Alexander Sartorius

Summary

Country: Germany

Publications

  1. ncbi request reprint [Treating depressive disorders with continuation electroconvulsive therapy]
    A Sartorius
    Zentralinstitut fur Seelische Gesundheit, J5, Mannheim
    Nervenarzt 76:1363-9. 2005
  2. ncbi request reprint Lithium and ECT--concurrent use still demands attention: three case reports
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    World J Biol Psychiatry 6:121-4. 2005
  3. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
  4. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
  5. ncbi request reprint Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 7:246-50. 2006
  6. doi request reprint Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
  7. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
  8. doi request reprint Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness
    Patrick Lugenbiel
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:329-33. 2010
  9. ncbi request reprint Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Neuroreport 14:2199-201. 2003
  10. doi request reprint Electroconvulsive therapy in a patient after radiation treatment of a brain metastasis: a case report
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    J ECT 28:250-1. 2012

Collaborators

Detail Information

Publications35

  1. ncbi request reprint [Treating depressive disorders with continuation electroconvulsive therapy]
    A Sartorius
    Zentralinstitut fur Seelische Gesundheit, J5, Mannheim
    Nervenarzt 76:1363-9. 2005
    ..Today, cECT is underindicated as a result of assumed problems, fears, and stigmas. We would therefore recommend broader use of this proven treatment tool for keeping major depression in remission...
  2. ncbi request reprint Lithium and ECT--concurrent use still demands attention: three case reports
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    World J Biol Psychiatry 6:121-4. 2005
    ..Clinical consequences are discussed and disturbances of the blood brain barrier system as a speculative cause are hypothesized taking previous studies, animal studies and an additional reported clinical case into account...
  3. doi request reprint Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
    ..4 T animal system seems a promising tool to study underlying mechanisms since it allows for an accurate quantification of metabolites with distinction of glutamate, GABA and glutamine, as well as separation of taurine from choline...
  4. doi request reprint Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain
    Alexander Sartorius
    Central Institute of Mental Health, J5, Mannheim, Germany
    J Neurosci Methods 172:215-9. 2008
    ..An influence of tCr on the brain's energy regulating system seems plausible...
  5. ncbi request reprint Correlation between MR-spectroscopic rat hippocampal choline levels and phospholipase A2
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 7:246-50. 2006
    ..Our data show a significant inverse correlation (p = 0.018) between PLA2 protein levels and MRS Cho/NAA levels suggesting a possible downregulation of PLA2 in compensation for an upregulation of other phospholipases...
  6. doi request reprint Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol
    Traute Demirakca
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Drug Alcohol Depend 114:242-5. 2011
    ..Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD)...
  7. ncbi request reprint Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users
    Derik Hermann
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 61:1281-9. 2007
    ..Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes...
  8. doi request reprint Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness
    Patrick Lugenbiel
    Central Institute of Mental Health, Mannheim, Germany
    World J Biol Psychiatry 11:329-33. 2010
    ..In WT animals there was no treatment effect. In summary, our data presented here suggest an association between depressive behavior and cellular energy metabolism in defined brain areas...
  9. ncbi request reprint Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Neuroreport 14:2199-201. 2003
    ..A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed...
  10. doi request reprint Electroconvulsive therapy in a patient after radiation treatment of a brain metastasis: a case report
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    J ECT 28:250-1. 2012
    ....
  11. doi request reprint Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats
    Derik Hermann
    Department of Addiction Medicine, Central Institute for Mental Health, Mannheim, Germany
    Biol Psychiatry 71:1015-21. 2012
    ..Our understanding of this pathophysiological mechanism originates largely from animal studies, but human data are needed for translation into successful medication development...
  12. doi request reprint Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula
    Carolin Hoyer
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Neuropsychobiology 65:147-52. 2012
    ..However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated...
  13. doi request reprint In vivo voxel based morphometry: detection of increased hippocampal volume and decreased glutamate levels in exercising mice
    Sarah Biedermann
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Mannheim, Germany
    Neuroimage 61:1206-12. 2012
    ..An inverse correlation of hippocampal gray matter volume and glutamate concentration indicates a possible implication of the glutamatergic system for hippocampal volume...
  14. doi request reprint Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 261:575-82. 2011
    ....
  15. ncbi request reprint Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Neuroreport 18:1469-73. 2007
    ..Our results corroborate previous findings of an amino-acid influence on the pathomechanisms of mood disorders...
  16. doi request reprint Abnormal amygdala activation profile in pedophilia
    Alexander Sartorius
    Central Institute of Mental Health, J5, 68159, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 258:271-7. 2008
    ..More extensive research in this field would be of benefit for both the victims and the offenders...
  17. doi request reprint Exercise boosts hippocampal volume by preventing early age-related gray matter loss
    Johannes Fuss
    RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim ZI, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Hippocampus 24:131-4. 2014
    ..Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology. © 2013 Wiley Periodicals, Inc. ..
  18. ncbi request reprint [Continuation ECT]
    Alexander Sartorius
    Zentralinstitut fur Seelische Gesundheit, Mannheim
    Psychiatr Prax 32:408-11. 2005
    ..We would therefore recommend a broader use of this proven treatment tool for keeping major depressions in remission...
  19. doi request reprint Burst suppression: a more valid marker of postictal central inhibition?
    Laura Kranaster
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
    J ECT 29:25-8. 2013
    ....
  20. doi request reprint Influence of anesthetic drugs and concurrent psychiatric medication on seizure adequacy during electroconvulsive therapy
    Bogata D Bundy
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    J Clin Psychiatry 71:775-7. 2010
    ..We hypothesized a negative influence of anesthetics and benzodiazepines but a positive effect of antidepressants and antipsychotics concurrently applied during ECT on seizure adequacy...
  21. doi request reprint Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge
    Peggy Schneider
    Central Institute of Mental Health, Institute of Psychopharmacology, 68159 Mannheim, Germany
    Brain Behav Immun 26:277-83. 2012
    ..The FACS analysis showed a significant increase in CD25(+) microglia in the hippocampus compared to controls. The results support the role of microglia as a mediator in the immune-CNS communication and the effects of peripheral IL-2...
  22. ncbi request reprint Diffusion weighted MRI in the early phase after electroconvulsive therapy
    Kristina Szabo
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Neurol Res 29:256-9. 2007
    ..These findings are in line with previous negative studies using conventional MRI. Higher resolution DWI and serial imaging may be necessary to visualize possible minimal signal changes after ECT...
  23. ncbi request reprint Subcortical and medial temporal MR-detectable metabolite abnormalities in unipolar major depression
    Gabriele Ende
    Division Neuroimaging, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 257:36-9. 2007
    ..Abnormal levels of choline-containing compounds most likely reflect altered membrane phospholipid metabolism. A reduced level in the hippocampus and an increased level in the putamen suggest regionally opponent membrane abnormalities...
  24. doi request reprint One ring to rule them all?--Temporospatial specificity of deep brain stimulation for treatment-resistant depression
    Carolin Hoyer
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, 68159 Mannheim, Germany Electronic address
    Med Hypotheses 81:611-8. 2013
    ....
  25. ncbi request reprint Deep brain stimulation of the lateral habenula in treatment resistant major depression
    Alexander Sartorius
    Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    Med Hypotheses 69:1305-8. 2007
    ..Possible criteria for patient selection, ethical issues and locus of DBS are carefully discussed...
  26. doi request reprint An integrated genome research network for studying the genetics of alcohol addiction
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Addict Biol 15:369-79. 2010
    ....
  27. pmc Electroconvulsive therapy induces neurogenesis in frontal rat brain areas
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    PLoS ONE 8:e69869. 2013
    ..We provide here the first evidence that ECT stimulates neurogenesis in areas outside the hippocampus. Our data may open research possibilities that focus on the plastic changes induced by ECT in frontal limbic circuitry. ..
  28. doi request reprint Efficacy and cognitive side effects of electroconvulsive therapy (ECT) in depressed elderly inpatients with coexisting mild cognitive impairment or dementia
    Lucrezia Hausner
    Department of Geriatric Psychiatry, Central Institute of Mental Health, Sq J5, D 68159 Mannheim, Germany
    J Clin Psychiatry 72:91-7. 2011
    ..To study cognitive performance in depressed geriatric inpatients with or without preexisting cognitive impairment who received a first course of electroconvulsive therapy (ECT)...
  29. ncbi request reprint Choline rise in the rat hippocampus induced by electroconvulsive shock treatment
    Alexander Sartorius
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 53:620-3. 2003
    ..We hypothesized a hippocampal choline increase in the rat brain under electroconvulsive shock (ECS) treatment...
  30. doi request reprint Genetic fate mapping of type-1 stem cell-dependent increase in newborn hippocampal neurons after electroconvulsive seizures
    Tillmann Weber
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, Mannheim, Germany Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, J5, 68159, Germany
    Hippocampus 23:1321-30. 2013
    ..The ability of high- and low-frequency ECS to induce normally quiescent type-1 cells to proliferate and generate new neurons sets it apart from other antidepressant treatments and may underlie the superior clinical efficacy of ECT...
  31. ncbi request reprint Management of severe postictal agitation after electroconvulsive therapy with bispectrum electroencephalogram index monitoring: a case report
    Laura Kranaster
    From the Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg and Department of Anaesthesiology and Critical Care Medicine, Medical Centre Mannheim, Mannheim, Germany
    J ECT 28:e9-e10. 2012
    ..1%. Bispectral index (BIS) monitoring made prediction and prevention of PIA possible to some degree. Postictal agitation might occur in vulnerable patients when initial depth of anesthesia is too light...
  32. ncbi request reprint Electroconvulsive therapy in a patient receiving rivastigmine
    Mathias Zink
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    J ECT 18:162-4. 2002
    ..The hypothesis that this drug may indeed protect against unfavorable side effects of ECT should be further tested in clinical trials...
  33. doi request reprint Implications of fMRI and genetics for the law and the routine practice of forensic psychiatry
    Harald Dressing
    Zentralinstitut fur Seelische Gesundheit Mannheim, Universitat Heidelberg, Mannheim, Germany
    Neurocase 14:7-14. 2008
    ..Rather, optimal integration of neurobiological findings requires cooperation among many disciplines such as medicine, criminology, sociology, psychology, politics and neuroscience...
  34. ncbi request reprint Clozapine-induced lupus erythematosus
    Joachim Wolf
    J Clin Psychopharmacol 24:236-8. 2004
  35. ncbi request reprint High-dose clozapine intoxication
    Alexander Sartorius
    J Clin Psychopharmacol 22:91-2. 2002