycol 42:485-98. 2004
    ..Recent evidence further suggests that TLRs cooperate with other immune receptors involved in fungal recognition and that the selective induction of adaptor proteins finally leads to distinct signalling events upon fungal challenge...
  51. ncbi request reprint In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment
    Claudia Borelli
    Department of Dermatology and Allergology, Ludwig Maximilian University of Munich, Germany
    Acta Derm Venereol 86:316-9. 2006
    ..Statistical analysis demonstrated a significant reduction in the porphyrin fractions only in the isotretinoin group which was associated with clinical improvement 2 months after starting therapy...
  52. doi request reprint A young woman with recurrent vesicles on the lower lip: fixed drug eruption mimicking herpes simplex
    Frauke Benedix
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Acta Derm Venereol 88:491-4. 2008
    ..Oral provocation tests with an alternative systemic antifungal treatment, itraconazole, were well tolerated, systemic therapy with itraconazole was initiated, and no further labial vesicles developed...
  53. pmc Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors
    Markus Niewerth
    Robert Koch Institut, 13353 Berlin, Germany
    Antimicrob Agents Chemother 47:1805-17. 2003
    ..Furthermore, neither the expression of certain multiple-drug resistance genes nor other resistance mechanisms caused C. albicans resistance to this drug even after long-term exposure...
  54. pmc The siderophore iron transporter of Candida albicans (Sit1p/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion
    Petra Heymann
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Infect Immun 70:5246-55. 2002
    ..albicans infection, namely epithelial invasion and penetration, while in the blood or within organs other sources of iron, including heme, may be used...
  55. pmc Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs
    Angelika Felk
    Institut fur Allgemeine Botanik, AMPIII, Universitat Hamburg, D 22609 Hamburg, Germany
    Infect Immun 70:3689-700. 2002
    ..In addition, it can be concluded that the reduced virulence of hypha-deficient mutants is not only due to the inability to form hyphae but also due to modified expression of the SAP genes normally associated with the hyphal morphology...
  56. ncbi request reprint Candida albicans PLD I activity is required for full virulence
    Joseph W Dolan
    Department of Stomatology College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA
    Med Mycol 42:439-47. 2004
    ..albicans-colonized mice...
  57. pmc Yersinia enterocolitica induces apoptosis and inhibits surface molecule expression and cytokine production in murine dendritic cells
    Stella E Erfurth
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Elfriede Aulhorn Strasse 6, D 72076 Tubingen, Germany
    Infect Immun 72:7045-54. 2004
    ..Together, these data demonstrate that Y. enterocolitica targets functions of murine DC that are required for T-cell activation. This might contribute to evasion of adaptive immune responses by Y. enterocolitica...
  58. pmc Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases
    Mahmoud Rouabhia
    Institut for Mikrobiologie, Universitätsstr 1 26 12, 40225 Dusseldorf, Germany
    Infect Immun 73:4571-80. 2005
    ..albicans and suggest that the importance of individual Pmt isoforms may differ in specific host niches. We propose that Pmt proteins may be suitable targets for future novel classes of antifungal agents...
  59. ncbi request reprint Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
    Marianne Kretschmar
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Microb Pathog 32:61-70. 2002
    ..We conclude that although Saps were produced, individual Saps were not indispensable factors for virulence during gastrointestinal infection of mice...
  60. pmc The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications
    Chantal Fradin
    Robert Koch Institute, Nordufer, 20, Berlin 13353, Germany
    Infect Immun 75:1493-501. 2007
    ..However, neutrophils exposed to C. albicans express genes involved in communication with other immune cells...
  61. ncbi request reprint Unusual trafficking pattern of Bartonella henselae -containing vacuoles in macrophages and endothelial cells
    Pierre A Kyme
    Institut fur Medizinische Mikrobiologie und Hygiene, Eberhard Karls Universitat, Elfriede Aulhorn Str 6, D 72076 Tubingen, Germany
    Cell Microbiol 7:1019-34. 2005
    ..We conclude that B. henselae has a specific capacity to actively avoid the host endocytic pathway after entry of macrophages and ECs, from within a specialized non-endocytic membrane-bound vacuole...
  62. ncbi request reprint Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions
    Antje Albrecht
    Robert Koch Institut, Berlin, Germany
    J Biol Chem 281:688-94. 2006
    ..albicans to epithelial cells and caused attenuated epithelial cell damage during experimental oral infection suggesting a unique role for these proteases in both cellular processes and host-pathogen interactions...
  63. ncbi request reprint In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination
    Katherina Zakikhany
    Division Mycology, Robert Koch Institute, Berlin, Germany
    Cell Microbiol 9:2938-54. 2007
    ..Our results suggest that the adaptive response and morphology of C. albicans play specific roles for host-fungal interactions during mucosal infections...
  64. ncbi request reprint Haemoperfused liver as an ex vivo model for organ invasion of Candida albicans
    Sascha Thewes
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    J Med Microbiol 56:266-70. 2007
    ..The advantage of this set-up compared with other models of invasion is discussed...
  65. ncbi request reprint In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion
    Sascha Thewes
    Division Mycology, Robert Koch Institute, Berlin, Germany
    Mol Microbiol 63:1606-28. 2007
    ..One of the genes identified as associated with liver invasion was DFG16, a gene crucial for pH-dependent hyphal formation, correct pH sensing, invasion at physiological pH and systemic infection...
  66. ncbi request reprint [Desmoglein 1-negative, desmoglein 3-positive pemphigus herpetiformis with involvement of oral mucous membranes]
    Corinna Brod
    Universitäts Hautklinik Tübingen
    J Dtsch Dermatol Ges 3:280-2. 2005
    ..In our patient, the explanation is that she had antibodies against desmoglein 3 but not desmoglein 1. Treatment with prednisolone and azathioprine caused rapid and complete healing...
  67. pmc Immunocytological and preliminary immunohistochemical studies of prothymosin alpha, a human cancer-associated polypeptide, with a well-characterized polyclonal antibody
    Persefoni Klimentzou
    Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research Demokritos, Aghia Paraskevi, Athens, Greece
    J Histochem Cytochem 56:1023-31. 2008
    ....
  68. doi request reprint Tinea incognito hidden under apparently treatment-resistant pemphigus foliaceus
    Emmanuella Guenova
    Acta Derm Venereol 88:276-7. 2008
  69. doi request reprint Eosinophilic fasciitis and combined UVA1--retinoid--corticosteroid treatment: two case reports
    Hans O Weber
    Acta Derm Venereol 88:304-6. 2008
  70. ncbi request reprint Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood
    Chantal Fradin
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Mol Microbiol 56:397-415. 2005
    ..However, C. albicans is equipped with several genes and transcriptional programmes, which may help the fungus to counteract the attack of neutrophils, to escape from the bloodstream and to cause systemic infections...
  71. pmc Bartonella adhesin a mediates a proangiogenic host cell response
    Tanja Riess
    Institut fur Medizinische Mikrobiologie und Hygiene, Eberhard Karls Universitat, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
    J Exp Med 200:1267-78. 2004
    ..Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders...
  72. pmc Bartonella quintana variably expressed outer membrane proteins mediate vascular endothelial growth factor secretion but not host cell adherence
    Berit Schulte
    Institut fur Medizinische Mikrobiologie und Hygiene, Elfriede Aulhorn Strasse 6, D 72076 Tubingen, Germany
    Infect Immun 74:5003-13. 2006
    ..quintana strains. Our results suggest that the Vomps play a leading role in the angiogenic reprogramming of host cells by B. quintana but not in the adherence to host cells...