Genomes and Genes
- Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesU Schaeper
Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
J Cell Biol 149:1419-32. 2000..Overexpression of a Gab1 mutant deficient in Shp2 interaction could also block HGF/SF-induced activation of the MAPK pathway, suggesting that Shp2 is critical for c-Met/Gab1-specific signaling...
- Essential role of Gab1 for signaling by the c-Met receptor in vivoM Sachs
Department of Growth and Differentiation, Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
J Cell Biol 150:1375-84. 2000..This is genetic evidence that Gab1 is essential for c-Met signaling in vivo. Analogy exists to signal transmission by insulin receptors, which require IRS1 and IRS2 as specific docking proteins...