F Schaeffel

Summary

Country: Germany

Publications

  1. doi request reprint Can the retina alone detect the sign of defocus?
    Frank Schaeffel
    Section of Neurobiology of Eye, Ophthalmic Research Institute, Tuebingen, Germany
    Ophthalmic Physiol Opt 33:362-7. 2013
  2. doi request reprint [Clinical risk factors for progressive myopia]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Forschungsinstitut für Augenheilkunde, Calwerstrasse 7 1, Tubingen, Germany
    Ophthalmologe 109:738-48. 2012
  3. ncbi request reprint Measurement of refractive state and deprivation myopia in two strains of mice
    Frank Schaeffel
    University Eye Hospital, Section for Neurobiology of the Eye, Tuebingen, Germany
    Optom Vis Sci 81:99-110. 2004
  4. ncbi request reprint Kappa and Hirschberg ratio measured with an automated video gaze tracker
    Frank Schaeffel
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    Optom Vis Sci 79:329-34. 2002
  5. ncbi request reprint [The myopia puzzle. Disorders in fine tuning of length and focal distance of the eye]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Calwerstrasse 7 1, Universitats Augenklinik, Abt II, 72076 Tubingen
    Ophthalmologe 99:120-39; quiz 139-41. 2002
  6. ncbi request reprint Noncycloplegic photorefractive screening in pre-school children with the "PowerRefractor" in a pediatric practice
    Frank Schaeffel
    Section of Neurobiology of Eye, University Eye Hospital, Tubingen, Germany
    Optom Vis Sci 84:630-9. 2007
  7. doi request reprint Binocular lens tilt and decentration measurements in healthy subjects with phakic eyes
    Frank Schaeffel
    Section of Neurobiology of the Eye, Institute for Ophthalmic Research, Calwerstrasse 7 1, Tubingen, Germany
    Invest Ophthalmol Vis Sci 49:2216-22. 2008
  8. ncbi request reprint Myopia: the importance of seeing fine detail
    Frank Schaeffel
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    Curr Biol 16:R257-9. 2006
  9. doi request reprint [Myopia update 2011]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Forschungsinstitut für Augenheilkunde, Eberhard Karls Universitat Tubingen, Tubingen
    Klin Monbl Augenheilkd 228:754-61. 2011
  10. ncbi request reprint Pupillographic evaluation of the time course of atropine effects in the mouse eye
    Frank Schaeffel
    University Eye Hospital, Section for Neurobiology of the Eye, 72076 Tuebingen, Germany
    Optom Vis Sci 82:215-20. 2005

Collaborators

Detail Information

Publications65

  1. doi request reprint Can the retina alone detect the sign of defocus?
    Frank Schaeffel
    Section of Neurobiology of Eye, Ophthalmic Research Institute, Tuebingen, Germany
    Ophthalmic Physiol Opt 33:362-7. 2013
    ..By their nature, views expressed in each section of the Point-Counterpoint article are those of the author concerned and may not reflect the views of all of the authors...
  2. doi request reprint [Clinical risk factors for progressive myopia]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Forschungsinstitut für Augenheilkunde, Calwerstrasse 7 1, Tubingen, Germany
    Ophthalmologe 109:738-48. 2012
    ..Development of myopia can be positively influenced by peripheral focusing, increased exposure to light and in the future possibly pharmacologically...
  3. ncbi request reprint Measurement of refractive state and deprivation myopia in two strains of mice
    Frank Schaeffel
    University Eye Hospital, Section for Neurobiology of the Eye, Tuebingen, Germany
    Optom Vis Sci 81:99-110. 2004
    ..We have investigated how precisely eyes of mice can be refracted and tested whether deprivation myopia can be induced by frosted diffusers...
  4. ncbi request reprint Kappa and Hirschberg ratio measured with an automated video gaze tracker
    Frank Schaeffel
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    Optom Vis Sci 79:329-34. 2002
    ..To develop a fast automated procedure to measure kappa and the Hirschberg ratio for immediate use in a video gaze tracker...
  5. ncbi request reprint [The myopia puzzle. Disorders in fine tuning of length and focal distance of the eye]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Calwerstrasse 7 1, Universitats Augenklinik, Abt II, 72076 Tubingen
    Ophthalmologe 99:120-39; quiz 139-41. 2002
  6. ncbi request reprint Noncycloplegic photorefractive screening in pre-school children with the "PowerRefractor" in a pediatric practice
    Frank Schaeffel
    Section of Neurobiology of Eye, University Eye Hospital, Tubingen, Germany
    Optom Vis Sci 84:630-9. 2007
    ..To evaluate the usefulness of the screening for refractive errors, we retrospectively analyzed the data of a large number of unselected children of different ages in a pediatric practice in Tuebingen, Germany...
  7. doi request reprint Binocular lens tilt and decentration measurements in healthy subjects with phakic eyes
    Frank Schaeffel
    Section of Neurobiology of the Eye, Institute for Ophthalmic Research, Calwerstrasse 7 1, Tubingen, Germany
    Invest Ophthalmol Vis Sci 49:2216-22. 2008
    ..A simple, portable, easy-to-use, and partially automated device was developed to study lens tilt and decentration in both eyes of 11 healthy subjects with phakic eyes...
  8. ncbi request reprint Myopia: the importance of seeing fine detail
    Frank Schaeffel
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    Curr Biol 16:R257-9. 2006
    ..Should we carefully avoid any defocus to avoid becoming myopic?..
  9. doi request reprint [Myopia update 2011]
    F Schaeffel
    Sektion für Neurobiologie des Auges, Forschungsinstitut für Augenheilkunde, Eberhard Karls Universitat Tubingen, Tubingen
    Klin Monbl Augenheilkd 228:754-61. 2011
    ..In part they can be slowed down by intravitreal anti-VEGF therapy. A long-term study from Denmark has shown that most patients with myopia of between 6-9 dpt during puberty reach retirement age without disabling visual loss...
  10. ncbi request reprint Pupillographic evaluation of the time course of atropine effects in the mouse eye
    Frank Schaeffel
    University Eye Hospital, Section for Neurobiology of the Eye, 72076 Tuebingen, Germany
    Optom Vis Sci 82:215-20. 2005
    ..Therefore, we have studied the duration of mydriasis in the mouse, a new model of myopia, after topical application of a single eye drop with different doses of atropine...
  11. ncbi request reprint How good is the match between the plane of the text and the plane of focus during reading?
    F Schaeffel
    University Eye Hospital, Tubingen, Germany
    Ophthalmic Physiol Opt 19:180-92. 1999
    ....
  12. ncbi request reprint The growing eye: an autofocus system that works on very poor images
    F Schaeffel
    University Eye Hospital Tubingen, Germany
    Vision Res 39:1585-9. 1999
    ..The most likely cues for emmetropization, spatial frequency content and image contrast, do therefore not correlate with the elongation of the eye. Rather, the sign of defocus was extracted even from very poor images...
  13. ncbi request reprint Effects of quisqualic acid on retinal ZENK expression induced by imposed defocus in the chick eye
    Michaela Bitzer
    University Eye Hospital, Section for Neurobiology of the Eye, Tuebingen, Germany
    Optom Vis Sci 81:127-36. 2004
    ..ZENK may, therefore, have an important role in emmetropization. To learn more about its regulation, we have studied its expression after retinal intoxication with quisqualic acid (QA, a glutamatergic excitotoxin)...
  14. ncbi request reprint Changes in contrast sensitivity induced by defocus and their possible relations to emmetropization in the chicken
    S Diether
    University Eye Hospital, Section of Neurobiology of the Eye, , Germany
    Invest Ophthalmol Vis Sci 42:3072-9. 2001
    ....
  15. ncbi request reprint Flicker parameters are different for suppression of myopia and hyperopia
    H N Schwahn
    Department of Experimental Ophthalmology, University Eye Hospital, Tubingen, Germany
    Vision Res 37:2661-73. 1997
    ..However, we did not find any correlation between the rate of dopamine release and the degree of inhibition of deprivation myopia in flickering light...
  16. ncbi request reprint Contrast sensitivity of wildtype mice wearing diffusers or spectacle lenses, and the effect of atropine
    Christine Schmucker
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    Vision Res 46:678-87. 2006
    ..To find out how spatial vision in mice is affected by wearing of spectacle lenses or diffusers, and by atropine eye drops. This information is necessary to determine which treatments could effectively induce refractive errors in young mice...
  17. ncbi request reprint ZENK expression of retinal glucagon amacrine cells in chicks: the effect of defocus presented in vivo, in vitro and under anesthesia
    Michaela Bitzer
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Vision Res 46:848-59. 2006
    ..To find out whether the retina by itself is able to perform the underlying image processing, we used ZENK to probe responses of amacrine cells to defined amounts of imposed defocus, both in vitro and in vivo...
  18. doi request reprint The effect of bright light on lens compensation in chicks
    Regan S Ashby
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, University of Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 51:5247-53. 2010
    ..This study was conducted to test how bright light interacts with compensation for imposed optical defocus. Furthermore, a dopamine antagonist was applied to test whether the protective effect of light is mediated by dopamine...
  19. ncbi request reprint Defocus-induced changes in ZENK expression in the chicken retina
    Michaela Bitzer
    Section for Neurobiology of the Eye, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 43:246-52. 2002
    ..ZENK was previously found to change in correlation with the sign (+ or -) of imposed defocus, making it a potential candidate for regulation of the synthesis of growth factors involved in emmetropization...
  20. ncbi request reprint Effects of atropine on refractive development, dopamine release, and slow retinal potentials in the chick
    H N Schwahn
    Department of Experimental Ophthalmology, University Eye Hospital, Tubingen, Germany
    Vis Neurosci 17:165-76. 2000
    ..We conclude that atropine, by inducing SD, boosts neurotransmitter release from cellular stores, which may cancel out a presumed retinal signal that controls eye growth and through this, myopia...
  21. ncbi request reprint Effects of muscarinic antagonists on ZENK expression in the chicken retina
    Michaela Bitzer
    Section for Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Exp Eye Res 82:379-88. 2006
    ....
  22. ncbi request reprint Peripheral defocus does not necessarily affect central refractive development
    Ruth Schippert
    Section of Neurobiology of the Eye, University Eye Hospital Tuebingen, Calwerstrasse 7 1, 72076 Tuebingen, Germany
    Vision Res 46:3935-40. 2006
    ..This raises the hypothesis that peripheral refractive errors imposed by the spectacle lens correction could influence foveal refractive development also in humans. We have tested this hypothesis in chicks...
  23. ncbi request reprint A paraxial schematic eye model for the growing C57BL/6 mouse
    Christine Schmucker
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Vision Res 44:1857-67. 2004
    ..We developed a paraxial schematic model of the growing eye for the most common laboratory mouse strain, the C57BL/6 mouse, for the age range between 22 and 100 days...
  24. doi request reprint Transforming growth factor-beta in the chicken fundal layers: an immunohistochemical study
    Ute Mathis
    Ophthalmic Research Institute, Section of Neurobiology of the Eye, Calwerstrasse 7 1, 72076 Tubingen, Germany
    Exp Eye Res 90:780-90. 2010
    ....
  25. ncbi request reprint Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken
    Christine Buck
    Section of Neurobiology of the Eye, University Eye Hospital, Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 45:402-9. 2004
    ..Furthermore, the abundance of glucagon and the glucagon receptor was studied in different fundal layers (retina, retinal pigment epithelium[RPE], choroid) and the blood...
  26. doi request reprint Effects of unilateral topical atropine on binocular pupil responses and eye growth in mice
    V A Barathi
    Ophthalmic Research Institute, Centre for Ophthalmology, University Eye Hospital of Tubingen, Section for Neurobiology of the Eye, Tubingen, Germany
    Vision Res 49:383-7. 2009
    ..In a second experiment, interocular differences in refractive development and axial eye growth were studied while atropine was applied daily to one eye...
  27. ncbi request reprint Relative axial myopia in Egr-1 (ZENK) knockout mice
    Ruth Schippert
    Section of Neurobiology of the Eye, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 48:11-7. 2007
    ....
  28. ncbi request reprint Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision
    Ute Mathis
    Section of Neurobiology of the Eye, University Eye Hospital Tubingen, Calwerstrasse 7 1, 72076 Tubingen, Germany
    Graefes Arch Clin Exp Ophthalmol 245:267-75. 2007
    ..To learn more about its possible role in emmetropization in mammals, we studied the expression of different members of the glucagon hormone family in mouse retina, and whether their abundance is regulated by visual experience...
  29. doi request reprint Spatial resolution, contrast sensitivity, and sensitivity to defocus of chicken retinal ganglion cells in vitro
    Erich Diedrich
    Section of Neurobiology of the Eye, Institute for Ophthalmic Research, Tuebingen, Germany
    Vis Neurosci 26:467-76. 2009
    ..Furthermore, there was no indication that the retinal ganglion cells responded differently to defocus of either sign, at least for the cells that were recorded in this study...
  30. ncbi request reprint Effects of intravitreally and intraperitoneally injected atropine on two types of experimental myopia in chicken
    Sigrid Diether
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Exp Eye Res 84:266-74. 2007
    ..Estimations of the scleral concentrations of atropine after intravitreal injection are compatible with the assumption that the suppression of myopia by atropine occurs by direct inhibition of scleral chondrocytes...
  31. pmc A microarray analysis of retinal transcripts that are controlled by image contrast in mice
    Christine Brand
    Section for Neurobiology of the Eye, University Eye Hospital Tuebingen, Tuebingen, Germany
    Mol Vis 13:920-32. 2007
    ..The aim of this study was to investigate the changes in retinal mRNA expression after different periods of visual deprivation in mice, while controlling for retinal illuminance...
  32. ncbi request reprint In vivo biometry in the mouse eye with low coherence interferometry
    Christine Schmucker
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Vision Res 44:2445-56. 2004
    ..Using this technique, ocular biometry was performed in mice with normal vision and after deprivation of form vision...
  33. ncbi request reprint Temporal changes of novel transcripts in the chicken retina following imposed defocus
    Sibylle Ohngemach
    Section of Neurobiology, University Eye Hospital, University of Tuebingen, Tuebingen, Germany
    Mol Vis 10:1019-27. 2004
    ..Moreover, we obtained more sequence information for a yet unidentified gene. We have studied the time course of expressions of these genes following lens or diffuser treatment...
  34. ncbi request reprint Pineal control of the dopamine D2-receptor gene and dopamine release in the retina of the chicken and their possible relation to growth rhythms of the eye
    S Ohngemach
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Germany
    J Pineal Res 31:145-54. 2001
    ..It can probably control the gain of dopaminergic transmission in the retina and deprivation myopia and mediate the interactions of the growth rhythms in both eyes...
  35. ncbi request reprint An evaluation of the lag of accommodation using photorefraction
    Anne Seidemann
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076, Tuebingen, Germany
    Vision Res 43:419-30. 2003
    ..Therefore, we have measured it with another technique, eccentric infrared photorefraction (the PowerRefractor), and studied how it can be modified...
  36. ncbi request reprint Effects of longitudinal chromatic aberration on accommodation and emmetropization
    Anne Seidemann
    University Eye Hospital, Section of Neurobiology of the Eye, Calwerstr 7 1, 72076, Tuebingen, Germany
    Vision Res 42:2409-17. 2002
    ..The apparently contradictory result was studied in more detail in humans and chickens...
  37. ncbi request reprint Regulation of Egr-1, VIP, and Shh mRNA and Egr-1 protein in the mouse retina by light and image quality
    Christine Brand
    Section for Neurobiology of the Eye, University Eye Hospital Tuebingen, Tuebingen, Germany
    Mol Vis 11:309-20. 2005
    ..Moreover, the influence of dark to light and light to dark transitions and of changes in retinal illumination on mRNA levels was investigated...
  38. ncbi request reprint Changes in scleral MMP-2, TIMP-2 and TGFbeta-2 mRNA expression after imposed myopic and hyperopic defocus in chickens
    Ruth Schippert
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72074 Tubingen, Germany
    Exp Eye Res 82:710-9. 2006
    ..These changes were confined to the eyes that also displayed reduced growth, suggesting a role of TGFbeta-2 in the final steps of visual eye growth regulation...
  39. ncbi request reprint Changes in retinal and choroidal gene expression during development of refractive errors in chicks
    M P Feldkaemper
    Division of Experimental Ophthalmology, University Eye Hospital Tubingen, Germany
    Invest Ophthalmol Vis Sci 41:1623-8. 2000
    ..In addition, because glucagon may be important in the visual control of eye growth, the transcript levels of proglucagon were studied...
  40. ncbi request reprint Mathematical procedures in data recording and processing of pupillary fatigue waves
    H Ludtke
    Universität Augenklinik Tübingen, Abt für Pathophysiologie des Sehens und Neuroophtalmologie, Germany
    Vision Res 38:2889-96. 1998
    ..One group rated themselves as alert (ten men), the other group as sleepy (12 men). The power and PUI were compared using the Mann-Whitney U-test. Both parameters show significant differences between the two groups...
  41. doi request reprint Insulin acts as a powerful stimulator of axial myopia in chicks
    Marita P Feldkaemper
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:13-23. 2009
    ..Glucagon may be involved in the sign of defocus detection, at least in chickens. Since glucagon and insulin often have opposite effects in metabolic pathways, the effect of insulin on eye growth was investigated...
  42. doi request reprint More irregular eye shape in low myopia than in emmetropia
    Juan Tabernero
    Section of Neurobiology of the Eye, Ophthalmic Research Institute, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:4516-22. 2009
    ..To improve the description of the peripheral eye shape in myopia and emmetropia by using a new method for continuous measurement of the peripheral refractive state...
  43. doi request reprint The effect of ambient illuminance on the development of deprivation myopia in chicks
    Regan Ashby
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, University of Tubingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:5348-54. 2009
    ..Axial length and refraction were measured at the commencement and cessation of all treatments, with corneal curvature measured additionally in paradigm 2...
  44. doi request reprint Effects of myopic spectacle correction and radial refractive gradient spectacles on peripheral refraction
    Juan Tabernero
    Section of Neurobiology of the Eye, Ophthalmic Research Institute, Calwerstrasse 7 1, 72076 Tuebingen, Germany
    Vision Res 49:2176-86. 2009
    ..In contrast, the newly designed RRG lens induced relative peripheral myopia. These results are of interest to analyze the effect that different optical corrections might have on the emmetropization process...
  45. doi request reprint Fast scanning photoretinoscope for measuring peripheral refraction as a function of accommodation
    Juan Tabernero
    Section of Neurobiology of the Eye, Ophthalmic Research Institute, Calwerstrasse 7 1, 72076 Tuebingen, Germany
    J Opt Soc Am A Opt Image Sci Vis 26:2206-10. 2009
    ..Peripheral refraction profiles were largely preserved during accommodation but were different in each individual. Apparently, the accommodating lens changes its focal length evenly over the central 90 degrees of the visual field...
  46. ncbi request reprint Peripheral refractive errors in myopic, emmetropic, and hyperopic young subjects
    Anne Seidemann
    University Eye Hospital, Section of Neurobiology of the Eye, Calwerstrasse 7 1, 72076 Tubingen, Germany
    J Opt Soc Am A Opt Image Sci Vis 19:2363-73. 2002
    ..The finding of general peripheral myopia was unexpected. Its possible roles in foveal refractive development are discussed...
  47. pmc Microarray analysis of retinal gene expression in Egr-1 knockout mice
    Ruth Schippert
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, University Eye Hospital Tuebingen, Tuebingen, Germany
    Mol Vis 15:2720-39. 2009
    ..To identify genes that could be responsible for the temporarily enhanced axial eye growth, a microarray analysis was performed in knockout and wild-type mice at the postnatal ages of 30 and 42 days...
  48. ncbi request reprint Evidence for a potential role of glucagon during eye growth regulation in chicks
    Marita P Feldkaemper
    University Eye Hospital Tuebingen, Section of Neurobiology of the Eye, Calwerstrasse 7 1 72076 Tuebingen, Germany
    Vis Neurosci 19:755-66. 2002
    ..The results of the study are in line with the hypothesis that glucagon plays a role in the visual control of eye growth in the chick...
  49. ncbi request reprint Localization and regulation of glucagon receptors in the chick eye and preproglucagon and glucagon receptor expression in the mouse eye
    Marita P Feldkaemper
    Section of Neurobiology of the Eye, University Eye Hospital Tuebingen, Calwerstrasse 7 1, 72076, Germany
    Exp Eye Res 79:321-9. 2004
    ....
  50. ncbi request reprint Posttranscriptional regulation of the immediate-early gene EGR1 by light in the mouse retina
    Perikles Simon
    Department of Neuroophthalmology and Pathophysiology of the Eye, Section of Neurobiology of the Eye, University of Tubingen, Germany
    Eur J Neurosci 20:3371-7. 2004
    ....
  51. ncbi request reprint Early transcriptional changes of retinal and choroidal TGFbeta-2, RALDH-2, and ZENK following imposed positive and negative defocus in chickens
    Perikles Simon
    Section of Neurobiology of the Eye, University Eye Hospital, Tuebingen, Calwerstr, Germany
    Mol Vis 10:588-97. 2004
    ..We have measured early changes in mRNA levels, in response to imposed negative and positive defocus, of the transcription factor ZENK, the retinoic acid synthesis enzyme RALDH-2, and the growth factor TGFbeta-2...
  52. ncbi request reprint Assessment of vision-related quality of life in patients with homonymous visual field defects
    Eleni Papageorgiou
    Centre for Ophthalmology, Institute of Ophthalmic Research, University of Tuebingen, Schleichstrasse 12 16, 72076 Tuebingen, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1749-58. 2007
    ....
  53. doi request reprint Neuronal adaptation to simulated and optically-induced astigmatic defocus
    Arne Ohlendorf
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, Calwerstrasse 7 1, 72076 Tubingen, Germany
    Vision Res 51:529-34. 2011
    ..We adapted subjects to "simulated" and optically-induced "real" astigmatic defocus, and studied how much they adapt and how selective adaptation was for the axis of astigmatism...
  54. ncbi request reprint Test systems for measuring ocular parameters and visual function in mice
    Frank Schaeffel
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstrasse 7 1, 72076 Tubingen, Germany
    Front Biosci 13:4904-11. 2008
    ..These variables are important for studies on myopia development in mice, but they are also valuable for phenotyping mouse mutants and for pharmacological studies...
  55. ncbi request reprint Stimulating human accommodation without changes in focus
    Monika Weiss
    Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr 7 1, 72076 Tuebingen, Germany
    Ophthalmic Physiol Opt 24:207-17. 2004
    ..If emmetropisation and accommodation use similar image processing algorithms, more accommodation would be expected with OFF stimulation...
  56. ncbi request reprint Molecular biology of myopia
    Frank Schaeffel
    University Eye Hospital, Section for Neurobiology of the Eye, Calwestr 7 1, 72076, Tubingen, Germany
    Clin Exp Optom 86:295-307. 2003
    ..We review several successful applications of this battery of techniques in myopia research...
  57. pmc Microarray analysis of retinal gene expression in chicks during imposed myopic defocus
    Ruth Schippert
    Institute for Ophthalmic Research, Section of Neurobiology of the Eye, University Eye Hospital Tuebingen, Tuebingen, Germany
    Mol Vis 14:1589-99. 2008
    ..To screen for new retinal candidate genes that could be involved in the inhibition of ocular growth, we used chick microarrays to analyze the changes in retinal mRNA expression after myopic defocus was imposed by positive lens wear...
  58. doi request reprint Contrast adaptation induced by defocus - a possible error signal for emmetropization?
    Arne Ohlendorf
    Ophthalmic Research Institute, Section of Neurobiology of the Eye, Calwerstrasse, Tubingen, Germany
    Vision Res 49:249-56. 2009
    ..To describe some features of contrast adaptation as induced by imposed positive or negative defocus. To study its time course and selectivity for the sign of the imposed defocus...
  59. ncbi request reprint Interactions of genes and environment in myopia
    Marita Feldkämper
    Section of Neurobiology, Eye University Eye Hospital Department II, Tubingen, Germany
    Dev Ophthalmol 37:34-49. 2003
    ..Since there is still no therapy against myopia development, research is directed toward the identification of genes that control the axial elongation of the eye...
  60. ncbi request reprint Grating acuity at different luminances in wild-type mice and in mice lacking rod or cone function
    Christine Schmucker
    Section of Neurobiology of the Eye, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 46:398-407. 2005
    ..Furthermore, mutant mice lacking either rods (RHO-/- and CNGB1-/-) or cones (CNGA3-/-), or both, were studied to determine the rod and cone contribution to visual acuity...
  61. doi request reprint The pupillary light reflex pathway: cytoarchitectonic probabilistic maps in hemianopic patients
    E Papageorgiou
    Centre for Ophthalmology, Schleichstrasse 12 16, 72076, Tuebingen, Germany
    Neurology 70:956-63. 2008
    ..Further, we suggest a new strategy of lesion analysis by combining established techniques with the stereotaxic probabilistic cytoarchitectonic atlas developed by the Jülich group...
  62. ncbi request reprint Identification of apolipoprotein A-I as a "STOP" signal for myopia
    Eric Bertrand
    Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    Mol Cell Proteomics 5:2158-66. 2006
    ..The correlation of elevated apoA-I levels with reduced ocular axial growth points toward a functional relationship with the observed morphological changes of the eye...
  63. ncbi request reprint Corneal topography, refractive state, and accommodation in harbor seals (Phoca vitulina)
    Frederike D Hanke
    University of Freiburg, Institute of Biology I Zoology, D 79112 Freiburg, Germany
    Vision Res 46:837-47. 2006
    ..The brightness distribution in the pupils suggest the presence of a multifocal dioptric apparatus in air and underwater. We found a first indication for accommodation by dynamic recordings underwater...
  64. pmc High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect
    Machelle T Pardue
    Rehabilitation Research and Development Center, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Invest Ophthalmol Vis Sci 49:706-12. 2008
    ..Nob mice share the same mutation in the Nyx gene that is found in humans with complete congenital stationary night blindness (CSNB1). Nob mutant mice were studied to determine whether this defect resulted in myopia, as it does in humans...
  65. ncbi request reprint Optical aberrations in the mouse eye
    Elena García de la Cera
    Instituto de Optica Daza de Valdes, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Vision Res 46:2546-53. 2006
    ..In this study, we measured the ocular aberrations in the wild type mouse...